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Variation in women's X chromosomes may explain differences among individuals, between sexes

The first comprehensive survey of gene activity in the X chromosomes of women has revealed an unexpected level of variation among individuals, according to new work by researchers at the Duke University Institute for Genome Sciences & Policy (IGSP) and Pennsylvania State University. The results may have important implications for understanding the differences in traits among women and...

Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.

Clams, mussels and oysters are important vehicles for the transmission of enteric diseases when consumed raw or undercooked. Vibrio species, including human pathogens, are particularly abundant in bivalve tissues, where they can persist even after cleaning procedures, thus representing a potential risk for human health. Although different environmental factors are well known to affect the persist...

Study reveals dramatic difference between breast cancers in US and Africa

A study comparing, for the first time, breast cancers from Nigeria, Senegal and North America has found that women of African ancestry are more likely to be diagnosed with a more virulent form of the disease than women of European ancestry. Researchers from the University of Chicago, working with colleagues at the University of Calabar in Nigeria and the University of North Carolina, foun...

Molecular fossils uncover link between viruses and the immune system

Researchers from the Viikki Biocenter, University of Helsinki, show that atomic structures can reveal evolutionary history of viruses in a similar fashion as fossils did for the dinosaurs and reptiles. Their article is published in the April 15 issue of Molecular Cell. These "molecular fossils" also revealed that viruses and proteins of immune system share the same structure. One plausibl...

Research may provide new link between soft drinks and weight gain

A University of Cincinnati (UC) study provides new evidence that drinking large amounts of beverages containing fructose adds body fat, and might explain why sweetening with fructose could be even worse than using other sweeteners. Researchers allowed mice to freely consume either water, fructose sweetened water or soft drinks. They found increased body fat in the mice that drank the fruct...

Genetic study of Neanderthal DNA reveals early split between humans and Neanderthals

In the most thorough study to date of the Neanderthal genome, scientists suggest an early human-Neanderthal split. The two species have a common ancestry, say the authors, but do not share much else after evolving their separate ways. The study, published in this week's issue of Science, also finds no evidence of genetic admixture between Neanderthals and humans. The study helps to explain...

Genes and genius: Researchers confirm association between gene and intelligence

If you're particularly good with puzzles or chess, the reason may be in your genes. A team of scientists, led by psychiatric geneticists at Washington University School of Medicine in St. Louis, has gathered the most extensive evidence to date that a gene that activates signaling pathways in the brain influences one kind of intelligence. They have confirmed a link between the gene, CHRM2,...

A new molecule discovered in the battle between plants and disease

Scientists at Washington State University in Pullman have discovered a molecule that plays a role in the battle plants must win against bacteria and fungi that would eat them for lunch. The group led by Professor Clarence A. "Bud" Ryan isolated a small protein called Pep1 that appears to act like a hormone, signaling to the rest of the plant to raise its defenses at the first sign of an infection...

'Underground' tunnels discovered as means for communication between immune system cells

University of Pittsburgh researchers first to report function of tunneling nanotubules Immune system cells are connected to each other by an extensive network of tiny tunnels that, like a building's hidden pneumatic tube system, are used to shoot signals to distant cells. This surprising discovery, being reported by two University of Pittsburgh School of Medicine researchers in the Septem...

New discovery blurs distinction between human cells and those of bacteria

UCLA biochemists reveal the first structural details of a family of mysterious objects called microcompartments that seem to be present in a variety of bacteria. The discovery was published Aug. 5 in the journal Science. "This is the first look at how microcompartments are built, and what the pieces look like," said Todd O. Yeates, UCLA professor of chemistry and biochemistry, and a member...

Plants discriminate between self and non self

Two peas in a pod may not be so friendly when planted in the ground and even two parts of the same plant, once separated may treat the former conjoined twin as an alien "enemy," according to a Penn State researcher. "We were looking at how plants determine who is a competitor when competing with other roots for limited resources," says Dr. Omer Falik, postdoctoral researcher in plant ecolo...

Genetic link confirmed between Polynesians and indigenous Taiwanese

According to folklore, Polynesians originated from a mythical homeland called Hawaiki. Their origins and the existence of such a place, however, have been the subject of much speculation. In a new study in the premier open access journal PLoS Biology, Jean Trejaut and colleagues now provide the first direct evidence for the common ancestry of Polynesians and indigenous Taiwanese. Genetic t...

European Commission funds EBI to do new research on synergies between bioinformatics and medical informatics

In findings with implications for pandemic influenza, a new study reports for the first time that a less-virulent strain of avian influenza virus can spread from poultry to humans. The research appears in the October 1 issue of The Journal of Infectious Diseases, now available online. Crossing the species barrier is an important step in the development of a flu virus with pandemic potenti...

