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Genetic finding could lead to targeted therapy for neuroblastoma

GAINESVILLE Researchers have identified a genetic glitch that could lead to development of neuroblastoma, a deadly form of cancer that typically strikes children under 2. Two University of Florida scientists are part of the multicenter team of researchers that made the discovery, which could p...

Breakthrough in radiotherapy promises targeted cancer treatment

Current radiation therapy treatment damages a patient's healthy tissue as well as eradicating the tumour it is intended to destroy, making the treatment especially invasive and often causing nasty side effects. A new development in radiotherapy will enable a far more precise and accurate treatm...

Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment

AUGUSTA, Ga. Metabolites are molecular fingerprints of what your cells are up to and Dr. Arun Sreekumar wants to know the impression made by cancer. You've likely heard about metabolites; your physician probably screens for some known ones such as triglycerides or cholesterol at your annual ph...

Cellular discovery may lead to targeted treatment for rare form of anemia

CINCINNATIUniversity of Cincinnati (UC) researchers have identified the specific biological mechanisms believed to lead to a rare and incurable blood disease known as Diamond Blackfan anemia (DBA). Scientists say with further investigation, their discoveries could result in drastic changes to curr...

On the trail of a targeted therapy for blood cancers

INDIANAPOLIS Investigators from the Herman B Wells Center for Pediatric Research at the Indiana University School of Medicine are focusing on a family of blood proteins that they hope holds a key to decreasing the toxic effects of chemotherapy in children and adults. Their findings may one d...

Consortium develops new method enabling routine targeted gene modification

A multi-institutional team led by Massachusetts General Hospital (MGH) investigators has developed a powerful new tool for genomic research and medicine a robust method for generating synthetic enzymes that can target particular DNA sequences for inactivation or repair. In the July 25 issue of ...

Newly identified role for 'power plants' in human cells could lead to targeted therapies

COLUMBUS, Ohio Scientists have determined that human cells are able to shift important gene products into their own mitochondria, considered the power plants of cells. The finding could eventually lead to therapies for dozens of diseases. The gene products, known as tRNAs, assemble amino acids...

New technique allows targeted inactivation of genes in research model

WORCESTER, Mass. Researchers at the University of Massachusetts Medical School (UMMS) report today on a new technique that improves the ability of scientists to target individual genes for inactivationa technique with broad potential implications for both basic science research and human disease. ...

Fishing throws targeted species off balance, Scripps study shows

Fishing activities can provoke volatile fluctuations in the populations they target, but its not often clear why. A new study published in the journal Nature by scientists at Scripps Institution of Oceanography at UC San Diego and colleagues has identified the general underlying mechanism. Rese...

Researchers combat slowing yields with targeted fertilizer applications

MADISON, WI, DECEMBER 10, 2007 Scientists at Punjab Agricultural University, the International Rice Research Institute, and Virginia Tech have been successful in increasing average rice yields in northwest India using site-specific nutrient management strategies. The Punjab province, which acco...

Microarray sequence capture speeds large-scale resequencing of targeted genomic regions

Researchers at Baylor College of Medicine and Roche NimbleGen Inc., a fully integrated part of Roche Applied Science, today have published details of a highly efficient and cost-effective method for capturing targeted regions of the genome via NimbleChip microarrays in preparation for high-through...

St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia

Results of a study by investigators at St. Jude Childrens Research Hospital provide strong evidence for why the targeted therapy drug, imatinib, or Gleevec, which has revolutionized the treatment of chronic myelogenous leukemia, (CML) is often unable to prevent relapse of a particularly aggressive...

Effective HIV control may depend on viral protein targeted by immune cells

An effective response of the immune system’s ‘killer?T cells against infection with HIV may depend on exactly which viral protein is targeted, according to an international group of researchers. A new study finds that HIV-infected individuals in whom virus-specific CD8 T cells are targeted against...

