Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients
PITTSBURGH, July 7 The first findings from a one-of-a-kind, patient-driven effort to provide lung tissue for research might help doctors predict when patients with idiopathic pulmonary fibrosis
(IPF) are becoming dangerously ill and also could point the way to interventions that could sustain the...
Cystic fibrosis testing -- next steps
San Juan Capistrano, CA and Chantilly, VA Three reports describing advances in cystic fibrosis
genetic testing appear in the May 2009 issue of The Journal of Molecular Diagnostics .
is a hereditary disease that affects mucus secretions in the lungs, liver, pancreas, and intes...
Two-pronged model could help foil tough cystic fibrosis infections
Hanover, NH--Dartmouth Medical School researchers have devised a novel approach for thwarting the relentless bacterial infections that thrive in the lungs of people with cystic fibrosis
(CF), unlocking new possibilities against a tenacious and toxic hallmark of the common genetic disease.
Nanoemulsion potent against superbugs that kill cystic fibrosis patients
ANN ARBOR, Mich. University of Michigan scientists report highly encouraging evidence that a super-fine oil-and-water emulsion, already shown to kill many other microbes, may be able to quell the ravaging, often drug-resistant infections that cause nearly all cystic fibrosis
New test promises quicker, more accurate evaluation for cystic fibrosis patients
Researchers at National Jewish Health have identified a simple gene-based blood test that more accurately and quickly measures cystic fibrosis
patients' response to therapy than current tests. The test, a measure of inflammatory gene expression, could improve patient care and help clear a backlog ...
New approach to treating cystic fibrosis lung infection shows promise
Toronto, ON (September 22, 2008) Researchers at the University of Calgary have found a new method of fighting severe lung infections in people with cystic fibrosis
(CF). These findings are published in Proceedings of the National Academy of Science USA, this week.
Communities of bacteria gr...
Study uncovers clues to cystic fibrosis gene dysfunction and gastrointestinal disease
PROVIDENCE, R.I. A new study by researchers at Hasbro Childrens Hospital, the pediatric division of Rhode Island Hospital, and Mount Sinai Hospital, New York, offers new insight into the role that the cystic fibrosis
gene plays in the development of gastrointestinal disease.
The cystic fibrosi...
Cystic fibrosis proteins photographed interacting
BIRMINGHAM, Ala. New microscopic pictures show the first-ever physical evidence of interaction between two proteins involved in Cystic Fibrosis
Researchers at the University of Alabama at Birmingham (UAB) studied a CF-causing protein and another protein called epithelial sodium c...
CU-Boulder technology used to identify unexpected bacteria in cystic fibrosis patients
Molecular technology developed by a University of Colorado at Boulder professor to probe extreme life forms in undersea hydrothermal vents has been used to identify unexpected bacteria strains in the lung fluid of Denver children suffering from cystic fibrosis, findings that may lead to more effec...
Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
Mechelen, Belgium and Bethesda, Maryland, USA; 29 November 2007 Galapagos NV (Euronext & LSE: GLPG) and Cystic Fibrosis
Foundation Therapeutics, Inc. (CFFT), the non-profit affiliate of the Cystic Fibrosis
Foundation, announced today a new collaboration aimed at discovering new treatments for cys...
Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials
CHAMPAIGN, Ill. By better understanding how antimicrobials bind and thereby get inactivated in the mucus of air passages, researchers at the University of Illinois may have found a way to help cystic fibrosis
patients fight off deadly infections.
While not a cure, this work has potential as a th...
Research yields potential target for cancer, wound healing and fibrosis
New Orleans, LA Research conducted by Allison Berrier, PhD, Assistant Professor of Oral and Craniofacial Biology at the LSU Health Sciences Center New Orleans School of Dentistry, and colleagues, provides insights that may help scientists design novel approaches to control wound healing and figh...
FSU researcher's discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
TALLAHASSEE, Fla. -- The discovery of a protein involved in the life-threatening mechanism of liver fibrosis
has helped a researcher at the Florida State University College of Medicine attract a $1.5 million grant from the National Institutes of Health.
Branko Stefanovic, associate professor in...
Computer simulations point to key molecular basis of cystic fibrosis
Researchers from the University of North Carolina at Chapel Hill have identified a key molecular mechanism that may account for the development of cystic fibrosis, which about 1 in 3000 children are born with in the US every year. The findings, published February 29 in the open-access journal PLo...
