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First genetically-engineered malaria vaccine to enter human trials

Walter and Eliza Hall Institute scientists have created a weakened strain of the malaria parasite that will be used as a live vaccine against the disease. The vaccine, developed in collaboration with researchers from the US, Japan and Canada, will be trialled in humans from early next year. Mala...

Purdue researchers obtain a snapshot clarifying how materials enter cells

WEST LAFAYETTE, Ind. - A group of Purdue University researchers has captured a key step in the metabolic process that allows materials, such as nutrients and drug treatments, to move in and out of cells. A research team led by Jue Chen, an associate professor of biological sciences, obtained a ...

Iowa State scientists demonstrate first use of nanotechnology to enter plant cells

A team of Iowa State University plant scientists and materials chemists have successfully used nanotechnology to penetrate plant cell walls and simultaneously deliver a gene and a chemical that triggers its expression with controlled precision. Their breakthrough brings nanotechnology to plant biol...

Chemical tests of cell growth enter third dimension

Ohio State University researchers have developed two new technologies for measuring cell growth in the laboratory. The first patent-pending technology provides a way for researchers to easily tell if cancer cells in the laboratory are responding to an anti-cancer drug. The second -- because it te...

Stolen gene allows insect virus to enter cells

A gene enabling an insect virus to enter new cells was likely stolen from a host cell and adapted for the virus's use, researchers at Boyce Thompson Institute (BTI) at Cornell University report. Virologists have long thought of baculoviruses, a group of viruses that can liquefy their insect hosts...

Hide and seek: Researchers discover a new way for infectious bacteria to enter cells

French scientists have learned how Listeria monocytogenes, which causes a major food-borne illness, commandeers cellular transport machinery to invade cells and hide from the body's immune system. They believe that other infectious organisms may use the same mechanism. The Listeria bacterium...

Navigating in the ocean of molecules

...enzyme is seen as a promising approach to the treatment of cancer and malaria. An even more detailed search can be carried out if the scientist can enter information about biological activity - if available - at the beginning of the navigation process. In this case, Scaffold Hunter only links the scaffo...

New cancer drug delivery system is effective and reversible

...nd compartments, called liposomes, are useful as drug-delivery vehicles. When linked to molecules that target receptors on cancer cells, liposomes can enter and dump their cancer-killing contents into those cells. Scientists have spent more than a decade trying to direct liposomes to specific cancer cel...

URI researcher sheds light on 'man-eating' squid; finds them timid, nonthreatening

...mendations for safely diving with the squid, including suggestions to always carry a back-up dive light and to be tethered to a boat. Any time humans enter the habitat of a large animal, there is potential for dangerous interactions, he said, so divers should use caution. "However, I want to spread th...

URI researcher sheds light on 'man-eating' squid; finds them timid, non-threatening

...mendations for safely diving with the squid, including suggestions to always carry a back-up dive light and to be tethered to a boat. Any time humans enter the habitat of a large animal, there is potential for dangerous interactions, he said, so divers should use caution. "However, I want to spread th...

UC San Diego's $3 million NSF grant to fund science festivals

...ocal science and research firms, museums, colleges and universities and other members of the San Diego science community. Nicole Garcia, who will enter UC San Diego as a freshman this fall, commented on the need for science outreach in the community: "Here in America, we take pride in providing the be...

Scientists link immune system's natural killer cells to infant liver disease

...urrent frontline treatment is surgery to remove and replace obstructed bile ducts with sections of the child's intestine. Without surgery, bile cannot enter the intestines to aid digestion, and instead backs up into and damages the liver. Corrective surgery is successful 65 to 85 percent of the time and is...

Study by NTU professors provides important insight into apoptosis or programmed cell death

...is, the cell's rescue mechanism is inhibited when certain proteins (i.e. 'anti-factors' that are necessary to keep a cell alive) are no longer able to enter the cell's nucleus, thus stopping the cell's ability to initiate its self-repair process. In addition, they also discovered that the protein RanGT...

