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Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

Philadelphia (July 27, 2009) DLX5, a gene crucial for embryonic development, promotes cancer by activating the expression of the known oncogene, MYC, according to researchers from Fox Chase Cancer Center. Since the DLX5 gene is inactive in normal adults, it may be an ideal target for future anti-...

Scientists uncover mode of action of enzyme linked with several types of cancer

This release is available in French . Scientists at the Institute for Research in Immunology and Cancer (IRIC) of the Universit de Montral have discovered a key mechanism used by cells to efficiently distribute chromosomes to new cells during cell multiplication. Published in the journal ...

Scientists find formula to uncover our planet's past and help predict its future

Studies of climate evolution and the ecology of past-times are often hampered by lost information lost variables needed to complete the picture have been long thought untraceable but scientists have created a formula which will fill in the gaps of our knowledge and will help predict the future. ...

Findings uncover new details about mysterious virus

WEST LAFAYETTE, Ind. - An international team of researchers has determined key structural features of the largest known virus, findings that could help scientists studying how the simplest life evolved and whether the unusual virus causes any human diseases. The mimivirus has been called a poss...

Yale researchers uncover secrets of salmonella's stealth attack

A single crafty protein allows the deadly bacterium Salmonella enterica to both invade cells lining the intestine and hijack cellular functions to avoid destruction, Yale researchers report in the April 17 issue of the journal Cell . This evolutionary slight-of-hand sheds new insights into t...

Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet

COLUMBUS, Ohio Scientists have determined that a specific gene plays a role in the weight-gain response to a high-fat diet. The finding in an animal study suggests that blocking this gene could one day be a therapeutic strategy to reduce diet-related obesity and associated disorders, such as ...

Scientists uncover new class of non-protein coding genes in mammals with key functions

A research team at the Broad Institute of Harvard and MIT and Beth Israel Deaconess Medical Center has uncovered a vast new class of previously unrecognized mammalian genes that do not encode proteins, but instead function as long RNA molecules. Their findings, presented in the February 1st advanc...

Scientists uncover new genetic variations linked to psoriasis

Two international teams of researchers have made significant gains in understanding the genetic basis of psoriasis, a chronic skin condition that can be debilitating in some patients. Their research, involving thousands of patients, is reported in two studies published this week in the advance onl...

Scientists uncover evolutionary keys to common birth disorders

Boston-- The work of Forsyth scientist Peter Jezewski, DDS, Ph.D., has revealed that duplication and diversification of protein regions ('modules') within ancient master control genes is key to the understanding of certain birth disorders. Tracing the history of these changes within the proteins ...

Researchers uncover world's oldest fossil impression of a flying insect

MEDFORD/SOMERVILLE, Mass. - While paleontologists may scour remote, exotic places in search of prehistoric specimens, Tufts researchers have found what they believe to be the world's oldest whole-body fossil impression of a flying insect in a wooded field behind a strip mall in North Attleboro, Ma...

Enzyme detectives uncover new reactions, products

UPTON, NY -- If your experiment doesn't go the way you expect, take a closer look -- something even more interesting may have happened. That strategy has led scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory to discover a fundamental shift in an enzyme's function t...

Scientists uncover Ebola cell-invasion strategy

GALVESTON, Texas University of Texas Medical Branch at Galveston researchers have discovered a key biochemical link in the process by which the Ebola Zaire virus infects cells a critical step to finding a way to treat the deadly disease produced by the virus. Ebola produces severe and often f...

Monash researchers uncover cancer survival secrets

A team of Monash University researchers has uncovered the role of a family of enzymes in the mutation of benign or less aggressive tumours into more aggressive, potentially fatal, cancers in the human body. The discovery, published today in the international journal Cancer Cell, provides val...

Indiana U scientists uncover potential key to better drugs to fight toxoplasmosis parasite

INDIANAPOLIS Discoveries by Indiana University School of Medicine scientists have opened a promising door to new drugs for toxoplasmosis and other parasites that now can evade treatments by turning dormant in the body. Their findings help explain how the parasite that causes toxoplasmosis tran...

