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Studies reveal methods viruses use to sidestep immune system

A series of studies by researchers at UT Southwestern Medical Center sheds light on the mechanisms used by viruses to thwart a host's immune defenses and may aid in the development of more effective drugs to fight hepatitis C and West Nile viruses, as well as the flu and the common cold. In a study to appear in a March issue of the Journal of Virology and currently available online, UT So...

New studies suggest airborne SARS transmission is possible

Two new studies present evidence that the virus causing severe acute respiratory syndrome (SARS) may spread through the air, not just through direct contact with contaminated water droplets as previous research had shown. SARS coronavirus was detected in the air in a patient's room during the 2003 outbreak in Toronto, according to a new study published in The Journal of Infectious Diseases...

Antibodies from plants protect against anthrax

Scientists have produced, in tobacco plants, human antibodies that could be used to treat anthrax exposure. They report their findings today at the 2005 American Society for Microbiology Biodefense Research Meeting. "The nature of bioterrorism is such that an aggressor is likely to strike at a time and place calculated to induce maximum terror through mass casualties. The unpredictable nat...

Vascular structure and function improve with diet and exercise

Some structural and functional measures of cardiovascular disease risk may improve by the eighth week of a diet and exercise regimen, according to a study presented today at the American Heart Association's Sixth Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology. "Our lifestyle management program appears to improve the health of the vasculature, so it might lower the r...

Mayo Clinic Researchers Create 'Obedient Virus'; First Step To Use Measles Virus Against Cancer

An international team of Mayo Clinic-led researchers is first to devise a system that consistently converts the measles virus into a therapeutic killer that hunts down and destroys cancer cells -- and cancer cells only. Their research findings appear as an advanced electronic article of Nature Biotechnology. The researchers harnessed the viral trait for attacking and commandeering cells,...

Live fast, die young true for forests too

Trees in the world¹s most productive forests -- forests that add the most new growth each year -- also tend to die young, according to a U.S. Geological Survey (USGS) study published in a recent issue of the journal Ecology Letters. This discovery could help scientists predict how forests will respond to ongoing and future environmental changes. "One implication of this fast turnover rate...

Grasping metaphors: UC San Diego research ties brain area to figures of speech

What does it take to fathom a proverb ?catch the figurative meaning of "an apple doesn't fall far from the tree"? According to research led by V. S. Ramachandran, director of the Center for Brain and Cognition at the University of California, San Diego, a region of the brain known as the angular gyrus is probably at least partly responsible for the human ability to understand metaphor.</p...

One gene links newborn neurons with those that die in diseases such as Alzheimer's

In certain parts of the brain, cells called neurons go through a cycle of death and replenishment. New research from Rockefeller University's Fernando Nottebohm, Ph.D., shows that these replaceable neurons share something in common with the neurons that die in people with diseases such as Alzheimer's and Parkinson's: both have unusually low levels of a protein called UCHL1. "It would be ir...

NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses

In mouse models of intestinal cancer, use of an anti-inflammatory drug eliminated all of the cancer-causing risks produced by a high-fat Western-style diet - even when several genetic brakes to cancer formation were missing in the animals, say researchers from the Albert Einstein Cancer Center. The investigators, who presented their findings at the 96th Annual Meeting of the American Assoc...

New book explains antibiotic resistance for a broad audience

Media coverage about "superbugs" that defy current treatments has increased the public's awareness of and fears surrounding the issue of antibiotic resistance. A new book from ASM Press, Revenge of the Microbes: How Bacterial Resistance is Undermining the Antibiotic Miracle, provides an in-depth overview of the subject in a reader-friendly, comprehensible style that will engage everyone from scie...

Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine

Two studies by researchers at the University of Chicago show how the bacteria that cause the plague manage to outsmart the immune system and how, by slightly altering one of the microbe's tools, the researchers produced what may be the first safe and effective vaccine. Both papers -- one published online July 28 in Science Express and one in the August issue of Infection and Immunity -- fo...

Excess liver gene protects against high-fat diet

A gene that senses fat in the liver can modulate the consequences of eating a high-fat, Western diet, new research published in the May issue of Cell Metabolism reveals. Mice with an excess of liver X receptor (LXRa), when fed a diet high in fat, remained free from the high cholesterol and blood vessel plaques exhibited by animals with the normal complement of receptors. Remarkably, in mi...

Two studies document rise of superbugs in the environment

As science gets wiser, so do the bugs. The rates of drug-resistant bacteria infecting patients in the community and in the hospital have been increasing steadily in recent years, according to two new studies in the June 15 issue of Clinical Infectious Diseases, now available online. Drug resistance in microorganisms has become a problem due in part to inappropriate prescribing and overuse...

