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N.Y. research team discovers how antidepressants and cocaine interact with brain cell targets

NEW YORK (July 28, 2008) -- In a first, scientists from Weill Cornell Medical College and Columbia University Medical Center have described the specifics of how brain cells process antidepressant drugs, cocaine and amphetamines. These novel findings could prove useful in the development of more ta...

Genes and environment interact in first graders to predict physical but not social aggression

Physical aggression in children comes from their genes and the environment in which they grow up. Social aggression, such as spreading rumors or ignoring other children, has less to do with genetic factors and more with environmental factors. One important environmental influence on children...

Monkeys use 'baby talk' to interact with infants

Female rhesus monkeys use special vocalizations while interacting with infants, the way human adults use motherese, or baby talk, to engage babies attention, new research at the University of Chicago shows. Motherese is a high pitched and musical form of speech, which may be biological in origin, ...

Researchers identify new way the malaria parasite and red blood cells interact

RICHMOND, Va. (March 10, 2009) -- Virginia Commonwealth University Life Sciences researchers have discovered a new mechanism the malaria parasite uses to enter human red blood cells, which could lead to the development of a vaccine cocktail to fight the mosquito-borne disease. Malaria is transm...

Study identifies substances in grapefruit juice that interact dangerously with some drugs

New research from the University of North Carolina at Chapel Hill has identified and established the substance in grapefruit juice that causes potentially dangerous interactions with certain medications. For almost a decade, people have been told by their doctors and pharmacists to avoid grapefru...

UNC plant researchers discover proteins interact to form hair-trigger protection against invaders

Experimenting with Arabidopsis, a fast-growing cousin of the humble mustard plant, scientists at the University of North Carolina at Chapel Hill got a big surprise while investigating how plants respond to attacks from disease organisms such as bacteria and viruses. "Contrary to what we thought w...

Carnegie donates landmark clones to biology

...cated that plants have a novel regulatory mechanism that controls nutrient uptakeneighboring pore-like structures at a plant cell's surface physically interact to control the uptake. "Since plants, animals, bacteria, and fungi all share similar genes for this activity, we wanted to see in this study if same f...

Researchers capture bacterial infection on film

...athogens such as Listeria and Trypanosomes. By observing how these bacteria interact with the immune system, researchers will gain a better understanding of how... really important to study whole organisms to fully understand how bacteria interact with their host." Dr Nick Waterfield, co-author on the study and Researc...

Skin-like tissue developed from human embryonic stem cells

...in Tissue Engineering Part A . "For the first time, we have established that a single source of hESC can provide the multiple cell types needed to interact within a three-dimensional tissue model to generate complex, multilayer tissues. We are a step closer to a practical therapy to help with diseases of...

Reviews of microbial gene language published in special issue of Trends in Microbiology

...crobiology publication describes how the PAMGO Consortium has developed more than 800 new Gene Ontology terms to assist in understanding how microbes interact with their hosts. The authors also point out that Gene Ontology terms will be of great benefit to metagenomics efforts the sequencing of mixtures of ...

Baylor researchers unravel mystery of DNA conformation

... Zechiedrich and her colleagues theorize that the base flipping, denaturation, and Pauling-like DNA caused by under- and overwinding allows DNA to interact with proteins during processes such as replication, transcription and recombination and allows the code to be read. And back to the idea of the "perf...

Hush little baby... Linking genes, brain and behavior in children

...s gene is a protective factor or a risk factor for soothability and attention problems. The authors cautioned that there are likely other factors that interact with these two measures in predicting children's temperament. ...

PNNL scientist garners early career presidential award

...nvironmental challenges. "Alex has been developing and using computational tools to help us understand how contaminants and water move through and interact with the rocks and bacterial communities in the subsurface. This work can lead to better solutions for environmental remediation and carbon storage." ...

22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey

...multiple sclerosis, Alzheimers and Parkinsons disease (Pachter et al., 2006). In studying how the brain cells, neurotransmitters and neuropeptides interact and communicate with the rest of the body, researchers are working to develop improved treatments for people incapacitated by psychiatric and neurolog...

