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Vaccines in Biological News

Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma

Hoag Memorial Hospital Presbyterian today announced promising data from a clinical study showing patient-specific cancer vaccines derived from patients' own cancer cells and immune cells were well tolerated and resulted in impressive long-term survival rates in patients with metastatic melanoma wh...

New type of vaccines deliver stronger and faster immune response

A new vaccine principle is being developed by scientists at the University of Copenhagen which if it works to its full expected potential could help to save millions of lives and revolutionise current vaccine technology. The 'InVacc' platform, as it is known, represents an advance on the origina...

Syracuse University partners with Serum Institute of India to develop vaccines for children

A unique partnership between Syracuse University and the Serum Institute of India could lead to better access to life-saving vaccines for children living in some of the most impoverished areas of the world. The Institute recently awarded $250,000 to a team of SU researchers led by Robert Doyle, a...

Prostate cancer vaccines more effective with hormone therapy

PHILADELPHIA Among patients with castration-resistant prostate cancer, the addition of hormone therapy following vaccine treatment improved overall survival compared with either treatment alone or when the vaccine followed hormone treatment, according to recent data published in the July 15 Clin...

From foe to friend: Researchers use salmonella as a way to administer vaccines in the body

TEMPE, Ariz. Researchers at the Biodesign Institute at Arizona State University have made a major step forward in their work to develop a biologically engineered organism that can effectively deliver an antigen in the body. The researchers report that they have been able to use live salmonella ba...

VaxInnate to discuss seasonal and pandemic flu vaccines during BIO 2008 this week

SAN DIEGO, CA, June 16, 2008 -- VaxInnate Corporation announced today that it will discuss its novel proprietary technology for producing seasonal and pandemic influenza vaccines during BIO 2008 here this week. VaxInnate will participate in the following three BIO 2008 panel discussions: ...

Pitt researchers find promising candidate protein for cancer prevention vaccines

PITTSBURGH, Aug. 4 Researchers at the University of Pittsburgh School of Medicine have learned that some healthy people naturally developed an immune response against a protein that is made in excess levels in many cancers, including breast, lung, and head and neck cancers. The finding suggests t...

Princeton team's analysis of flu virus could lead to better vaccines

A team of Princeton University scientists may have found a better way to make a vaccine against the flu virus. Though theoretical, the work points to the critical importance of what has been a poorly appreciated aspect of the interaction between a virus and those naturally produced defensive p...

Iowa State researchers look for smaller, cheaper, 1-dose vaccines

A team of Iowa State University researchers is examining a new vaccine method that may change the way we get vaccinations. Michael Wannemuehler and his team of researchers is hoping to find a way to produce vaccines that work better, use smaller doses and require only one trip to the doctor's o...

Smallpox outbreak: How long would it take for vaccines to protect people? Would it work?

In the event of a smallpox outbreak in the United States, how long would it take for a vaccinSLU scientist leads national studye to start protecting Americans by stimulating an immune response? A new national study led by Saint Louis University School of Medicine will attempt to answer this ques...

Cancer vaccines -- Taking a jab at cancer by stimulating the immune system

As the first FDA-approved cancer vaccine, designed to protect against human papillomavirus, has moved from scientific discussion to social debate, other vaccine studies are continuing to make progress. While HPV vaccine efforts had the "benefit" of a viral source for the disease, other researchers ...

Handling HPV vaccines and screening: The views of 100 authors

Amsterdam, 21 September, 2006 - Elsevier is delighted to announce the publication of a unique supplement to the journal Vaccine: HPV Vaccines and Screening in the Prevention of Cervical Cancer. This special monograph provides a comprehensive and invaluable update for paediatricians, gynaecologists,...

High-dose flu vaccines appear to safely boost immunity in elderly

High-dose influenza vaccines may increase elderly patients' immune response without significant adverse effects, offering this vulnerable population additional protection against the flu, according to an article in the May 22 issue of Archives of Internal Medicine, one of the JAMA/Archives journals...

