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Therapeutic in Biological News

New DNA and RNA aptamers offer unique therapeutic advantages

New Rochelle, NY, August 5, 2009A novel class of drugs composed of single strands of DNA or RNA, called aptamers, can bind protein targets with a high strength and specificity and are currently in clinical development as treatments for a broad range of common diseases, as described in a comprehens...

Got zinc? New zinc research suggests novel therapeutic targets

Everyone knows that vitamins "from A to zinc" are important for good health. Now, a new research study in the August 2009 print issue of the Journal of Leukocyte Biology ( http://www.jleukbio.org ) suggests that zinc may be pointing the way to new therapeutic targets for fighting infections. Spe...

Stem cell research: From molecular physiology to therapeutic applications

Stem cell research promises remedies to many devastating diseases that are currently incurable, ranging from diabetes and Parkinson's disease to paralysis. Totipotent embryonic stem cells have great potential for generating a wide range of different human cells that can be used to restore malfunct...

Triggering muscle development -- a therapeutic cure for muscle wastage?

Scientists in the UK and Denmark have shown that if elderly men were given growth hormone and exercised their legs showed an appreciable muscle mass increase. Dr. Geoff Goldspink (Royal Free and University College Medical School, UK) says: "This raises the question: Can age-related loss of muscle ...

New nanoparticles could revolutionize therapeutic drug discovery

A revolutionary new protein stabilisation technique has been developed by scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) which could lead to 30 per cent more proteins being available as potential targets for drug development - opening up exciting possibilit...

New therapeutic strategy could target toxic protein in most patients with Huntington's disease

Howard Hughes Medical Institute researchers have designed tiny RNA molecules that shut off the gene that causes Huntington's disease without damaging that gene's healthy counterpart, which maintains the health and vitality of neurons. Laboratory studies suggest that a single small interfering RNA ...

Alzheimer's disease therapeutic prevents long-term damage from TBI in pre-clinical studies

WASHINGTON, D.C. A class of Alzheimer's disease drugs currently studied in clinical trials appears to reduce damage caused by traumatic brain injury in animals, researchers at Georgetown University Medical Center report in an upcoming advance online publication of Nature Medicine . They say t...

Magnetic nanoparticles navigate therapeutic genes through the body

Health professionals send genes and healthy cells on their way through the bloodstream so that they can, for example, repair tissue damage to arteries. But do they reach their destination in sufficient quantities? Scientists of the PTB have developed a highly sensitive measuring method with which ...

New potential therapeutic target discovered for genetic disorder -- Barth syndrome

Researchers at NYU Langone Medical Center may have discovered a new targeted intervention for Barth Syndrome (BTHS). BTHS, a sometimes fatal disease, is a serious genetic disorder occurring predominantly in males that leads to infection or heart failure in childhood. The new study entitled, "Role ...

Mitochondria could be a target for therapeutic strategy for Alzheimer's disease patients

New York (Sept. 21, 2008) A study in the Sept. 21 on-line edition of Nature Medicine describes the function and interaction of a critical molecule involved in cell death in Alzheimer's disease patients. These new findings reveal that blocking this molecule, called Cyclophilin D (CypD), and deve...

New therapeutic target identified for rheumatoid arthritis

Researchers at Hospital for Special Surgery have identified a potential new therapeutic target that could be used to treat inflammatory disorders, such as rheumatoid arthritis. The study, published online ahead of print, will appear Nov. 15 in the journal Immunity . Specifically, the study re...

Simple chemical procedure augments therapeutic potential of stem cells

BOSTON, Mass. (Oct. 31, 2008) Adult stem cells resemble couch potatoes if they hang out and divide in a dish for too long. They get fat and lose key surface proteins, which interferes with their movement and reduces their therapeutic potential. Now, via a simple chemical procedure, researchers ha...

3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), disrupt the quality of life for patients, put a tremendous burden on family caregivers, and cost society billions of dollars annually. The most consistent risk factor for develop...

