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Trials in Biological News

Results from trials of DHA in Alzheimer's disease and age-related cognitive decline

Vienna, July 12, 2009 Results from two large studies using DHA, an omega 3 fatty acid, were reported today at the Alzheimer's Association 2009 International Conference on Alzheimer's Disease (ICAD 2009) in Vienna. One of the trials was conducted by the Alzheimer's Disease Cooperative Study (A...

SNM's clinical trials network gains added support from industry leader

Reston, Va.The SNM Clinical Trials Network, an initiative designed to address the need for streamlined drug discovery through the integration of imaging biomarkers into multi-center clinical trials, recently added Genentech, Inc. as a supporter. SNM, the world's largest medical and scientific s...

Clinical trials for shingles drug take an important step forward

A possible new anti-viral drug designated FV-100, which could alleviate the suffering of millions of people with herpes zoster or shingles, has entered the second stage of clinical testing in patients. Developed and patented by scientists based at Cardiff University, a Phase II clinical trial ...

First results from hospital trials testing

NEW YORK, NY (October 28, 2008) The first stage of the U.S. Department of Defense-funded clinical trials exploring the role of hospital touch surfaces in the transmission of infectious pathogens has been completed and the researchers reported their findings in a poster session at the Interscience...

NCI grant launches clinical trials for colon cancer screening

EVANSTON, Ill. --- A Northwestern University biomedical engineer who has developed optical technology shown to be effective for the early detection of colon cancer has received a $7.5 million grant over five years from the National Cancer Institute to further study an instrument that potentially c...

Findings released from 1 of the largest percutaneous coronary intervention trials ever

NEW YORK (May 23, 2008) A study led by Gregg W. Stone, M.D., professor of medicine at Columbia University Medical Center/NewYork-Presbyterian and chairman of the Cardiovascular Research Foundation, has shown that heart attack patients who were administered the direct thrombin inhibitor bivalirudi...

Contrast agent trials in swine

This release is available in German . Mammography continues to be the method of choice for the early detection of breast cancer. However, because this technique is not as selective or specific as one would wish, and does not deliver reliable results for every level of tissue density, altern...

Vitamin E trials 'fatally flawed'

CORVALLIS, Ore. Generations of studies on vitamin E may be largely meaningless, scientists say, because new research has demonstrated that the levels of this micronutrient necessary to reduce oxidative stress are far higher than those that have been commonly used in clinical trials. In a new s...

First genetically-engineered malaria vaccine to enter human trials

Walter and Eliza Hall Institute scientists have created a weakened strain of the malaria parasite that will be used as a live vaccine against the disease. The vaccine, developed in collaboration with researchers from the US, Japan and Canada, will be trialled in humans from early next year. Mala...

UC Davis bench-to-bedside research: Promising treatment in clinical trials

DAVIS, CALIF.A new drug developed at the University of California, Davis to treat diabetes, hypertension and inflammatory has entered Phase II of human clinical trials to evaluate its efficacy. The compound, a soluble epoxide hydrolase enzyme (s-EH) inhibitor, is "a first-in-class drug which m...

30+ AIDS vaccine clinical trials in 24 countries, research occurring on every continent

The International AIDS Vaccine Initiative's (IAVI) January 2007 Annual Issue of VAX, an editorially independent bulletin on AIDS vaccine research published by IAVI, reports that 13 new preventive AIDS vaccine trials were initiated in eight countries around the world in 2006. There are now more than...

Kenya halts first field trials of GM maize

Kenyan authorities began destroying the country's first genetically modified (GM) maize growing in open field trials. The government halted the research and ordered the destruction after discovering that a technician had sprayed a restricted pesticide on maize modified to resist attack by insects...

Why were the HIV prevention trials in commercial sex workers abandoned?

One promising approach to help stem the global HIV epidemic is to give commercial sex workers an HIV medication (such as the drug tenofovir) before they have high risk sex in the hope of reducing their chances of becoming infected, an approach called "pre-exposure prophylaxis" (PREP). But activist ...

