interact

Virus-host interactions at sea effect global photosynthesis

Agilent Technologies Inc. (NYSE: A) today announced that it has for the first time released the chip design, probe sequence and annotation information for all of its microarrays. The release of this information is expected to improve cross-laboratory experimental research and cross-platform data comparison. "Full release of the probe sequences is an admirable and responsible position for A...

Future diabetes drugs may target new protein interaction

In the March 3 issue of Nature, Johns Hopkins researchers report that two proteins best known for very different activities actually come together to turn the liver into a sugar-producing factory when food is scarce. Because the liver's production of sugar is a damaging problem in people with diabetes, the proteins' interaction might be a target for future drugs to fight the disease, the research...

Computational verification of protein-protein interactions by orthologous co-expression

In the March 3 issue of Nature, Johns Hopkins researchers report that two proteins best known for very different activities actually come together to turn the liver into a sugar-producing factory when food is scarce. Because the liver's production of sugar is a damaging problem in people with diabetes, the proteins' interaction might be a target for future drugs to fight the disease, the research...

UNC plant researchers discover proteins interact to form hair-trigger protection against invaders

Experimenting with Arabidopsis, a fast-growing cousin of the humble mustard plant, scientists at the University of North Carolina at Chapel Hill got a big surprise while investigating how plants respond to attacks from disease organisms such as bacteria and viruses. "Contrary to what we thought we'd find, our experiments showed that at least three different proteins work in concert with on...

Confirmation of human protein interaction data by human expression data

As the brain develops, neurons reach out helter-skelter forming new connections, only a small number of which take hold. How the brain chooses which connections to keep and which to prune back appears to be governed by which branches have the most electrical activity—a finding that could help to explain how early experiences guide brain development. The work, published in the April 21 issu...

Physical and functional interaction of key cell growth molecules linked to cancer

Scientists have uncovered new information about a specific mechanism involved in the biology of malignant human tumor cells. The findings, published in the June issue of Cancer Cell, significantly advance knowledge about epidermal growth factor receptor (EGFR). EGFR is a well-studied cell surface receptor that stimulates cell growth by transmitting growth factor signals acting outside the...

Complex gene interactions account for autism risk

Using a novel analysis of the interactions among related genes, Duke University Medical Center researchers have uncovered some of the first evidence that complex genetic interactions account for autism risk. The Duke team found that the brain mechanism that normally stops or slows nerve impulses contributes to the disease. The team's findings implicate the so-called GABA receptor genes, wh...

Image of myosin-actin interaction revealed in cover story of Molecular Cell

Scientists from the Burnham Institute for Medical Research and the University of Vermont have captured the first 3-dimensional (3D) atomic-resolution images of the motor protein myosin V as it "walks" along other proteins, revealing new structural insights that advance the current model of protein motility and muscle contraction. The culmination of four years of work, this collaboration among bi...

Scientists directly view immune cells interacting to avert autoimmunity

Using a new form of microscopy to penetrate living lymph nodes, UCSF scientists have for the first time viewed immune cells at work, helping clarify how T cells control autoimmunity. The technique, known as two-photon laser-scanning microscopy, was able to focus deep within the lymph node of a diabetic mouse, allowing the researchers to show that immune cells known as T regulatory, or Tre...

Interactive 3-D atlas of mouse brain now available on web

Researchers at the U.S. Department of Energy's Brookhaven National Laboratory have just launched a web-based 3-D digital atlas browser and database of the brain of a popular laboratory mouse (see "Neuroscientists around the world can now download these extremely accurate anatomical templates and use them to map ot...

A real time look at interactions between RNA and proteins

For the first time, researchers can now peer inside intact cells to not only identify RNA-binding proteins, but also observe–in real-time–the intricate activities of these special molecules that make them key players in managing some of the cell's most basic functions. Researchers at the University of Pennsylvania School of Medicine who developed the new technology see this advance as one of the...