Plant protein 'doorkeepers' block invading microbes, study finds

...a membrane that encases the cell on the inside of the cell wall. It has been unclear exactly how the protein and the two branches of the immune system interact to trigger an immune response in the plant. THE NEW FINDINGS In studying the RIN4 protein, Coaker and her colleagues identified six previousl...

Reading the brain without poking it

... allow a high level of control over a prosthetic limb or computer interface," Greger says. "It will enable amputees or people with severe paralysis to interact with their environment using a prosthetic arm or a computer interface that decodes signals from the brain." The study is scheduled for on...

Plant protein 'doorkeepers' block invading microbes, study finds

...a membrane that encases the cell on the inside of the cell wall. It has been unclear exactly how the protein and the two branches of the immune system interact to trigger an immune response in the plant. THE NEW FINDINGS In studying the RIN4 protein, Coaker and her colleagues identified six previousl...

Dolphins get a lift from delta wing technology

... through water. Their finlike flippers seem perfectly adapted for maximum aquatic agility. However, no one had ever analysed how the animals' flippers interact with water; the hydrodynamic lift that they generate, the drag that they experience or their hydrodynamic efficiency. Laurens Howle and Paul Weber fro...

MicroRNAs help control HIV life cycle

... enhances viral replication and infectivity. The scientists further demonstrated that strains of HIV-1 with mutations in the region of the genome that interact with miR29 are not inhibited by miR29. "We think the virus may use this mechanism to modulate its own lifecycle, and we may be able to use this to...

Environmental cues control reproductive timing and longevity, University of Minnesota study shows

...uces the number of kids you have during your lifetime." Fluctuations in testosterone levels provide an example of how the environment and organisms interact to guide reproduction, explains R. Ford Denison, adjunct professor in the College of Biological Sciences and Ratcliff's adviser. Testosterone suppress...

Proteins in gel

...n it comes to proteins, such chips are difficult to produce. This is because the proteins have a defined three-dimensional structure by which they can interact specifically with other molecules and control biological processes. If they bind to a surface, such as on a biochip, the structure can be destroyed an...

A Canada-wide technology platform for mapping the human interactome

...nd institutions." According to Dr. Coulombe, understanding the interactome's organization by mapping the dynamic networks that proteins form when they interact together and with other molecules such as RNAs or DNA will allow us to better define the very bases of life and the misfunctions that lead to illness ...

NIH expands Human Microbiome Project; funds sequencing centers and disease projects

...se information about the microbiome to improve human health. "This effort will accelerate our understanding of how our bodies and microorganisms interact to influence health and disease," said Acting NIH Director Raynard S. Kington, M.D., Ph.D. "Examining the differences between the microbiomes of healt...

Toxic molecule may help birds 'see' north and south

... occur quickly enough to be governed by pure quantum mechanics. "Prior to our work, it was thought that this was impossible because magnetic fields interact so weakly with molecules," he said. Such chemical reactions involve electron transfers, Schulten said, "which result in freely tumbling spins of el...

Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease

...ep proper conformation and function. It can be bad news when they don't. When proteins start unfolding, amino acids that shouldn't get exposed can interact with other proteins to form unhealthy aggregates, such as the brain plaque that is the hallmark of Alzheimer's, Dr. Chadli says. "The role of molecul...

Research explores interactions between nanomaterials, biological systems

...als' surface may be coated with proteins. Understanding how these protein layers change the properties of the nanomaterials and the ways in which they interact in the body can provide valuable information on how to alter the protein coatings to allow for targeted delivery of nanomaterials to specific tissues,...

Cancer-causing protein can also help fight the tumors it causes

...d biochemistry of life is supposed to happen within the boundaries of an individual cell," he says. "Here we show that when cells in the immune system interact with other cells, proteins are exchanged without being secreted from the cell, and act in both the immune and original cells alike." "When Ras tra...

