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A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020

Based on successful animal studies, a novelvaccine that uses immune cells as factories to produce Her2/neu proteinmay offer a way to treat some human breast cancers, say researchers atThe University of Texas M. D. Anderson Cancer Center. [Ed : is a protein often present / surexpressed in <a href="http://en.wikipedia.org/...

NYC's First Rapid HIV Drug-resistant AIDS Case Prompts Call to Step Up HIV Prevention

New York City's Public Health Department today issued a public health advisory after reporting the first documented case of an alarming, new, rapidly-progressing and highly drug resistant strain of HIV in a New York man who progressed from his initial HIV infection, thought to have occurred in mid-October 2004, to a largely untreatable strain of AIDS in just three months. According to City...

Antiretroviral therapy may prevent excess risk of some cancers in people with HIV

In people infected with human immunodeficiency virus (HIV), highly active antiretroviral therapy (HAART) may prevent most excess cases of Kaposi sarcoma and non-Hodgkin lymphoma, according to a new study in the March 16 issue of the Journal of the National Cancer Institute. Studies of people with acquired immunodeficiency syndrome (AIDS) have reported increased risks of several cancers, in...

Rare surgery performed to remove pancreas, prevent diabetes

In a 12-hour, dual-stage surgery known to be performed at only two other centers in the U.S., doctors at the University of Alabama at Birmingham on Tuesday returned a patient's own insulin-producing cells to him after surgically removing his pancreas to eliminate constant, severe pain from chronic pancreatitis. The patient, Leonard Stewart, 47, of Panama City, Fla., remained anesthetized i...

Yeast Network Prevents Damage By Oxygen Radicals

Reactive oxygen species (ROS), or 'oxygen radicals', have been identified as major contributors to signs of premature aging, increased cancer prevalence linked to inflammation-associated syndromes and a variety of human diseases. Now scientists at the University of California, San Diego Branch of the Ludwig Institute for Cancer Research (LICR) have identified a key network of DNA repair and cell...

Different microarray systems more alike than previously thought

A multicenter comparison of equipment that can analyze the expression of thousands of genes at once to create a genetic "fingerprint," suggests these different microarray technologies are more alike than once thought. Published in the May 2005 issue of Nature Methods, the study provides new hope that the mounds of information generated by these systems might actually be comparable, even t...

Undesirable expatriates: Preventing the spread of invasive animals

Reconsider relocating aquarium fish into your backyard pond. Restrain yourself from ordering exotic pets off the Internet, no matter how interesting they might look in the pictures. And vote for politicians that encourage sound port inspection. Because, according to recent Proceedings of the National Academy of Sciences article by Drs. Jonathan M. Jeschke and David L. Strayer, our best defense in...

Oceans more vulnerable to agricultural runoff than previously thought, study finds

Researchers have long suspected that fertilizer runoff from big farms can trigger sudden explosions of marine algae capable of disrupting ocean ecosystems and even producing "dead zones" in the sea. Now a new study by Stanford University scientists presents the first direct evidence linking large-scale coastal farming to massive algal blooms in the sea. Writing in the March 10 issue of th...

Protein prevents detrimental immune effects of bacterial sepsis

The anti-inflammatory protein annexin 1 may protect patients from the detrimental effects of severe inflammatory response syndrome, as reported by researchers at Barts and the London, Queen Mary's School of Medicine and Dentistry. The paper by Damazo et al., "Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation," appears in the June issue of The Americ...

Atmosphere may cleanse itself better than previously thought

A research team from Purdue University and the University of California, San Diego has found that the Earth’s atmosphere may be more effective at cleansing itself of smog and other damaging hydrocarbons than was once thought. Scientists, including Joseph S. Francisco, have learned that some naturally occurring atmospheric chemicals react with sunlight more effectively than previously thou...

Active Vaccine Prevents Mice From Developing Prion Disease

NYU School of Medicine scientists have created the first active vaccine that can significantly delay and possibly prevent the onset of a brain disease in mice that is similar to mad cow disease. The new findings, published online this week in the journal Neuroscience, could provide a platform for the development of a vaccine to prevent a group of fatal brain diseases caused by unusual infectious...

Understanding how bacteria communicate may help scientists prevent disease

Rahul Kulkarni, assistant professor of physics at Virginia Tech, has been awarded a Ralph E. Powe Junior Faculty Enhancement Award from Oak Ridge Associated Universities to continue his research on quorum sensing in bacteria. He is modeling the sequence of events that initiate activity, such as virulence, by a bacteria colony once it has reached a critical size. The Powe award provides see...

Antiretroviral Therapy May Prevent HIV Transmission From Breastfeeding Mothers To Infants

Two new studies support the hypothesis that combination antiretroviral drug therapy may reduce the risk of mother-to-child HIV transmission through breastfeeding, findings that could have significant implications in the developing world. Researchers in the first study found mothers pass antiretroviral medications on to their breastfeeding infants in concentrations high enough to prevent in...

Does vitamin C help prevent or treat the common cold? Maybe not, after all.

