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Tumor in Biological News

La Jolla Institute discovers novel tumor suppressor

SAN DIEGO (August 3, 2009) La Jolla Institute for Allergy & Immunology researchers studying an enzyme believed to play a role in allergy onset, instead have discovered its previously unknown role as a tumor suppressor that may be important in myeloproliferative diseases and some types of lymphoma...

Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth

PHILADELPHIA Nanoparticle delivery of diphtheria toxin-encoding DNA selectively expressed in ovarian cancer cells reduced the burden of ovarian tumors in mice, and researchers expect this therapy could be tested in humans within 18 to 24 months, according to a report in Cancer Research , a journ...

Potential for non-invasive brain tumor treatment

DURHAM, N.C. -- Duke University engineers have taken a first step toward a minimally invasive treatment of brain tumors by combining chemotherapy with heat administered from the end of a catheter. The proof-of-concept study demonstrated that it should be technically possible to treat brain tum...

Computer model predicts brain tumor growth and evolution

PROVIDENCE, R.I. [Brown University] Researchers from Brown University and other institutions have developed a computational computer model of how brain tumors grow and evolve. The model is the product mathematical formulas based on the first principals of physics, such as conservation of mass,...

From cars to cancer: UH professor employs auto industry tools for tumor therapy

An effort is under way at the University of Houston to use technologies with origins in the automobile industry to develop new tools that will help doctors and technicians better plan radiation therapy for patients with head and neck cancer. Dr. Ali Kamrani, founding director of the Design and ...

Hebrew University researchers neutralize tumor growth in embryonic stem cell therapy

Jerusalem, May 5, 2009 Researchers at the Hebrew University of Jerusalem have discovered a method to potentially eliminate the tumor-risk factor in utilizing human embryonic stem cells. Their work paves the way for further progress in the promising field of stem cell therapy. Human embryonic ...

A longer lasting tumor blocker

On the heels of dismaying reports that a promising antitumor drug could, in theory, shorten patients' long-term survival, comes a promising study by a Japanese team of researchers that suggests a potentially better option. The study appears in the May 11 issue of the Journal of Experimental Medic...

How tumor cells move

If cancer cells lack a certain protein, it could be much easier for them to penetrate healthy body tissue, the first step towards forming metastases. Scientists at the Pharmacology Institute of the University of Heidelberg have discovered the previously unknown cell signal factor SCAI (suppressor ...

Skin cancer study uncovers new tumor suppressor gene

National Institutes of Health (NIH) researchers have identified a gene that suppresses tumor growth in melanoma, the deadliest form of skin cancer. The finding is reported today in the journal Nature Genetics as part of a systematic genetic analysis of a group of enzymes implicated in skin cance...

Regulatory molecule for tumor formation or suppression identified by Singapore, US researchers

One of the small regulatory molecules, named microRNA-125b, is a novel regulator of p53, an important protein that safeguards cells against cancers, Singapore and U.S. scientists report in the March 17, 2009 issue of the journal Genes & Development . The scientists found that during embryonic ...

New tumor markers determine therapy intensity

Characteristic changes in the DNA of medulloblastoma, the most frequent malignant brain tumor in childhood, indicate precisely how aggressively the tumor will continue to spread and what the chances of disease relapse are. Researchers at the Center for Pediatric and Adolescent Medicine at the Heid...

Tiny tool to control growing blood vessels opens new potential in tumor research

Researchers at Uppsala University have developed a new tool that makes it possible to study the signals in the body that control the generation of blood vessels. The researchers' findings, published in the new issue of Lab on a Chip , enable scientists to determine what signals in the body attra...

Researchers isolate protein domain linked to tumor progression

Troy, N.Y. When a promising cancer drug reached clinical trials in the 1990s, researchers were disappointed by the debilitating side effects that limited the trials. The drug inhibited a family of enzymes known as matrix metalloproteinases (MMPs). Now, researchers at Rensselaer Polytechnic Instit...

