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Synthetic cocoa chemical slows growth of tumors in human cell lines

Washington, D.C. A synthetic chemical based on a compound found in cocoa beans slowed growth and accelerated destruction of human tumors in laboratory studies, and should be tested further for cancer chemoprevention or even treatment, say researchers at Georgetown University Medical Center. "We...

Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines

Publication in September issue of Nature Methods Shows Application of Bioinformatics tools to Identify The Most Powerful Matrix Attachment Regions Applied to Boost Transgene Expression. GENEVA, Switzerland, Aug. 21 /PRNewswire/ -- Researchers at Selexis SA and The University of L...

Unique soybean lines hold promise for producing allergy-free soybeans

Researchers have isolated two Chinese soybean lines that grow without the primary protein linked to soy allergies in children and adults. The two lines already are adapted to Illinois-like conditions and will be given away to breeders seeking to produce new varieties of allergy-free soybeans withou...

Wisconsin scientists grow two new stem cell lines in animal cell-free culture

Scientists working at the WiCell Research Institute, a private laboratory affiliated with the University of Wisconsin-Madison, have developed a precisely defined stem cell culture system free of animal cells and used it to derived two new human embryonic stem cell The new work, which is reported...

HIV-1 spread through six transmission lines in the UK

Contrary to the prevailing belief that the HIV epidemic in the UK can be traced back to one source, a new study suggests that HIV spread via at least six independent virus introductions and subsequent transmission chains. The findings, published in the latest issue of the Proceedings of the Nationa...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

Currently available lines of human embryonic stem cells have been contaminated with a non-human molecule that compromises their potential therapeutic use in human subjects, according to research by investigators at the University of California, San Diego (UCSD) School of Medicine and the Salk Insti...

Navigating in the ocean of molecules

...ble chemical structures, are unimaginable: it is estimated to contain up to 10160 different molecules. Written out in full, this figure would fill two lines of closely-spaced numbers on a typed page. However, only some of these - 1060 molecules according to the estimates - are potential active agents. Iden...

Restoring a natural root signal helps to fight a major corn pest

...is responsible for enormous financial losses. Current methods to control the rootworm pest include insecticides, crop rotation and transgenic Bt maize lines that are not yet approved in Europe. After first invading the Balkans, the pest has since 2007 also been found in southern Germany. The corn rootworm ...

Jet-propelled imaging for an ultrafast light source

...rays. The entire device which the researchers call a gas dynamic virtual nozzle (GDVN) is only about a millimeter in diameter (not counting feed lines and cables) and fits to the side of the beamline's vacuum chamber. After passing through the beam, the liquid droplets and the gas (typically carbon d...

Stem cell research: From molecular physiology to therapeutic applications

...ll Bank in Beijing, where clinical grade stem cell lines and patient specific cell lines have been created for future drug target candidate...g versatile patient-specific pluripotent stem cell lines that can be reliably used to fulfill the promise o...

Earliest animals lived in a lake environment, research shows

...ould expect for marine deposits. This was an important indicator that the rocks hosting the fossils were not marine in origin. Taken together, several lines of evidence indicated to us that these early animals lived in a lake environment." Bristow noted that the new research gives scientists a glimpse i...

DOE-funded research projects win 46 R&D 100 Awards for 2009

...ector Systems Operating at High Temperatures (MELCOT) - predicts the service life of conductor-connector systems. The splices connecting the conductor lines are literally the weak links in power transmission systems. With this new method of investigating performance and integrity of the power line systems,...

Skin-like tissue developed from human embryonic stem cells

...ipotency of human embryonic stem cells (hESC) to generate complex, multilayer tissues that mimic human skin and the oral mucosa (the moist tissue that lines the inside of the mouth). The proof-of-concept study is published online in advance of print in Tissue Engineering Part A . "For the first time, w...

Playing it safe

... three of them will be found among the 10,000 cells in the testis tissue of a mouse. However, they can be isolated individually and reproduced as cell lines with stable characteristics. Under the usual cell culturing conditions, they retain their unipotency for weeks and years. Consequently, all they can d...