Linus Pauling's book Vitamin C and The Common Cold, published in 1970, was a bestseller and led many people to believe in the value of the vitamin for cold prevention and treatment. But an article in this month's PLoS Medicine reviewing all of the best clinical research on this topic, suggests that the public's enthusiasm for the vitamin may be unjustified. Robert M Douglas of the Australi...

Cancer related gene p53 not regulated as indicated by previous tissue culture research

The cellular cascade of molecular signals that instructs cells with fatally damaged DNA to self-destruct pivots on the p53 tumor suppressor gene. If p53 is inactivated, as it is in over half of all human cancers, checks and balances on cell growth fail to operate, and body cells start to accumulate mutations, which ultimately may lead to cancer. Not surprisingly, the regulation of this vital safe...

Late peak may have prevented severe flu season from becoming worse

The 2004-2005 flu season was at least as severe as the 2003-2004 season, but peaked later according to data from Solucient, a leading provider of healthcare information. This later peak may have prevented the most recent flu season from being even worse. A flu season's severity is reflected in hospital admissions for community-acquired pneumonia (CAP), one of the most common complications...

A protein in the eye may prevent immune response and protect eyes from disease

Scientists at The Schepens Eye Research Institute have discovered that a protein known as F4/80 found on immune cells in the eye and other parts of the body may have a function in the regulation of the body's immune response and protect delicate tissues that cannot survive the "inflammation" inherent in full-blown immunity. "We believe that this discovery may ultimately help in the develop...

Size matters: Preventing large mammal extinction

Saving large mammals such as elephants and rhino from extinction could be made more effective by focusing efforts on individual species as well as their habitats. Scientists at the Zoological Society of London's Institute of Zoology (IoZ) and Imperial College London have identified fundamental new approaches to improve the success of large mammal conservation. Published today in the journa...

Six previously blind patients detect light, motion, identify objects with retinal prostheses

Researchers from the University of Southern California and the Doheny Eye Institute's Doheny Retina Institute will be presenting data on the first six patients implanted with an intraocular retinal prosthesis-more popularly referred to as an artificial retina-developed and manufactured in partnership with Second Sight Medical Products, Inc., of Sylmar, Calif. According to Mark Humayun, pro...

President Bush's cut to AIDS prevention in Africa would be devastating

Twenty-eight years after intense selective logging stopped in the region now known as Uganda's Kibale National Park, the red-tailed guenon (Cercophithecus ascanius) is a primate still in decline. The logging practice, scientists report in a new study, changed the ecological balance for these monkeys, leading to behavioral changes and opening the door for multiple parasitic infections. The...

Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy

A common chemical used in the manufacturing and pharmaceutical industries can repair damage to cardiac muscle cell membranes and prevent heart failure in mice with the genetic mutation that causes Duchenne muscular dystrophy, according to scientists at the University of Michigan Medical School. The mutation in the dystrophin gene causes the progressive deterioration of skeletal muscles see...

Vaginal gel may provide a new approach to HIV prevention

Research with female monkeys at the Tulane National Primate Research Center has for the first time shown that three different anti-viral agents in a vaginal gel protect the animals against an HIV-like virus. The research suggests that a microbicide using compounds that inhibit the processes by which HIV attaches to and enters target cells could potentially provide a safe, effective and practical...

Brain works more chaotically than previously thought

The brain appears to process information more chaotically than has long been assumed. This is demonstrated by a new study conducted by scientists at the University of Bonn. The passing on of information from neuron to neuron does not, they show, occur exclusively at the synapses, i.e. the junctions between the nerve cell extensions. Rather, it seems that the neurons release their chemical messeng...

Why were the HIV prevention trials in commercial sex workers abandoned?

One promising approach to help stem the global HIV epidemic is to give commercial sex workers an HIV medication (such as the drug tenofovir) before they have high risk sex in the hope of reducing their chances of becoming infected, an approach called "pre-exposure prophylaxis" (PREP). But activist groups, including Act Up-Paris have "halted the progress of at least two important clinical trials o...

Suppressing growth hormone in early adulthood may prevent cancer

A modest suppression of growth hormone and related compounds beginning in early adulthood may delay the onset or progression of several types of cancer, researchers from Wake Forest University School of Medicine and other centers reported today at ENDO 2005, the annual meeting of the Endocrine Society, in San Diego. Suppression of growth hormone and insulin-like growth factor (IGF-1) also...

WCS says avian flu prevention should focus on farms, markets

Wildlife health experts from the Bronx Zoo-based Wildlife Conservation Society (WCS) warn that efforts to control the spread of avian flu across Asia and beyond must focus on better management practices on farms and in markets. WCS is currently working with Mongolian agencies on the ground in Mongolia's Kovsgol province, collecting samples from wild birds that have recently contracted the...

Trio of plant genes prevent 'too many mouths'

A signaling pathway required for plants to grow to their normal size appears to have an unexpected dual purpose of keeping the plant from wallpapering itself with too many densely clustered stomata. "It's surprising that size and stomata patterning ?both key to plants being able to survive on dry land ?are using the same signaling components," says Jessica McAbee, a University of Washingto...