Singapore research organisations team up to advance drug discovery using brain tumor stem cells

Lilly Singapore Centre for Drug Discovery (LSCDD), Singapore's National Neuroscience Institute (NNI), and the Singapore Institute for Clinical Sciences (SICS), have teamed up to advance drug discovery using adult brain tumour stem cells. NNI is one of the institutions of SingHealth, the larges...

Scattered light rapidly detects tumor response to chemotherapy

DURHAM, N.C. -- New technology developed by Duke University bioengineers can help clinicians more precisely detect whether specific cancer drugs are working, and should give basic researchers a powerful new tool to better understand the underlying mechanisms of cancer development. By interpreti...

New technique images tumor vessel leakiness to predict breast cancer chemotherapy outcome

Chemotherapy is an integral part of modern cancer treatment, but it's not always effective. Successful chemotherapy depends on the ability of anticancer drugs to escape from the bloodstream through the leaky blood vessels that often surround tumors. Predicting chemotherapy's efficacy could save...

Jefferson Department of Surgery announces new pancreas tumor registry

PHILADELPHIA Charles J. Yeo, M.D., Samuel D. Gross Professor and Chair, Department of Surgery at Jefferson Medical College of Thomas Jefferson University, announces the establishment of the new Jefferson Pancreas Tumor Registry (JPTR). "The purpose of the registry is to further study whether p...

A link between mitochondria and tumor formation in stem cells

Researchers report on a previously unknown relationship between stem cell potency and the metabolic rate of their mitochondria a cell's energy makers. Stem cells with more active mitochondria also have a greater capacity to differentiate and are more likely to form tumors. These findings, appe...

Fly studies reveal immune cell responses to tumor and tissue damage

September 17, 2008, Cambridge, UK Knee scrapes and tumor growth might have more in common than you think. The idea that tumor growth triggers the same immune response as a cut or wound was once a highly controversial notion. However, increasing evidence supports the idea that the same ce...

Normalizing tumor vessels to improve cancer therapy

Chemotherapy drugs often never reach the tumors they're intended to treat, and radiation therapy is not always effective, because the blood vessels feeding the tumors are abnormal"leaky and twisty" in the words of the late Judah Folkman, MD, founder of the Vascular Biology program at Children's Ho...

New insights into the regulation of PTEN tumor suppression function

BOSTON -- The PTEN tumor suppressor gene controls numerous biological processes including cell proliferation, cell growth and death. But PTEN is frequently lost or mutated; in fact, alteration of the gene is so common among various types of human cancer that PTEN has become one of the most frequen...

Gene's newly explained effect on height may change tumor disorder treatment

St. Louis, August 11, 2008 A mutation that causes a childhood tumor syndrome also impairs growth hormone secretion, researchers at Washington University School of Medicine in St. Louis have found. The discovery provides new insights into an old mystery, revealing why patients with neurofibroma...

Counting tumor cells in blood predicts treatment benefit in prostate cancer

Counting the number of tumor cells circulating in the bloodstream of patients with castration-resistant prostate cancer can accurately predict how well they are responding to treatment, new results show. At the ESMO Conference Lugano (ECLU) organized by the European Society for Medical Oncology...

Blue light used to harden tooth fillings stunts tumor growth

A blue curing light used to harden dental fillings also may stunt tumor growth, Medical College of Georgia researchers say. "The light sends wavelengths of blue-violet light to the composite, which triggers hardening," says Alpesh Patel, a rising MCG School of Dentistry junior. "The light waves...

Refusal of suicide order: Why tumor cells become resistant

Cells with irreparable DNA damage normally induce programmed cell death, or apoptosis. However, this mechanism often fails in tumor cells so that transformed cells are able to multiply and spread throughout the body. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentru...

To fight the cancer before the tumor grows

Researchers in Heidelberg have discovered a new strategy for an immunization against certain forms of cancer. They have determined that immune cells react strongly to the modified proteins in tumor cells in which a DNA repair defect has occurred. It is estimated that this repair defect is present ...

Researchers find way to make tumor cells easier to destroy

Tumors have a unique vulnerability that can be exploited to make them more sensitive to heat and radiation, researchers at Washington University School of Medicine in St. Louis report. The Washington University radiation oncology researchers found that tumors have a built-in mechanism that prot...