Plant-derived vaccines safeguard against deadly plague

Through an innovative feat of plant biotechnology and vaccine design, researchers in the Biodesign Institute at Arizona State University have successfully turned tobacco plants into vaccine production factories to combat the deadliest form of plague. The vaccine elicits a protective immune response...

Medical experts: US unlikely to have enough vaccines to stop avian flu

A group of medical experts who attended a national avian flu conference last fall believe there is little chance the United States will be able to manufacture and stockpile enough vaccine or antiviral medication to stop a bird flu pandemic should the virus mutate into a form that can be spread easi...

Designing vaccines by computer

Having vaccines developed by computer may sound unnerving but the increasing role of computer modelling in the development of new vaccines could bring new products onto the market quicker, benefiting patients and saving pharmaceutical companies millions of pounds. Researchers using informatics an...

Live vaccines more effective against horse herpes virus

Following the recent deadly outbreak of equine herpes virus at Churchill Downs, home of the Kentucky Derby, a Cornell University virologist says his preliminary research indicates that vaccines containing weakened live viruses, called modified live vaccines (MLV), appear to be more effective in pre...

Scientists decoding genomic sequences of H1N1 using isolates from outbreak in Argentina

...165 people in Argentina, more than any nation with the exception of the U.S. Any significant changes in the virus might influence the effectiveness of vaccines or drugs used to fight the pandemic. "No one knows how this pandemic will evolve. Continuous surveillance will be essential to focusing both resea...

First genetically-engineered malaria vaccine to enter human trials

...s of the National Academy of Sciences USA. Professor Cowman said similar vaccines had been tested in mice and offered 100 per cent protection against malaria...ection in animal models and humans in developing the vaccine. "Although vaccines are under development that use whole malaria parasites weakened by irradiat...

Tips from the journals of the American Society for Microbiology

...ccine strategies that can induce cross-reactive immunity against multiple strains of influenza viruses. In prior research virus-like particle (VLP) vaccines have proven to be a promising new technology at preventing diseases in humans. VLPs resemble their live-virus counterparts and are readily processed ...

Targeting children effective use of limited supplies of flu vaccine and could help control flu spread

..., closing schools and stopping public transport) and quarantining infected individuals. Pharmaceutical companies have also stepped up production of vaccines effective against this particular strain of the virus. However, if the spread of the disease increases significantly in the autumn, as some scientists...

American Chemical Society weekly presspac -- June 10, 2009

...ng a food poisoning microbe to carry medicines and vaccines Molecular Pharmaceutics Scientists have us... potential new way of giving patients medicine and vaccines in pills rather than injections. The study is in t...nconvenience of injections. But many medicines and vaccines cannot be given by mouth because they would be des...

Amarna Therapeutics B.V. and TNO announce SVac research and development partnership

...ial has been validated. The whole vector production process is similar to the current manufacturing processes of the polio, rabies and influenza virus vaccines in which a master seed virus is seeded to producer cells in large fermentors. Because of its immunological inertia in man SVac is the only vector syst...

Partnership to accelerate Trudeau Institute discoveries to patient care

...ith spinal cord injuries, and several pharmaceuticals. "As a basic research institution, discoveries made at the Trudeau Institute often lead to vaccines and other therapeutic strategies that improve human health," stated David L. Woodland, president of the institute. "Trudeau's mission is to improve he...

American Chemical Society's Weekly PressPac -- May 20, 2009

...hose proteins could serve as the basis for a test to identify workplace contamination with M. immunogenum , and targets for developing medications or vaccines to treat and prevent the condition, the study says. ARTICLE #1 FOR IMMEDIATE RELEASE "Immunoproteomic Identification of Secretory and Subcellula...

Preventing ear infections in the future: Delivering vaccine through the skin

...once a week for three weeks. All animals were then inoculated with NTHi through the nose and directly into the middle ears. Animals that received the vaccines were able to very rapidly reduce, or completely eliminate NTHi from the nose and ears, but animals that received a placebo did not. ...