Controlling wildlife trade key to preventing health crises, study says

According to a study by the New York-based Wildlife Conservation Society, controlling the movements of wildlife in markets is a cost-effective means of keeping potential deadly pandemics such as SARS and influenza from occurring. The study appears in the July edition of the journal Emerging Infectious Diseases. The cost of controlling the spread of diseases afflicting both human and animal popula...

Immune system has evolved to prevent autoimmune disease

Study suggests chronic infections may create autoimmune response New research finds the human immune system has foregone evolutionary changes that would allow it to produce better antibodies in less time because the improved antibodies would be far more likely to attack the body's own tissues. The Rice University study finds the immune system has evolved a near-perfect balance for produci...

New study shows measles immunization may prevent fatal brain infection

A new study has found wild-type measles virus in tissues from patients who died of a fatal brain infection, providing evidence against the notion that the strain of virus in the measles vaccine caused the infection. The study, in the November 15 issue of The Journal of Infectious Diseases, now available online, also concludes that vaccination against measles could prevent many more cases of the...

Preventing a pandemic: Study suggests strategies for containing a flu outbreak

Though quick to caution about the many things that could go wrong, researchers say that it may be possible to contain a Southeast Asian outbreak of avian influenza in humans, buying precious time for the production of a vaccine. Using a computer model to simulate an outbreak in a rural Southeast Asian population, the scientists have shown how a combination of strategies, including targeted...

Gene therapy works in mice to prevent blindness that strikes boys

University of Florida scientists used a healthy human gene to prevent blindness in mice with a form of an incurable eye disease that strikes boys. Writing in the August issue of Molecular Therapy, scientists from the UF Genetics Institute describe how they successfully used gene therapy in mice to treat retinoschisis, a rare genetic disorder that is passed from mothers, who retain their s...

Katrina floodwaters not as toxic to humans as previously thought, study says

The floodwaters that inundated New Orleans immediately following Hurricane Katrina were similar in content to the city?s normal storm water and were not as toxic as previously thought, according to a study by researchers at Louisiana State University. Their study, the first peer-reviewed scientific assessment of the water quality of the Katrina floodwaters, is good news for those who've been expo...

Microbes under Greenland Ice may be preview of what scientists find under Mars' surface

A University of California, Berkeley, study of methane-producing bacteria frozen at the bottom of Greenland's two-mile thick ice sheet could help guide scientists searching for similar bacterial life on Mars. Methane is a greenhouse gas present in the atmospheres of both Earth and Mars. If a class of ancient microbes called Archaea are the source of Mars' methane, as some scientists have p...

In SAD patients, autumn antidepressants can prevent winter depression

For patients with seasonal affective disorder (SAD), starting treatment with an antidepressant medication during the fall can reduce the risk of developing depression throughout the fall and winter months, reports a study in the Oct. 15 issue of Biological Psychiatry, official journal of the Society of Biological Psychiatry, published by Elsevier, a world-leading scientific and medical publisher....

Mouse study: New muscle-building agent beats all previous ones

The Johns Hopkins scientists who first created "mighty mice" have developed, with pharmaceutical company Wyeth and the biotechnology firm MetaMorphix, an agent that's more effective at increasing muscle mass in mice than a related potential treatment for muscular dystrophy now in clinical trials. The new agent is a version of a cellular docking point for the muscle-limiting protein myostat...

Free HIV tests cheaper than charging when goal is preventing AIDS

Offering free HIV tests instead of charging a small fee is more cost-effective at preventing HIV infections and draws in three times as many people for testing, according to a Duke University Medical Center study conducted in Tanzania. The Duke researchers provided free HIV tests and counseling during a two-week pilot program in 2003. The number of people seeking tests increased from 4.1...

Successful cell engineering may lead to mad cow prevention, say researchers

Researchers at Texas A&M University have successfully "knocked down" the expression of possible disease-causing genes in a cloned goat fetus, perhaps paving the way for breeding disease resistance in other animals, even those genes that might cause bovine spongiform encephalopathy (BSE), commonly known as Mad Cow Disease. Researchers Mark Westhusin and Charles Long in Texas A&M's C...

Genomics-based vaccine could prevent deadly cattle disease

Every year, East Coast fever destroys the small farmer's dream of escaping poverty in Africa. Killing more than a million cattle and costing some $200 million annually, this tick-borne disease rages across a dozen countries in eastern and central Africa. Now, an international team of scientists has taken the first major step toward a vaccine to prevent East Coast fever. Their work, published in t...

Anti-HIV drug has potential to prevent transmission in women

A new study from infectious disease researchers at The Miriam Hospital and Brown Medical School finds that a drug already given orally to treat HIV is also safe when applied as a vaginal microbicide gel. Microbicides are designed to prevent the sexual transmission of HIV and other sexually transmitted diseases and may be formulated as vaginal gels, foams, creams, or suppositories. "The re...