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gene in Biological News

Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols

COLD SPRING HARBOR, N.Y. (Wed., Aug. 5, 2009) Vectors derived from retroviruses are useful tools for long-term gene transfer because they allow stable integration of transgenes and propagation into daughter cells. Lentiviral vectors are preferred because they can transduce non-proliferating ce...

Cancer's distinctive pattern of gene expression could aid early screening and prevention

AUGUSTA, Ga. Distinctive patterns of genes turned off or left on in healthy versus cancerous cells could enable early screening for many common cancers and maybe help avoid them, Medical College of Georgia scientists say. Researchers are comparing chemical alterations, called DNA methylatio...

Newly discovered gene fusion may lead to improved prostate cancer diagnosis

Researchers from NewYork-Presbyterian Hospital/Weill Cornell Medical Center have discovered a new gene fusion that is highly expressed in a subset of prostate cancers. The results may lead to more accurate prostate cancer testing and new targets for potential treatments. Experts believe that gene ...

Scientists discover gene mutation responsible for hereditary neuroendocrine tumor

SALT LAKE CITY University of Utah researchers and their colleagues have identified the gene that is mutated in a hereditary form of a rare neuroendocrine tumor called paraganglioma (PGL). The gene, called hSDH5, is required for activation of an enzyme complex that plays a critical role in the che...

Reviews of microbial gene language published in special issue of Trends in Microbiology

Blacksburg, Va. -- Ten articles describing how a universal language to describe genes is bringing benefits to the study of the microbial world have been published in a special issue of Trends in Microbiology , co-edited by Virginia Bioinformatics Institute professor Brett Tyler. The Gene Ontology...

Further gene mutations linked to autism risk

Pieces in the complex autism inheritance puzzle are emerging in the latest study from a research team including geneticists from the University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia (CHOP). The study identified 27 different genetic regions where rare copy n...

Tumor suppressor gene in flies may provide insights for human brain tumors

SINGAPORE and DURHAM, N.C. In the fruit fly's developing brain, stem cells called neuroblasts normally divide to create one self-renewing neuroblast and one cell that has a different fate. But neuroblast growth can sometimes spin out of control and become a brain tumor. Researchers at Duke-NU...

Researchers identify new risk factor gene for rheumatoid arthritis

Scientists at The Feinstein Institute for Medical Research and a team of collaborators from across the country have identified a new risk factor gene for rheumatoid arthritis. The paper will be published in Nature Genetics and the finding brings light to the nature of the disease. The gene, dubb...

Small molecules mimic natural gene regulators

ANN ARBOR, Mich.---In the quest for new approaches to treating and preventing disease, one appealing route involves turning genes on or off at will, directly intervening in ailments such as cancer and diabetes, which result when genes fail to turn on and off as they should. Scientists at the Un...

Omega fatty acid balance can alter immunity and gene expression

For the past century, changes in the Western diet have altered the consumption of omega-6 fatty acids (w6, found in meat and vegetable oils) compared with omega-3 fatty acids (w3, found in flax and fish oil). Many studies seem to indicate this shift has brought about an increased risk of inflammat...

UF makes gene therapy advance in severe genetic disorder

GAINESVILLE A dog born with a deadly disease that prevents the body from using stored sugar has survived 20 months and is still healthy after receiving gene therapy at the University of Florida putting scientists a step closer to finding a cure for the disorder in children. Called glycogen st...

Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?

This release is available in Chinese . Researchers at Iowa State University have found that increased expression of a form of cytochrome P-450 (CYP4B1) is a key marker of inhibition of colitis in mice by ca...

The evolution of gene regulation

Even microbes are governed by the principle of supply and demand at least at the genetic level. Not all of their gene products, the blueprints for proteins, are required at all times. That means most of their genes only become active when they are needed, as is the case in higher organisms. In th...

P[acman]-generated fruit fly gene 'library': A new research tool

HOUSTON -- (May 24, 2009) -- Using a specially adapted tool called P[acman], a collaboration of researchers led by Baylor College of Medicine has established a library of clones that cover most of the genome of Drosophila melanogaster (fruit fly) and should speed the pace of genetic research. ...

