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Transplants in Biological News

Researchers engineer pancreatic cell transplants to evade immune response

In a finding that could significantly influence the way type 1 diabetes is treated, researchers at Albert Einstein College of Medicine of Yeshiva University have developed a technique for transplanting insulin-producing pancreatic cells that causes only a minimal immune response in recipients. ...

Neural cell transplants may help those with Parkinson's disease

Tampa, Fla. (May 19, 2008) The current issue of CELL TRANSPLANTATION (Vol. 17:4) features a number of publications by researchers seeking new ways to treat Parkinsons disease (PD), a neurological disease characterized by muscle rigidity, tremor and slowed physical movements related to insufficien...

Medical breakthrough for organ transplants and cardiovascular diseases by Flemish researchers

Leuven, Belgium - When a blood vessel clogs up, a localized deficiency of oxygen results, causing the surrounding tissue to die. However, working with mice, VIB scientists connected to the Katholieke Universiteit Leuven have been able to prevent muscular tissue with severe hypoxia from dying. The ...

Cell transplants may improve severe urinary incontinence

Tampa, Fla. (November 8, 2007) Estimates are that up to 70 million people worldwide may be suffering from severe urinary incontinence. A major cause of urinary incontinence is a deficiency of the urethral sphincter muscle, often associated with trauma during child birth, resulting from prostate s...

Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants

CINCINNATI Screening for mutations in a gene that helps the body metabolize a kidney transplant anti-rejection drug may predict which children are at higher risk for side effects, including compromised white blood cell count or organ rejection, according to new research. Published online Feb. ...

High blood sugar's impact on immune system holds clues to improving islet cell transplants

AUGUSTA, Ga. A biological tit for tat may hold clues to improving the success of islet cell transplants intended to cure type 1 diabetes, according to a Medical College of Georgia scientist. In type 1, the immune system attacks insulin-producing cells causing high blood glucose levels that ma...

NC State first university in nation to offer canine bone marrow transplants

Dogs suffering from lymphoma will be able to receive the same type of medical treatment as their human counterparts, as North Carolina State University becomes the first university in the nation to offer canine bone marrow transplants in a clinical setting. Dr. Steven Suter, assistant professor...

Ikaria(R) Receives FDA Orphan Drug Designation for Inhaled Carbon Monoxide for Delayed Graft Function in Solid Organ Transplants

CLINTON, N.J., July 28 /PRNewswire/ -- Ikaria Holdings, Inc., a fully integrated critical care biotherapeutics company, announced today that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation for inhaled carbon monoxide for use in the reduction of the incidence and...

Ikaria(R) Receives FDA Orphan Drug Designation for Inhaled Carbon Monoxide for Delayed Graft Function in Solid Organ Transplants

CLINTON, N.J., July 28 /PRNewswire/ -- Ikaria Holdings, Inc., a fully integrated critical care biotherapeutics company, announced today that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation for inhaled carbon monoxide for use in the reduction of the incidence and...

Stroke victims may benefit from stem cell transplants

Tampa, Fla. (Jan. 28, 2008) According to two studies published in the current issue of CELL TRANSPLANTATION (Vol.16 No.10), stroke victims may benefit from human mesenchymal stem cell (hMSC) or bone marrow stromal cell (BMSCs) transplantation. In both studies, the migration of chemically tagged t...

Thymus transplants gives hope to babies with fatal immune disease

"My baby is doing what other babies her age are doing -- she's feeding herself, putting on her own clothes and she loves to dance." Lolita Harding is describing her daughter Dave'yana, who will turn three in September, thanks in large part to a thymus transplant she received at Duke University Me...

Stem cell transplants explored at Stanford as a possible treatment for hearing loss

Stefan Heller's dream is to someday find a cure for deafness. As a leader in stem cell-based research on the inner ear at the Stanford University School of Medicine, he's got a step-by-step plan for making this dream a reality. It may take another decade or so, but if anyone can do it, he'...

Leading reason for corneal transplants comes into focus

Guided by families with an unusual number of cases, scientists at Johns Hopkins have discovered the genetic origins of at least one form of Fuchs corneal dystrophy, FCD, the leading reason for corneal transplantation in the United States. In one form or another, FCD's trademark deterioration of t...

