Tulane receives grant to study limb regeneration
Could the salamander's natural ability to grow back severed appendages lead to a scientific breakthrough for humans who have lost limbs?
With the help of a $6.25 million U.S. Department of Defense grant, Tulane University professor Ken Muneoka, the John L. and Mary Wright Ebaugh chair in scienc...
Resilin springs simplify the control of crustacean limb movements
Animals can simplify the brain control of their limb
movements by moving a joint with just one muscle that operates against a spring made of the almost perfect elastic substance called resilin. This principle is analysed and illustrated by striking photographs and high-speed video footage, publish...
Motor nerve targeting to limb muscles is controlled by ephrin proteins
Montral, December 24, 2008 A study from a team of researchers including Dr. Artur Kania, Director of the Neural Circuit Development Research Unit at the IRCM, and Dr. Dayana Krawchuk, postdoctoral fellow, shows how a family of proteins present in the developing limb
control nerve targeting from t...
Leptin found to control appetite and limb development in frogs
Leptin, the hormone secreted by fat cells that plays an important role in food intake, has been described for the first time in a cold-blooded vertebrate, the South African clawed frog Xenopus.
As it does in humans and other mammals, leptin acts on the frog brain to suppress appetite. But the ho...
Some people would give life or limb not to be fat
Nearly half of the people responding to an online survey about obesity said they would give up a year of their life rather than be fat, according to a study by the Rudd Center for Food Policy and Obesity at Yale.
The 4,000 respondents in varying numbers between 15% and 30% also said they would ra...
MicroRNA may have fail-safe role in limb development
A tiny strand of molecules plays a role in how our arms and legs develop and grow - a finding that sheds light on perplexing bits of material once dismissed as genetic "junk," say scientists at the University of Florida and Harvard University.
The research, available today in the online edition o...
Knee injuries may start with strain on the brain, not the muscles
...likelier to tear this ligament than men while playing the same sport. However, the study showed that men and women showed significant changes in lower limb
mechanics during unanticipated single leg landings. Again, the findings point to the brain, McLean says.
During testing, a flashing light cued the...
Reading the brain without poking it
...vert the thoughts to audible words.
For people who have lost a limb
or are paralyzed, "this device should allow a high level of control over a prosthetic limb
or computer interface," Greger says. "It will enable amputees or people wit...
CWRU receives $5 million from Ohio Third Frontier Commission
... company from Marc Penn (CC), will develop its lead drug product, stromal cell derived factor 1 (SDF-1), through a Phase I clinical trial for critical limb
With further refinement of already established proof of concept, the following programs could mature into signif...
Brain-computer interface, developed at Brown, begins new clinical trial
... dystrophy, amyotrophic lateral sclerosis (ALS) or limb
loss turn their thoughts into actions, restoring i...eural signals associated with the intent to move a limb
can be "decoded" by a computer in real time and us...ies on a computer screen, controlling a prosthetic limb
or a robotic arm, controlling functional electrica...
Embryology study offers clues to birth defects
...ave clarified the role that retinoic acid plays in limb
development. The study showed that retinoic acid ...esearch corrects longstanding misconceptions about limb
development and provides new insights into congenital limb
defects. The study was published online in the jou...
March of Dimes awards $250,000 prize to scientists unraveling the causes of muscular dystrophy
...ted by the nine forms of muscular dystrophy and other related neuromuscular disorders. Among this group are facioscapulohumeral muscular dystrophy and limb
girdle muscular dystrophy, as well as childhood conditions such as Duchenne and Becker muscular dystrophies and congenital muscular dystrophy.
Grouping muscles to make controlling limbs easier
... have shown that it could be possible to control a limb
by stimulating groups of muscles rather than indiv...simulation, shows that researchers can control the limb
using muscle groups just about as well as if they ...The idea that the body's nervous system controls a limb
using muscle groups, or "synergies," has been a co...
UF scientist tapped by Howard Hughes Medical Institute to pursue 'best ideas'
...dying chick embryos, a classic scientific model of limb
development. At University College London, he discovered that the embryonic master switch for limb
formation was a multifunctional protein called fib...ng similarities between the processes that control limb
development and those that regulate development of...
