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Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols

COLD SPRING HARBOR, N.Y. (Wed., Aug. 5, 2009) Vectors derived from retroviruses are useful tools for long-term gene transfer because they allow stable integration of transgenes and propagation into daughter cells. Lentiviral vectors are preferred because they can transduce non-proliferating ce...

New stem cell research could reduce number of animal experiments

Researchers from the University of Bath are embarking on a project to use stem cell technology that could reduce the number of animal experiments used to study conditions such as motor neurone disease. Dr Vasanta Subramanian, from the University's Department of Biology & Biochemistry, will be d...

Placenta-derived stem cells may help sufferers of lung diseases

Tampa, Fla. (July 27, 2009) An Italian research team, publishing in the current issue of Cell Transplantation (18:4), which is now available on-line without charge at http://www.ingentaconnect.com/content/cog/ct , has found that stem cells derived from human placenta may ultimately play a role...

Skin-like tissue developed from human embryonic stem cells

BOSTON (July 21, 2009) Dental and tissue engineering researchers at Tufts University School of Dental Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts have harnessed the pluripotency of human embryonic stem cells (hESC) to generate complex, multilayer tissues that mimic hu...

First cGMP feeder-independent pluripotent stem cell banks released for distribution

MADISON The WiCell Research Institute and the Waisman Clinical Biomanufacturing Facility (WCBF) announced today (July 6) the release of the first current Good Manufacturing Practices (cGMP) feeder-independent pluripotent stem cell banks available for sale and distribution to researchers worldwide...

Neural stem cell differentiation factor discovered

Neural stem cells represent the cellular backup of our brain. These cells are capable of self-renewal to form new stem cells or differentiate into neurons, astrocytes or oligodendrocytes. Astrocytes have supportive functions in the environment of neurons, while oligodendrocytes form the myelin lay...

Xie Lab uncovers molecular machinery related to stem cell fate

The Stowers Institute's Xie Lab has revealed how the BAM protein affects germline stem cell differentiation and how it is involved in regulating the quality of stem cells through intercellular competition. The work was published today by PNAS Early Edition. Maintaining the proper balance betw...

Children's Hospital Oakland scientists first to discover new source for harvesting stem cells

June 23, 2009Oakland, Calif. A groundbreaking study conducted by Children's Hospital & Research Center Oakland is the first to reveal a new avenue for harvesting stem cells from a woman's placenta, or more specifically the discarded placentas of healthy newborns. The study also finds there are fa...

UCLA cancer researchers develop model that may help identify cancer stem cells

Researchers at UCLA's Jonsson Comprehensive Cancer Center, on a quest to find lung cancer stem cells, have developed a unique model to allow further investigation into the cells that many believe may be at the root of all lung cancers. If researchers could find a way to isolate and grow lung c...

Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine

(PHILADELPHIA) Scientists at Jefferson Medical College have received a five-year, $1.7 million National Institutes of Health grant funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases to study mechanisms regulating stem cell self-renewal and differentiation with the...

Engineered pig stem cells bridge the mouse-human gap

The discovery that adult skin cells can be 'reprogrammed' to behave like stem cells has been a major scientific boon, providing a way to tap the potential of embryonic stem cells without the associated ethical quandaries. Now, in a study appearing online in JBC, researchers have created a line of ...

Combined stem cell-gene therapy approach cures human genetic disease in vitro

LA JOLLA, CAA study led by researchers at the Salk Institute for Biological Studies, has catapulted the field of regenerative medicine significantly forward, proving in principle that a human genetic disease can be cured using a combination of gene therapy and induced pluripotent stem (iPS) cell t...

Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue

BUFFALO, N.Y. -- University at Buffalo researchers have demonstrated for the first time that injecting adult bone marrow stem cells into skeletal muscle can repair cardiac tissue, reversing heart failure. Using an animal model, the researchers showed that this non-invasive procedure increased...

Activated stem cells in damaged lungs could be first step toward cancer

DURHAM, N.C. Stem cells that respond after a severe injury in the lungs of mice may be a source of rapidly dividing cells that lead to lung cancer, according to a team of American and British researchers. "There are chemically resistant, local-tissue stem cells in the lung that only activate...

