approach

Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.

Few things about growing older are asinevitable and obvious as “going gray,?yet scientists have been unableto explain the precise cause of this usually unwelcome transformation.In a report posted today on the Web site of the journal Science,researchers from Dana-Farber Cancer Institute and Children’s HospitalBoston say they have found the cellular cause of graying hair whileinvestigating th...

MSI releases 'moleculizer' - a new approach to simulation of intracellular biochemical networks

Dr. Roger Brent, President and Director of Research at the the release of a new approach to simulation of intracellularbiochemical networks in the January 2005 edition of NatureBiotechnology.The research article, entit...

Discovery Could Lead To Novel Approaches In HIV Treatment

,the Canadian Network for Vaccines and Immunotherapeutics, has announcedthe development of a new method to assess how well the thymus (an organlocated at the base of the neck) works and the discovery of afunctional abnormality of this organ in HIV-infected individuals. Theteam of investigators led by Dr. Rafick-Pierre Sékaly, professor atUniversi...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

New insights by Duke University Medical Center researchers as to how HIV evades the human immune system may offer a new approach for developing HIV vaccines. The findings suggest some HIV vaccines may have failed because they induce a class of antibodies that a patient's own immune system is programmed to destroy. The Duke team discovered that certain broadly protective antibodies, which...

Stopping smallpox in its tracks: A new anti-viral approach

Natural or deliberate exposure to smallpox poses a great health threat, especially since routine smallpox vaccinations have been discontinued and no clinically approved treatment currently exists. In the February 1 issue of the Journal of Clinical Investigation, Ellis Reinherz and colleagues from Harvard Medical School propose a new antiviral therapy ?a low molecular weight inhibitor of signaling...

New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal

Call it a chemical crystal ball. A new approach to predict whether a drug in development is likely to work and which dose is best could get antibiotics to market faster and more cheaply, say University of Florida researchers. In recent years, scientists worldwide have sounded the alarm: There simply aren’t enough drugs to combat bad bugs. Bacteria are increasingly adept at outwitting the t...

Building a protein name dictionary from full text: a machine learning term extraction approach

The majority of information in the biological literature resides in full text articles, instead of abstracts. Yet, abstracts remain the focus of many publicly available literature data mining tools. Most literature mining tools rely on pre-existing lexicons of biological names, often extracted from curated gene or protein databases. This is a limitation, because such databases have low coverage o...

NCI Researchers Confirm the Effectiveness of Immunotherapy Approach to Treating Melanoma

A team of researchers, led by Steven A. Rosenberg, M.D., at the National Cancer Institute, part of the National Institutes of Health, have found that patients with advanced melanoma who had not responded to previous therapies experienced a significant reduction in the size of their cancers as a result of receiving a new immunotherapy. This immunotherapy consisted of a combination of chemotherapy...

Vaginal gel may provide a new approach to HIV prevention

Research with female monkeys at the Tulane National Primate Research Center has for the first time shown that three different anti-viral agents in a vaginal gel protect the animals against an HIV-like virus. The research suggests that a microbicide using compounds that inhibit the processes by which HIV attaches to and enters target cells could potentially provide a safe, effective and practical...

Rensselaer researchers develop approach that predicts protein separation behavior

Applying math and computers to the drug-discovery process, researchers at Rensselaer Polytechnic Institute have developed a method to predict protein separation behavior directly from protein structure. This new multi-scale protein modeling approach may reduce the time it takes to bring pharmaceuticals to market and may have significant implications for an array of biotechnology applications, inc...

Huntington's cure in flies lays groundwork for broader treatment approaches

Boosting levels of two critical proteins that normally shut down during Huntington's disease, researchers at the University of Wisconsin-Madison and the Cold Spring Harbor Laboratory have cured fruit flies of the genetic, neurodegenerative condition. The study results,...

Results of world's first gene therapy trial for arthritis show approach safe, feasible

Gene therapy for arthritis and other non-terminal, debilitating conditions and diseases is both feasible and safe, report researchers who conducted the world's first such test on the approach in patients with advanced rheumatoid arthritis. The results, published in this week's online edition of the Proceedings of the National Academy of Sciences (PNAS), indicate that introducing a new gene has th...

Clinical trial to test stem cell approach for children with brain injury

A unique clinical trial will gauge the safety and potential of treating children suffering traumatic brain injury with stem cells derived from their own bone marrow starting early next year at The University of Texas Medical School at Houston and Memorial Hermann Children's Hospital. The clinical trial is the first to apply stem cells to treat traumatic brain injury. It does not involve...

Study in Science holds promise for a new approach to drug therapy

Researchers believe they have found a way to change the action of 60 percent of currently available medications, in some cases making them many times more effective, according to an article published in the April 21 edition of the journal Science. The discovery has the potential to improve treatments for diseases including heart disease, cancer, diabetes, depression and arthritis. The study descr...

U-M researchers take new approach to defeating Gram-negative bugs

Ronald Woodard's team set out looking for a way to kill a stubborn type of bacteria and they succeeded---but not in the way he expected. Woodard is senior author of an article describing way he and his...

New approach to vaccine development provides potent, long-lasting immunity

By training a group of human subjects to operate a robot-controlled joystick, Johns Hopkins researchers have shown that the slower the brain "learns" to control certain muscle movements, the more likely it is to remember the lesson over the long haul. The results, the investigators say, could alter rehabilitation approaches for people who have lost motor abilities to brain injuries like strokes....

Cells use mix-and-match approach to tailor regulation of genes

Scientists eager to help develop a new generation of pharmaceuticals are studying cellular proteins called transcription factors, which bind to upstream sequences of genes to turn the expression of those genes on or off. Some pharmaceutical companies are also hoping to develop drugs that selectively block the binding of transcription factors as a way to short-circuit the harmful effects of diseas...