What animals can tell us about hemorrhage, organ transplants and aging

The stereotype of a scientist as a man in a white lab coat hunched over a microscope in a laboratory is far from real life. Consider the scientists who will meet at The American Physiological Society's conference, Comparative Physiology 2006: Integrating Diversity, taking place October 8-11 in Virg...

Stem cell transplants improve recovery in animal models for stroke, cerebral palsy

A single dose of adult donor stem cells given to animals that have neurological damage similar to that experienced by adults with a stroke or newborns with cerebral palsy can significantly enhance recovery from these types of injuries, researchers say. Using a commonly utilized animal model for s...

Pennsylvania researchers find liver transplants provide metabolic cure for rare genetic disease

Liver transplants cured the metabolic symptoms of 11 patients with a rare but devastating genetic condition known as Maple Syrup Urine Disease (MSUD), according to a study by researchers from Children's Hospital of Pittsburgh and the Clinic for Special Children. All patients from the study (rangi...

Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

Scientists at Washington University School of Medicine in St. Louis have learned that a temporal "window of opportunity" was critical to their earlier successes in treating diabetic rats with embryonic pig tissues. In those experiments, published in 2004, researchers were surprised to find that ...

First human gets new antibody aimed at hepatitis C virus

...drugs, liver transplantation is the only option. HCV is the leading indication for liver transplantation, diagnosed in about half of the 6,000 liver transplants done each year in the United States. Transplantation can be a life-saving treatment; however, in nearly all cases the patient's new liver is eventuall...

Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients

...iopathic pulmonary fibrosis (IPF) are becoming dangerously ill and also could point the way to interventions that could sustain them until life-saving transplants can be performed. According to senior author Naftali Kaminski, M.D., associate professor of medicine, computational biology and pathology, and dire...

Ovarian transplantation: New technique gives greatly improved results in this delicate operation

...therlands: Ultra-fast freezing of ovarian tissue from women who have lost their fertility as a result of cancer treatment can lead to it being used in transplants with the same success rate as fresh tissue, a researcher told the 25th annual conference of the European Society of Human Reproduction and Embryology ...

Children's Hospital Oakland scientists first to discover new source for harvesting stem cells

...of stem cells in placentas will likely increase the chance that an HLA (human leukocyte antigen) matched unit of stem cells engrafts, making stem cell transplants available to more people. The more stem cells, the bigger the chance of success," said Dr. Kuypers. Drs. Kuypers and Serikov have also developed a...

New device detects heart disease using less than one drop of blood

...ssmann, M.D., Editor-in-Chief of The FASEB Journal . "In addition, this moves much closer to a future where new blood vessels, veins and arteries for transplants no longer need to be grafted from patient's bodies. The amount of pain and recovery times for bypass surgeries would be reduced significantly." ...

Combined stem cell-gene therapy approach cures human genetic disease in vitro

... in one of 13 Fanconi anemia (FA) genes, the disease often leads to bone marrow failure, leukemia, and other cancers. Even after receiving bone marrow transplants to correct the hematological problems, patients remain at high risk of developing cancer and other serious health conditions. After taking hair or...

Novel antibody prevents infection by hepatitis C virus

... For the most serious cases of HCV that do not respond to antiviral drugs, liver transplantation is the only option. Typically 2,000 to 4,000 liver transplants are done each year in the United States (far less than the number of people on the waiting list for available organs). Transplantation can be a life s...

World premiere in stem cell research in Montreal

... next few years. "It could be possible to envision transplants for all adults from existing umbilical cord blood ...use in adults," Dr. Sauvageau affirmed. Organ transplants without side effects: the medicine of the future? ...e of the leading centres in Canada where stem cell transplants are performed. "If only one of the ten proteins al...

Scientists identify key gene that protects against leukemia

...scientists uncovered evidence that could lead to a protocol for bone marrow transplants that could boost the chance of a cure in some patients. The research, ...myeloma and certain cancers. "Currently, patients undergoing bone marrow transplants may not be getting enough of the quiescent transplanted HSCs that are optim...

Amniotic fluid may provide new source of stem cells for future therapies

... (bone marrow, spleen, thymus, and lymph nodes) of the mice were dissected. transplants using mouse AFKL cells were found to be successful; newly formed white bloo...ed and their hematopoietic organs examined after 10-13 weeks. The secondary transplants with mouse AFKL cells were partially successful with some of the mice engra...