UCLA scientists uncover mechanism of response to targeted therapy

UCLA researchers knew - based on two clinical trials - that a subset of kidney cancer patients responded well to an experimental targeted therapy, but they didn't know why. If they could determine the mechanism behind the response, they would be able to predict which patients would respond and pers...

New hybrid virus provides targeted molecular imaging of cancer

Researchers at The University of Texas M. D. Anderson Cancer Center have created a new class of hybrid virus and demonstrated its ability to find, highlight, and deliver genes to tumors in mice. Researchers say the advance, reported in the journal Cell, is potentially an important step in making ...

UCLA scientists find male gene in brain area targeted by Parkinson's

UCLA scientists have discovered that a sex gene responsible for making embryos male and forming the testes is also produced by the brain region targeted by Parkinson's disease. Published in the Feb. 21 edition of Current Biology, the new research may explain why more men than women develop the deg...

Light activated anticancer drug targeted to DNA using cisplatin like sub-units

One of the most effective chemotherapy drugs against cancer is cisplatin because it attaches to cancer DNA and disrupts repair. However, it also kills healthy tissue. Many scientists are creating alternative drugs or cisplatin analogs in attempts to find treatments without side effects. One approac...

Pretreating rogue cancer cells with aspirin cripples their resistance to targeted therapy

Safeguarding 595 sites around the world would help stave off an imminent global extinction crisis, according to new research published today in the Proceedings of the National Academy of Sciences ( www.pnas.org ). Conducted by scientists working with the 52 member organizations of the Alliance fo...

Affymetrix and ParAllele Launch Industry's Most Comprehensive Product Line for Targeted Genotyping

Twenty-eight years after intense selective logging stopped in the region now known as Uganda's Kibale National Park, the red-tailed guenon (Cercophithecus ascanius) is a primate still in decline. The logging practice, scientists report in a new study, changed the ecological balance for these monkey...

Navigating in the ocean of molecules

...ee of charge on the Internet. The source code can also be obtained: advanced users can thus adapt the program to their requirements and embark on more targeted explorations of the chemical space. ...

NIH stimulus funding supports Emory biomedical scientists

...agnetic resonance spectroscopy as a way to spot these chemicals in the brain. Impact of video viewing on infant learning TV programs and videos targeted at infants are flourishing, despite the recommendation by the American Academy of Pediatrics that watching videos is potentially harmful to the develo...

Protein handlers should be effective treatment target for cancer and Alzheimer's

... on developing mice that lack molecular chaperones or heat shock factors in targeted areas, such as liver or breast tissue, as well as mice in which these can b...ype of cancer or neurodegenerative disease which will help in the design of targeted therapies. With the VA-funded study, for example, when they remove a spe...

The way you eat may affect your risk for breast cancer

... "Understanding how calorie restriction provides protection against the development of mammary tumors should help us identify pathways that could be targeted for chemoprevention studies," said Margot P. Cleary, Ph.D., professor at the Hormel Institute, University of Minnesota. "Further identification of ser...

Parasites ready to jump

...y. "We will now test whether the mechanism we have found in Drosophila also exists in mammalian cells. We would also like to know how the mechanism is targeted specifically against sequences present in high copy numbers". ...

UCSF researchers identify new drug target for Kaposi's sarcoma

...virus infectious, but require the two clamshell halves to bind together to be activated, according to the paper. The HIV protease was successfully targeted for drug development in the 1980s, by blocking the active site on the surface of the dimer, but the herpes virus protease dimer has consistently elude...

Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth

...ate director for clinical research at the Greenebaum Cancer Center at the University of Maryland, said this report illustrates significant progress in targeted therapy. "In oncology we have been studying ways to kill tumors for a long time, but much of this has run up against the real estate principle of l...

Study reveals a reprogrammed role for the androgen receptor

... receptor directs a distinct gene pathway in androgen-independent prostate cancers may lead to the identification of genes in that pathway that can be targeted by future therapies." Prostate cancers whose growth is fed by androgen are commonly treated with androgen-blocking drugs. Such medications can hold t...

