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Stowers researchers develop whole genome sequencing approach for mutation discovery

The Stowers Institute's Hawley Lab and Molecular Biology Facility have developed a "whole-genome sequencing approach" to mapping mutations in fruit flies. The novel methodology promises to reduce the time and effort required to identify mutations of biological interest. The work was published in t...

New computational technique allows comparison of whole genomes as easily as whole books

Berkeley -- Taking a hint from the text comparison methods used to detect plagiarism in books, college papers and computer programs, University of California, Berkeley, researchers have developed an improved method for comparing whole genome sequences. With nearly a thousand genomes partly or f...

Students eat more whole grains when it's gradually added to school lunch

Elementary school students will eat more whole grains when healthier bread products are gradually introduced into their school lunches, a new University of Minnesota study shows. Whole grain breads are strongly recommended as part of a healthy diet, but children and pre-teens won't always eat t...

Earlier global warming produced a whole new form of life

Researchers from McGill University, along with colleagues from the California Institute of Technology, the Curie Institute in Paris, Princeton University and other institutions, have unearthed crystalline magnetic fossils of a previously unknown species of microorganism that lived at the boundary ...

Big Mac: The whole world on your plate

A burger and fries may be the quintessential North American meal but it can also be viewed as the perfect example of humanitys increasingly varied diet, according to researchers who have conducted a unique study of the plants used around the world for food. In the first-ever study of the phylog...

In the mind's eye: How the brain makes a whole out of parts

When a human looks at a number, letter or other shape, neurons in various areas of the brain's visual center respond to different components of that shape, almost instantaneously fitting them together like a puzzle to create an image that the individual then "sees" and understands, researchers at T...

First Whole Genome Map of Genetic Variability in Parkinson’s Disease

In findings with implications for pandemic influenza, a new study reports for the first time that a less-virulent strain of avian influenza virus can spread from poultry to humans. The research appears in the October 1 issue of The Journal of Infectious Diseases, now available online. Crossing t...

A whole lot of shaking goin' on triggers early hatching in red-eyed tree frogs

Embryos distinguish vibrational differences, hatching early to snake attacks but not to rain At the edge of Ocelot Pond, Panama, red-eyed tree frog embryos still in their eggs are about to make a life-or-death decision. The egg clutch, a gelatinous blob clinging to a leaf overhanging the water, ...

Argonne to showcase science and technology at community open house

...ne National Laboratory will open its gates to the community on Saturday, August 29, from 9:00 a.m. to 4:30 p.m. for a day of discovery and fun for the whole family. The event is free and open to the public. "The open house will be great fun for everyone," said Eric Isaacs, director of Argonne National L...

Urban water ecology at the ESA annual meeting

... 8 million gallons of water per year, or about 10 percent of its yearly water loss. "We need to understand what implementing these greenroofs at the whole watershed scale can do," she says. "Getting people to learn about this technology and providing incentives is the first step." ...

Parasites ready to jump

...tary material of humans and other organisms. They can replicate and the new copies can insert at novel sites in the genome. Because this threatens the whole organism, molecular mechanisms have evolved which can repress transposon activity. Professor Klaus Frstemann of the Gene Center of Ludwig-Maximilians-...

Reprogramming human cells without inserting genes

...markers of pluripotency may be, it suggests there is a natural mechanism at work in these cells regulating the stem cell gene expression. That opens a whole new line of inquiry." ...

First genetically-engineered malaria vaccine to enter human trials

... vaccine development using a weakened form of the whole organism that causes a particular disease has pro... "Although vaccines are under development that use whole malaria parasites weakened by irradiation to prote...ovides a safe and reproducible way of developing a whole organism malaria vaccine." Professor Cowman said...

Researchers capture bacterial infection on film

...etri dish these signals are lost. Therefore it is really important to study whole organisms to fully understand how bacteria interact with their host." Dr...the microscopic battle between single bacterial cells and immune cells in a whole animal and in real time is astounding. "It will ultimately allow us to ...