A matter of density, not quantity

...sed by bacteria called Pseudomonas aeruginosa. Once they reach a certain density, colonies of Pseudomonas aeruginosa produce virulence factors and can enter into a slimy state, a biofilm, which prevents antibiotics from penetrating. The process of quorum sensing, which cells use to "sense" cell density, is...

Army study improves ability to predict drinking water needs

...d amount of energy expended. However, the researchers hope to develop either a table or an online application program in which an individual could enter variables such as height and weight, how hard and long they would be active and what the environmental conditions would be (temperature, humidity, sun...

Study finds role for parasites in evolution of sex

... extinction at the hands of parasites. The scenario works on mathematical models, but there have been few attempts to see if it holds in nature. enter Potamopyrgus antipodarum , a snail common in fresh water lakes in New Zealand. What makes these snails interesting is that there are sexual and asexu...

Singapore nanotechnology combats fatal brain infections

...nal antibiotics because the molecular structure of most drugs is too big to enter the membrane. "Our treatment damages the structure of the pathogen and ...ponents on their surface," Dr. Yang added. "These nanoparticles can easily enter bacteria, yeast or fungal cells and destabilize them to cause cell death. F...

Study on keeping nuclear bombs from US ports shows misplaced fear over cargo scanning cost

...iginating outside the U.S. would receive a rapid screening via low-cost, drive-through radiation and medium energy x-ray radiographic portals as they enter an international port. Containers that fail will not be placed in stacks for outbound containers, but will be flagged immediately and removed for a mo...

'Bycatch' whaling a growing threat to coastal whales

.... "Given these financial incentives, you have to wonder how many of these whales are, in fact, killed intentionally." In Japan, whale-meat products enter into the commercial supply chain that supports the nationwide distribution of whale and dolphin products for human consumption, including products fro...

Waste water treatment plant mud used as 'green' fuel

...r getting rid of mud that would have had to be dumped elsewhere, while also powering the plant". "As this mud is already waste, burning it does not enter into the atmospheric CO 2 emissions assigned to each country under the Kyoto Protocol", Jos Luis Domingo, lead author of the study and director of th...

Research explores interactions between nanomaterials, biological systems

...e forms in different natural environmental contexts. When nanomaterials enter a biological fluid for example, blood, plasma or interstitial fluid the m... other characteristics could greatly affect the ability of nanomaterials to enter a cell; this could determine whether a material can be useful in nanomedici...

Research vessel Polarstern starts 24th Arctic season

... and whales in the framework of a long-term project to document their distribution, just like in the first journey stage. RV Polarstern is expected to enter port in Bremerhaven on September 25th. ...

Dioxins in food chain linked to breastfeeding ills

...he legislative process." Much of Lawrence's research focuses on a transcription factor known as aryl hydrocarbon receptor, or AhR. When pollutants enter the body they bind to AhR, which then turns on certain genes responsible for detoxification. By using dioxin to activate AhR, researchers have learned...

Equity concerns raised by congestion pricing can be addressed to make approach viable

..., job opportunities, schools, places of worship and other destinations when considering congestion pricing. Cordon pricing, where drivers pay a fee to enter a particular area, can be progressive, regressive or neutral, depending where low-income drivers live, according to the RAND study. High-occupancy ...

International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury

...nd on both the Nature Genetics ( http://www.nature.com/ng/index.htm ) and the SAEC's ( www.saeconsortium.org ) websites. Qualified researchers, who enter into a data use agreement, can obtain free access via the SAEC's website to the supporting study data, for use exclusively in biomedical research. ...

Old stain in a new combination

... Malaria pathogens need humans and mosquitoes When the Anopheles mosquito bites, the malaria parasites (plasmodia) in the saliva of the mosquito enter the human body, reproduce in liver cells and then attack the red blood cells. This causes severe symptoms such as high fever or anemia; children in pa...

