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New piece found in the puzzle of epigenetics

This release is available in German . For many years scientists have known that the numerous biological functions of an organism are not regulated solely by the DNA sequence of its genes: Superordinate regulatory mechanisms exist that contribute to determining the fate of genes. Although ...

Aerosol: A key piece of the climate change puzzle

Fitting all the different pieces of the climate change puzzle together is one of the major challenges of our age. Aerosol is a key piece of this puzzle, but the size and shape of its effect is still unclear a fact that jeopardises the reliability of all current predictions of climate change. ...

Missing piece of plant clock found

Biologists at the University of California, San Diego have identified a key protein that links the morning and evening components of the daily biological clock of plants. Their discovery, detailed in the March 13 issue of Science , solves a longstanding puzzle about the underlying biochemical ...

Researchers solve piece of large-scale gene silencing mystery

A team led by Craig Pikaard, Ph.D., WUSTL professor of biology in Arts & Sciences, has made a breakthrough in understanding the phenomenon of nucleolar dominance, the silencing of an entire parental set of ribosomal RNA genes in a hybrid plant or animal. Since the machinery involved in nucleo...

Hopkins researchers piece together gene 'network' linked to schizophrenia

Reporting this week in the Archives of General Psychiatry, researchers at the Johns Hopkins University School of Medicine have uncovered for the first time molecular circuitry associated with schizophrenia that links three previously known, yet unrelated proteins. "This is very exciting becaus...

Iowa State researchers help piece together the corn genome's first draft

AMES, Iowa Iowa State University researchers helped write the first draft of the corn genome sequence that will be announced Thursday, Feb. 28, at the 50th Annual Maize Genetics Conference in Washington, D.C. Patrick Schnable, a Baker Professor of Agronomy and director of the Center for Plant ...

Researchers uncover new piece to the puzzle of human height

In studies involving more than 35,000 people and a survey across the entire human genome, an international team supported in part by the National Institutes of Health (NIH) has found evidence that common genetic variants recently linked to osteoarthritis may also play a minor role in human height....

Scientists unveil piece of HIV protein that may be key to AIDS vaccine development

In a finding that could have profound implications for AIDS vaccine design, researchers led by a team at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), have generated an atomic-level picture of a key portion of an HIV surface prot...

Engineering the heart piece by piece

Some day, heart attack survivors might have a patch of laboratory-grown muscle placed in their heart, to replace areas that died during their attack. Children born with defective heart valves might get new ones that can grow in place, rather than being replaced every few years. And people with clog...

'Sinkers' provide missing piece in deep-sea puzzle

One of the biggest questions in modern oceanography is how animals in the deep sea get enough to eat. Marine biologists at the Monterey Bay Aquarium Research Institute (MBARI) recently published a paper that helps answer this question, at least for animals that live on the deep seafloor off the coa...

Massey Cancer Center researcher helps to identify a piece of the cancer puzzle

A structural biologist from the Virginia Commonwealth University Massey Cancer Center, in collaboration with researchers at Memorial Sloan-Kettering Cancer Center, has identified the crystal structure of a protein that plays a role in supplying nutrients to solid tumors. This identification may h...

Biochemists report discovery of structure of major piece of telomerase; implications for cancer

UCLA biochemists have determined the three-dimensional structure of a major domain of telomerase, the enzyme that helps maintain telomeres ?small pieces of DNA on the ends of chromosomes that act as protective caps -- allowing DNA ends to be copied completely when cells are replicated. This is t...

A puzzle piece found in unraveling the wiring of the brain

The complexity of the brain and, more specifically, how nerve cells form billions of contacts when there are fewer than 30,000 human genes is still a scientific mystery. A team headed by Drs. Robin Hiesinger and Hugo J. Bellen at Baylor College of Medicine in Houston have unraveled a piece of tha...