Multiple route bone marrow stem cell injections show promise to treat spinal cord injury

...CI transplanted with autologous BMCs." In eight patients who received BMC transplants through various routes and followed for two years, the scientists reported ...t their study marked the first time a gunshot wound victim had received BMC transplants through multiple routes. "It is important to note," concluded Dr. Silva,"...

Shorter wait means longer life for kidney transplant candidates

...t 70,000 patients were on waiting lists for kidney transplants at one of 240 centers around the country, accordin...n of non-ideal donors and number of deceased-donor transplants a center does a year. Waiting time had the stro...rvival. Contrary to expectations, the number of transplants a center does a year was not associated with patie...

2009 Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research

...row Transplant Safety Bone marrow transplantation is frequently used to treat cancer, mainly leukemias and lymphomas. When successful, bone marrow transplants literally offer a new lease on life for patients. However, despite close matching of donors to patients, sometimes transplanted cells do not recogniz...

Human beta cells can be easily induced to replicate, according to study in Diabetes

...dels, and could lead to techniques to generate new beta cells in patients with diabetes. In the future, it also could allow more effective therapeutic transplants of insulin-producing cells either by expanding the numbers of cells available from a single cadaveric donor or from a gene-enhanced version of the pa...

Vidalia onions: Alternative to hand-transplanting proven effective

...cers in the Vidalia region have traditionally used transplants to produce dry bulb onions. transplants are grown on farms in high-density plantings, then...duction", stated Boyhan. He noted that onions from transplants will likely predominate in the Vidalia region for ...

Stowers Institute's Linheng Li Lab expands understanding of bone marrow stem cell niche

...oral Research Fellow, is also a co-equal first author on the paper. A better understanding of the HSC niche may lead to more effective bone marrow transplants since a more precise understanding of the microenvironment that nurtures these therapeutically valuable cells will give physicians greater control ove...

Gene therapy corrects sickle cell disease in laboratory study

...nly permanent cure for the disease is a bone marrow transplant to give recipients blood-forming cells that will form normal beta-globin. However, such transplants are rare because of the lack of compatible donors. Researchers have long known that symptoms of the disease could be alleviated by persistence in t...

Researcher tricks immune system in diabetic mice

...d he was happily surprised to see that such a high percentage of recipients of the transplanted islet cells -- greater than 70 percent -- maintained transplants long-term. His research showed the host's tolerance to these transplanted cells seemed to be permanent, lasting for at least 150 days. Xunrong Luo, as...

New technique eliminates toxic drugs in islet transplant in diabetic mice

...d he was happily surprised to see that such a high percentage of recipients of the transplanted islet cells -- greater than 70 percent -- maintained transplants long-term. His research showed the host's tolerance to these transplanted cells seemed to be permanent, lasting for at least 150 days. Xunrong Luo, as...

American Chemical Society's Weekly PressPac -- Nov. 19, 2008

...OR IMMEDIATE RELEASE Gene "silencing" may improve success of islet cell transplants for diabetes Molecular Pharmaceutics Scientists in Tennessee are repo...ilencing" shows promise for improving the effectiveness and expanded use of transplants of insulin-producing cells to treat diabetes. The study is scheduled for th...

Intraspinal implant of mesenchymal stem cells may not heal the demyelinated spinal cord

...fibers of the spinal cord. Therapeutic hope for curing multiple sclerosis and other demyelinating diseases has included the possibility that stem cell transplants could help remyelinate the spinal cord. Accordingly, researchers from the University of Cambridge (UK) conducted experiments using animal models to se...

Heart valves that grow with the patient

...h and his team provide child patients with significantly improved chances of survival and a better quality of life. In Europe around 1,200 heart valve transplants a year are performed on children. The mechanical heart valves normally used in these operations have the disadvantage that they require lifelong blood...

Fat-regenerating 'stem cells' found in mice

... report in the October 17th issue of the journal Cell, a Cell Press publication. Although they have yet to show that the cells can renew themselves, transplants of the progenitor cells isolated from the fat tissue of normal mice can restore normal fat tissue in animals that are otherwise lacking it. The findi...
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