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disorder in Biological News

Scripps Research scientists observe human neurodegenerative disorder in fruit flies

La Jolla, CA, June 24, 2009 -- A team of scientists from The Scripps Research Institute, Katholeike Universiteit Leuven, and the University of Antwerp, Belgium, among other institutions, has created a genetically modified fruit fly that mimics key features of Charcot-Marie-Tooth disease, a common ...

Scientists discover new genetic immune disorder in children

Your immune system plays an important function in your healthit protects you against viruses, bacteria, and other toxins that can cause disease. In autoinflammatory diseases, however, the immune system goes awry, causing unprovoked and dangerous inflammation. Now, researchers from the National Ins...

UC Davis bioengineer receives Hartwell Foundation grant to address skull fusion disorder of infants

With support from a foundation that champions cutting-edge medical research, a biomedical engineer at UC Davis will start work this month on developing a new treatment for infants born with disorders that cause the sutures of their skulls to prematurely fuse together. The new approach is based ...

New potential therapeutic target discovered for genetic disorder -- Barth syndrome

Researchers at NYU Langone Medical Center may have discovered a new targeted intervention for Barth Syndrome (BTHS). BTHS, a sometimes fatal disease, is a serious genetic disorder occurring predominantly in males that leads to infection or heart failure in childhood. The new study entitled, "Role ...

Statins may treat blood vessel disorder that can lead to fatal strokes

SALT LAKE CITY In a finding that could save thousands of lives a year, University of Utah School of Medicine researchers have shown that a blood vessel disorder leading to unpredictable, sometimes fatal, hemorrhagic strokes, seizures, paralysis or other problems is treatable with the same statin ...

Mayo Clinic: Brain disorder suggests common mechanism may underlie many neurodegenerative diseases

JACKSONVILLE, Fla. A Mayo Clinic-led international consortium has found a mechanism that may help explain Parkinson's and other neurological disorders. Studying just eight families worldwide, the international team of researchers have discovered a genetic defect that results in profound depre...

Bipolar disorder genes, pathways identified by Indiana University neuroscientists

INDIANAPOLIS Neuroscientists at the Indiana University School of Medicine have created the first comprehensive map of genes likely to be involved in bipolar disorder, according to research published online Nov. 21 in the American Journal of Medical Genetics . The researchers combined data fro...

Seasonal affective disorder may be linked to genetic mutation, study suggests

With the days shortening toward winter, many people will begin to experience the winter blahs. For some, the effect can be devastating. About 6 percent of the U.S. population suffers from seasonal affective disorder, or SAD, a sometimes-debilitating depression that begins in the fall and conti...

Vitiligo skin disorder could yield clues in fight against melanoma

MAYWOOD, Ill. About 1 million Americans suffer a skin disorder called vitiligo, which causes unsightly white patches on the face, hands and other parts of the body. A Loyola University Hospital researcher has won a five-year, $1.7 million federal grant to investigate a new way to treat vitilig...

Rare genetic disorder gives clues to autism, epilepsy, mental retardation

A rare genetic disorder called tuberous sclerosis complex (TSC) is yielding insight into a possible cause of some neurodevelopmental disorders: structural abnormalities in neurons, or brain cells. Researchers in the F.M. Kirby Neurobiology Center at Children's Hospital Boston, led by Mustafa Sahin...

Gene's newly explained effect on height may change tumor disorder treatment

St. Louis, August 11, 2008 A mutation that causes a childhood tumor syndrome also impairs growth hormone secretion, researchers at Washington University School of Medicine in St. Louis have found. The discovery provides new insights into an old mystery, revealing why patients with neurofibroma...

Should embryos with a hereditary disorder be transferred if no unaffected embryos are available?

Barcelona, Spain: The numbers of cycles of preimplantation genetic diagnosis or screening are rising steadily in Europe with over 2,700 reported in 2004 (the most recent year for which data are available). Fertility centres are able to screen for a growing number of genetically related conditions,...

A new gene trigger for pregnancy disorder identified

BOSTON The COMT gene known already for its role in schizophrenia has been found to play a role in preeclampsia, according to a report in todays advance on-line issue of Nature. Led by researchers at Beth Israel Deaconess Medical Center (BIDMC), the study further suggests that a steroid molec...