Scary ancient spiders revealed in 3-D models, thanks to new imaging technique

...iled into precise 3D models, using custom-designed software. Both Cryptomartus hindi and Eophrynus prestivicii were around the size of a 50 pence piece and they roamed the Earth during the Carboniferous period, 359 299 million years ago. This was a time before the dinosaurs, when life was emerging fr...

Structure of protective protein in the eye lens revealed

... "molecular machines" depend largely on their three-dimensional structure. In the first instance, proteins are long chains of amino acids, like a long piece of woolen thread. So-called chaperones help them to fold in the desired three-dimensional form after their production. If this folding process fails, ...

Douglas-fir, geoducks make strange bedfellows in studying climate change

...show annual growth through rings. They recently discovered that wider growth rings reflect low river flows during that year, which is another valuable piece of climate information. "We're not sure why low river flows are associated with good growth in freshwater mussels," Black said. "High-flow events m...

Cancer's distinctive pattern of gene expression could aid early screening and prevention

...Center, Cecil F. Whitaker Jr., M.D./Georgia Research Alliance Eminent Scholar in Cancer and Georgia Cancer Coalition Scholar. DNA methylation is a piece of a relatively new research field called epigenetics that looks more globally at which genes are turned off and on with an eye on early identificatio...

Sticky protein helps reinforce fragile muscle membranes

...n called alpha dystroglycan as the "glue" that binds muscle membranes to a tough layer of extracellular proteins called the basal lamina. Just as a piece of sticky tape can prevent a pin from bursting a balloon, the sturdy basal lamina reinforces muscle cell membranes and keeps small tears from bursting...

'Science Under Siege'

...f responses (many angry) and was selected by Richard Dawkins for the Best Science and Nature Writing of 2003. Carl Sagan's final question-and-answer piece on the topic of science and skeptical inquiry. Ann Druyan's beautifully expressed "Science, Religion, Wonder, and Awe." NASA scientist Stuart Jord...

Exploring standards to advance microbial genomics

...at lie beyond the present anthropocentric focus and would also institute shared standards for genomic data collection and analysis. In a perspective piece published in the July issue of the journal Nature Biotechnology , Kyrpides reflects on the role of microbial studies in the genomics revolution of th...

Analysis of Copernicus putative remains support identity

...f the putative remains of Copernicus. A DNA-analysis of shed of hairs found in a book from Museum Gustavianum, Uppsala University, was one interesting piece in the project. The efforts to identify the remains of Nicolaus Copernicus (1473-1543), found under the cathedral in Frombork, was made in a collab...

Hurricane Katrina: Phone home

... signals collected from cell phone towers as they communicate with base stations and our handsets, weather forecasters will now have a crucial missing piece of information for flood prediction that they never had before. It will permit forecasters and residents alike to more accurately gauge the danger the...

Chromosomal problems affect nearly all human embryos

...PGD is carried out where one or both parents have a known genetic abnormality, in this case an X-linked disorder or the microdeletions (loss of a tiny piece of a chromosome) that can cause such disorders as the cancer predisposition syndrome neurofibromatosis type 1. The embryos are screened to avoid the i...

Scripps Research scientists observe human neurodegenerative disorder in fruit flies

...g steps in gene expression. Basically, when a gene is expressed, its double-stranded DNA is first transcribed into a corresponding single-stranded piece of messenger RNA. Then an enzyme called the ribosome uses the mRNA as a template to make a protein by reading out its genetic sequence and then transl...

Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease

...at p23 and other co-chaperones helping Hsp90 are driving these hormone-driven cancers," Dr. Chadli says. "We think the Hsp90 machinery is an important piece of cancer development. Whatever we can do to modulate Hsp90 machinery, by targeting it directly or its helpers, is a good thing." While every cell ...

Autonomous robot detects shrapnel

...al-time imaging of blood vessels in the heart and brain. In the latest experiments, the robot successfully performed its main task: locating a tiny piece of metal in a water bath, then directing a needle on the end of the robotic arm to it. The researchers had previously used this approach to detect mic...