Ants more rational than humans

...ve robotics is that the individual robots can be relatively simple and unsophisticated, but you can still get a complex, intelligent result out of the whole group," says Pratt. "The ability to function without complex central control is really desirable in an artificial system and the idea that limitations...

In vitro antibody production enables HIV infection detection in window period -- key to safer blood

...09 issue of Experimental Biology and Medicine , show that pre-treating the whole blood sample in the SMARTube containing immune potentiating agents promoted...o, led to the production of detectable levels of anti-HIV antibodies in the whole blood sample and to the detection of potentially infectious blood units whi...

$2 million grant aids study of lung cancer in people who never smoked

...st promising biomarkers. "What we're missing right now is sequencing the whole genome for each patient's specimens," Dr. Gazdar said. "We think that sequencing the whole genome is going to be crucial, but we're still seeking additional funding f...

International research team seeks to unravel flatworm regeneration

...nto human regeneration and stem cell biology, the researchers are convinced. The researchers looked for small RNAs in stem cells as well as in the whole planarian organism. They discovered 60 new microRNA genes and could demonstrate that ten microRNAs are specifically linked to stem cell biology and ma...

Wolf reintroduction proposed in Scottish Highland test case

...ations and behavior of red deer that in the past 250 years have changed the whole nature of large ecosystems. The proposal is modeled after research done ...ves might have a large impact. A controlled experiment demonstrating the whole ecosystem benefits that might result from such an approach, the researchers...

A 'heart healthy' diet and ongoing, moderate physical activity may protect against cognitive decline

...ient components -- fruit, vegetables, nut/legumes, whole grains, low-fat dairy, sodium, sweets, non-fish me...endently associated with 3MS scores -- vegetables, whole grains, low-fat dairy, nut/legumes. The scientists... (p-values "Our results suggest that including whole grains, vegetables, low-fat dairy foods, and nuts ...

Our 'caveman logic' embraces ESP over evolution

...selfish behavior, we can learn to use critical thinking and the insights of science to guide individual effort and social action in the service of our whole species. ...

Finding the constant in bacterial communication

...ammed bacteria would exist as a synthetic ecosystem. "Each population will synthesize a subset of enzymes that are required for the population as a whole to produce desired proteins or chemicals in a coordinated way," You said. "We may even be able to re-engineer bacteria to deliver different types of d...

Study finds role for parasites in evolution of sex

... same genes, each has the same genetic vulnerabilities to parasites. If a parasite emerges that can exploit those vulnerabilities, it can wipe out the whole population. On the other hand, sexual offspring are genetically unique, often with different parasite vulnerabilities. So a parasite that can destroy ...

Dogs, humans, put heads together to find cure for brain cancer

... They believed that the deletion of NF2, with its tumor suppressing abilities, could trigger tumor growth. In looking at genetic changes across the whole genome, Breen's team compared human chromosome 22 to its canine counterpart. In dogs, the region shared with 22 is "split up" across three separate do...

Pitt team finds molecule that regulates heart size by using zebrafish screening model

...tments that restore normal function to damaged or diseased tissues, it will help us to know the biologic pathways and signals that formed these organs whole and healthy in the first place. This information can be gained by studying developmental biology." Zebrafish are vertebrate animals whose transpare...

Pacific Northwest forests could store more carbon, help address greenhouse issues

...hern California, as far south as San Francisco, holds a total live biomass of about two billion tons of carbon about 14 percent of the biomass in the whole nation; If forests in this region were managed over hundreds of years to maximize carbon sequestration, the carbon in live and dead biomass could ...

Chromosomal problems affect nearly all human embryos

...uman embryogenesis, the process that begins once an egg has been fertilised. Using new technologies that can detect chromosomal aberrations in the whole genome (all human chromosomes) of a single cell, the team was able to screen embryonic cells at a much higher resolution than previously, and hence id...