Researchers uncover mechanism of action of antibiotic able to reduce neuronal cell death in brain

Research Highlights: Mechanism of action of compound found to induce neurotransmitter activity in brain cells The findings may lead researchers to develop potential novel therapies to treat Alzheimer's disease, amyotrophic lateral sclerosis, Huntingtons disease, epilepsy, stroke/ischemia, d...

USC School of Dentistry researchers uncover link between osteoporosis drugs and jaw infection

A group of University of Southern California School of Dentistry researchers says it has identified the slimy culprits killing the jawbones of some people taking drugs that treat osteoporosis. Microbial biofilms, a mix of bacteria and sticky extracellular material, are causing jaw tissue infect...

Deadly dose: Rensselaer heparin expert helps uncover source of lethal contamination

Troy, N.Y. -- The mysterious death of patients around the world following a routine dosage of the common blood thinner, heparin, sent researchers on a frantic search to uncover what could make the standard drug so toxic. A researcher at Rensselaer Polytechnic Institute was among a small group of s...

Researchers uncover details about how dietary restriction slows down aging

University of Washington scientists have uncovered details about the mechanisms through which dietary restriction slows the aging process. Working in yeast cells, the researchers have linked ribosomes, the protein-making factories in living cells, and Gcn4, a specialized protein that aids in the e...

Scientists uncover the potential to control adult stem cells

Research being presented today (10 April) at the UK National Stem Cell Network Annual Science Meeting in Edinburgh represents a step towards the use of Adult Stem Cells (ASCs) to repair damaged tissue. Speaking at the conference in Edinburgh, Professor Cay Kielty of the University of Manchester d...

Pitt and University of Chicago researchers uncover process behind heart muscle contraction

PITTSBURGHResearchers from the University of Pittsburgh and the University of Chicago were able to control heart muscle function in a new way after discovering the previously unknown role of two enzymes in heart muscle contraction, as detailed in the April 11 cover story of the Journal of Biologic...

Scientists uncover a novel mechanism that regulates carbon dioxide fixation in plants

A team of Biotechnology and Biological Sciences Research Council (BBSRC) funded scientists at the University of Essex has discovered a new mechanism that slows the process of carbon dioxide fixation in plants. The research, published today (4 March 2008) in the Proceedings of the National Acad...

Columbia geneticists uncover new gene involved in determining hair texture and density in humans

NEW YORK (Feb. 25, 2008) A Columbia University Medical Center research team has discovered a new gene involved in determining hair texture in humans. The team's genetic analysis demonstrated that mutations in a gene, known as P2RY5, cause hereditary "woolly hair" hair that is coarse, dry, tightl...

Researchers uncover new piece to the puzzle of human height

In studies involving more than 35,000 people and a survey across the entire human genome, an international team supported in part by the National Institutes of Health (NIH) has found evidence that common genetic variants recently linked to osteoarthritis may also play a minor role in human height....

Researchers uncover key trigger for potent cancer-fighting marine product

An unexpected discovery in marine biomedical laboratories at Scripps Institution of Oceanography at UC San Diego has led to new, key information about the fundamental biological processes inside a marine organism that creates a natural product currently being tested to treat cancer in humans. The ...

UT-Houston's Northrup and colleagues uncover genetic link to spina bifida

HOUSTON (Dec. 18, 2007)Researchers at The University of Texas Medical School at Houston have discovered an association between genes regulating glucose metabolism and spina bifida. The decade-long study looked at more than 1,500 DNA samples from parents and their children with that birth defect. ...

Scientists uncover how hormones achieve their effects

New insights into the cellular signal chain through which pheromones stimulate mating in yeast have been gained by scientists at the European Molecular Biology Laboratory (EMBL). Similar signal chains are found in humans, where they are involved in many important processes such as the differentiat...

