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Zebrafish in Biological News

Drug-proof zebrafish reveal secrets of addiction

The effects of amphetamines on gene expression in zebrafish have been uncovered. This new study, published in BioMed Central's open access journal Genome Biology , provides clues to the genetics that underlie susceptibility to addiction by describing the nad zebrafish mutant, which does not feel ...

Pitt team finds molecule that regulates heart size by using zebrafish screening model

PITTSBURGH, July 5 Using zebrafish, researchers at the University of Pittsburgh have identified and described an enzyme inhibitor that allows them to increase the number of cardiac progenitor cells and therefore influence the size of the developing heart. The findings are described in the advance...

AZTI-Tecnalia coordinates a platform promoting the use of zebrafish in scientific research

This release is available in Spanish . AZTI-Tecnalia is coordinating the First Spanish Technological Platform on the promotion of zebrafish as an animal model in all fields of scientific research. The platform, known as DareNET, has the support of the Spanish Ministry of Science and Innov...

NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays

Cambridge, MA January 7, 2009 Phylonix Pharmaceuticals, Inc. today announced that it has been awarded a $1,250,369 Phase II Small Business Innovation Research Grant (SBIR) from the National Institute of General Medical Sciences of the National Institutes of Health (NIH) to develop in vivo zebra...

Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate

Researchers at the European Molecular Biology Laboratory (EMBL) have generated a digital zebrafish embryo - the first complete developmental blueprint of a vertebrate. With a newly developed microscope scientists could for the first time track all cells for the first 24 hours in the life of a zebr...

A screening strategy using zebrafish targets genes that protect against hearing loss

A small striped fish is helping scientists understand what makes people susceptible to a common form of hearing loss, although, in this case, its not the fishs ears that are of interest. In a study published on February 29 in the open-access journal PLoS Genetics, researchers at the University of ...

Study shows how the zebrafish gets his stripe

Scientists have discovered how the zebrafish (Danio rerio) develops one of its four stripes. Their findings add to the growing list of tasks carried out by an important molecule that is involved in the arrangement of everything from nerve cells to reproductive cells in the developing embryo. ...

Deadly genetic disease prevented before birth in zebrafish

By injecting a customized "genetic patch" into early stage fish embryos, researchers at Washington University School of Medicine in St. Louis were able to correct a genetic mutation so the embryos developed normally. The research could lead to the prevention of up to one-fifth of birth defects ...

Key to zebrafish heart regeneration uncovered

When a portion of a zebrafish's heart is removed, the dynamic interplay between a mass of stem cells that forms in the wound and the protective cell layer that covers the wound spurs the regeneration of functional new heart tissue, Duke University Medical Center scientists have found. The scienti...

How does a zebrafish grow a new tail?

If a zebrafish loses a chunk of its tail fin, it'll grow back within a week. Like lizards, newts, and frogs, a zebrafish can replace surprisingly complex body parts. A tail fin, for example, has many different types of cells and is a very intricate structure. It is the fish version of an arm or leg...

Glow-in-the-dark zebrafish at UH hold keys to biological clocks

Using genetically altered zebrafish that glow in the dark, University of Houston researchers have found new tools that shed light upon biological clock cycles. Gregory M. Cahill, associate professor of biology and biochemistry at UH, and Maki Kaneko, a fellow UH researcher who is now at the Univ...

2 Fred Hutchinson Cancer Research Center scientists receive Presidential Early Career Award

... Malik, the Hutchinson Center is home to three other Presidential Early Career Award recipients: basic scientist Cecilia Moens, Ph.D., who studies the zebrafish as a model of vertebrate developmental biology; clinical researcher William Grady, M.D., who studies the mechanisms of colorectal-cancer development; ...

The SIB recognizes the next generation of bioinformaticians

... constraints on the genome. Mr. Roux studied the effect of gene expression over vertebrate developmental time (from early to late development) in both zebrafish and mice. Results indicate "a strong effect of constraints, which are progressively weaker towards late development, in early development on the genom...

