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degeneration in Biological News

New treatment for age-related macular degeneration within sight

With 8 million people at high risk for advanced age-related macular degeneration, researchers from Harvard and Japan discovered that the experimental drug, endostatin, may be the cure. A research report published in the December 2007 issue of The FASEB Journal, describes how giving endostatin to m...

Genes identified that are linked to spinal disc degeneration

Lumbar disc degeneration is an uncomfortable condition that affects millions of people, but two University of Alberta researchers have identified some of the genes that are causing problems. Michele Crites-Battie and Tapio Videman, in the Faculty of Rehabilitation Medicine, have discove...

Gene therapy restores vision to mice with retinal degeneration

Massachusetts General Hospital (MGH) researchers have used gene therapy to restore useful vision to mice with degeneration of the light-sensing retinal rods and cones, a common cause of human blindness. Their report, appearing in the Oct. 14 Proceedings of the National Academy of Sciences, desc...

Songbirds may hold key to advances in treatment of brain degeneration

BETHLEHEM, PA, August 5, 2008 -- Ongoing research at Lehigh University may one day help make strides toward therapeutic advances in the treatment of diseases that involve the loss of memory and brain degeneration such as Alzheimer's, Parkinson's, and stroke. Colin Saldanha, associate professor of ...

Massive microRNA scan uncovers leads to treating muscle degeneration

Researchers have discovered the first microRNAs tiny bits of code that regulate gene activity linked to each of 10 major degenerative muscular disorders, opening doors to new treatments and a better biological understanding of these debilitating, poorly understood, often untreatable diseases. Th...

New gene reduces retinal degeneration in fruit flies

Johns Hopkins researchers have discovered a gene in fruit flies that helps certain specialized neurons respond more quickly to bright light. The study, published in the April 4 issue of Current Biology, also has implications for understanding sensory perception in mammals. In teasing apart the mo...

New compound stops brain cell degeneration in Alzheimer's disease

Drug discovery researchers at Northwestern University have developed a novel orally administered compound specifically targeted to suppress brain cell inflammation and neuron loss associated with Alzheimer's disease. The compound is also rapidly absorbed by the brain and is non-toxic ?important c...

Stem cell research: From molecular physiology to therapeutic applications

...s. On the other hand, recent post mortem analysis of patients who received fetal brain cell transplantation revealed that implanted cells are prone to degeneration just like endogenous neurons. Thus it appears that future cell replacement studies will have to focus on ameliorating disease symptoms as well as on s...

Experimental treatment halts hypoxic-ischemic brain injury in newborns

...lied magnetic resonance imaging tests and microscopic analysis of brain tissues, which showed that PAI-1 treatment greatly reduced brain edema, axonal degeneration and the loss of brain tissue. Dr. Kuan said additional studies are needed to test the effectiveness and safety of PAI-1 therapy in other experimen...

Children's Hospital of Pittsburgh of UPMC scientists identify enzyme important in aging

...by intervening at an early age, we may be able to delay or even prevent the degeneration of the thymus in order to maintain our immune defenses throughout life," sa...uction of T cells without consuming precursor cells, thereby preventing the degeneration of the thymus. "Controlling the availability of IGF in the thymus by tar...

Work in mice will contribute to the study of hereditary diseases that lead to blindness

...elease is available in Spanish . Researchers of the University of Granada (Spain) have used a technique consisting of the induction of neuronal degeneration neuronal for intense light exposure in the mouse's retina that will be helpful for the study of retinitis pigmentosa (RP), a group of hereditary disea...

Xie Lab uncovers molecular machinery related to stem cell fate

... proper balance between stem cell self-renewal and differentiation is critical for normal homeostasis. An imbalance between the two can lead to tissue degeneration and to the development of tumors. It has long been known that the BAM protein is necessary for germline stem cell differentiation, but the specific mo...

Engineering innovative solutions for 21st century medicine

...s we get older, through improved prosthetic implants and technologies to help our tissues regenerate. We are also looking to understand the process of degeneration so we can accurately diagnose its early stages and deliver appropriate and timely interventions. Our work is all driven by the concept of 50 more year...