Global warming may warrant new approaches to ecosystem restoration

Ecosystems behave in unpredictable ways and, because of this, restoration ecologists are often faced with unforeseen challenges. Researchers, in a recent article published in Restoration Ecology, argue that restoration methods of the past may not always be applicable in the future They see the largest potential challenge ahead is restoring environments undergoing the most rapid rate of change...

Plant-cell-produced technologies-cutting edge approach to bringing solutions to the market

Four months after the world's first vaccine made in plant cells has received regulatory approval in the US, Dow AgroSciences is organising a Science Conference in Brussels on 7 June 2006 in order to share this knowledge with European researchers, scientists, decision-makers and industry representatives. The pioneering vaccine developed by Dow AgroSciences works against the Newcastle diseas...

Killing brain tumors from within: A 'Trojan horse' approach

A new method for targeting malignant brain tumors through inducing the cancerous cells to "commit suicide" has been developed by a team of researchers headed by a Hebrew University of Jerusalem professor of biochemistry. Alexander Levitzki, who is the Wolfson Family Professor of Biochemistry, his research associate, Dr. Alexei Shir, and his colleagues from the Ludwig-Maximilians Univers...

Using nature's most primitive anti-viral defense system to find new approaches to cancer research

The humble fruit fly and a grant from the AICR ?the Association for International Cancer Research - are helping a leading scientist in London identify potential targets for drugs that block the spread of cancer. In one of the first studies of its kind, Dr Buzz Baum of the UCL Branch of the global Ludwig Institute for Cancer Research (LICR) is using the tiny fruit fly, Drosophila, as a sim...

Carnegie Mellon scientists use 'green' approach to transform plastics manufacturing

Using environmentally safe compounds like sugars and vitamin C, scientists at Carnegie Mellon University have vastly improved a popular technology used to generate a diverse range of industrial plastics for applications ranging from targeted drug delivery systems to resilient paint coatings. The revolutionary improvement in atom transfer radical polymerization (ATRP) now enables large-scal...

A new approach to growing heart muscle

It looks, contracts and responds almost like natural heart muscle ?even though it was grown in the lab. And it brings scientists another step closer to the goal of creating replacement parts for damaged human hearts, or eventually growing an entirely new heart from just a spoonful of loose heart cells. This week, University of Michigan researchers are reporting significant progress in grow...

Einstein researchers demonstrate a novel approach to treating AIDS

Using a radically new strategy featuring radioactive "guided missiles," researchers at the Albert Einstein College of Medicine of Yeshiva University have successfully targeted and destroyed human immune cells infected with HIV, the virus that causes AIDS. "This study in mice supports the idea that radioimmunotherapy might help in treating people infected with HIV," says Dr. Arturo Casadev...

New approach to BSE successful in lab

A new method of treatment can appreciably slow down the progress of the fatal brain disease scrapie in mice. This has been established by researchers from the Universities of Munich and Bonn together with their colleagues at the Max Planck Institute in Martinsried. To do this they used an effect discovered by the US researchers Craig Mello and Andrew Fire, for which they were awarded this year’s...

New approach could lower antibiotic requirements by 50 times

Antibiotic doses could be reduced by up to 50 times using a new approach based on bacteriophages. It is the phages' abili...

Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment

Researchers at the University of Pennsylvania School of Medicine have discovered that an enzyme produced by lung-infecting bacteria further shuts down a protein that is defective in cystic fibrosis patients. The disruption to this protein that conveys ions from lung cells to airways causes thick mucus to buildup inside the lung. The finding suggests a new therapeutic target for treating lung infe...

Cheaper, better disease treatments expected from faster approach to developing antibodies

A method of mass-producing disease-fighting antibodies entirely within bacteria has been developed by a research group at The University of Texas at Austin. The group led by Dr. George Georgiou developed the new antibody-production approach to improve upon processes used previously to identify new drugs. Drug companies have used those more time- and labor-intensive processes to develop a...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

Kaposi’s sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi’s sarcoma and primary effusion lymphoma (PEL). PELs are aggressive lymphomas with reported median survival time shorter than six months after diagnosis. Researchers at the University of Helsinki have discovered that activation of the p53 pathway offers a novel effective treatment modality for KSHV-infec...

Soft-cell approach cuts animal tests

The new in-vitro technique pioneered by Dr Amanda Hayes and her UNSW colleagues, Shahnaz Bakand and Chris Winder, directly exposes human cells to airborne toxicants and measures cytotoxic effects. The cells are grown on a porous polyester membrane inside a small diffusion chamber and then exposed to selected toxic air pollutants. After as little as one hour's exposure, they can study cell growth...

Gut research yields new anti-cancer approach

Researchers believe they have discovered by chance a new way to fight colorectal cancer, and potentially cancers of the esophagus, liver and skin. Early work shows that a group of compounds called peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibitors may have an unexpected cancer-fighting effect, according to research published today in the journal International Cancer Research....

Sandia researchers take new approach to studying how cells respond to pathogens

A Sandia National Laboratories research team led by Anup Singh is taking a new approach to studying how immune cells respond to pathogens in the first few minutes and hours of exposure. Called the Microscale Immune Studies Laboratory (MISL) Grand Challenge, the work is in its second of...

Reconstructing the biology of extinct species: A new approach

An international research team has documented the link between the way an animal moves and the dimensions of an important part of its organ of balance, the three semicircular canals of the inner ear on each side of the skull. The team's article on its research will be published on 26 June in the print edition of the Proceedings of the National Academy of Sciences and in the journal's online e...