Previous claims of siRNA therapeutic effects called into question by report in human gene therapy

New Rochelle, NY, September 2, 2008The many recent reports documenting the therapeutic efficacy of short interfering RNAs (siRNAs) in animal models of human disease may actually be describing non-specific therapeutic effects related to the ability of siRNA to activate an immune response, according...

AACR hosts Molecular Diagnostics in Cancer Therapeutic Development Meeting

What: The AACR Molecular Diagnostics in Cancer Therapeutics Development Meeting features the latest findings in laboratory, translational and clinical cancer research. This year's meeting focuses on new biologic markers and imaging methods. To help you take advantage of the meeting's scienti...

Michael J. Fox Foundation awards $2.4M for validation of therapeutic targets for Parkinson's

The Michael J. Fox Foundation for Parkinson's Research today announced approximately $2.4 million in total funding to nine research teams under its Target Validation initiative. This annual MJFF program provides intellectual and financial resources to help push potential PD drug targets forward to...

TG2 identified as potential therapeutic target in chemo-resistant ovarian cancer

HOUSTON, TX Scientists from The University of Texas M. D. Anderson Cancer Center have found overexpression of tissue type transglutaminase (TG2) in ovarian cancer is associated with increased tumor cell growth and adhesion, resistance to chemotherapy and lower overall survival rates. When resea...

Novel therapeutic strategy for colon cancer treatment

A team of scientists at the Genome Institute of Singapore (GIS), a research institute of the Asian city-state's Agency for Science, Technology and Research (A*STAR), and the University of California at San Francisco have developed a pharmacological approach to kill colon cancer cells. Genetic...

New technology enhances therapeutic potential of cord blood stem cells

A CD26 Inhibitor increases the efficiency and responsiveness of umbilical cord blood for bone marrow transplants and may improve care for blood cancer patients according to research from Rush University Medical Center being presented at the 6th Annual International Umbilical Cord Blood Transplanta...

Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find

DALLAS April 4, 2008 Researchers at UT Southwestern Medical Center have developed a simple and inexpensive method to screen small synthetic molecules and pull out a handful that might treat cancer and other diseases less expensively than current methods. In one screen of more than 300,000 suc...

Methadone even at therapeutic levels can kill

PORTLAND, Ore. Methadone is a possible cause of sudden cardiac death even when it isnt overdosed but is taken at therapeutic levels primarily for relief of chronic pain or drug addiction withdrawal, a new study by Oregon Health & Science University researchers suggests. The studys findings, de...

Potential new therapeutic molecular target to fight cancer

Researchers at the Virginia Commonwealth University Massey Cancer Center have identified the enzyme sphingosine kinase 2 as a possible new therapeutic target to improve the efficacy of chemotherapy for colon and breast cancer. In the Nov. 1 issue of the journal Cancer Research, researchers exam...

The endocannabinoids: Functional roles and therapeutic opportunities

Cannabis (marijuana) is the most widely produced plant-based illicit drug worldwide and the illegal drug most frequently used in Europe. Its use increased in almost all EU countries during the 1990s, in particular among young people, including school students. Cannabis use is highest among 15- to ...

Using evolution, UW team creates a template for many new therapeutic agents

MADISON - By guiding an enzyme down a new evolutionary pathway, a team of University of Wisconsin-Madison researchers has created a new form of an enzyme capable of producing a range of potential new therapeutic agents with anticancer and antibiotic properties. Writing in the current issue (Sep...

Nucleonics initiates hepatitis B clinical trial with expressed interfering RNA therapeutic

HORSHAM, PA (January 11, 2008): Nucleonics, Inc., a privately held biotechnology company focused on the development of novel RNA interference (RNAi)-based therapeutics, announced today that the company has begun treating patients in a Phase 1 human safety study of its experimental treatment for c...

Blood-brain barrier breached by new therapeutic strategy

A major obstacle in the treatment of infections and other diseases of the brain is the blood-brain barrier, which prevents systemically delivered therapeutic drugs from reaching the brain. Grantees of the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Hea...

Putting feelings into words produces therapeutic effects in the brain

Why does putting our feelings into words — talking with a therapist or friend, writing in a journal — help us to feel better" A new brain imaging study by UCLA psychologists reveals why verbalizing our feelings makes our sadness, anger and pain less intense. Another study, with the same partici...