UD plant biologists uncover top wetland plant's hidden weapon

Scientists at the University of Delaware have uncovered a hidden weapon that one of the most invasive wetland plants in the United States uses to silently and efficiently bump off its neighbors. The invasive strain of Phragmites australis, or common reed, believed to have originated in Eurasia,...

Joslin researchers uncover potential role of leptin in diabetes

BOSTONOctober 1, 2007A new Joslin-led study has shown that leptin, a hormone known mainly for regulating appetite control and energy metabolism, plays a major role in islet cell growth and insulin secretion. This finding opens up new avenues for studying leptin and its role in islet cell biology,...

Scientists uncover link between ocean's chemical processes and microscopic floating plants

Scientists have discovered that increased levels of ocean acidity and carbon dioxide concentrations have resulted in unexpected changes in oceanic chemical processes. Their research results are published in the March 7, 2007, issue of the journal Geophysical Research Letters. Oliver Wingenter of ...

Researchers uncover protection mechanism of radiation-resistant bacterium

Recent discoveries by researchers at the Uniformed Services University of the Health Sciences (USU) could lead to new avenues of exploration for radioprotection in diverse settings. Michael J. Daly, Ph.D., an associate professor in USU's Department of Pathology, and his colleagues have uncovered ev...

Scientists uncover new target in cancer mutation puzzle

University of Rochester scientists, while investigating the two most frequent types of mutations in cancer, discovered a possible new route to treatment that would take advantage of the mutations instead of trying to repair them. The research is reported online this week in the journal Nature Struc...

Jefferson researchers uncover new way nature turns genes on and off

Peering deep within the cells of fruit flies, developmental biologists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia may have discovered a new way that genes are turned on and off during development. If they're right, and the same processes are at work in higher organis...

Researchers uncover new mechanism of tumor suppressor

Researchers from the University of Colorado-Denver and Health Sciences Center and Stanford University have discovered a molecular mechanism that explains how cells respond to DNA damage and other acute stresses, and if disrupted can cause cancer. Their findings, which could lead to new diagnostic ...

FSU biologists uncover mechanisms that shape cells for better or worse

In a landmark study, biologists at Florida State University have uncovered a specific genetic and molecular mechanism that causes cell polarity -- the asymmetric shape or composition critical to a cell's proper functioning. Their findings in fruit fly eggs may help to clarify how muscular dystrophy...

Scientists uncover rules for gene amplification

Gene amplification plays an important role in causing cancers via activation of oncogenes. If scientists can determine the rules as to which segments of genetic material become amplified and how, oncologists and drug researchers may be able to interrupt that process and prevent the formation and gr...

UCLA scientists uncover mechanism of response to targeted therapy

UCLA researchers knew - based on two clinical trials - that a subset of kidney cancer patients responded well to an experimental targeted therapy, but they didn't know why. If they could determine the mechanism behind the response, they would be able to predict which patients would respond and pers...

Researchers uncover mechanisms of estrogen in promoting cell death in breast cancer

A laboratory study has uncovered new details about how estrogen can activate natural pathways that kill certain breast cancer cells or tumors. The results raise the possibility that estrogen therapy may overcome resistance to certain breast cancer hormonal therapies. The study appears in the Decemb...

SLU researchers uncover direct evidence on how HIV invades healthy cells

Using sophisticated detection methods, researchers at the Saint Louis University Institute for Molecular Virology (IMV) have demonstrated the molecular mechanism by which the HIV virus infects, or integrates, healthy cells. The discovery could lead to new drug treatments for HIV. Although scienti...

MSKCC researchers uncover structure of key protein complex in cells

Scientists at Memorial Sloan-Kettering Cancer Center (MSKCC) have uncovered the structure of a network of proteins that help regulate the life cycle of cells. Understanding the network's physical layout is an important step toward learning its precise function, and in finding ways to correct flaws ...

Scientists uncover new clues about brain function in human behavior

Researchers at the National Institute of Mental Health (NIMH), part of the National Institutes of Health, have discovered a genetically controlled brain mechanism responsible for social behavior in humans--one of the most important but least understood aspects of human nature. The findings are repo...
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