Research links evolution of fins and limbs with that of gills
... embryonic skates (a living relative of sharks that has gill rays) responds to treatment with the vitamin A derivative retinoic acid in the same way a limb
or fin skeleton does: by making a mirror image duplicate of the structure as the embryo develops. According to the researchers, the genetic circuitry ...
Promising 3-year data: Saving limbs with drug-eluting stents
... Calif. (March 10, 2009)Attempts to treat critical limb
ischemia in peripheral arterial disease (PAD) pati...is encouraging news for PAD patients with critical limb
ischemia. The smaller blood vessels below the knee...dovascular treatment of PAD patients with critical limb
ischemia," he added. An interventional radiologist...
Society of Interventional Radiology hosts 34th annual scientific meeting
... are available.
Seeing the Promise of Drug-Eluting Stents for Critical limb
Interventional radiologists are helping peripheral arterial disease (PAD) patients with critical limb
ischemia avoid amputation by exploring the treatment of the smaller blood v...
Register now for the Society of Interventional Radiology's 34th Annual Scientific Meeting
...en's health: making childbirth safer
Finding that age doesn't matter: AV fistulas and dialysis
Seeing the promise of drug-eluting stents: critical limb
Recommending treatment for "Silent Killer": abdominal aortic aneurysm
Visit www.SIRmeeting.org to register online (free), view scienti...
Single adult stem cell can self renew, repair tissue damage in live mammal
...and its differentiated descendants restored lost function to mice with hind limb
muscle tissue damage.
The adult stem cells used in the study, conducted ...essed "nude" mice whose muscle satellite cells had been wiped out in a hind limb
The mice would only be able to repair injury if the tra...
Transplanted fat cells restore function after spinal cord injury
...ctional recovery after spinal cord injury (SCI)," said Ohta. "Transplanting DFAT cells into SCI rats significantly promoted the recovery of their hind limb
"These studies demonstrate the ability to obtain stem cells from a patient's own fat that can help repair injury to the spinal cord," sai...
HJF nursing specialist wins prestigious Celina Field Cargiver Award
...e hospital's policies on pain management through the creation of a Pain Process Improvement Team. Most of Rupprecht's patients have experienced severe limb
injuries or amputations.
Rupprecht also created and leads the Pain Management Task Force, which trains hospital staff on the ever-changing issue o...
New CU-Boulder study shows diversity decreases chances of parasitic disease
...gray tree frogs reduce their chances of parasitic infections known to cause limb
malformations has strong implications for the benefits of biodiversity on e...ith the parasitic trematodes -- tiny worms whose larvae burrow into tadpole limb
regions and disrupt normal leg development -- 40 percent of the emerging fr...
Swamping bad cells with good in ALS animal models helps sustain breathing
... The new work supports the hypothesis that artificially outnumbering unhealthy cells with healthy ones in targeted parts of the spinal cord preserves limb
strength and breathing and can increase survival.
An account of the work appears online this week in Nature Neuroscience .
Two parts of the stu...
Reproducing early and often is the key to rapid evolution in plants
...f such hypotheses are based on less than 50 species in total," said Yale graduate student and lead author Stephen Smith .
For each branch on each limb
of the "tree," the researchers calculated the rate of molecular evolution by determining the number of DNA nucleotide substitutions per site per milli...
Galloping and breathing at high speed
...ng or racing.
The researchers focused their efforts on understanding why this occurs. They found
that two principal muscular factors in the fore limb
guide a horse's forward movement. The first is the springy "pogo-stick" quality of the superficial digital flexor tendon, which provides the "bouncin...
Taking the next step toward advanced artificial limbs
...cial limbs that are connected to the nervous system so they can be controlled directly by the brain and provide sensory feedback to the brain, such as limb
orientation, temperature of surfaces, and so on.
Stephen Lambert, research associate professor with BEI, will direct basic science studies needed ...
Combining advanced medical and information technologies offers pathway to lower health care costs
... underscored by Dr. David G. Armstrong, DPM, PhD, Professor of Surgery, University of Arizona College of Medicine and Director of the Southern Arizona limb
Salvage Alliance (SALSA), a noted expert on diabetes care, who said that the current expenditures for caring for the feet of people with diabetes exc...
Thumbs up -- a tiny ancestral remnant lends developmental edge to humans
..., influence the molecular machinery to yield human limb
and thumb development patterns.