Award for pioneering stem cell research to mend broken bones

Funding from the Biotechnology and Biological Sciences Research Council (BBSRC) could lead to the development of new and better treatments for broken bones and other orthopaedic problems associated with ageing. Nearly 4M has been awarded to scientists from the universities of Keele, Imperial Co...

Gene therapy could expand stem cells' promise

Once placed into a patient's body, stem cells intended to treat or cure a disease could end up wreaking havoc simply because they are no longer under the control of the clinician. But gene therapy has the potential to solve this problem, according to a perspective article from physician-scienti...

BIO 2009 -- R&D session: New stem cell research unlocks unknown therapies

Meet Dr Jonas Frisen, one of the most successful scientists within stem cell research, at an R&D session in the worlds largest convention for biotech and pharmaceuticals, BIO 2009 in Atlanta, USA. The session is arranged by the Swedish medical university Karolinska Institutet, SwedenBIO and Invest...

How an enzyme tells stem cells which way to divide

Driving Miranda, a protein in fruit flies crucial to switch a stem cell's fate, is not as complex as biologists thought, according to University of Oregon biochemists. They've found that one enzyme (aPKC) stands alone and acts as a traffic cop that directs which roads daughter cells will take. ...

WARF signs license agreement with Pfizer for human embryonic stem cells

MADISON Pfizer Inc., a major biopharmaceutical company, and the Wisconsin Alumni Research Foundation (WARF), the private, nonprofit patenting and licensing organization for the University of Wisconsin-Madison, announced May 5 that they have signed a license for human embryonic stem (hES) cell pat...

Hebrew University researchers neutralize tumor growth in embryonic stem cell therapy

Jerusalem, May 5, 2009 Researchers at the Hebrew University of Jerusalem have discovered a method to potentially eliminate the tumor-risk factor in utilizing human embryonic stem cells. Their work paves the way for further progress in the promising field of stem cell therapy. Human embryonic ...

Scientists shed light on inner workings of human embryonic stem cells

(Santa Barbara, Calif.) Scientists at UC Santa Barbara have made a significant discovery in understanding the way human embryonic stem cells function. They explain nature's way of controlling whether these cells will renew, or will transform to become part of an ear, a liver, or any other part...

Study finds blood cells can be reprogrammed to act as embryonic stem cells

(WASHINGTON, April 20, 2009) - In a recent study, U.S. researchers have reprogrammed cells found in circulating blood into cells that are molecularly and functionally indistinguishable from embryonic stem cells, a revolutionary achievement that provides a readily accessible source of stem cells an...

Nutrition experts propose new class of low-sugar drinks to help stem obesity and diabetes epidemics

Boston, MA -- Strong evidence developed at Harvard School of Public Health (HSPH) and elsewhere shows that sugary drinks are an important contributor to the epidemic rise of obesity and type 2 diabetes in the United States. Faced with these growing public health threats, experts from the Departmen...

World premiere in stem cell research in Montreal

A team from the Institute for Research in Immunology and Cancer (IRIC) at Universit de Montral has succeeded in producing a large quantity of laboratory stem cells from a small number of blood stem cells obtained from bone marrow. The multidisciplinary team, directed by Dr. Guy Sauvageau, thus too...

Amniotic fluid may provide new source of stem cells for future therapies

(WASHINGTON, March 31, 2009) - For the first time, scientists have shown that amniotic fluid (the protective liquid surrounding an embryo) may be a potential new source of stem cells for therapeutic applications. The study was prepublished online on February 12, 2009, in Blood , the official jour...

Novocell awarded seminal stem cell patent

San Diego, CA (March 31, 2009) Novocell, Inc., a stem cell engineering company, today announced that it has received U.S. Patent 7,510,876 with claims covering human definitive endoderm cells, an essential cell for generating not only pancreatic type cells, which Novocell is developing for use as...

Eye cells believed to be retinal stem cells are misidentified

Cells isolated from the eye that many scientists believed were retinal stem cells are, in fact, normal adult cells, investigators at St. Jude Children's Research Hospital have found. If retinal stem cells could be obtained, they might provide the basis for treatments to restore sight to millions o...