Moffitt-USF head toward first human trials of anti-cancer drug that targets protein AKT

H. Lee Moffitt Cancer Center & Research Institute, working in partnership with the University of South Florida (USF), has discovered a new use for an old, previously discredited anti-cancer drug that could add another weapon in the arsenal against several cancers, including tumors of the breast...

Use of PET can reduce, may eliminate more strenuous drug development trials with animals

A number of articles explore the use of positron emission tomography (PET) and small animal imaging--nonsurgical techniques that open the door to understanding and treating human diseases--in the April issue of the Society of Nuclear Medicine's Journal of Nuclear Medicine. A major benefit of smal...

Advances in lung cancer research announced at conference

...for brain metastasis, so that informed therapeutic trials can be undertaken, could enable a paradigmatic shi...le Healthcare of results from two Phase I clinical trials for a drug called TH-302. The two clinical trials are both evaluating the safety and effectiveness o...

Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth

...f the nanoparticle construct molecule, but the ability to deliver the toxin to the tumor cells," said Sausville, who agrees that inception of clinical trials could be just 18 months away. ...

Stem cell research: From molecular physiology to therapeutic applications

... of Medical Sciences is Executive Director of the National Center for Stem Cell Research. His group has taken stem cell therapy into phase II clinical trials in China, and is the leading runner in stem cell therapeutics. They have identified a mesenchymal stem cell (MSC) population from human fetal bone mar...

Scientists closer to making implantable bone material, thanks to new research

...cells and stem cells. All of these cell types are attracting considerable interest as promising candidates for future implants in people with clinical trials already underway. However, scientists still need to thoroughly explore and understand the in-depth chemical properties and structure of the bone-like ...

New drug may reduce heart attack damage

...d muscle death in the aftermath of a heart attack, trials in preclinical models have found. The drug als...of a full recovery after a heart attack. Safety trials of Dz13 are now underway ahead of Phase 1 human tr...d. Professor Khachigian said other, independent trials of Dz13 were about to get underway to target c-Jun...

Short stressful events may improve working memory

...n. However, acute stress -- a short stressful incident -- may enhance learning and memory. Researchers at the University at Buffalo have shown, in trials using rodents as an animal model, that acute stress can produce a beneficial effect on learning and memory, through the effect of the stress hormone c...

Scientists link immune system's natural killer cells to infant liver disease

...atology and Nutrition at Cincinnati Children's. "The next steps for translating these findings into clinical application would include pre-clinical trials of biologics to halt disease progression by blocking the Nkg2d receptor and depleting NK cells at the time biliary atresia is diagnosed," he added. ...

Genetic tests advertised directly to the consumer

...rs of health professions, the authors conclude, "Clinical pharmacology will have a voice in how the evolving science translates not only into clinical trials and patient care but also into regulations involving the promotion and advertising of all genetic tests. Clinical pharmacologists can help ensure that...

A 'heart healthy' diet and ongoing, moderate physical activity may protect against cognitive decline

... be an important public health strategy to reduce or prevent memory loss and other symptoms of mental decline in the elderly. Future rigorous clinical trials are needed to confirm these findings," Obisesan added. ...

Parascript Signature Verification Technology Used by Moscow Law Firm to Detect Signature Fraud in $160,000 Debt Collection Case

...inesses in Russia and represents clients' interest in courts of all instances. Knowledge of the law, high qualifications, and experience in conducting trials enable unconventional approach to judicial proof issues required by the customers. Clients include Russian and Forbes 500 international companies. ...

New lab test offers better prediction of HIV microbicide safety

...al microbicide gels have been assessed in clinical trials after passing laboratory and animal safety tests. ...predictive of safety before proceeding to clinical trials that typically cost millions of dollars, involve t...cide safety before advancing a product to clinical trials involving thousands of women," she adds. Dr. H...

Genetic factors implicated in survival gap for breast, ovarian or prostate cancer

...ncer Institute (JNCI). The study analyzed patient records from clinical trials going back as far as 1974 conducted by the Southwest Oncology Group (SWOG...data from 634 breast cancer patients who participated in two SWOG-conducted trials was led by first author Dr. Hershman. Findings revealed that African-Americ...