Zebrafish provide a model for cancerous melanoma in humans

... Disease Models & Mechanisms , scientists use the zebrafish to gain insight into the influence of known cancer...ty Hospital Zrich in Switzerland generated several zebrafish with changes in RAS or other RAS-regulated protein...an be used to study and understand human melanoma. zebrafish are a useful tool to understand human disease beca...

Alzheimer cell death in Zebrafish: Demise of neurons observed live for the first time

... life imaging. The scientists inserted a gene into zebrafish that leads to a severe form of Alzheimer's in huma...e it was happening. "The translucent larvae of the zebrafish can be studied under a laser microscope over an ex...able to block the disease-related processes in the zebrafish at least to some extent." The work has already ...

Regulatory molecule for tumor formation or suppression identified by Singapore, US researchers

...s not a co-author of the paper. Professor of Cell Biology at the Harvard Medical School, Frank McKeon, Ph.D., commented, "This is an elegant use of zebrafish models to uncover how a single microRNA can regulate the p53 tumor suppressor gene. The strength of this regulation suggests that we will hear more a...

Phylonix to present at 2009 Society of Toxicology Annual Meeting

... will be presented on Monday, March 16 and Tuesday, March 17, respectively. Podium Presentation "Assessment of Ototoxicity and Otoprotection in a zebrafish Hair Cell Model" Tuesday, March 17, 10:36 am - 10:59 am, Room 308 Poster Presentations "Assessment of Drug Induced Cardiotoxicity in Transparent ...

Why 'lazy Susan' has a weak heart

...animal model. Just one "false" amino acid can give zebrafish a heart condition. Since the fish have a genetic m...eart function. Some 70 percent of the genes of zebrafish and humans are identical Can these research results be transferred from zebrafish to humans? In the next step, the Heidelberg cardio...

Newly found enzymes may play early role in cancer

... genes that could trigger cancer or numerous other diseases and birth defects. The research is published in the December 26 issue of Cell . Using zebrafish that share similar genetics to humans, the HCI scientists identified a previously unknown enzyme process that controls the levels of DNA methylation o...

More freedom to take risks: DFG funds the first Reinhart Koselleck Projects

...ogy at the cellular level in fish. Schuster will combine behavioural physiology, electrophysiology, functional imaging, computational neuroscience and zebrafish genetics. He aims to determine how the world is represented at the level of very small decision-making networks in the mammalian brain in such a way t...

BioScience tip sheet, December 2008

...ges of Aquatic Vertebrate Ecotoxicology. Michael J. Carvan III, John P. Incardona, and Matthew L. Rise. As a model organism for ecotoxicology, the zebrafish can be used to develop mechanistic models of interactions between genes and the environment that will provide a foundation for genomic resources in ot...

International team discovers gene associated with epilepsy

...nimal model involved a surprising coincidence: Bassuk, who had only recently joined the UI, realized through online research that the PRICKLE1 gene in zebrafish had been previously identified by another University of Iowa researcher, Diane Slusarki, Ph.D., associate professor of biology in the UI College of Li...

Primordial fish had rudimentary fingers

... When they examined genes that are necessary for the evolution of fins in zebrafish (a ray-finned fish that is a distant relative of coelacanth fishes) and com...ene that regulates the development of limbs in mice, researchers found that zebrafish lacked the genetic mechanisms that are necessary for the development of fin...

Charcot-marie-tooth disease research funding

...characterized by degeneration of long motor and sensory axons, which results in muscle atrophy and skeletal deformities. Hutson's research will use zebrafish as a model system to investigate disease mutations in two small heat shock proteins, HSP27 and HSPB8, which can cause either CMT or the closely relate...

New technique allows targeted inactivation of genes in research model

...ction enzyme that inactivates a specific gene in a zebrafish embryo. The paper, Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases appears as ...technologies that facilitate biological studies in zebrafish to better understand development and disease. ...

Bloodless worm sheds light on human blood, iron deficiency

...s, much like birth defects. The gene removal also resulted in a severe form of anemia usually caused by iron deficiencies. When they substituted the zebrafish gene with the worm HRG-1 gene, the mutant fish returned to normal, indicating that the fish and worm genes are interchangeable, irrespective of the an...