UI researcher studies deafness in fruit flies, humans

University of Iowa Biological Sciences Professor Daniel F. Eberl and his colleagues at Duke University have uncovered genetic defects leading to deafness in fruit flies that may shed light on deafness in humans. Their research paper, "Myosin VIIA Defects, which Underlie the Usher 1B Syndrome in Humans, Lead to Deafness in Drosophila," is scheduled for publication in the May 10 issue of the journa...

First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology

Chicken-produced antibodies demonstrate enhanced cell killing compared to conventionally produced anti-cancer antibodies Origen Therapeutics today announced the first published scientific report of fully functional, human sequence monoclonal antibodies (mAbs) produced in chickens. The antibodies were expressed solely in the chicken oviduct and deposited into egg white in concentrations of...

Report calls for improved monoclonal antibodies against solid tumors

A new report by leading experts in monoclonal antibody research for oncology offers a conceptual framework for future research in the design of antibody therapies against solid tumors. Writing in the January 15, 2007 issue of CANCER ( ), a peer-reviewed journal of the American Cancer So...

Biased reporting found in cancer prognostic studies

Selective reporting biases may taint many published studies of so-called prognostic factors--biologic or genetic markers that may predict how a patient may fare during or after treatment, according to a new study in the July 20 issue of the Journal of the National Cancer Institute. In recent years, researchers have raced to discover and publish papers on prognostic factors for cancer and o...

Fruit fly studies open new window on cancer research

Scientists studying the humble fruit fly have found a family of proteins that enhances the sensitivity of a cell to a hormone that can trigger abnormal growth and cancer. Their discovery could lead to a completely new approach to tackling some cancers and the development of new drugs to stop uncontrolled growth in a wide variety of tumour cells. The researchers at the University of Oxford,...

Why do aneurysms form? New studies suggest leading role for white blood cells

Each year, 200,000 Americans find out that the largest blood vessel in their body, the aorta, may burst open at any time. About 20,000 die suddenly from such a rupture. And another 36,000 have surgery to repair or replace the swelling section of aorta before time runs out. But despite the deadly toll of this condition, called abdominal aortic aneurysm or AAA ("triple A"), experts know very...

Use of high hydrostatic pressure to inactivate Hepatitis A virus in oysters studied

NOAA/Virginia Sea Grant has awarded Virginia Tech $119,000 to study whether high hydrostatic pressure will inactivate Hepatitis A virus in both shucked and unshucked oysters. The project, led by Daniel Holliman, an M.D. with the High Pressure Processing Laboratory, and Laura Douglas, lab manager, will identify one or more effective high pressure processing schedules. The laboratory is a fa...

Gradient guides nerve growth down spinal cord

The same family of chemical signals that attracts developing sensory nerves up the spinal cord toward the brain serves to repel motor nerves, sending them in the opposite direction, down the cord and away from the brain, report researchers at the University of Chicago in the September 2005 issue of Nature Neuroscience (available online August 14). The finding may help physicians restore function...

Green diesel: New process makes liquid transportation fuel from plants

University of Wisconsin-Madison College of Engineering researchers have discovered a new way to make a diesel-like liquid fuel from carbohydrates commonly found in plants. Reporting in the June 3 issue of the Journal Science, Steenbock Professor James Dumesic and colleagues detail a four-phase catalytic reactor in which corn and other biomass-derived carbohydrates can be converted to sulfu...

Ethanol and biodiesel from crops not worth the energy

Turning plants such as corn, soybeans and sunflowers into fuel uses much more energy than the resulting ethanol or biodiesel generates, according to a new Cornell University and University of California-Berkeley study. "There is just no energy benefit to using plant biomass for liquid fuel," says David Pimentel, professor of ecology and agriculture at Cornell. "These strategies are not su...

Studies clarify risk factors for mother-to-child transmission of hepatitis C virus

Breastfeeding does not raise the risk of mother-to-child transmission of hepatitis C virus (HCV), according to two new studies published in the December 1 issue of The Journal of Infectious Diseases, now available online. One study found that infant girls are twice as likely to be infected as infant boys. Both studies provide new information with which to counsel pregnant women infected...

Studies on human genome variation provide insight into disease

The International HapMap Project was initiated with the primary goal of facilitating medical studies and understanding the genomic basis for human diseases. To coordinate with the journal is announcing a special issue entitled "Human Genome Variation," which is entirely devoted to studies using these data to pr...

Underlying cause of massive pinyon pine die-off revealed

The high heat that accompanied the recent drought was the underlying cause of death for millions of pinyon pines throughout the Southwest, according to new research. The resulting landscape change will affect the ecosystem for decades. Hotter temperatures coupled with drought are the type of event predicted by global climate change models. The new finding suggests big, fast changes in ecos...

Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies

Improved materials may allow stents, tiny metal scaffolds inserted into blood vessels, to better deliver beneficial genes to patients with heart disease, by reducing the risk of inflammation that often negates initial benefits. The new technique, using a compound that binds in an extremely thin layer to bare metal surfaces, may have potential uses in other areas of medicine that make use of metal...

Sahara's edge studied from ground, air and space to improve water management

An international team worked on the verge of the Sahara to gather data on the ground and in the air, to be compared with imagery of the same region acquired by ESA satellites. The results will be used in support of an ambitious project to apply satellite remote sensing to improve monitoring and management of vast water aquifers concealed beneath the desert. High-resolution radar as well as...

Phenolic compounds may explain Mediterranean diet benefits

Phenolic compounds in olive oil, which have antioxidant, anti-inflammatory and anti-clotting properties, may explain cardiovascular health benefits associated with the so-called Mediterranean Diet, according to a new study in the Nov. 15, 2005, issue of the Journal of the American College of Cardiology. "It could be that the beneficial effect of the Mediterranean diet on cardiovascular dis...

Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned

Scientists have completed the first human clinical trial of a recombinant vaccine for the deadly toxin ricin ?a potential bioterror threat ?and the results indicate the vaccine is safe and effective in eliciting ricin-neutralizing antibodies, the UT Southwestern Medical Center researchers report. The nearly year-long pilot study involved three groups of five volunteers each. Individuals in...

Diabetes researchers pioneer islet cell xenotransplantation in primate studies

A team of researchers from the University of Alberta, the Yerkes National Primate Research Center of Emory University and the Emory Transplant Center has successfully transplanted insulin-producing neonatal porcine islet cells into monkeys, a procedure the researchers say represents a promising intermediate solution to the critical supply problem in clinical islet cell transplantation. "Ou...

Pair of studies offer new clues to combat antibiotic resistance

In the continuing battle against antibiotic resistance, two new studies shed light on the complex defense mechanisms pathogenic bacteria use to evade antibiotic attack, an understanding of which could lead to new, more effective antibiotics to help save lives and combat the growing problem of antibiotic resistance. The studies, both of which target chemical components in the protective membrane s...

Horse antibodies against the bird flu virus H5N1 are effective as treatment in mice

Antibodies against the bird flu virus H5N1, derived from horses, prevent mice infected with H5N1 from dying from the virus. ) reveals that a dose of 100 µg of horse anti-serum effectively protects infected mice. These results suggest that an...

New RNAi tools enable systematic studies of gene function

An international public-private research team led by scientists at the Broad Institute of MIT and Harvard announced today the construction and availability of an extensive library of molecular reagents to silence most human and mouse genes. As described in the March 24 issue of Cell, this library consists of small RNA molecules that can switch off genes individually, allowing the user to d...

Ernst Mayr's theory illustrated in genetic epidemiology studies

The late, famed evolutionary biologist Ernst Mayr's theory of genetic revolution , introduced in 1954, remains controversial to this day and has many detractors. Mayr believed that genes interacted with one another, and that this genetic interaction in turn led to an interaction of natural selection with genetic drift that could cause genetic revolution ?new directions of evolutionary ch...

Mice studies illustrate potential of chimp/human antibodies to protect against smallpox

Results from a new study indicate that hybrid laboratory antibodies derived from chimpanzees and humans may provide a potentially safe and effective way to treat the serious complications that can occur following smallpox vaccination--and possibly may even protect against the deadly disease itself. The study, led by researchers with the National Institute of Allergy and Infectious Diseases (NIAID...

Red Tide causes sea turtle die-off in El Salvador

A "Red Tide" event that occurred off the coast of El Salvador late last year directly caused the deaths of some 200 sea turtles, according to test results released today by the Wildlife Conservation Society (WCS) and other organizations. Responding to requests from the Salvadoran government and the US Agency for International Development (USAID)for assistance, WCS veterinary pathologist Dr...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

Researchers at GlycoFi and Dartmouth College have reported the first production of monoclonal antibodies with human sugar structures in yeast. This research, published online January 22 and in the February issue of the journal Nature Biotechnology, demonstrates that antibodies with human sugar structures (glycosylation) can be produced in glyco-engineered yeast cell lines, and that by con...

Behavioral studies show UV contributes to marsupial color vision

Work reported this week provides new evidence that marsupials, like primates, have functional color vision based on three different types of color photoreceptor cones--but unlike primates, a component of marsupial color vision includes sensitivity to ultraviolet wavelengths. In the study, researchers employed behavioral tests to show that at least one type of marsupial uses its detection...

UC San Diego partners with Venter Institute to build marine microbial genomics cyberinfrastructure

Researchers at the University of California, San Diego (UCSD) will build a state-of-the-art computational resource and develop software tools to decipher the genetic code of communities of microbial life in the world's oceans. The new resource will help scientists understand how microbes function in their natural ecosystems, enable studies on the effect humans are having on the environmen...