Association for Molecular Pathology joins ACLU to challenge gene patents

Washington, DC May 13, 2009 The Association for Molecular Pathology (AMP) announced today that it is working with the American Civil Liberties Union (ACLU) and the Public Patent Foundation to bring a lawsuit charging that patents on two human genes associated with breast and ovarian cancer are u...

UMMS researchers isolate first 'neuroprotective' gene in patients with amyotrophic lateral sclerosis

WORCESTER, Mass. A genetic variant that substantially improves survival of individuals with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, has been indentified by a consortium of researchers led by John Landers, PhD, Associate Professor of Neurology and Robert Brown, MD...

Preclinical work shows how one gene causes severe mental retardation

Durham, N.C., and Chapel Hill, N.C. -- Researchers at Duke University Medical Center and the University of North Carolina have discovered in mice how a single disrupted gene can cause a form of severe mental retardation known as Angelman syndrome. In a study published in the journal Nature N...

Random picks better than complicated process in gene identification

WEST LAFAYETTE, Ind. - Researchers at Purdue University have found a way to save time, money and a little frustration in searches for specific genes that shed light on the biological processes associated with all forms of life. Andrew DeWoody, a professor of genetics, and postdoctoral associate...

Moving gene therapy forward with mobile DNA

Gene therapy Gene therapy is the introduction of genetic material into a patient's cells resulting in a cure or a therapeutic effect. In recent years, it has been shown that gene therapy is a promising technology to treat or even cure several fatal diseases for which there is no attractive alt...

Single gene defect can cause stroke, other artery diseases

HOUSTON(May 1, 2009) For the first time, scientists have discovered a single gene defect that causes thoracic aortic aneurysms and dissections as well as early onset coronary artery disease, ischemic stroke and Moyamoya disease. The research is led by scientists at The University of Texas Health ...

International team finds key gene that allows plants to survive drought

A team of scientists from Canada, Spain and the United States has identified a key gene that allows plants to defend themselves against environmental stresses like drought, freezing and heat. "Plants have stress hormones that they produce naturally and that signal adverse conditions and help t...

Simulated gene therapy

COLLEGE PARK, MARYLAND, April 29, 2009 -- In a recent issue of The Journal of Chemical Physics , published by the American Institute of Physics (AIP), a group of researchers at the University of California, Berkeley and Los Alamos National Laboratory describe the first comprehensive, molecular-le...

Researchers discover that gene switches on during development of epilepsy

WINSTON-SALEM, N.C. A discovery made by researchers at Wake Forest University School of Medicine while studying mice may help explain how some people without a genetic predisposition to epilepsy can develop the disorder. In a study published this month in the Journal of Neuroscience , senior ...

Plant gene mapping may lead to better biofuel production

UPTON, NY -- By creating a "family tree" of genes expressed in one form of woody plant and a less woody, herbaceous species, scientists at the U.S. Department of Energy's Brookhaven National Laboratory have uncovered clues that may help them engineer plants more amenable to biofuel production. The...

Scientists identify key gene that protects against leukemia

Researchers have identified a gene that controls the rapid production and differentiation of the stem cells that produce all blood cell types -- a discovery that could eventually open the door to more streamlined treatments for leukemia and other blood cancers, in which blood cells proliferate out...

Altered gene can increase risk of schizophrenia

NEW BRUNSWICK, N.J. Rutgers geneticist Linda Brzustowicz and her colleagues have identified a specific DNA change that is likely to increase risk for developing schizophrenia in some people. It provides a potential mechanism that may be a point of entry for drug therapy, consistent with the growi...

GEN highlights increasing use of digital gene expression profiling

New Rochelle, NY, April 3, 2009A novel technique for carrying out gene-expression profiling is set to challenge the market dominance of the current, widely used methodology, reports Genetic Engineering & Biotechnology News ( GEN ). Some scientists believe that digital gene-expression profiling, ...

