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Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols

COLD SPRING HARBOR, N.Y. (Wed., Aug. 5, 2009) Vectors derived from retroviruses are useful tools for long-term gene transfer because they allow stable integration of transgenes and propagation into daughter cells. Lentiviral vectors are preferred because they can transduce non-proliferating ce...

Spring cold snap helps with stream ecosystem research

OAK RIDGE, Tenn., July 23, 2009 -- A rare April freeze in 2007 provided researchers at the Department of Energy's Oak Ridge National Laboratory with further evidence that climate change could have negative effects on stream and forest ecosystems. As warm weather arrives sooner in many parts of ...

Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols

COLD SPRING HARBOR, N.Y. Many proteins do not function by themselves as stand-alone units. Instead, multiple proteins associate to form larger structures called protein complexes. The May issue of Cold Spring Harbor Protocols ( www.cshprotocols.org/TOCs/toc5_09.dtl ) features a set of metho...

Basic guides to PCR, labeling neurons featured in Cold Spring Harbor Protocols

COLD SPRING HARBOR, N.Y. (Wednesday, April 1, 2009) Along with new cutting-edge methods, Cold Spring Harbor Protocols is home to an in-depth library of basic laboratory methods. The April issue ( www.cshprotocols.org/TOCs/toc4_09.dtl ) features two of these standard techniques. From molecul...

Catching the common cold virus genome

Catching the common cold virus: BYU researchers coming down with the rhinovirus genome A new study by Brigham Young University researchers on the virus behind nearly half of all cold infections explains how and where evolution occurs in the rhinovirus genome and what this means for possible vacc...

Protein function and chromatin structure methods featured in Cold Spring Harbor Protocols

COLD SPRING HARBOR, N.Y. (Tues., March 3, 2009) Two new methods for analyzing the roles played by proteins in cells are featured in the March issue of Cold Spring Harbor Protocols ( www.cshprotocols.org/TOCs/toc3_09.dtl ). Thomas J. Wandless and colleagues from Stanford University ( http://w...

How cold is too cold for newborn calves?

GLASGOW, MONTANA (February 26, 2009) It has been estimated that in the United States, nearly 100,000 calves die of cold stress annually, costing livestock producers millions of dollars a year and resulting in a desperate need for effective mitigation strategies. Consequently, a University of Miam...

Very cold ice films in laboratory reveal mysteries of universe

The universe is full of water, mostly in the form of very cold ice films deposited on interstellar dust particles, but until recently little was known about the detailed small scale structure. Now the latest quick freezing techniques coupled with sophisticated scanning electron microscopy techniqu...

First comprehensive genomic study of common cold reveals new treatment targets

Cincinnati, OH (October 24, 2008) Today, scientists from Procter & Gamble (P&G), the University of Calgary and the University of Virginia announced results from the first study to examine the entire human genome's response to the most common cold virus, human rhinovirus. The research confirmed, ...

ST Kinetics and NTU set up Southeast Asia's first cold spray research center

Singapore, 5 September 2008 - Singapore Technologies Kinetics Ltd's (ST Kinetics) joint venture company, Advanced Technology Research Centre (ATREC), and Nanyang Technological University (NTU) today officially opened Southeast Asia's first research and development centre in Cold Spray technology. ...

Key discovered to cold tolerance in corn

Demand for corn -- the world's number one feed grain and a staple food for many -- is outstripping supply, resulting in large price increases that are forecast to continue over the next several years. If corn's intolerance of low temperatures could be overcome, then the length of the growing seas...

Racing cane toads reveals they get cold feet on Southern Australia invasion

Cane toads weren't allowed to compete in the Olympics, but scientists have raced cane toads in the laboratory and calculated that they would not be able to invade Melbourne, Adelaide or Hobart and are unlikely to do well in Perth or Sydney, even with climate change. According to research by Dr ...

A 'field guide' to the landscape of Cold Spring Harbor Laboratory

COLD SPRING HARBOR, N.Y. A new book, Grounds for Knowledge , is an attractive guide to CSHL's mix of historic and modern buildings and the striking landscape that surrounds them. It was written by historic preservationist and tree enthusiast Elizabeth L. Watson, who, together with her husba...