'The Vision Revolution': Eyes are the source of human 'superpowers'

...uman beings do, indeed, have superpowers. And it turns out that these superpowers, all related to vision, have been instrumental in shaping the way we interact with and see the world. The end result of Changizi's eye-opening efforts is The Vision Revolution: How the Latest Research Overturns Everything We ...

TRAPping proteins that work together inside living cells

...ng out which proteins work together to make cells function. For example, drug researchers seek chemicals that disrupt or otherwise change how proteins interact to combat diseases; environmental scientists need to understand how proteins collaborate in ecosystems to make them thrive or fail. To learn about...

'Honey bee health' of concern at Western Apicultural Society conference

...reek Inn and Krug Event Center, 198 Dry Creek Road. "The conference provides an opportunity to learn about bee health and disease research and to interact with professionals," said president Eric Mussen of Davis, Cooperative Extension apiculturist and member of the UC Davis Department of Entomology facul...

Story tips from the Department of Energy's Oak Ridge National Laboratory, June 2009

...t new standards in the field. "This technology will give biologists the third dimension they need to study cells in great detail and it allows them to interact with a cell to see how it reacts to various drugs," said Chris Mann, a Wigner Fellow and member of Oak Ridge National Laboratory's Measurement Science...

Horse whisperers, lion tamers not needed: Scientists find genetic regions that soothe savage beasts

...g ), should help animal breeders, farmers, zoologists, and anyone else who handles and raises animals to more fully understand what makes some animals interact with humans better than do others. It may also lead to more precise breeding strategies designed to pass specific genes from one generation to the nex...

Researchers shed light on trading behavior in animals -- and humans

...rooming for food, but the ability does not seem to extend to trading commodities. Most of the trading of services seems to occur between partners who interact a lot, and so are familiar with each others' behavior. The chimpanzees thus know whether the risk is likely to pay off, and most of the time, what's b...

New research program BioInterfaces launched

...opers. In the subsequent stages, multifunctional molecular devices or advanced surface modifications will be designed and built in order to target and interact with the key molecular control points and thereby to control cell behaviour." The interdisciplinary nature of the BioInterfaces programme demands a...

Faculty of Translational Medicine boosts support for biomedical researchers

...hemes and fora to keep people abreast of developments both locally and further afield. 'Our new Faculty will provide opportunities for members to interact and collaborate and to become leaders in translational medicine, thereby accelerating advances that will benefit patient care.' Over 250 people fro...

Simple drug treatment may prevent nicotine-induced SIDS: Study

...says Colin Nurse, academic advisor on the study and a professor in the department of Biology. "We speculated that chemicals released from nerves might interact with adrenal cells and cause them to lose oxygen sensitivity. It turns out that nicotine mimics the effects of one of these chemicals, thereby allowin...

Design input accelerates new technologies' route to market

...omputer Science has developed a powerful Mixed Reality Architecture (MRA) system that can be utilised to enable geographically dispersed co-workers to interact as they would in a normal office environment. By joining spaces as opposed to individuals ad-hoc interactions can be supported as well as pre-organise...

Equity concerns raised by congestion pricing can be addressed to make approach viable

...liver clean air and less gridlock to everyone." The RAND study evaluated alternative ways of defining and measuring equity and how such approaches interact with alternative forms of pricing, as well as the context in which congestion pricing is imposed. Light and study co-author Liisa Ecola reviewed dozen...

Scientists explain how 'death receptors' designed to kill our cells may make them stronger

... the various molecular pathways activated by death receptors and the proteins involved in the process. Specifically, they looked at how these proteins interact with each other and how they redistribute within a cell. Death receptors are an essential tool for the immune system to eliminate cells that have been...

Sweden to host 1.3 billion Euro research center

...brecen, in Hungary, and Bilbao, in Spain. Neutron imaging is a crucial tool for looking at how the atoms within materials are arranged and how they interact with each other. This information can help scientists modify and tailor materials to specific needs. The uses for this technology range from producing...
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