Translational research patented first experimental treatment against idiopathic pulmonary fibrosis
This release is available in Spanish .
Idiopathic pulmonary fibrosis
is a disease with unknown cause with a very severe prognosis; when detected, it is already in an advanced stage. Patients suffering from it cannot develop with normality pulmonary gas exchange, and have a very reduced qual...
Extra-aggressive form of idiopathic pulmonary fibrosis identified
Idiopathic pulmonary fibrosis
(IPF) is a chronic and progressive lung disorder from which most patients die within 5 years after diagnosis. The disease is characterized by the insidious onset of dyspnea or cough and usually evolves slowly.
Now, Selman and coworkers present in an article publ...
Gene expression patterns predict rapid decline in idiopathic pulmonary fibrosis patients
Idiopathic pulmonary fibrosis
(IPF) is a chronic lung disease typically characterized by the slow but progressive onset of shortness of breath or cough. Most patients live about five years after diagnosis. However, according to a new study being published today in the online journal PLoS ONE, a su...
Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment
Researchers at the University of Pennsylvania School of Medicine have discovered that an enzyme produced by lung-infecting bacteria further shuts down a protein that is defective in cystic fibrosis
patients. The disruption to this protein that conveys ions from lung cells to airways causes thick mu...
Key found to kill cystic fibrosis superbug
Researchers from the Schulich School of Medicine & Dentistry at The University of Western Ontario , working with a group from Edinburgh, have discovered a way to kill the cystic fibrosis
superbug, Burkholderia cenocepacia. These investigators, under the leadership of Dr. Miguel Valvano, Departm...
Clues to gene expression in cystic fibrosis will guide research
Genetics tests could help provide cystic fibrosis
(CF) patients with targeted treatment in future, pilot study authors suggest. Results from a French clinical trial published today in BMC Medicine show how a small percentage of CF sufferers with a rare genetic stop mutation responded positively to ...
Discovery could aid fight against cystic fibrosis infection
Harvard Medical School researchers have discovered one way that a hardy disease-causing bacteria could be surviving in the lungs of chronically infected cystic fibrosis
"This work is important because pathogenic bacteria such as Pseudomonas aeruginosa (PA) use protein secretion s...
Scientists discover basic defect in cystic fibrosis airway glands
Scientists at Stanford University have determined that the buildup of sticky mucus found in cystic fibrosis
is caused by a loss in the epithelial cell's ability to secrete fluid. This research appears as the "Paper of the Week" in the March 17 issue of the Journal of Biological Chemistry, an Ameri...
Test helps in fight against lung infections and for treating other life-threatening infections
...or serious lung infections in patients with Cystic fibrosis
(CF), a population recognized as having among the ...edicine and Dr. Neil Brown, Director, Adult Cystic fibrosis
Clinic conducted the clinical research from 2007 t...clinical research involved 14 patients with cystic fibrosis
at the University of Alberta hospital CF clinic. ...
Placenta-derived stem cells may help sufferers of lung diseases
...ultimately play a role in the treatment of lung diseases, such as pulmonary fibrosis
and fibrotic diseases caused by tuberculosis, chemical exposure, radiation ...cells as a therapeutic tool for disorders characterized by inflammation and fibrosis
is supported in previous studies," says Dr. Ornella Parolini, the study's l...
New test can detect both genetic and chromosomal abnormalities in embryos
... the first time they have been able to demonstrate that the test can work in cells taken from embryos that have already been diagnosed with the cystic fibrosis
gene mutation using conventional preimplantation genetic diagnosis (PGD).
Gary Harton, PGD scientific director of the Genetics & IVF Institute in F...
CSHL scientists harness logic of 'Sudoku' math puzzle to vastly enhance genome-sequencing capability
...lected DNA from thousands of members of orthodox Jewish communities. The organization's aim is to prevent genetic diseases such as Tay-Sachs or cystic fibrosis
that occur frequently within specific ethnic populations. The team's new method will now allow the many thousands of DNA samples gathered by Dor Yesho...