The study rein...hat the human sequence enhances gene expression in limb
and braina gain of function.
The next ques...contributed to uniquely human aspects of digit and limb
patterning," Rubin said. "We suspect the gain of ...
Gene enhancer in evolution of human opposable thumb
...y far the most striking candidate.
Remarkably, HACNS1 was found to play a unique human-specific gene-activating role in a region of the developing limb
that eventually forms the junction of the wrist and thumb, and also extends partially into the developing thumb. A similar, though weaker activating r...
NIH EUREKA award funds research at WPI aimed at turning adult skin cells into stem-like cells
... a ball of undifferentiated cells that in amphibians forms from cells that remain at the site of an amputation. It is capable of regrowing the missing limb
by forming all of the required tissue typesskin, muscle, bone, connective, and nerve. Mammals cannot generate blastemas, but instead heal injuries by ...
Technique used in human ankle injuries modified to treat dogs' knees
...unds for the Tightrope CCL method to be feasible. In addition, dogs that cannot follow a physical rehabilitation protocol after surgery and dogs with limb
deformities are not candidates for this technique. The 10- to 12-week rehabilitation period is very important for any surgical technique for CCL defic...
Satellites illuminate pollution's influence on clouds
...rain, we can see the clouds every day and we're getting confirmation on a global scale that we have an issue here."
Jiang's team used the Microwave limb
Sounder on the A-Train's Aura satellite to measure the level of carbon monoxide in clouds. The presence of carbon monoxide implies the presence of smo...
Key molecule discovered in Venus's atmosphere
The band of atmosphere in which the glowing hydroxyl molecules are located is very narrow; it is only about 10 km wide. By looking at the limb
of the planet, Venus Express looked along this faint atmospheric layer, increasing the signal strength by about 50.
Hydroxyl is thought to be impo...
Accelerometer backpacks aid study of gliding behavior in the 'flying' lemur
...lude lemurs as well as humans. Common throughout Southeast Asia, the colugo looks like a very large squirrel with membranous skin stretching from each limb
and even between its toes to catch the wind and work as a parachute. When fully spread, the skin flaps reach the size of a large doormat.
Cell Therapy for Cardiovascular Diseases
...mary mechanism by which bone marrow cells help patients with acute myocardial infarction
Bone marrow-derived stem cells for patients with critical limb
ischemia, presented by both Drs. Berthold Amann and Brian Annex
Transplantation of bone marrow stem cells for persistent, refractory angina, prese...
Top scientists meet for global conference on stem cell therapy for cardiovascular diseases
...m by which bone marrow cells help patients with acute myocardial infarction
Bone marrow-derived stem cells for patients with critical limb
ischemia, presented by both Drs. Berthold Amann and Brian Annex
Transplantation of bone marrow stem cells for persistent, refractory ...
Fourth Annual International Conference on Cell Therapy for Cardiovascular Diseases
... cell infusion in patients with heart attack, presented in detail here by Dr. Hyo-Soo Kim
Bone marrow-derived stem cells for patients with chronic limb
ischemia, presented by Dr. Brian Annex
Transplantation of bone marrow stem cells for persistent, refractory angina, presented and discussed by Drs...
Massive microRNA scan uncovers leads to treating muscle degeneration
...Medical Institute, was senior investigator.
The disorders include the muscular dystrophies (Duchenne muscular dystrophy, Becker muscular dystrophy, limb
girdle muscular dystrophies, Miyoshi myopathy, and fascioscapulohumeral muscular dystrophy); the congenital myopathies (nemaline myopathy); and the in...
Nutrient pollution drives frog deformities by ramping up infections, says CU-Boulder study
...n as cercariae, can kill or deform a single tadpole by burrowing into their limb
regions and disrupting normal leg development, he said. A single infected ...rging disease, the researchers are now exploring how nutrient pollution and limb
malformations contribute to the pattern, Johnson said.
NASA keeps eye on ozone layer amid Montreal Protocol's success
...awan Bhartia, project scientist for the mission. In addition, measurements from the Stratospheric Aerosol and Gas Experiment, along with the Microwave limb
Sounder and the Halogen Occultation Experiment aboard the Upper Atmospheric Research Satellite, were important to scientists' understanding of ozone. ...