RNA interference therapy heals growth deficiency disorder in a live animal

A team of Vanderbilt researchers have demonstrated for the first time that a new type of gene therapy, called RNA interference, can heal a genetic disorder in a live animal. The study, which was published online Nov. 15 by the journal Endocrinology, shows that RNA interference can rescue a strain...

Drug commonly used to treat bipolar disorder dramatically increases lifespan in worms

Nematode worms treated with lithium show a 46 percent increase in lifespan, raising the tantalizing question of whether humans taking the mood affecting drug are also taking an anti-aging medication. Results of the Buck Institute study, led by faculty member Gordon J. Lithgow, PhD, are currently p...

Colony collapse disorder symposium added to ESA Annual Meeting

Lanham, MD; October 17, 2007A late-breaking symposium, Colony Collapse Disorder in Honey Bees: Insight Into Status, Potential Causes, and Preventive Measures, has recently been added to the 55th Annual Meeting of the Entomological Society of America (ESA), to be held in San Diego, December 9-12. T...

Abnormal brain circuits may prevent movement disorder

MANHASSET, NY -- Most people who carry a genetic mutation for a movement disorder called dystonia will never develop symptoms, a phenomenon that has puzzled scientists since the first genetic mutation was identified in the 1990's. Now, scientists at The Feinstein Institute for Medical Research hav...

Fate in fly sensory organ precursor cells could explain human immune disorder

HOUSTON (June 21, 2009) Notch signaling helps determine the fate of a number of different cell types in a variety of organisms, including humans. In an article that appears in the current issue of Nature Cell Biology , researchers at Baylor College of Medicine report that a new finding about th...

UF makes gene therapy advance in severe genetic disorder

GAINESVILLE A dog born with a deadly disease that prevents the body from using stored sugar has survived 20 months and is still healthy after receiving gene therapy at the University of Florida putting scientists a step closer to finding a cure for the disorder in children. Called glycogen st...

Mouse model provides a new tool for investigators of human developmental disorder

April 21, 2009, Cambridge, UK Wolf-Hirschhorn Syndrome (WHS) is a human disease caused by spontaneous genetic deletions. Children born with WHS have a characteristic set of facial features, including a wide flat nose bridge, downturned mouth, high forehead, and highly arched eyebrows. Other sym...

New hope for treatment of neurodegenerative disorder

LOS ANGELES Researchers from the University of Southern California have taken an important first step toward protecting against Huntington disease using gene therapy. Huntington Disease is an incurable neurological disorder characterized by uncontrolled movements, emotional instability and los...

Lancet study supports new, highly effective treatment for blood disorder

NEW YORK (March 20, 2009) -- Patients suffering from a blood disorder that prevents proper clotting have the option of a new medication that may dramatically improve their health. There are estimated to be between 50,000 and 100,000 individuals in the U.S. diagnosed with chronic immune thrombocyto...

MU researcher identifies possible genetic causes of borderline personality disorder

COLUMBIA, Mo. According to the National Institute of Mental Health, borderline personality disorder (BPD) is more common than schizophrenia or bipolar disorder and is estimated to affect 2 percent of the population. In a new study, a University of Missouri researcher and Dutch team of research co...

Inherited genetic cause, possible treatment found for complex lung disorder

CINCINNATI A tale of two sisters has helped researchers solve a medical mystery and discover a familial genetic mutation that causes an inherited form of the lung disease Pulmonary Alveolar Proteinosis (PAP). Reporting their results in the Nov. 24 Journal of Experimental Medicine , a research...

Study provides insight on a common heart rhythm disorder

University of Iowa researchers and colleagues in France have identified a gene variant that causes a potentially fatal human heart rhythm disorder called sinus node disease. Also known as "sick sinus syndrome," the disease affects approximately one in 600 heart patients older than 65 and is respon...

Anti-cancer drug prevents, reverses cardiovascular damage in mouse model of premature aging disorder

An experimental anti-cancer drug can prevent -- and even reverse -- potentially fatal cardiovascular damage in a mouse model of progeria, a rare genetic disorder that causes the most dramatic form of human premature aging, National Institutes of Health (NIH) researchers reported today. In a s...