First cGMP feeder-independent pluripotent stem cell banks released for distribution

... are produced using H9 (WA09), one of the original lines derived by stem cell pioneer James Thomson at the ...able a wide variety of other cGMP lines, including lines produced from newly derived, fully compliant human...ese cGMP stem cell banks and matched research cell lines should open the door to more rigorous, reliable an...

Finding the constant in bacterial communication

...le, You has already gained insights into the relationship between predators and prey by creating a synthetic circuit involving two genetically altered lines of bacteria. The findings from that work helped define the effects of relative changes in populations. ...

Female human embryos adjust the balance of X chromosomes before implantation

... is from these cells that mice embryonic stem cell lines are made; these ES cells have two active X chromos...tem (ES) cell research. "Human embryonic stem cell lines are derived from blastocysts that, we know now, al... for ES cell derivation. The current human ES cell lines may, therefore, still have the first wave of XCI. ...

Ability to literally imagine oneself in another's shoes may be tied to empathy

...derstanding of others' mental states," Katharine N. Thakkar, a psychology graduate student at Vanderbilt and the report's lead author, said. "Separate lines of neuroimaging research have noted involvement of the same brain area, the parietal cortex, during tasks involving visuo-spatial processes and empath...

Shape matters in the case of cobalt nanoparticles

...chainslining up as a string of microscopic magnets. Then, when placed in an external magnetic field, the individual chains bundle together in parallel lines to form thick columns aligned with the field. These induced columns, says NIST physicist Angela Hight Walker, imply that the external magnetic fields ...

Major breakthrough in early detection and prevention of AMD

...des nourishment and oxygen to the eye. Central vision loss occurs when these abnormal blood vessels invade the retina, the light-sensitive tissue that lines the inner surface of the eyeball. "Once the vessels invade the retina, the horse has already left the barn," Ambati said. "At that point, drugs ca...

Fossil bone bed helps reconstruct life along California's ancient coastline

...y of British Columbia. "If you look at the geology of this fossil bed, it's not intuitive how it formed," Pyenson said. "We really put together all lines of evidence, with the fossil evidence being a big part of it, to obtain a snapshot of that period of time." Pyenson and his colleagues, totaling fi...

Healing wounds with lasers, vehicles that drive themselves, other cutting-edge optics

... HEALING WITH LIGHT Star Trek scanners that fix injuries with beams of light may not be science fiction after all. A new optical technology that lines up living cells and controls their movements has opened the door to better artificial tissues and wounds that heal faster with less scarring. For y...

Is vitamin D deficiency linked to Alzheimer's disease and vascular dementia?

...ng inflammation, and ample biological evidence to suggest an important role for vitamin D in brain development and function. Given these supportive lines of evidence, Dr. Grant suggests that studies of incidence of dementia with respect to prediagnostic serum 25(OH)D or vitamin D supplementation are war...

The evolution of gene regulation

... by a repressor that is removed only when the gene is needed. Which of these two regulation mechanisms will develop is a question of demand, along the lines of a "use-it-or-lose-it" principle: if genes are frequently active, then, as a rule, they will be directly induced. Genes that encode more rarely used...

ExcellGene SA first company to offer contract manufacturing in 250 Liter OrbShake bioreactor

...ts customers, from DNA to scalable manufacturing under cGMP. Additionally, the company provides protein production services, based both on stable cell lines and on large-scale transient gene expression. The company is located in Monthey, Switzerland.  For additional information, please visit http://w...

Protein identified as critical to insulating the body's wiring could also become treatment target

...mmunicate with each other or another cell type, such as a muscle cell, they reach out with an arm or extension called an axon. Much like the telephone lines that line roadways, these arms require proper insulation, called myelin, composed mostly of lipids and some proteins. Axons that transmit quick mes...

SRI International to screen drugs that fight 2009 H1N1 influenza A

...guidelines prescribed by the Centers for Disease Control and Prevention (CDC) for handling this strain of influenza. SRI researchers will culture cell lines and study H1N1 virus growth under well-controlled conditions. Next, they will begin testing the first round of drugs. Assuming that some drugs show wo...