Protein linked to change in tissue that surround and support breast tumors
...issue, they found that the tissue in mice with the splice variant of AIB1 was thicker than that seen in mice with too much of the parent protein. This fibrosis
may be related to the hard, scar-like tissue frequently seen around a breast tumor, Furth says. "What we don't know is whether generation of this dens...
American Society for Microbiology honors Melissa B. Miller
...utstanding laboratory research in clinical microbiology or antimicrobial agents.
Dr. Miller has contributed significantly to the fields of cystic fibrosis
microbiology and detection and epidemiology of MRSA, and is known for her research on the development and application of molecular assays for use in t...
American Chemical Society's weekly PressPac -- May 27, 2009
...ows promise as a potential new treatment for liver fibrosis
the disease that leads to cirrhosis scientists i...ted States.
Ram Mahato and colleagues note that fibrosis
involves build-up of scar tissue in the liver from... alcohol abuse, toxins, or other factors. Advanced fibrosis
can lead to cirrhosis, a condition in which the li...
Liver disease 'shrunk' by blood-pressure drug
...f losartan, a drug normally prescribed for hypertension, on 14 patients in Spain, who had Hepatitis C.
The illness was at an advanced stage causing fibrosis
- scarring in the liver - which would usually have progressed to liver failure.
Half of the patients in the trial saw the scars in their liver shri...
'Disordered' amino acids may really be there to provide wiggle room for signaling protein
...1 is representative of a large class of proteins with an array of biological roles, including signaling pathways implicated in diseases such as cystic fibrosis
and breast cancer.
"Here we have a molecule that serves an important role in how cells function and survive, but it contains these puzzling 'junk' ...
Tips from the American Journal of Pathology
... glomerular filtration rate in human patients.
The biomarkers identified by Dr. Bttinger, Dr. Kretzler, and colleagues "predict progressive renal fibrosis
in mice and may [therefore] be useful molecular predictors of [chronic kidney disease] progression in humans."
Ju W, Eichinger F, Bitzer M, Oh J, ...
Researchers identify a molecule that increases the risk of cardiac insufficiency
... people have a life expectancy of less than five years. The accumulation of fibrosis
in the heart has been proven to have a significant influence on the develop...ciency do not actually inhibit the enzyme lysyl oxidase, nor do they reduce fibrosis
or improve heart functions. Other drugs however, which are less commonly us...
Sugar on bacteria surface serves as base for a web of resistance
... COLUMBUS, Ohio The bacteria responsible for chronic infections in cystic fibrosis
patients use one of the sugars on the germs' surface to start building a structure that helps the microbes resist efforts to kill them, new research s...
No hiding place for infecting bacteria
...icult to treat. P. aeruginosa biofilms cause disease in burns, wounds, contact lens infections and are particularly prevalent in the lungs of cystic fibrosis
"We specifically targeted the F-actin protein with a negatively charged peptide, and the DNA with the enzyme DNase, which both prevented...
Plasminogen activator inhibitor type-1 -- a potential link between heart failure and diabetes
.... Histochemical analysis demonstrated 33% more LV fibrosis
as well. The increased fibrosis
associated with increased PAI-1 was accompanied by... after coronary occlusion accompanied by increased fibrosis
and functional derangements indicative of both sys...
Gene therapy demonstrates benefit in patients with rheumatoid arthritis
...d by an investigator at Beth Israel Deaconess Medical Center (BIDMC).
Originally conceived as a means of treating genetic diseases, such as cystic fibrosis
and hemophilia, gene therapy involves implanting a normal gene to compensate for a defective gene in the patient. The first clinical trial to test gen...
Research elucidates way lungs fight bacteria and prevent infection
...nflammation, interfering with breathing and damaging the airways.
is one disease where this work might have particular import, Dr. Chun says. People with cystic fibrosis
possess an abnormal gene that causes normal mucus to become thick and stick...
UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
In the U.S., about 200,000 patients have IPF, and about 40,000 patients die from the disease each year, according to the Pulmonary fibrosis
Foundation. The disease typically strikes people in their 50s and older, causing severe scarring of the lungs. Death usually occurs within three years...
Reducing the damage of a heart attack
...he journal has selected the study as an issue highlight.
"Treatments for fibrosis
in the heart are relatively limited, making it important to develop new and...g that may one day inhibit the functioning of the protein in order to limit fibrosis
within the heart," says Dr. Sato. "Doing so may aid in controlling the degr...