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mice in Biological News

Work in mice will contribute to the study of hereditary diseases that lead to blindness

This release is available in Spanish . Researchers of the University of Granada (Spain) have used a technique consisting of the induction of neuronal degeneration neuronal for intense light exposure in the mouse's retina that will be helpful for the study of retinitis pigmentosa (RP), a g...

Genetically engineered mice yield clues to 'knocking out' cancer

Deleting two genes in mice responsible for repairing DNA strands damaged by oxidation leads to several types of tumors, providing additional evidence that such stress contributes to the development of cancer. That's the conclusion of a recent study* in DNA Repair by researchers at the National I...

Universitat Autonoma de Barcelona researchers first to clone mice in Spain

Researchers at the Department of Cell Biology, Physiology and Immunology at Universitat Autnoma de Barcelona (UAB) are the first to have cloned mice in Spain. Cloe, Cleo and Clona are three female brown-coloured mice and were born respectively on 12 May, 3 June and 10 June. By means of nuclear tra...

Bisphenol A exposure in pregnant mice permanently changes DNA of offspring

Exposure during pregnancy to the chemical bisphenol A, or BPA, found in many common plastic household items, is known to cause a fertility defect in the mother's offspring in animal studies, and now researchers have found how the defect occurs. The results of the new study will be presented Saturd...

Researchers engineer metabolic pathway in mice to prevent diet-induced obesity

In recent years, obesity has taken on epidemic proportions in developed nations, contributing significantly to major medical problems, early death and rising health care costs. According to Centers for Disease Control and Prevention estimates, at least a quarter of all American adults and more tha...

Honest crabs, power to the hungry, nice mice and clever meerkats: News from the American Naturalist

For copies of any of these articles, please contact Kevin Stacey at 773-834-0386 or kstacey@press.uchicago.edu . HOW OFTEN DO ANIMALS LIE ABOUT THEIR INTENTIONS? An article by Princeton Biologist Mark Laidre suggests that when an animal signals an intent to attack, chances are it's not bl...

Reproductive life of male mice is increased by living with females

Living with a female of its species can extend the reproductive life of a male mouse by a dramatic 20 percent, according to a study reported at the online site of the journal Biology of Reproduction . In the research, conducted by a team at the University of Pennsylvania School of Veterinary M...

Disabling enzyme allows mice to gorge without becoming obese, new study finds

Berkeley -- Researchers at the University of California, Berkeley, have identified a new enzyme that plays a far more important role than expected in controlling the breakdown of fat. In a new study to be published Jan. 11 in the journal Nature Medicine , researchers report that mice that have ha...

Pigs and dogs can bridge gap between mice and humans in developing new therapies

Human and veterinary medicine could receive a big boost through use of larger animals, especially pigs and dogs, in research, with Europe at the forefront. There is the prospect of bringing drugs to the market more quickly at less cost, as well as accelerating progress in other forms of therapy, n...

Gene therapy restores vision to mice with retinal degeneration

Massachusetts General Hospital (MGH) researchers have used gene therapy to restore useful vision to mice with degeneration of the light-sensing retinal rods and cones, a common cause of human blindness. Their report, appearing in the Oct. 14 Proceedings of the National Academy of Sciences, desc...

New research on pre-eclampsia in mice may have important implications for humans

WHITE PLAIN, N.Y., JULY 27, 2008 In a new March of Dimes-funded study of pre-eclampsia, a serious and potentially deadly disorder that affects about 5 percent of pregnancies, researchers have found results in mice that may have important implications for diagnosis and treatment in humans. Yang...

Pregnant mice block out unwelcome admirers to protect their pups

Mouse mothers-to-be have a remarkable way to protect their unborn pups. Because the smell of a strange male's urine can cause miscarriage and reactivate the ovulatory cycle, pregnant mice prevent the action of such olfactory stimuli by blocking their smell. Researchers from the European Molecular ...

Long-term study of middle-aged mice shows

CAMBRIDGE, Mass., July 3, 2008 -- Sirtris, a GlaxoSmithKline company focused on discovering and developing small molecule drugs to treat diseases of aging such as Type 2 Diabetes, is included among a research team that reported in today's online edition of Cell Metabolism that mice treated at mi...

Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find

DALLAS May 20, 2008 Mutations in two genes that control electrical excitability in a portion of the brain involved in sleep create a human-like insomnia disorder in mice, UT Southwestern Medical Center researchers have found. The findings may help scientists better understand the disorder and pr...

Intravenous gene therapy protects normal tissue of mice during whole-body radiation

LOS ANGELES, Oct. 28 Gene therapy administered intravenously could be an effective agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb, according to an animal study presented today by University ...

Of mice and men: similarities between skeletons of both

Jerusalem -- A new book by researchers at the Hebrew University of Jerusalem that details the skeletal structure of the mouse demonstrates a surprising similarity between mice and humans. The book,Micro-Tomorgrphic Atlas of the Mouse Skeleton, was authored by a team from the Hebrew University...

Common allergy drug reduces obesity and diabetes in mice

BOSTON, Mass. (July 26, 2009) Crack open the latest medical textbook to the chapter on type 2, or adult-onset, diabetes, and you'll be hard pressed to find the term "immunology" anywhere. This is because metabolic conditions and immunologic conditions are, with a few exceptions, distant cousins. ...

Lack of happiness hormone serotonin in the brain causes impaired maternal behavior in mice

A lack of serotonin, commonly known as the "happiness hormone", in the brain slows the growth of mice after birth and is responsible for impaired maternal behavior later in life. This was the result of research conducted by Dr. Natalia Alenina, Dana Kikic, and Professor Michael Bader of the Max De...

Researcher tricks immune system in diabetic mice

CHICAGO -- The body's immune system hates strangers. When its security patrol spots a foreign cell, it annihilates it. This is the problem when people with type 1 diabetes undergo human islet cell transplantation. The islet cells from a donor pancreas produce robust amounts of insulin for the r...

New technique eliminates toxic drugs in islet transplant in diabetic mice

CHICAGO -- The body's immune system hates strangers. When its security patrol spots a foreign cell, it annihilates it. This is the problem when people with type 1 diabetes undergo human islet cell transplantation. The islet cells from a donor pancreas produce robust amounts of insulin for the r...

Resveratrol prevents fat accumulation in livers of 'alcoholic' mice

BETHESDA, Md. (Oct. 14, 2008) − The accumulation of fat in the liver as a result of chronic alcohol consumption could be prevented by consuming resveratrol, according to a new study with mice. The research found that resveratrol reduced the amount of fat produced in the liver of mice fed alc...

Fat-regenerating 'stem cells' found in mice

Researchers have identified stem cells with the capacity to build fat, according to a report in the October 17th issue of the journal Cell, a Cell Press publication. Although they have yet to show that the cells can renew themselves, transplants of the progenitor cells isolated from the fat tiss...

No helicopter moms among Rutgers mutant mice

NEW BRUNSWICK, N.J. First, he discovered a gene that controls innate fear in animals. Now Rutgers geneticist Gleb Shumyatsky has shown that the same gene promotes "helicopter mom" behavior in mice. The gene, known as stathmin or oncoprotein 18, motivates female animals to protect newborn pups and...

Slipping through cell walls, nanotubes deliver high-potency punch to cancer tumors in mice

The problem with using a shotgun to kill a housefly is that even if you get the pest, you'll likely do a lot of damage to your home in the process. Hence the value of the more surgical flyswatter. Cancer researchers have long faced a similar situation in chemotherapy: how to get the most medica...

Human vascular system in mice

The formation of new blood vessels, or angiogenesis, is an Achilles heel of tumor growth, because tumors depend on the supply of oxygen and nutrients for survival. Therefore, for some years now substances called angiogenesis inhibitors have been used in cancer treatment to suppress this process. I...

Blood vessel protein reverses macular degeneration, diabetic retinopathy in mice

SALT LAKE CITY Two major eye diseases and leading causes of blindnessage-related macular degeneration and diabetic retinopathycan be reversed or even prevented by drugs that activate a protein found in blood vessel cells, researchers at the University of Utah School of Medicine and several other i...