Stem cell breakthrough: Monitoring the on switch that turns stem cells into muscle

In a genetic engineering breakthrough that could help everyone from bed-ridden patients to elite athletes, a team of American researchersincluding 2007 Nobel Prize winner Mario R. Capecchihave created a "switch" that allows mutations or light signals to be turned on in muscle stem cells to monitor...

Rensselaer receives more than $2 million from New York State to fund stem cell research

Troy, N.Y. Two groups of Rensselaer researchers each have received a $1.08 million grant from New York through the state's stem cell research initiative. Both grants will fund research on the growth and development of stem cells and will provide some of the first insights available into the role ...

CEL-SCI Corporation to Launch Aseptic Filling for Stem Cell Produced Therapies and Other Biological Products

VIENNA, Va., March 10 /PRNewswire-FirstCall/ -- CEL-SCI Corporation (NYSE Alternext US: CVM) announced today that it is planning to launch a new manufacturing process that could allow drugs developed using stem cells and other biological products to maintain their potency and thereby potentially ...

Protein is key to embryonic stem cell differentiation

LA JOLLA, Calif., March 18, 2009 -- Investigators at Burnham Institute for Medical Research (Burnham) have learned that a protein called Shp2 plays a critical role in the pathways that control decisions for differentiation or self-renewal in both human embryonic stem cells (hESCs) and mouse embryo...

Multiple route bone marrow stem cell injections show promise to treat spinal cord injury

Tampa, Fla. (Mar. 12, 2009) Researchers from DaVinci Biosciences, Costa Mesa, California, in collaboration with Hospital Luis Vernaza in Ecuador, have determined that injecting a patient's own bone marrow-derived stem cells (autologous BMCs) directly into the spinal column using multiple routes c...

Empire State Stem Cell Board awards $12.7 million to Albert Einstein College of Medicine

March 10, 2009 ─ (BRONX, NY) ─ For the third time in 14 months, the Empire State Stem Cell Board has awarded Albert Einstein College of Medicine of Yeshiva University funding for stem cell research. The new grants, totaling $12.7 million, will help create technologies for treating sick...

'Seeing' stem cells helps in fight against peripheral arterial disease

SAN DIEGO, Calif. (March 10, 2009)Interventional radiologists are fitting together the puzzle pieces of how to use stem cells to create new or more blood vessels to treat peripheral arterial disease (PAD) in those individuals with extensively narrowed or clogged arteries. That puzzle may be closer...

Mount Sinai Hospital researcher makes stem cell breakthrough

(Toronto, ON, February 25, 2009) In a study to be released on March 1, 2009, Mount Sinai Hospital's Dr. Andras Nagy discovered a new method of creating stem cells that could lead to possible cures for devastating diseases including spinal cord injury, macular degeneration, diabetes and Parkinson...

Ex vivo neural stem cell expansion

In the March 1 issue of G&D, Dr. Christopher Fasano (Memorial Sloan-Kettering Cancer Center) and colleagues lend new mechanistic insight into the effective generation of neural stem cells outside of the neurogenic niche. Their upcoming paper demonstrates that the polycomb group protein, Bmi-1, ...

Researchers piggyback to safer reprogrammed stem cells

Austin Smith and his research team at the Centre for Stem Cell Research in Cambridge have just published in the journal Development ( http://dev.biologists.org/ ) a new and safer way of generating pluripotent stem cells the stem cells that can give rise to every tissue of the body. Rapid deve...

From stem cells to new organs: Stanford and NYU scientists cross threshold in regenerative medicine

By now, most people have read stories about how to "grow your own organs" using stem cells is just a breakthrough away. Despite the hype, this breakthrough has been elusive. A new report published in the March 2009 issue of The FASEB Journal ( http://www.fasebj.org ) brings bioengineered organs ...

UCLA stem cells scientists make electrically active motor neurons from iPS cells

Stem cells scientists at UCLA showed for the first time that human induced pluripotent stem (iPS) cells can be differentiated into electrically active motor neurons, a discovery that may aid in studying and treating neurological disorders. Additionally, the motor neurons derived from the iPS c...

Researcher seeks to turn stem cells into blood vessels

A Johns Hopkins engineer is trying to coax human stem cells to turn into networks of new blood vessels that could someday be used to replace damaged tissue in people with heart disease, diabetes and other illnesses. Sharon Gerecht, an assistant professor of chemical and molecular engineering in...
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