Watson-inspired innovation in research at Cold Spring Harbor Laboratory

COLD SPRING HARBOR, N.Y. The appointment of James Watson as Director of Cold Spring Harbor Laboratory in 1968 set off an explosive development of research at Cold Spring Harbor Laboratory (CSHL), as he recruited widely and wisely teams of investigators with diverse scientific interests. In a n...

Exeter scientists pour cold water on EU bird policy

New research from the University of Exeter in collaboration with the University of Texas at Austin published in the journal Science (22 February 2008) questions claims that EU conservation policy has been successful in protecting endangered birds. Introduced in 1979, the EU Birds Directive set...

RNA-based methods for developmental studies are featured in Cold Spring Harbor Protocols

COLD SPRING HARBOR, N.Y. (Fri., Feb. 1, 2008) This months issue of Cold Spring Harbor Protocols ( www.cshprotocols.org/TOCs/toc2_08.dtl ) highlights two methods to understand developmental processes in plants and flies. Both methods involve work with RNA and are freely accessible on the Web ...

From brains to behavior: Cold Spring Harbor Protocols features methods for neuroscience research

COLD SPRING HARBOR, N.Y. (Mon., Oct. 1, 2007) Research in the field of neuroscience is constantly expanding to provide knowledge about biological mechanisms that underlie our ability to experience and interact with the world around us. To facilitate such research, two neuroscience methods are fea...

Scripps research team sheds light on long-sought cold sensation gene

The discovery, reported in the May 3 issue of the journal Neuron, might one day lead to the development of drugs that induce cold sensation as an analgesic, or block it to prevent certain forms of chronic pain associated with cold sensation. "This study represents the first demonstration that a s...

Lighting up life: Cold Spring Harbor Protocols presents tips for creating glowing plants

Just over a decade ago, biologists isolated a unique protein from jellyfish that could be inserted into other organisms—from E. coli to pigs—and cause them to radiate a brilliant green color. This green fluorescent protein (GFP) has allowed biologists to make many new discoveries regarding how li...

Female Antarctic seals give cold shoulder to local males

Female Antarctic fur seals will travel across a colony to actively seek males which are genetically diverse and unrelated, rather than mate with local dominant males. These findings, published in this week's Nature, suggest that female choice may be more widespread in nature than previously believ...

Health Canada approves cold and flu medicine

Health Canada, the Canadian government regulatory agency, has approved wide-ranging new health claims for COLD-fX®, the most popular cold/flu remedy in Canada. After an extensive review, the Natural Health Products Directorate (NHPD) ?a division of Health Canada responsible for evaluating the safe...

Common cold virus may kill breast cancer cells

University of Newcastle researcher Kathryn Skelding, funded by the National Breast Cancer Foundation and Viralytics Ltd, has been working on a new treatment which only affects cancer cells ?this would be an improvement on conventional chemotherapy and radiation treatment, which also impact on norma...

Why do cold animals make bigger babies?

Reproduction involves a critical decision: Should an organism invest energy in a few large offspring or many small ones? In a new study from The American Naturalist, Michael Angilletta (Indiana State University), Chris Oufiero (University of California, Riverside), and Adam Leaché (University of Ca...

Common cold virus leads to death in lung transplant patients

Human rhinovirus (HRV), the leading cause of most common colds, struck two immunosuppressed lung transplant patients, leading to progressive respiratory failure, graft dysfunction and death. The two were part of a group of 11 transplant patients who suffered clinically significant respiratory infec...

Plant protection from cold decoded

In response to cold, plants trigger a cascade of genetic reactions that allow them to survive. University of California, Riverside Professor of Plant Cell Biology Jian-Kang Zhu has described how a little-known biochemical reaction regulates that genetic cascade. Zhu's findings were published in t...

Argonne to showcase science and technology at community open house

... Test your sense of smell against an electronic nose View a chain reaction Calculate your environmental footprint Have fun with extreme cold and cryogenics Witness how ice slurry can save lives Turn matter into energy See how science is helping to restore sight to the blind ...