MIT’s implantable device offers continuous cancer monitoring

...s coated with antibodies specific to the target molecules. Target molecules enter the implant through a semipermeable membrane, bind to the particles and cau...edic implants. The semipermeable membrane, which allows target molecules to enter but keeps the magnetic nanoparticles trapped inside, is made of polycarbona...

UC Davis bioengineer receives Hartwell Foundation grant to address skull fusion disorder of infants

...demonstrate the feasibility of this approach in laboratory rats. "What we want to do is make a scaffold a material that the bone-forming cells can enter that supplies them with the proper directions for how much bone they should be forming and how fast they should be doing it," he said. Leach will ...

Bacteria create aquatic superbugs in waste treatment plants

...on cold or the flu, Xi said. Also, instead of flushing unused drugs, they should be saved and disposed of at designated collection sites so they don't enter the sewer system. The next step, said Xi, is to see how far downstream the superbugs survive and try to understand the link between aquatic and hu...

NOAA awards $22.5 million to Harbor Branch/FAU and UNCW for new cooperative institute

...primary NOAA partner, which will replace the four east coast centers of NOAA's Undersea Research Program. "We are thrilled by this opportunity to enter into an equal partnership with FAU, taking full advantage of the specific areas of expertise and research strengths of both institutions," said Dr. St...

WARF signs license agreement with Pfizer for human embryonic stem cells

...e benefit to public health could be tremendous as we pursue our discoveries to advance the treatment of debilitating diseases." "We are pleased to enter into this licensing agreement with Pfizer," said Carl E. Gulbrandsen, managing director of WARF. "Pfizer's access to this key intellectual property ma...

Simulated gene therapy

..."The genetic material must be protected during transit to a cell, it must pass into a cell, it must survive the cell's defense mechanisms, and it must enter into the cell's guarded nucleus." If all of these barriers can be overcome, gene therapy would be a valuable technique with profound clinical impli...

Mites on hissing coackroach may benefit humans with allergies

...sent on and around this species of cockroach, including several fungi associated with allergies and others that can cause secondary infections if they enter the lungs or an open wound. The mites eat saliva and organic debris that collects between the cockroaches' legs, eliminating material that would fo...

Blood testing, mosquito style

...uter or a monitoring instrument worn on the wrist. The system could even be connected to an alarm to alert patients or doctors when blood sugar levels enter the danger zone. "This is a dramatic improvement over manual poking, particularly for children and elderly patients," says Martin Mintchev, directo...

A genomic CluE for cloud computing

...red to analyze these data. Expensive to establish and maintain, these computer clusters are generally available only to labs that can afford them. enter Mihai Pop, an assistant professor in the department of computer science and in the Center for Bioinformatics and Computational Biology at the Universi...

MIT: Jeremy Nathans to deliver Scolnick Prize lecture

...telliform type of macular dystrophy is caused by abnormalities in a member of a previously unknown family of ion channels proteins that allow ions to enter and exit cells. ...

Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck

..."This agreement exemplifies our ability to execute our corporate strategy combining creative science with an industry-leading platform to successfully enter into partnerships that are financially attractive and value-enhancing," said Howard H. Pien, chairman and chief executive officer of Medarex. "We will...

Unlikely life thriving at Antarctica's Blood Falls

...during the Antarctic summer, temperatures rise just enough for glaciers protruding into the valleys to begin melting. The meltwater forms streams that enter lakes covered by ice that is two-to-three-stories thick. Even less forgiving are the conditions found below the Taylor Glacier, an outlet glacier o...

Caltech researchers train computers to analyze fruit-fly behavior

...analyze something like 2,000 pairs of flies," says Anderson. "It's been virtually impossible to do this without a small army of graduate students." enter Perona and Heiko Dankert, a postdoctoral scholar in electrical engineering. Using the techniques of machine vision and combining them with other engin...

Ambati study published in PNAS

... Addditionally, they showed, using time-lapse studies, that siRNA does not enter cells without a cell-permeating moiety such as cholesterol. This is important, because siRNA must enter cells in order to function as intended by specifically degrading intracellu...
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