Largest study of human 'interactome' reveals a novel way

Discoveries made during the first large-scale analysis of interactions between proteins in our cells hold promise for identifying new genes involved in genetic diseases, according to researchers at Johns Hopkins and the Institute of Bioinformatics (IOB) in Bangalore. The findings, reported in the March issue of Nature Genetics, were made using a database of more than 25,000 protein-protein...

U of MN researchers develop way to visualize synchronized interactions of nerve cells in the brain

Researchers at the University of Minnesota Medical School and the Brain Sciences Center at the Minneapolis VA Medical Center have discovered a new way to assess how brain networks act together. Work funded by the MIND Institute (New Mexico) led Apostolos P. Georgopoulos, M.D., Ph.D., professor of neuroscience, neurology, and psychiatry, and collaborators to a novel way to assess the dyna...

Biologists visualize protein interaction that may initiate viral infection

Biologists at Purdue University have taken a "snapshot" of a Velcro-like protein on a cell's surface just after it attached to the dengue virus, a linkup thought to initiate the early stages of infection. During the earliest stages o...

Biologists develop genome-wide map of miRNA-mRNA interactions

Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans). MicroRNAs bind to messenger RNA (mRNA) in a specific section, called 3'UTR, and are known to regulate them. Parts of th...

Man's best friend: Study shows lonely seniors prefer playtime with pooch over human interaction

A new Saint Louis University study shows there is some truth in the old cliché that describes a dog as "man's best friend." Nursing...

APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal

The saying goes that a picture is worth a thousand words. But these pictures could one day be worth much more -- the lives saved by the development of new vaccines. Harvard University researcher Ulrich H. von Andrian showed the immune system of a live mouse being challenged by a foreign microbe during a presentation at Experimental Biology 2006. The footage gave many of the physiologists i...

Small molecule interactions were central to the origin of life

In an important new paper forthcoming in the June issue of The Quarterly Review of Biology, Robert Shapiro (New York University) argues against the widely held theory that the origin of life began with the spontaneous appearance of a large, replicating molecule such as RNA. Instead, Shapiro raises an alternative that does not depend on a "stupendously improbable accident," presenting the more pl...

Study identifies substances in grapefruit juice that interact dangerously with some drugs

New research from the University of North Carolina at Chapel Hill has identified and established the substance in grapefruit juice that causes potentially dangerous interactions with certain medications. For almost a decade, people have been told by their doctors and pharmacists to avoid grapefruit juice if they are being treated with certain medications, including some drugs that control...

Electronic chip, interacting with the brain, modifies pathways for controlling movement

Researchers at the University of Washington (UW) are working on an implantable electronic chip that may help establish new nerve connections in the part of the brain that controls movement. Their most recent study, to be published in the Nov. 2, 2006, edition of Nature, showed such a device can induce brain changes in monkeys lasting more than a week. Strengthening of weak connections through thi...

Interaction between lymph and liver cells may affect immune response

A new study on the ability of liver cells to interact with T cells (lymph cells that play a role in regulating the immune response) found that such interactions do occur and demonstrated the mechanism by which they may take place. The results may help explain the altered immune responses that occur with aging and other conditions and may be useful in developing therapies for viral hepatitis and a...

Novel system developed to turn data into real-time, interactive 3-D images

Seeing is believing, especially in medicine. From magnetic resonance imaging (MRI) to computed tomography (CT) scan, images of the body’s tissues and organs have become the primary tools physicians use to diagnose disease and make recommendations for effective treatment. New, innovative data display technology developed at Kent State University will provide doctors with a dramatically im...

Scientists discover rare 'gene-for-gene' interaction that helps bacteria kill their host

Scientists have discovered that a cousin of the plague bacterium uses a single gene to out-fox insect immune defences and kill its host. In research published in the journal Proceedings of the National Academy of Science, scientists have found that Photorhabdus bacteria produce an antibiotic which inhibits the work of an enzyme that insects' immune systems use to defend themselves from att...