Largest study of its kind implicates gene abnormalities in bipolar disorder

The largest genetic analysis of its kind to date for bipolar disorder has implicated machinery involved in the balance of sodium and calcium in brain cells. Researchers supported in part by the National Institute of Mental Health, part of the National Institutes of Health, found an association bet...

Statin does not appear helpful for children with learning disabilities caused by genetic disorder

Use of simvastatin by children with neurofibromatosis type 1 (NF1), a genetic disorder that can cause learning disabilities, did not result in improved cognitive function, according to a study in the July 16 issue of JAMA . Characteristics of NF1 (incidence 1:3,000) include skin disorders, pro...

Drug reverses mental retardation caused by genetic disorder

UCLA researchers discovered that an FDA-approved drug reverses the brain dysfunction inflicted by a genetic disease called tuberous sclerosis complex (TSC). Because half of TSC patients also suffer from autism, the findings offer new hope for addressing learning disorders due to autism. Nature ...

Europe's most common genetic disease is a liver disorder

Much less widely known than the dangerous consequences of iron deficiencies is the fact that too much iron can also cause problems. The exact origin of the genetic iron overload disorder hereditary hemochromatosis (HH) has remained elusive. In a joint effort, researchers from the European Molecul...

Natural compound in broccoli could treat devastating genetic skin disorder

Washington, D.C. -- The compound sulforaphane whose natural precursors are found at high levels in broccoli and other cruciferous vegetables has been hailed for its chemopreventive powers against cancer. Now sulforaphane has demonstrated new skills in treating a genetic skin blistering disorder c...

Journal Sleep: Insomniacs are more likely to report a family history of the sleep disorder

WESTCHESTER, Ill. Individuals with either current or past insomnia are more likely to report a family history of insomnia than are those who have never had the sleep disorder, according to a study published in the December 1 issue of the journal SLEEP. The study, authored by Simon Beaulieu-Bon...

Brain pattern associated with genetic risk of obsessive compulsive disorder

Cambridge researchers have discovered that individuals with obsessive compulsive disorder (OCD) and their close family members have distinctive patterns in their brain structure. This is the first time that scientists have associated an anatomical trait with familial risk for the disorder. The...

Genetic roots of bipolar disorder revealed by first genome-wide study of illness

The likelihood of developing bipolar disorder depends in part on the combined, small effects of variations in many different genes in the brain, none of which is powerful enough to cause the disease by itself, a new study shows. However, targeting the enzyme produced by one of these genes could l...

Gene found for rare disorder may reveal new pathway in mental retardation

Studying mutations that give rise to a rare genetic disease, genetics researchers have identified a novel biological pathway that may have a broader role during human development, potentially in cases of mental retardation and autism. An international team of researchers identified two genes tha...

Origin of inherited pain disorder pinpointed

The genetic basis for a rare inherited disorder that causes severe burning pain with no warning has been pinpointed by researchers. They found that paroxysmal extreme pain disorder (PEPD) is caused by specific mutations in porelike sodium channels in peripheral nerve cells—a discovery that they sai...

Tests for 'face-blindness' reveal disorder may not be so rare

Researchers at Harvard University and University College London have developed diagnostic tests for prosopagnosia, a socially disabling inability to recognize or distinguish faces. They've already used the new test and a related web site ( www.faceblind.org ) to identify hundreds of "face-blind" in...

Mystery Blood Vessel Disorder Implicated In 'Mini' Strokes

Physicians have long been puzzled by a condition called intracranial arterial dolichoectasia, in which the larger arteries of the brain become elongated and misshapen. Typically, it has been considered a complication of atherosclerosis ("hardening of the arteries"), and not directly life-threatenin...

Association of herpesvirus with lung disorder questioned

Contrary to the results of a recent U.S. study, investigators in Japan found no association between a herpesvirus infection and a potentially life-threatening form of high blood pressure, as reported in the March 1 issue of The Journal of Infectious Diseases, now available online. The researcher...

Brain holds clues to bipolar disorder

Looking into the brain is yielding vital clues to understanding, diagnosing and treating bipolar disorder, according to findings being presented today at the Seventh International Conference on Bipolar Disorder. Two studies, featured in a press briefing held at 12:15 p.m., Thursday, June 7, have h...
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