UF scientist finds unexpected link between cat and human AIDS viruses

Emerging relationships between the two viruses could one day lead to a vaccine for human A University of Florida researcher has discovered an unexpected link between the viruses that cause feline and human AIDS: Cats vaccinated with an experimental strain of the human AIDS virus appear to be at least as well-protected against the feline version of the disease as those immunized with the v...

A new link between stem cells and tumors

Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Institute of Biomedical Research of the Parc Cient�fic de Barcelona (IRB-PCB) have now added key evidence to claims that some types of cancer originate with defects in stem cells. The study, reported this week in the on-line edition of (September 4) shows that if key molecules aren't place...

No link found between caffeine intake and development of hypertension in women

Habitual coffee drinking is not associated with an increased risk of hypertension in women, although an association was found with the consumption of sugared or diet colas, according to a study in the November 9 issue of JAMA. Approximately 50 million people in the United States have hypertension, and the prevalence is increasing, according to background information in the article. Hyperte...

New study identifies key gene in development of connections between brain and spinal cord

A new study, presented at the American College of Neuropsychopharmacology's (ACNP) Annual Meeting, has identified a specific gene that is necessary for the development of connections between the brain and the spinal cord. This research, conducted by Stanford University through a grant from the National Institutes of Health (NIH), could be critical for future understanding of the development of...

A real time look at interactions between RNA and proteins

For the first time, researchers can now peer inside intact cells to not only identify RNA-binding proteins, but also observe–in real-time–the intricate activities of these special molecules that make them key players in managing some of the cell's most basic functions. Researchers at the University of Pennsylvania School of Medicine who developed the new technology see this advance as one of the...

New evidence questions the simple link between prion proteins and madcow disease

While newly published research confirms that under laboratory circumstances prion-protein can be absorbed across the gut, it also shows that this is unlikely to occur in real life. In addition, the results show that the places in the gut that do take up these disease-associated proteins are different from the locations where infectivity is known to be amplified. The findings will be published in...

A link is found between morphine addiction and the tendency to explore

A team of researchers from the UAB has found experimental evidence in rats showing a link between addiction to morphine and the tendency to explore perseveringly. This is the first time a direct relationship has been found without other psychological characteristics, such as anxiousness, that might affect results. Published in Behavioural Brain Research, the results of this study are useful for p...

Scientists discover interplay between genes and viruses in tiny ocean plankton

New evidence from open-sea experiments shows there's a constant shuffling of genetic material going on among the ocean's tiny plankton. It happens via ocean-dwelling viruses, scientists report this week in the journal Science. Conducted by biological oceanographers Sallie Chisholm and her colleagues at the Massachusetts Institute of Technology, the research is uncovering a new facet of evo...

Nano machine switches between biological and silicon worlds

"Frankly, some researchers didn't think what we were attempting was possible," says Dr Keith Firman, at Portsmouth University and Mol-Switch project coordinator, funded under the European Commission's Future and Emerging Technologies initiative. "However, we got our molecular switch to work." The upshot is that the Mol-Switch project was far more successful than expected. The team's switch...

Darkness unveils vital metabolic fuel switch between sugar and fat

Constant darkness throws a molecular switch in mammals that shifts the body's fuel consumption from glucose to fat and induces a state of torpor in mice, a research team led by scientists at The University of Texas Medical School at Houston reports in the Jan. 19 edition of Nature. While their findings could provide new insight into mammalian hibernation, researchers note that the pivota...

Stanford study of owls finds link in brain between sight and sound

Just imagine listening to someone talk and also hearing the buzz of the overhead lights, the hum of your computer and the muffled conversation down the hallway. To focus on the person speaking to you, your brain clearly can't give equal weight to all incoming sensory information. It has to attend to what is important and ignore the rest. Two scientists at the Stanford University School of...

Study outlines genetic differences between potential pandemic influenza strains

An analysis of H5N1 influenza samples in Southeast Asia shows not only how the two strains that have caused human disease are related but also that they belong to two different, distinct genetic subgroups. Researchers from the Centers for Disease Control and Prevention report their findings today at the International Conference on Emerging Infectious Diseases. "As the virus continues its...

Study reveals classic symbiotic relationship between ants, bacteria

Ants that tend and harvest gardens of fungus have a secret weapon against the parasites that invade their crops: antibiotic-producing bacteria that the insects harbor on their bodies. Writing today in the journal Science, an international team led by University of Wisconsin-Madison bacteriologist Cameron Currie illustrates the intricate and ancient nature of this mutualistic relationship....

Fruit fly reveals a potential connection between dementia and cancer

By expressing a protein associated with Alzheimer's disease in the brain of the fruit fly, researchers have demonstrated an intriguing link between neuronal death and proteins previously associated with cancer. Neurons in the brai...