One therapeutic dose of radiation causes 30 percent spongy bone loss in mice

Mice receiving just one therapeutic dose of radiation lost up to 39% of the spongy portion of their inner bone, reducing the inner bone's weight bearing connections by up to 64%, researchers reported. The study, which appears in the online edition of the Journal of Applied Physiology, has implicati...

T cells activated to fight HIV basis for dendritic cell therapeutic vaccine

Having their immune system cells go through a laboratory version of boot camp may help patients win their battle against HIV, believe University of Pittsburgh researchers. In essence, that's the concept behind the development of a novel therapeutic vaccine loaded with a patient's own souped up dend...

New Therapeutic Target Identified In Inherited Brain Tumor Disorder

With preliminary results from a study in Botswana, Harvard School of Public Health researchers have found that people with HIV-1 subtype C in resource-poor settings, who receive antiretroviral (ARV) therapy, can achieve comparable results to those in the developed world. A fully supported health ca...

Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects

nterferon -- a critical protein that mediates the body's defense against a wide variety of infectious agents and tumors -- may soon have greater therapeutic value as the result of a new study by researchers at Washington University School of Medicine in St. Louis. "Essentially, we found a way to...

Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease

Scientists at the Johns Hopkins Kimmel Cancer Center have found that a gene pathway linked to a deadly form of leukemia may provide a new way to treat autoimmune diseases, including multiple sclerosis. Their tests in cell cultures and mice suggest that blocking the pathway by interfering with a blo...

Tetanus toxin found to have therapeutic properties

A team of researchers from the Department of Biochemistry and Molecular Biology and the Institute of Neuroscience at the Universitat Autònoma de Barcelona has discovered that tetanus toxin, which causes tetanus, could be extremely useful as a therapy against psychological disorders such as depressi...

Advances in lung cancer research announced at conference

...tastasis in patients with non-small cell lung cancer," Dr. Weiss said. "Identifying the highest-risk population for brain metastasis, so that informed therapeutic trials can be undertaken, could enable a paradigmatic shift in treating these patients." The study team included researchers from: TGen; the Virgin...

New cancer drug delivery system is effective and reversible

...tibodies spur an immune response, requiring extra steps to create a useable therapeutic agent, and the ability of antibody-conjugated liposomes to bind to cancer c...an change aptamers to target a different type of cancer, you can change the therapeutic molecules to fight cancer or other diseases, and you can reverse the dose,"...

Scientists open doors to diagnosis of emphysema

... allow us to use MMP12 as a biomarker to monitor disease evolution and the risk of emphysema formation. It could also serve to examine the response to therapeutic interventions in patients with inflammatory lung diseases," says Marcus Mall, group leader at the Children's Hospital at the University of Heidelberg....

Scientists uncork a potential secret of red wine's health benefits

...rnessable as a treatment for inflammatory diseases and may also lead to entirely new resveratrol-based drugs that are even more effective. "The therapeutic potential of red wine has been bottled up for thousands of years," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal , "and now that ...

Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth

....D., a professor at the Lankenau Institute for Medical Research. Sawicki and colleagues at the Massachusetts Institute of Technology evaluated the therapeutic efficacy of a cationic biodegradable beta-amino ester polymer as a vector for the nanoparticle delivery of a DNA encoding diphtheria toxin suicide gen...

Experimental treatment halts hypoxic-ischemic brain injury in newborns

...he study also shows this system may be a promising therapeutic target in infants suffering hypoxic-ischemic encep...to brain injury. This makes it a better target for therapeutic intervention to shut down the injury process early...n activator in HIE, the research team examined the therapeutic effect of injecting PAI-1 into newborn rats suffer...

Researchers team up to provide new hope for childhood hunger

...h innovation; his peanut butter-based ready-to-use therapeutic food (RUTF) for the treatment of severe acute maln...ate malnutrition. Develop a more cost-effective therapeutic feeding regimen for home-based therapy for severe ...or moderate malnutrition and a more cost-effective therapeutic feeding regimen for home-based therapy for severe ...
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