Neuropathic pain: The sea provides a new hope of relief

...mildly uncomfortable stimuli as very painful (hyperalgesia), or stimuli that would normally induce no discomfort at all as painful (allodynia). Thus, cold drafts or lightly brushing the skin can produce intense pain, severely affecting the person's quality of life. The treatments that give some relief...

Plankton Power and RTDC announce proposed algae-to-biofuels pilot facility on Cape Cod

...facility will provide the required infrastructure for testing commercial scale-up of a breakthrough algae-growth technology resulting from 20 years of cold saltwater species research and production. The biodiesel from Plankton Power algae is a "drop-in" replacement for home heating oil and petroleum diese...

August 2009 Geology and GSA Today media highlights

...ding from Siberia in the west to Yukon in the east. Lying in the rain shadow of the St. Elias Mountains, this great region, now known as Beringia, was cold but too dry for the development of glaciers. Instead, the region consisted of a great Arctic steppe, bound by mountains to the south and continental g...

Results of national assessment of first responder location systems to be announced Aug. 3

... of a wall someone is located or to find someone in a space filled with dense smoke. "WPI began work on this problem after the December 1999 Worcester cold Storage Warehouse fire, which took the lives of six firefighters who could not find their way out of the building," notes David Cyganski, professor of...

Warming climate threatens California fruit and nut production

...ng dormancy in years of insufficient winter chill," Luedeling said. About winter chill Most fruit and nut trees from nontropical locations avoid cold injury in the winter by losing their leaves in the fall and entering a dormant state that lasts through late fall and winter. In order to break dor...

Tires made from trees -- better, cheaper, more fuel efficient

... required to produce the tire, reduce costs, and better resist heat buildup. Early tests indicate that such products would have comparable traction on cold or wet pavement, be just as strong, and provide even higher fuel efficiency than traditional tires in hot weather. "We were surprised at how favora...

Ethiopian government celebrates rinderpest eradication

...ccine is ineffective. "It was extremely challenging to keep the vaccine cold while traveling to isolated areas," said Catley, who is also an assistant p...e and Policy at Tufts. "It required refrigeration facilities, ice machines, cold boxes and fleets of vehicles. They needed an easier way to deliver the vacc...

University of Hawaii at Manoa professor published in science journal

...ediment that can persist for greater than seven years. These habitats are very similar in intensity to the chemosynthetic habitats created by deep-sea cold seeps and hydrothermal vents. ...

Arctic climate under greenhouse conditions in the Late Cretaceous

...sea ice in shallow coastal seas during autumn storms but suggests the absence of larger drop-stones suggests that the winters, although cold, were not cold enough to support thick glacial ice or large areas of anchored ice. Commenting on the findings, Professor Kemp said: "Although seasonally-resolved...

Fruit and vegetable intake in pregnant women reduces risk of upper respiratory tract infection

...oping an upper respiratory tract infection (URTI). The BUSM study appears online in the journal Public Health Nutrition. URTIs include the common cold and sinus infections, which can lead to lower respiratory problems, such as asthma or pneumonia. Even though the majority of URTIs are uncomplicated ...

All in sight

..., thus making it visible for humans: the brighter a spot, the warmer it is. The warm spout of a whale clearly stands out against the background of the cold North Atlantic or Antarctic waters. Infrared thermography is already in use with great success, for example to examine the heat insulation of build...

CSHL scientists harness logic of 'Sudoku' math puzzle to vastly enhance genome-sequencing capability

... cold Spring Harbor, N.Y. A math-based game that has taken the world by storm wi...field of medical genetics, suggests a new report by a team of scientists at cold Spring Harbor Laboratory (CSHL). The report will be published as the cover ...

Broecker: 'What we need are tougher measures against climate change'

...obal precipitation will change as the planet warms", especially in the world's drylands. This means sifting through the climate records available from cold basin lakes and cave stalagmites. More renewable energies, but also CO 2 sequestration The question is not if but how our planet will change...

A tiny frozen microbe may hold clues to extraterrestrial life

... under extreme conditions on Earth may provide insight into what sorts of life forms could survive elsewhere in the solar system. "These extremely cold environments are the best analogues of possible extraterrestrial habitats", said Dr Loveland-Curtze, "The exceptionally low temperatures can preserve ...
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