New supplement may help slow sight loss in elderly

... Vision and Vascular Science (CVVS), co-ordinated the study, which looked at nutritional supplements for patients with early age-related macular (AMD) degeneration and found they helped sharpen vision. Details of the findings are being presented in Belfast today (Friday) by Professor Chakravarthy and Dr Stephen...

Omega-3 fatty acids appear to impact AMD progression

... BOSTON (June 18, 2009) - Omega-3 fatty acids found in fatty fish such as tuna and salmon may protect against progression of age-related macular degeneration (AMD), but the benefits appear to depend on the stage of disease and whether certain supplements are taken, report researchers at the Laboratory for N...

Major breakthrough in early detection and prevention of AMD

...logical marker for neovascular age-related macular degeneration (AMD), the leading cause of blindness in older adu...ure . "This is a major paradigm shift in macular degeneration research," said Ambati, a professor of physiology,...ernon and Eloise C. Smith Endowed Chair in Macular degeneration at the UK College of Medicine. "With CCR3, we have...

Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine

...rmine factors which govern their activities in health and disease. "Disc degeneration and the associated back pain that goes with it costs the U.S. healthcare in...bral disc structure and function." A variety of factors contribute to the degeneration of the intervertebral disc including age, genetics and biomechanical factor...

MIT: Jeremy Nathans to deliver Scolnick Prize lecture

...al cells. These studies have revealed several defects that lead to human retinal diseases including Stargardt disease, the most common type of macular degeneration in children and young adults. Nathans and colleagues also determined that the vitelliform type of macular dystrophy is caused by abnormalities in a...

ASBMB Annual Meeting to feature talks on the biochemistry of aging

...eased liver and kidney function, and osteoporosis. These mice offer a great system to identify the mechanisms by which DNA damage can drive the tissue degeneration associated with aging as well as a platform to test anti-aging therapies like stem cells and free radical scavengers. ...

The story of X -- evolution of a sex chromosome

... is an asexual chromosome, and it pays a price for that: It keeps losing genes." Bachtrog, whose career has revolved mostly around the study of the degeneration of the Y chromosome, decided to focus on the X chromosome several years ago and went about searching for sex chromosome pairs that have arisen more re...

Jefferson researcher awarded Landenberger Foundation grant for ALS research

... the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle move...

Ambati study published in PNAS

... discovered previously unrecognized immune side effects of siRNA, which is currently in FDA trials for numerous diseases including age-related macular degeneration and life-threatening viral infections. Specifically, they showed that in two different established animal models of new blood vessel growth, siRNA...

Redefining what it means to be a prion

...entified disease infected more than 100,000 British cows and spread to humans, eventually killing more than 200 people. The disease causes progressive degeneration of physical and mental abilities, which ultimately lead to death. Scientists found the infectious agent was a prion, a misfolded version of the PrP...

International prize for Nottingham spine research

...g medicine in Newcastle. The research looked at problems of treating the degeneration of the intervertebral discs the soft discs in between the bones of the spi...nditions. The results of the study could help to inform the way in which degeneration of the intervertebral discs is medically managed in the future this could ...

Eye cells believed to be retinal stem cells are misidentified

...ly promising alternative is the possibility of taking samples of adult cellssuch as fibroblasts that form connective tissuefrom a patient with retinal degeneration and exposing them to genetic cues that induce them to revert to stem cells. Those induced pluripotent stem cells could then be manipulated to develop ...

Tips from the American Journal of Pathology

...s, but were absent in tangle neurons. This report suggests that "unfolded protein response activation occurs at an early stage of neurofibrillary degeneration and that the prolonged activation of the [unfolded protein response] is involved in both tau phosphorylation and neurodegeration in [Alzheimer's Dise...

Pitt researchers describe molecular '2-step' leading to protein clumps of Huntington's disease

...N-terminus in initiating aggregation gives us another possible molecular target." Huntington's disease is an inherited disease in which progressive degeneration of certain brain neurons causes uncontrolled writhing, twisting and jerking movements, and cognitive and psychiatric problems. It was once called Hunt...