New study shows Dermytol produces pronounced decrease in malignant melanoma tumor volume

SAN DIEGO, CA., April 7 . . .A new study presented at the Experimental Biology Annual Meeting shows that a proprietary blend extracted from canola, Dermytol, produces a pronounced reduction of malignant melanoma cell growth. Dermytol, a proprietary compound developed by KGK Synergize Inc., a biot...

Gene dose affects tumor growth

Researchers at Johns Hopkins and Ohio State University have found that the number of copies of a particular gene can affect the severity of colon cancer in a mouse model. Publishing in the Jan. 3 issue of Nature, the research team describes how trisomy 21, or Down syndrome in humans, can repress t...

Gene variation may elevate risk of liver tumor in patients with cirrhosis

A particular gene variation appears to significantly increase the risk that individuals with cirrhosis of the liver will go on to develop hepatocellular carcinoma (HCC), a liver tumor that is the third leading cause of cancer death. In the January 2 Journal of the American Medical Association, re...

Novel 3-D cell culture model shows selective tumor uptake of nanoparticles

A nanoparticle drug delivery system designed for brain tumor therapy has shown promising tumor cell selectivity in a novel cell culture model devised by University of Nottingham scientists. The project, conducted jointly in the Schools of Pharmacy, Biomedical Sciences and Human Development, will b...

Scientists discover gene mutation responsible for hereditary neuroendocrine tumor

SALT LAKE CITY University of Utah researchers and their colleagues have identified the gene that is mutated in a hereditary form of a rare neuroendocrine tumor called paraganglioma (PGL). The gene, called hSDH5, is required for activation of an enzyme complex that plays a critical role in the che...

Researchers identify Achilles heel of common childhood tumor

BOSTON, Mass. (Oct. 19, 2008) Researchers have discovered a mechanism for the rapid growth seen in infantile hemangioma, the most common childhood tumor. The tumors, which are made up of proliferating blood vessels, affect up to 10 percent of children of European descent, with girls more fre...

Migration alert -- How tumor cells home in on the lymphatic system

A Swiss-based research team has published a new mechanistic description of how tumor cells migrate to the lymphatic system in the early stages of tumor metastasis. This new understanding holds significant potential for developing anti-metastasis therapies. Scientists know that tumor cells sprea...

UCSD researchers discover variants of natural tumor suppressor

Building on their 2005 discovery of an enzyme that is a natural tumor suppressor, researchers at the University of California, San Diego (UCSD) School of Medicine have now identified two variants of that enzyme which could provide new targets for therapies to treat diabetes, heart and neurological ...

RNA splicing factor implicated in ovarian tumor cell growth

An RNA-binding protein that is overproduced in ovarian cancer may present a new target for diagnosis or treatment of ovarian and other cancers, according to researchers at the University of Illinois at Chicago. Researchers in the UIC College of Pharmacy found that interfering with the production ...

Mechanisms involved with tumor relapse identified

Researchers at Virginia Commonwealth University’s Massey Cancer Center studying the interaction between the immune system and cancer cells have identified interferon gamma as one of the signaling proteins involved with tumor relapse. The findings may help researchers develop tailored vaccines and...

MicroRNAs as tumor suppressors

In the May 1st issue of G&D, Drs. Yong Sun Lee and Anindya Dutta (UVA) reveal that microRNAs can function as tumor suppressors in vitro. "Overexpression of HMGA2 is an important feature of many medically important tumors like uterine fibroids,?explains Dr. Dutta. “It is very exciting to real...

UCSF brain tumor vaccine trial shows promising results

A vaccine for treating a recurrent cancer of the central nervous system that occurs primarily in the brain has shown promise in preliminary data from a clinical trial at the University of California, San Francisco. Known as a glioma, this cancerous tumor is always fatal. Findings from a group ...

MicroRNAs can be tumor suppressors

University of Virginia researchers have discovered that microRNAs, a form of genetic material, can function as tumor suppressors in laboratory studies. In the May 1 issue of Genes & Development, UVa researchers Drs. Yong Sun Lee and Anindya Dutta have shown that microRNAs can suppress the ov...
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