Promising new drug targets identified for Huntington's disease

...igraine and hypertension are able to stimulate autophagy in fruit flies and zebrafish through unexpected pathways. "By screening a number of drugs that have a...ate the toxicity of the Huntingtons disease mutation in cell-based, fly and zebrafish models. The big question for us is whether they will do the same in humans....

Proposal to step up cardiovascular disease research

...the European key opinion leaders in cardiovascular disease. On the scientific front, EVBI will exploit existing project platforms, notably the EVGNs zebrafish animal model, which allows vascular disease progression and the action of therapies to be monitored and analysed closely. The aim is to build on these...

Going live with click chemistry

...ding authority on glycobiology. We are already using our copper-free click chemistry technique to probe glycan dynamics in living cells and in live zebrafish embryos, which serve as a standard model of developmental biology, she said. Bertozzi is the lead author on a paper published in the Proceedings of...

Scientists alter sexual orientation in worms

...imeter-long (one twenty-fifth of an inch) worms that live in soil and eat bacteria. Because the same genes are found in many animals, nematodes, mice, zebrafish and fruit flies often are used as models for humans in research. Nematode worms lack eyes, so attraction is based only on the sense of smell. Ther...

Decoding effects of toxins on embryo development

... Changes in gene expression patterns in zebrafish embryos resulting from exposure to environmental t... journal Genome Biology. The genetic response of zebrafish to each toxin can be read like a barcode, offering... of the toxin on developing vertebrate embryos. zebrafish embryos were exposed to eleven common pollutants, ...

Study reveals a key to blood vessel growth and possible drug target

...UCSF professor of biochemistry and biophysics. The zebrafish has proven to be an important model for discoverin...lood vessel wall during vascular development -- in zebrafish embryos. The pathway these molecules make up d... scientists started the investigation by examining zebrafish with unusual physical characteristics and working ...

Zebrafish to shed light on human mitochondrial diseases

... zebrafish can now be used to study COX deficiencies in human...nd organs during early development. The case for zebrafish (Danio rerio) as an alternative research model is ...in the zebrafish. "The unique characteristics of zebrafish make them an ideal model for studying the effects ...

Fat fish put obesity on the hook

...eing able to model human disorders like obesity in zebrafish allows scientists to understand the molecular basi...” In the study, researchers caused obesity in zebrafish by introducing the same type of genetic mutation t...e once crucial to the survival of our species. The zebrafish has become a model animal for the study of many di...

Fast and slow -- How the spinal cord controls the speed of movement

...ation and how it was associated with speed of movement. He is the lead author on the study. The researchers worked with 4 millimeter-long larval zebrafish (Danio rerio) because they are transparent and researchers can see their cells. Fetcho and his colleagues injected the fishes?spinal cords with a fluo...

Why is the heart heart-shaped?

...logy, Heidi Auman, Deborah Yelon, and colleagues found, by using transgenic zebrafish in which they can watch individual cardiac cells, that cells change size an... develops, they asked whether cardiac function influences cell shape. Using zebrafish mutants with functional defects, they found that both blood flow and cardia...

Reversing cancer cells to normal cells

...nd her colleagues used the microenvironment of the zebrafish to study whether the tumor cells could communicate with the zebrafish stem cells and affect their early development. The zebrafish is a widely-used organism for genetic and developm...

How fish mend a broken heart

...f Cell, published by Cell Press. The researchers found that the hearts of zebrafish harbor progenitor cells that spring into action to restore wounded heart mu...t, in mammals." In an earlier study, Poss and his colleagues found that zebrafish have a unique ability to regenerate cardiac muscle after major injury. They...

Mutant gene causes severe kidney disease in infants

...leagues will continue searching for the causes of nephrotic syndrome. Using zebrafish that lack working copies of plce1, they hope to identify drugs that could r...e of finding ways to modify its activity," Hildebrandt explains. "Using the zebrafish model, we can do high-throughput screening of many possible drug candidates...

A fisheye view of the deadliest breast cancer

...ated to be immune suppressed. In recent years, the zebrafish has vaulted to the top as a laboratory model organism. The zebrafish is tough, easy to breed, and a vertebrate, just li...ues see their xenografted, genetically engineered zebrafish as a potential front runner. ...
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