The sound of light: Innovative technology shatters the barriers of modern light microscopy

...vers without harm following the procedure. Dr. Daniel Razansky, who played a pivotal role in developing the method, says, "This opens the door to a whole new universe of research. For the first time, biologists will be able to optically follow the development of organs, cellular function and genetic exp...

Single thawed embryo transfer after PGD does not affect pregnancy rates

...e, they might have little use. Now, these frozen blastocysts offer them the chance of an additional healthy pregnancy without having to go through the whole treatment cycle again." The first author of the paper in Human Reproduction, Dr Tarek El-Toukhy, a consultant in reproductive medicine and PGD at t...

Researchers see evidence of memory in the songbird brain

...before it heard a recording of a new song. The recording was then repeated every 10 seconds for up to three hours. "The most important thing in its whole life is the sound of another bird of its species singing," Clayton said. "And what we found is that 24 hours after the experience its brain is stil...

Cells use import machinery to export their goods as well

...maintenance of all eukaryotic cells. This sort of shipping was assumed to end with the vesicles fusing completely to the membrane and delivering their whole load of proteins and lipids, in contrast to the more discriminating process by which similar container ships import proteins from outside the cell, ca...

CSHL scientists harness logic of 'Sudoku' math puzzle to vastly enhance genome-sequencing capability

...ific patterns, thereby creating pools of samples. And instead of tagging the individual samples within each pool, the scientists tagged each pool as a whole with one barcode. "Since we know which pool contains which samples, we can link a sequence to an individual sample with high confidence," says Erlich....

Waste water treatment plant mud used as 'green' fuel

... The researchers say it is essential to carry out separate studies for each plant because "we still don't know whether this will be positive for the whole cement industry", according to Domingo. However, if the conditions are right, using mud from waste water treatment plants in cement factories is "a ve...

Improved method developed to test carcinogen risk

...ies have been "severely limited by inadequate experimental data at environmentally relevant exposures," the researchers wrote in their report. "The whole foundation of modern toxicology is that the dose makes the poison," said George Bailey, an OSU distinguished professor emeritus of molecular and envir...

Research vessel Polarstern starts 24th Arctic season

...the Helmholtz Association, will begin its 24th Arctic expedition on Saturday, June 20th. 119 scientists from seven different nations will research the whole spectrum of current Arctic topics in three journey stages: climate history and current climate development, effects on the ecosystem ranging from bact...

Omega-3 fatty acids appear to impact AMD progression

...se they trigger a sharp rise and fall of blood sugar. Low-GI foods, such as whole grain versions of pasta and bread, have a milder effect on blood sugar resp...ished by Taylor and Chiu suggests that daily substitution of five slices of whole grain bread for white bread out of a total intake of 250 g of carbohydrate ...

Beaked, bird-like dinosaur tells story of finger evolution

... of dinosaurs. The discovery is reported in a paper published in this week's edition of the journal Nature . "This work on dinosaurs provides a whole new perspective on the evolution of bird manual digits," said H. Richard Lane, program director in the National Science Foundation (NSF)'s Division of...

Sands of Gobi Desert yield new species of nut-cracking dinosaur

...ally out of proportion to its three-foot body length," Sereno explained. Technically speaking, the dinosaur is also important because it displays a whole new way of chewing, which Sereno and co-authors have dubbed "inclined-angle" chewing. "The jaws are drawn backward and upward instead of just closing ...

Potential for non-invasive brain tumor treatment

...al methods, which have drawbacks and side effects of their own. "Surgery is invasive, and chemotherapy that is injected or taken orally affects the whole body and has difficulty crossing the blood-brain barrier in sufficient concentrations," Herickhoff said. The blood-brain barrier restricts the passage...

TRAPping proteins that work together inside living cells

...e inside cells, so you can't find all the interactions that proteins would normally engage in." Proteins are the workhorses in an organism's cells. whole fields of research are dedicated to teasing out which proteins work together to make cells function. For example, drug researchers seek chemicals that...
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