Trans fats hinder multiple steps in blood flow regulation pathways

...irst time that trans fatty acids have been shown to interfere with yet another part of the blood-flow process," Kummerow said. This study adds another piece of evidence to a long list that points to trans fats as significant contributors to heart disease, he said. Kummerow believes the U.S. Food and Dru...

Stress puts double whammy on reproductive system, fertility

... Berkeley-- University of California, Berkeley, researchers have found what they think is a critical and, until now, missing piece of the puzzle about how stress causes sexual dysfunction and infertility. Scientists know that stress boosts levels of stress hormones - glucocorti...

TRAPping proteins that work together inside living cells

...e proteins to which it has become attached. TRAP can also be easily unlinked from the tag with a simple biochemical treatment, allowing researchers to piece out the coworker from their original protein of interest. The team also tested the method on other proteins, such as those found in young muscle ce...

Promising device snags young inventors coveted spot at IShow

...ert to win." Though the team's device looks a lot like a standard bathroom scale connected to a bicycle-like handlebar, it is actually a heavy-duty piece of technology meant to offer congestive heart failure patients both peace of mind and significant health-care costs savings. "Nithan and Steve are...

Urban myth disproved: Fingerprints do not improve grip friction

...wo solid materials is usually related to the force of one of the materials pressing against the other, Ennos and Warman had to find a way of pushing a piece of acrylic glass (Perspex) against Warman's finger before pulling the Perspex along the student's finger to measure the amount of friction between the...

Manatees can probably hear which directions boats approach from

...equally well. Crucially, the animals can probably hear approaching speed boats and tell which direction they are coming from, which is an essential piece of information for conservation organisations as they battle to save this gentle giant. ...

Discovery raises new doubts about dinosaur-bird links

...re could not have had a lung that worked like that in birds. Their abdominal air sac, if they had one, would have collapsed. That undercuts a critical piece of supporting evidence for the dinosaur-bird link. "A velociraptor did not just sprout feathers at some point and fly off into the sunset," Ruben s...

Integrated Biometrics Adds Security Industry Veteran to Sales Staff

...ur fingerprint-based identity solutions and is well respected in the security industry for his leadership, knowledge and experience. He will be a key piece in our aggressive growth strategy." Prior to rejoining Integrated Biometrics, Johnson served in sales development and account management roles as...

A quicker, cheaper SARS virus detector -- one easily customizable for other targets

...ctronic detectors for viruses and other biological materials one that may be a valuable addition to the battle against epidemics. It consists of a piece of synthetic antibody attached to a nanowire that's attached to an electrical base, immersed in liquid. If the protein the antibody binds to is pre...

Wings that waggle could cut aircraft emissions by 20 percent

...ing the project, said: "This has come as a bit of a surprise to all of us in the aerodynamics community. It was discovered, essentially, by waggling a piece of wing from side to side in a wind tunnel." "The truth is we're not exactly sure why this technology reduces drag but with the pressure of climat...

UCSD researchers make first direct observations of biological particles in high-altitude ice clouds

...extremely low concentrations and are inherently difficult to measure, means you can further understand processes that result in precipitation. Any new piece of information you can get is critical." The findings suggest that the biological particles that get swept up in dust storms help to induce the for...

Diuscovery in amber reveals ancient biology of termites

... CORVALLIS, Ore. The analysis of a termite entombed for 100 million years in an ancient piece of amber has revealed the oldest example of "mutualism" ever discovered between an animal and microorganism, and also shows the unusual biology that h...

Exhibition showcases the 'art of science'

...5.49 The Art of Science "People's Choice" award of $196.53 (the geometric mean of the first and second prizes) will be awarded to the artist of the piece that receives the most online votes as of July 1, 2009 at noon EDT. Viewers can vote for their favorite Art of Science images at: www.princeton...

Study reveals conflict between doctors, midwives over homebirth

... to explore the nature of home birth in Oregon. She's also working on education programs for midwives in rural areas, including a cultural competency piece as demographics in Oregon continue to change. ...
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