ExcellGene and Khner achieved milestone in development of novel 250 Liter mammalian cell culture bioreactors

...ts customers, from DNA to scalable manufacturing under cGMP. Additionally, the company provides protein production services, based both on stable cell lines and on large-scale transient gene expression. The company is located in Monthey, Switzerland.  For additional information, please visit http://w...

Lyncean Technologies Inc. receives $1.2 M from NCRR to develop new imaging technique

...ase of the x-ray wave front, and a third image sensitive to the local scattering power. This technique has been primarily developed at the x-ray beam lines in large synchrotrons, and it relies on a small point-like, monochromatic x-ray source to achieve the coherence necessary for the fringes. The DPCI t...

WARF signs license agreement with Pfizer for human embryonic stem cells

...mation for development of future inventions. "Our license with WARF provides us with information and materials that will allow us to use their cell lines to explore a whole new range of therapies," says Ruth McKernan, chief scientific officer of Pfizer Regenerative Medicine. "Stem cells can be used to c...

New early detection studies of lung cancer in non-smokers launched today

...e: Protein biomarker discovery: Proteomic Analysis of Lung Cancer Cell lines (PI: Hanash) Tumor biomarker discovery: Biomarker Discovery for Lung Cance... Smokers (PI: Gazdar) Genome analysis: Genomic Studies of Lung Cancer Cell lines from Lung Cancers Arising in Current, and Never Smokers (PIs: Lam and Lam) ...

Stem cell focus for IBD wound healing

...s, it may also reduce the chance of needing surgery further down the line." In the early stages of the project, the pathologists will be using cell lines in the lab to study CD24 at a cellular and molecular level to discover the mechanisms by which it operates and encourages cell migration and other ass...

CSC Awarded $570 Million IT Services Contract by UK Identity and Passport Service

...ces for governments worldwide." About CSC CSC is a global leader in providing technology-enabled solutions and services through three primary lines of business. These include Business Solutions & Services, Global Outsourcing Services and the North American Public Sector. CSC's advanced capabil...

Study finds blood cells can be reprogrammed to act as embryonic stem cells

...unctionally similar to ES cells, the scientists analyzed the CD34+ iPS cell lines to see if they had acquired stem cell "markers," the unique combination of ...urface and distinguish them from other types of cells. Indeed, the iPS cell lines expressed the same markers as ES cells and further shared the capacity to d...

Indigenous peoples at world summit to share climate change observations, coping techniques

...runt of its impact," says Patricia Cochran, Chair of both the Inuit Circumpolar Council and the April Summit. "Indigenous Peoples are on the front lines of this global problem at a time when their cultures and livelihoods in traditional lands are already threatened by such trends as accelerating natura...

Newly discovered epidermal growth factor receptor active in human pancreatic cancers

...se for treatment of these specific lung cancers. But would the drug work in pancreatic cancers? Dr. Pandey's group moved from studies of human cell lines to studies in mice in which human pancreatic tumor cells with activated EGFT had been placed. The tumors began growing. But when treated with erlotini...

For cancer cells, genetics alone is poor indicator for drug response

...nted to figure out why. The researchers took both cancerous and non-cancerous cells and exposed them to varying doses of TRAIL. Although these cell lines were known to be vulnerable to the molecule, a fraction always managed to survive. The researchers noticed that when this outlier group was isolat...

CSHL-led team identifies key decision-point at which cells with broken DNA repair themselves or die

... route of apoptosisthey programmed themselves to die. 'A lovely moment' of discovery Tonks says the finding is "a powerful example of multiple lines of research and different kinds of expertise coming together" in what he describes as "a lovely moment" of synthesis and discovery. An important coll...

CSC Awarded $570 Million IT Services Contract by UK Identity and Passport Service

...ces for governments worldwide." About CSC CSC is a global leader in providing technology-enabled solutions and services through three primary lines of business. These include Business Solutions & Services, Global Outsourcing Services and the North American Public Sector. CSC's advanced capabil...

Altered gene can increase risk of schizophrenia

...rzustowicz and her team will be looking at the altered gene's frequency in DNA samples from the National Institute of Mental Health collection of cell lines housed in the Rutgers University Cell and DNA Repository. The collection includes samples drawn from large populations of Asian, Caucasian, African Am...
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