Scientists track impact of DNA damage in the developing brain

..., published in the August issue of the journal Nature Neuroscience, also provides the first evidence that cells known as cerebellar interneurons are targeted for DNA damage and are a likely source of neurological problems in humans. The cerebellum coordinates movement and balance. The cerebellar interneuron...

Grant supports LSUHSC research on how like cell receptor systems determine very different functions

...s in which the EGF receptor family drives growth and survival. "Our studies might provide insight into how specific functions of a pathway might be targeted therapeutically while not eliminating all essential housekeeping functions of the pathway," Dr. Catling says. "The beauty of research is that no one k...

New drug may reduce heart attack damage

...he blockage on the heart once it's happened," said lead investigator Professor Levon Khachigian, from UNSW's Centre for Vascular Research. "It's a targeted therapy that can be used to complement other procedures and improve chances of a normal recovery," he said. The heart muscle suffers damage at two ...

When children have breathing problems

... time ago (traffic and industrial air pollution), it had not previously been possible to distinguish clearly between these two factors so as to have a targeted impact on them. Researchers at the Helmholtz Centre for Environmental Research (UFZ) and the University of Leipzig carried out research in this area t...

Iowa State University researchers develop process for 'surgical' genetic changes

...sociate scientist, and Jeffery Townsend, an assistant scientist, and allows targeted genetic manipulations in plant DNA, which could have a huge impact on plant...isely introduce DNA at a predetermined location in the plant genome through targeted DNA breaks generated by zinc finger nucleases. This occurs about 1 in 50 at...

UCLA researchers discover new molecular pathway for targeting cancer, disease

... involved in physiological processes that can also stimulate the development of cancer and other diseases. The findings may lead to new treatments and targeted drugs using this approach. In the study, which is currently available in the online edition of the journal Molecular Endocrinology , scientists...

Chasing tiny vehicles

...side-effects. Nanoferries, on the other hand, have been tailored to deliver genes or drugs directly to the target without side-effects. For such a targeted delivery, however, nanoferries need a kind of search mechanism to guide them to where their cargo is needed. Magnetic particles have already been trie...

Scientists report first remote, underwater detection of harmful algae, toxins

...osystem." For the first demonstration of the ESP's ability to detect HABs and their toxins, Doucette and his MBARI colleague, Chris Scholin, Ph.D., targeted certain members of the algal genus Pseudo-nitzschia and their neurotoxin, domoic acid in Monterey Bay, Calif. Pseudo-nitzschia and domoic acid have...

LincRNAs serve as genetic air-traffic controllers

...lly determines which genes are accessible for transcription." But he adds, it has been a mystery as to how this chromatin structure is so precisely targeted by specific enzymes and not others. "By utilizing a technology known as RIP-Chip we were able to examine RNA-protein interaction on a large scale ...

Avoiding hysterectomy: Major interventional radiology E-collection info available

...chair of the Department of Radiology at Georgetown University Medical Center in Washington, D.C. Uterine artery embolization, a minimally invasive, targeted treatment, offers less risk, less pain and less recovery time than traditional surgery. Interventional radiologists use expertise in imaging to delive...

Smaller plants punch above their weight in the forest, say Queen's biologists

...ound them. But new research has proven that this is not generally the case in natural vegetation. In the Queen's project, PhD student Laura Keating targeted the largest individuals or "host plants" of 16 woody plant species growing in the Okanagan Valley, British Columbia. The research team calculated the ...

$29.4 million grant establishes CTSI at NYU in partnership with Health and Hospitals Corporation

...rom the lab to the patient to the community and to allow researchers to explore mechanisms of health disparities and develop evidence-based approaches targeted at their reduction. With this grant, NYU, the NYU School of Medicine and HHC will become part of a network of 46 existing Clinical and Translational ...

Munich researchers discover new target for tailored antibiotics

...ack for developing substances that block the terminal step in the bacterial synthesis of isoprene building blocks, thereby killing pathogens in a very targeted way. Since the enzyme and the associated reaction do not appear in mammals, these compounds should have few or no side effects in humans." ...
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