Changes in gene may stunt lung development in children

PITTSBURGH, March 26 Mutations in a gene may cause poor lung development in children, making them more vulnerable to diseases such as chronic obstructive pulmonary disease (COPD) later in life, say researchers at the University of Pittsburgh Graduate School of Public Health and the German Researc...

Common gene variants influence risk factor for sudden cardiac death

A new study has identified several common genetic variants related to a risk factor for sudden cardiac death. The report receiving early online release in the journal Nature Genetics identifies variants in genes, some known and some newly discovered, that influence the QT interval measured on th...

Plant biologists discover gene that switches on 'essence of male'

Biologists at the University of Leicester have published results of a new study into plant sex and discovered that a particular gene switches on 'the essence of male'. The study takes to a new level understanding of the genes needed for successful plant reproduction and seed production. Pro...

Doubling a gene in corn results in giant biomass

University of Illinois plant geneticist Stephen Moose has developed a corn plant with enormous potential for biomass, literally. It yields corn that would make good silage, Moose said, due to a greater number of leaves and larger stalk, which could also make it a good energy crop. The gene know...

Researchers discover gene mutations that cause childhood brain cancer

March 8, 2009 TORONTO Researchers funded by the Canadian Cancer Society have discovered eight similar genes that, when mutated, appear to be responsible for medulloblastoma the most common of childhood brain cancers. The findings are published today in the online edition of the journal Nature G...

Pulmonary hypertension in children may result from reduced activity of gene regulator

AUGUSTA, Ga. - Too little activity by gene regulators called PPARs appears to be a major player in the irreversible lung damage that can occur in children with heart defects, researchers say. If they are right, drugs already under study to boost PPAR signaling in adults with lung injuries, may ...

U-M researchers ID gene involved in pancreatic cancer

ANN ARBOR, Mich. Researchers from the University of Michigan Comprehensive Cancer Center have identified a gene that is overexpressed in 90 percent of pancreatic cancers, the most deadly type of cancer. Expression of the gene, Ataxia Telangiectasia Group D Complementing gene, called ATDC, is o...

Doubling a gene in corn results in giant biomass

University of Illinois plant geneticist Stephen Moose has developed a corn plant with enormous potential for biomass, literally. It yields corn that would make good silage, Moose said, due to a greater number of leaves and larger stalk, which could also make it a good energy crop. The gene know...

USC researchers identify gene variant associated with both autism and gastrointestinal dysfunction

A study led by researchers at the University of Southern California (USC) and Vanderbilt University have identified a specific gene variant that links increased genetic risk for autism with gastrointestinal (GI) conditions. The findings suggest that disrupted signaling of the MET gene may contr...

Newly discovered gene plays vital role in cancer

[PRESS RELEASE, 27 February 2009] Gene p53 protects against cancer and is usually described as the most important gene in cancer research. However, scientists at the Swedish medical university Karolinska Institutet have now shown that a previously unknown gene, Wrap53, controls the activity of p53...

Calculating gene and protein connections in a Parkinson's disease model

FINDINGS: Researchers have created an algorithm that meshes existing data to produce a clearer step-by-step flow chart of how cells respond to stimuli. Using this new method, Whitehead Institute and Massachusetts Institute of Technology scientists have analyzed alpha-synuclein toxicity to identify...

CSHL researchers identify gene that helps plant cells keep communication channels open

Plant cells communicate via microscopic channels called plasmodesmata that are embedded in their cell walls. For the stem cells in the plants' growing tips, called "meristems," the plasmodesmata are lifelines, allowing nutrients and genetic instructions for growth to flow in. Developmental and ...

Researchers identify gene linked to aggressive progression of liver cancer

RICHMOND, Va. (Feb. 17, 2009) Virginia Commonwealth University researchers have identified a gene that plays a key role in regulating liver cancer progression, a discovery that could one day lead to new targeted therapeutic strategies to fight the highly aggressive disease. Hepatocellular carc...
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