Cats' eye diseases genetically linked to diseases in humans

...e the same treatment methods and tools in cats that they use in humans." Human autosomal recessive RP is among the most common cause of retinal degeneration and blindness, with no therapeutic intervention available. Initially it leads to night blindness, then loss of peripheral vision and, with progression...

Researchers generate functional neurons from somatic cells

...ity of iPS-derived neurons and further suggest the feasibility of using these cells to explore how changes in motor neuron activity contributes to the degeneration of these cells underlying these disorders," the authors state. Led by William Lowry, and in collaboration with Bennett Novitch, Harley Kornblum, a...

Diet could reduce onset of eye disease by 20 percent

... University of Liverpool scientists claim that the degeneration of sight, caused by a common eye disease, could be...ables and nuts in the diet. Age-related Macular degeneration (AMD) is the leading cause of blindness in the UK,... The recipes will help AMD sufferers slow down the degeneration process by increasing micronutrient, vitamin and a...

While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy

...ysics and Clyde and Helen Wu Professor of Molecular Cardiology. "If it works in people, our drug won't be a cure, but it could slow the pace of muscle degeneration and extend the lives of people with Duchenne." The study was published online Feb. 8 in Nature Medicine . Though the new drugs are not FDA-approve...

GEN reports on strategies to overcome blood-brain barrier

...before mechanisms of CMT were known) is L-DOPA, the major current drug for Parkinson's disease. L-DOPA is used to replace dopamine that is lost due to degeneration of dopaminergic neurons in the substantia nigra of the brain. Another major system that is used in normal mammalian physiology to enable needed mol...

Protecting neurons could halt Alzheimer's, Parkinson's diseases

...at Dallas (UTD) have identified a group of chemical compounds that slow the degeneration of neurons, a condition behind old-age diseases like Alzheimer's, Parkinson...cations only alleviate the symptoms but do not affect the underlying cause degeneration of neurons. The identification of compounds that inhibit neuronal death is...

Scientist clears hurdles for muscular dystrophy therapy

...on that disrupts the production of a protein known as dystrophin. Absence of this protein starts a chain reaction that eventually leads to muscle cell degeneration and death. Eventually, the damaged muscle tissue is replaced by fibrous, bony or fatty tissue and loses function. In the heart, this leads to severe h...

3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions

... Current medications for neurodegenerative diseases alleviate only the symptoms associated with these diseases but do not affect the underlying cause degeneration of neurons. Because neuronal loss continues unabated, such palliative treatments have no effect on disease progression. The identification of small-...

Diabetes researcher gets $5M boost

...s at varying degrees of severity, which causes the degeneration of nerves, mostly in the arms and leg. Profess... study will test whether looking at their level of degeneration in these nerves over a period of time would match the nerve degeneration found in arms and legs. "We want to see how wel...

Researchers identify Achilles heel of common childhood tumor

...at obstruct vision, respiration, or other bodily functions. Anti-VEGF therapies have already been approved for other conditions, including macular degeneration and certain types of cancer. The next step for Olsen's team is to get approval to test these therapies in clinical trials. Meanwhile, Olsen and hi...

Genetic finding implicates innate immune system in major cause of blindness

...developed countries. The research, published online today in the Lancet , adds to the growing understanding of the genetics of age-related macular degeneration (AMD), which the researchers believe should ultimately lead to novel treatments for the disease. Almost two-thirds of people aged 80 years or older...

Discovery of natural compounds that could slow blood vessel growth

...chers say the findings could lead to developing treatments to fight diseases that depend on the growth of new blood vessels, including cancer, macular degeneration and rheumatoid arthritis. "Before, there were only 40 known antiangiogenesis peptides," says Aleksander Popel, Ph.D., a professor of biomedical en...

NIH awards Clemson bioengineer $1.5 million to improve durability of tissue heart valves

... Aortic valves taken from pigs are used in thousands of human heart valve replacement surgeries annually, but they have a high rate of failure due to degeneration and calcification. It is estimated more than 50 percent fail within five to 15 years of implantation. Vyavahare's goal is to extend the biological dur...
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