Clinical trial shows quadriplegics can operate powered wheelchair with tongue drive system

...x commands appeared on the computer screen, the subject was instructed to issue that command within a specified time period. Each subject completed 40 trials for each time period. After the computer sessions, the subjects were ready for the wheelchair driving exercise. Using forward, backward, right, lef...

New test can detect both genetic and chromosomal abnormalities in embryos

...ting of the European Society of Human Reproduction and Embryology in Amsterdam today (Tuesday) that, as a result, they would be able to offer clinical trials to couples seeking fertility treatment later this year. The researchers based in the USA and the UK have been able to prove that the technique, kno...

Debate on admin. of magnesium sulfate to pregnant women to prevent cerebral palsy in pre-term infants

...iew and meta-analysis of six randomized controlled trials involving 4796 women and 5357 infants. Writing in ...d conversation, they each talk about the available trials and observational studies and the strengths and we...s that "three large, randomized placebo-controlled trials of antenatal magnesium sulfate (MgSO4) for fetal n...

Engineering innovative solutions for 21st century medicine

...neering Centre will break down the barriers between engineering, the physical sciences, and biology and medicine. We will conduct world-class clinical trials to show the benefit of new discoveries in imaging technology that the centre will produce. I see patients in my clinic every day, so I have a very cle...

Parascript Signature Verification Technology Used by Moscow Law Firm to Detect Signature Fraud in $160,000 Debt Collection Case

...inesses in Russia and represents clients' interest in courts of all instances. Knowledge of the law, high qualifications, and experience in conducting trials enable unconventional approach to judicial proof issues required by the customers. Clients include Russian and Forbes 500 international companies. ...

UC Davis grant zeroes in on novel asthma diagnosis and treatment

...tists use to distinguish a diseased state from a healthy state. "Our study also will evaluate if there is a scientific basis to do human clinical trials on soluble epoxide hydrolase (sEH) inhibitors in asthma, which has recently been demonstrated as a novel therapeutic treatment for treating inflammati...

Green tea may affect prostate cancer progression

...cancer, according to Cardelli. However, some human trials have found contradictory results. The few trials conducted to date have evaluated the clinical effi...elli suggested that additional controlled clinical trials should be done to see if combinations of different...

New supplement may help slow sight loss in elderly

...lurring of central vision because of its effects on the macula, the central part of the retina. Over 400 people across Ireland took part in clinical trials investigating whether carotenoids, rich antioxidants which are found in fruit and vegetables, could prevent progression to the more serious late AMD. ...

Discovery of a water snake that startles fish in a way that makes them flee into its jaws

...g peculiar. When the fish that the snake targets turn to flee, most of them turn toward the snake's head and many literally swim into its jaws! In 120 trials with four different snakes, in fact, he discovered that an amazing 78 percent of the fish turned toward the snake's head instead of turning away. N...

Antibiotics take toll on beneficial microbes in gut

...ckly. Not a lesson applicable to humans? In patients with refractory antibiotic-associated diarrhea due to C. difficile , there have been limited trials of treatments using "fecal transplants" to replace lost gut microbiota. Although this is a pretty unpalatable treatment at first glance, the clinical ...

Another JDRF partner moves research forward with collaboration agreement for diabetes treatment

...e biotech partnerships and carry the products through expensive, late-stage trials and regulatory approvals. The goal, he said, is to bring cures and treatme...py with Lilly. Bayhill's BHT-3021 compound is now in Phase I/II clinical trials supported by JDRF, is a plasmid encoding proinsulin designed to target spec...

Enzyme doesn't act alone in atrial fibrillation

...p the specific calcium channel from being affected by the enzyme. Further studies with similar models showed this as an effective treatment. "More trials are needed, but this is a promising way to target one regulatory event that contributes to atrial fibrillation," Wehrens said. "These findings could ...

Major breakthrough in early detection and prevention of AMD

... reduced CNV in mice by about 70 percent, as opposed to 60 percent with VEGF-based treatments currently in clinical use. Ambati says Phase I clinical trials are not far off. "The identification of CCR3 on the endothelial cells of CNV in human AMD is a major breakthrough," said Dr. Patricia A. D'Amore, pr...
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