ASU researchers find link between social behavior, maternal traits in bees

One of the puzzling questions in the evolution of bees is how some species developed social behaviors. Arizona State University Life Sciences associate professor Gro Amdam thinks part of the answer can be traced back to bee reproductive traits. A paper describing Amdam's experiments, "Complex social behavior derived from maternal reproductive traits," is the cover story of the current iss...

Novel connection found between biological clock and cancer

Dartmouth Medical School geneticists have discovered that DNA damage resets the cellular circadian clock, suggesting links among circadian timing, the cycle of cell division, and the propensity for cancer. Their work, reported June 29 in Science Express, the advance electronic publication of Science, implies a protective dimension for the biological clock in addition to its pacemaker funct...

A switch between life and death

The breakthrough came as Barry Thompson from Stephen Cohen's group at EMBL looked at a recently discovered signaling pathway called "Hippo." "Hippo acts as a switch between cell division and death," says Barry Thompson, "If the pathway is too active, tissues overgrow because too many cells divide and too few die. But until now, we hadn't found a connection between the signals and the cell...

Johns hopkins researchers find link between cell's energy use and genome health

While studying how a cell keeps its genetic material intact, scientists at Johns Hopkins got busy alternately knocking out two catalysts vital to managing a yeast cell's energy. They discovered to their complete surprise that the removal of one of them led the cell to turn off 70 percent of its 5,000 genes and die. "We were completely unprepared for such a dramatic event," says Jef Boeke...

Links between DNA damage and breast cancer studied

Researchers from the Pacific Northwest Research Institute (PNRI) and the National Institute of Standards and Technology (NIST) have uncovered a pattern of DNA damage in connective tissues in the human breast that could shed light on the early stages of breast cancer and possibly serve as an early warning of a heightened risk of cancer. In the United States, breast cancer is the second lea...

New study finds similarities between monkey business and human business

Little attention has been paid to whether systematic economic biases such as risk-aversion are learned behaviors ?and thus easily ameliorated through market incentives ?or biologically based, arising in novel situations and in spite of experience. In a groundbreaking new study from the Journal of Political Economy, Yale researchers extend this question across species, exploring how a colony of ca...

Genetic 'roadmap' charts links between drugs and human disease

A research team led by scientists at the Broad Institute of MIT and Harvard announced today the development of a new kind of genetic "roadmap" that can connect human diseases with potential drugs to treat them, as well as predict how new drugs work in human cells. Called the "Connectivity Map," the new tool and its uses are described in the September 29 issue of Science and in separate publicatio...

Striking the right balance between excitation and inhibition

Neurons in the brain and spinal cord come in two flavors, excitatory neurons that transmit and amplify signals, and inhibitory neurons that inhibit and refine those signals. Although investigators have long appreciated that these two classes of neurons exist in the central nervous system, little is known about how cells decide to become inhibitory or excitatory during embryonic development. Rese...

Study suggests evolutionary link between diet, brain size in orangutans

In a study of orangutans living on the Indonesian islands of Borneo and Sumatra, scientists from Duke University and the University of Zurich have found what they say is the first demonstration in primates of an evolutionary connection between available food supplies and brain size. Based on their comparative study, the scientists say orangutans confined to part of Borneo where food suppli...

Age-related changes in DNA repair illuminate the connection between age and genetic damage

Researchers have uncovered a new way in which the aging process is linked to DNA damage--which occurs normally as a result of cell metabolism and environmental influences--and the various ways in which cells repair that damage. In the new work, researchers found that cells in young fruit flies make use of a different mix of molecular DNA-repair mechanisms compared to cells in older flies. The fin...

'Killer' B cells demonstrate evolutionary link between fish and mammal immune systems

Researchers from the University of Pennsylvania School of Veterinary Medicine have discovered a unique evolutionary link between the immune systems of fish and mammals in the form of a primitive version of B cells, white blood cells of the immune system. Their studies link the evolution of the adaptive immune system in mammals, where B cells produce antibodies to fight infection, to the more pri...

Bad blood between boys and girls

Women infected with dormant toxoplasmosis are more likely to give birth to boys than women who are Toxoplasma negative, according to research by S. Kankova and colleagues from the Departments of Parasitology, Microbiology and Zoology, Charles University; the Centre of Reproductive Medicine; and GynCentrum, in the Czech Republic. They found that the presence of the parasite Toxoplasma gondii in t...

Interaction between lymph and liver cells may affect immune response

A new study on the ability of liver cells to interact with T cells (lymph cells that play a role in regulating the immune response) found that such interactions do occur and demonstrated the mechanism by which they may take place. The results may help explain the altered immune responses that occur with aging and other conditions and may be useful in developing therapies for viral hepatitis and a...