Novel vaccine approach offers hope in fight against HIV

...es or killer cells that would eliminate the virus before or after it infected cells in the body. However, clinical trials have been disappointing. HIV vaccines have not elicited protective immune responses, just as the body fails on its own to produce an effective response against HIV during natural HIV infec...

Breakthrough in the treatment of bacterial meningitis

...ccal bacteria is able to break through the body's natural defence mechanism and attack the brain. The discovery could lead to better treatment and vaccines for meningitis and could save the lives of hundreds of children. Bacterial meningitis in childhood is almost exclusively caused by the respiratory ...

UCI awarded $45 million for infectious disease research

...n be started as soon as possible," said UCI's Michael Buchmeier, the center's deputy director. "Our other efforts will focus on new treatments and new vaccines to prevent infections from occurring." ...

Personalized treatment for early lung cancer

... Cancer vaccines and targeted therapies are beginning to offer new treatment options following surgery for patients with early stages of lung cancer, experts said at t...

Social separation stops flu spread, but must be started soon

...ar to have a key role to play in delaying the development of a 'worst case' influenza epidemic. They may be critical in holding back an epidemic until vaccines are deployed on a sufficient scale that subsequent relaxation of these rigorous measures will not result in a consequential acceleration in the scale ...

Avian flu research sheds light on swine flu outbreak

...ein, one of the sites where human antibodies created in response to current vaccines would bind. "Because the binding site of the mutant virus is different f...usly anticipated," said Perez. "We should keep this in mind when designing vaccines for an avian flu pandemic in humans." However, scientists cannot predic...

UC Davis launches 'One Health' care for wild mountain gorillas and human neighbors

...les or influenza in the local community of people living near a gorilla park, it could spread to the gorillas. Some other serious diseases do not have vaccines and cannot be immunized against even if it were feasible. In addition to diseases, threats to gorilla populations are habitat loss and poaching. ...

Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection

... one arm. In addition, they found that larger versions of 4E10 were less effective than smaller ones. These results highlight potential obstacles that vaccines designed to elicit antibodies similar to 4E10 might face. But b12 has its own obstacles to overcome as well. In fact, when the researchers looked m...

HIV pays a price for invisibility

... infection to rapidly proceed to clinical illness. This study suggests that vaccines should be designed to produce a T cell response against a number of different viral peptides something that experimental human vaccines so far have yet to achieve. ...

American Society for Microbiology to host 109th general meeting in Philadelphia

...ination from farm to table Emerging infections Plugging microbial activities and genomes into the energy grid New concepts and strategies for vaccines Updates on MRSA. Is nasal screening alone enough? The connections between human, animal and environmental health Latest research on the human...

American Chemical Society Weekly PressPac -- April 1, 2009

...lytical gear. They identified 72 different proteins, including several new to science. These proteins could serve as the basis for developing drugs or vaccines against diseases transmitted by the black fly and other blood-sucking insects, including mosquitoes, midges, and sand flies, the researchers say. - MT...

New evidence explains poor infant immune response to certain vaccines, says MU researcher

...ht require some time after birth to mature to a point where the benefits of vaccines can be fully realized. Habib Zaghouani, a professor of molecular microbi...hat had responded to the antigen given at birth. "Perhaps we should test vaccines at a very early age in animals to establish a regimen with the most effecti...

A natural approach for HIV vaccine

...may be an advantage over a single super antibody that focuses on only one part of the virus, which can mutate. The findings suggest that research into vaccines that mimic this natural antibody response could pay off. ...

A worm-and-mouse tale: B cells deserve more respect

...sts are discovering that B cells do much more, resulting in new information about our immune system that could be useful for developing more effective vaccines and better treatments for many types of disease. In the past few years, Frances Lund, Ph.D., professor of Medicine in the Division of Allergy/Immun...
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