Genetic tags reveal secrets of memories' staying power in mice

A better understanding of how memory works is emerging from a newfound ability to link a learning experience in a mouse to consequent changes in the inner workings of its neurons. Researchers, supported in part by the National Institutes of Health's National Institute of Mental Health (NIMH), have...

Elusive pancreatic stem cells found in adult mice

Just as many scientists had given up the search, researchers have discovered that the pancreas does indeed harbor stem cells with the capacity to generate new insulin-producing beta cells. If the finding made in adult mice holds for humans, the newfound progenitor cells will represent an obvious t...

Earlier bites by uninfected mosquitoes boost West Nile deaths in lab mice

GALVESTON, Texas Theres one more reason to try to avoid being bitten by mosquitoes, scientists have discovered: bites from mosquitoes that arent infected by the West Nile virus may make the disease worse in people who acquire it later from West Nile-infected mosquitoes. Researchers from the Un...

Interaction of just 2 genes governs coloration patterns in mice

CAMBRIDGE, Mass. -- Biologists at Harvard University and the University of California, San Diego, have found that a simple interaction between just two genes determines the patterns of fur coloration that camouflage mice against their background, protecting them from many predators. The work, publ...

Hormone helps mice 'hibernate,' survive starvation

A key hormone enables starving mice to alter their metabolism and “hibernate” to conserve energy, revealing a novel molecular target for drugs to treat human obesity and metabolic disorders, UT Southwestern Medical Center researchers have found. The starvation-fighting effects of the hormone, ...

'Smart' mice teach scientists about learning process, brain disorders

Mice genetically engineered to lack a single enzyme in their brains are more adept at learning than their normal cousins, and are quicker to figure out that their environment has changed, a team led by researchers at UT Southwestern Medical Center has found. The results, appearing today in the...

Peramivir protects mice from lethal H5N1 infection

The antiviral drug peramivir might offer humans significant protection during a pandemic of the avian influenza virus H5N1, according to results of mouse studies conducted by investigators at St. Jude Children's Research Hospital. Peramivir, an antiviral drug, blocks the ability of influenza vi...

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease

Human embryonic stem cells (hESCs) hold great promise for benefiting degenerative diseases, and do so by invoking multiple mechanisms. Such cells can be grown in a manner compatible with clinical use (i.e., without animal feeder layers) and even without the need for immunosuppression. These were a ...

Scientists clone mice from adult skin stem cells

For cells that hold so much promise, stem cells' potential has so far gone largely untapped. But new research from Rockefeller University and Howard Hughes Medical Institute scientists now shows that adult stem cells taken from skin can be used to clone mice using a procedure called nuclear transfe...

Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight

The Scripps Research team, led by neuroscientists Manuel Sanchez-Alavez and Tamas Bartfai, discovered that mice genetically altered to lack a molecule known as the EP3 receptor tend to be more active during their normal sleep cycle and to eat more. In the study, this led to weight increases of up t...

Penn researchers replace organ in adult mice using 'single-parent' stem cells

Researchers at the University of Pennsylvania School of Veterinary Medicine have derived uniparental embryonic stem cells - created from a single donor's eggs or two sperm - and, for the first time, successfully used them to repopulate a damaged organ with healthy cells in adult mice. Their findi...

Making mice with enhanced color vision

Researchers at the Johns Hopkins School of Medicine and their colleagues have found that mice simply expressing a human light receptor in addition to their own can acquire new color vision, a sign that the brain can adapt far more rapidly to new sensory information than anticipated. This work, a...

Drug treatment improves learning in mice with Down syndrome symptoms, Stanford/Packard study shows

A once-a-day, short-term treatment with a drug compound substantially improved learning and memory in mice with Down syndrome symptoms, say researchers at the Stanford University School of Medicine and Lucile Packard Children’s Hospital. What’s more, the gains lasted for months after the treatment ...

White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells

The discoverers of the unique mouse line that is resistant to cancer have begun to pin down how the process works and found that white blood cells in these mice overwhelm normal defenses of cancer cells. In a report in Cancer Immunity, a journal of the Academy of Cancer Immunology, posted on line...
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