TAT in Biological News

High blood sugar's impact on immune system holds clues to improving islet cell transplants

... AUGUSTA, Ga. A biological tit for tat may hold clues to improving the success of islet cell transplants intended to cure type 1 diabetes, according to a Medical College of Georgia scientis...

Researchers discover how stealthy HIV protein gets into cells

...gs appears this month in Angewandte Chemie. The tat protein transduction domain of the HIV virus has s...roperties. First, it is a tiny part of the overall tat protein, containing only 11 amino acids. Second, a...components and are designed to keep things out. tat is extremely good at getting through cell membrane...

Researchers reveal HIV peptide's possible pathway into the cell

...sts have known that a positively charged, 11-amino-acid chain of HIV (HIV-1 tat protein) can do the nearly unthinkable X cross through the cell membrane. Sometimes referred to as an "arrow protein," HIV-1 tat pierces the cell membrane and carries a cargo though the cell membrane. ...

Scientists find potential 'off-switch' for HIV virus

...ous studies by others, they have proposed that the tat protein and the enzymes that modify it serve as a ...ecular Biology. "Understanding how to activate the tat resistor to interrupt the reactions leading to vir...s in a loop. First, one of HIV's genes creates the tat protein, which is part of the chemical signal for ...

HIV protein enlisted to help kill cancer cells

...ish Hospital. "A portion of the HIV protein called tat can transport biologically active compounds into cells. tat is small, but it can move massive molecules. You could almost hook tat up to a train, and...

A simple feedback resistor switch keeps latent HIV from awakening

...ription. HIV's transcriptional activator, the tat gene, is encoded in the HIV genome. Once tat is transcribed, it can rapidly increase transcript...at ultimately lead to viral replication. Thus, the tat protein acts like a molecular switch, making it a ...

Hopkins study suggests commercially available antibiotic may help fight dementia in HIV patients

...ng so. The study looked at two proteins, called tat and gp120, that are part of the virus that causes ...dy's lead author. HIV is the only virus that makes tat and gp120, which are produced during its normal li...ents for this complication. According to Rumbaugh, tat and gp120 are believed to cause dementia by reduci...

Random gene expression may drive HIV into hiding

...of HIV's replication machinery: a gene called Tat. tat facilitates transcription of HIV's entire genome, ...eates a positive-feedback loop: If a little bit of tat is around, then the HIV genome is transcribed effi...l, it is copied into DNA, and then a little bit of tat is made before the virus integrates into the host ...

Ancient immune defense mechanism is no match for HIV-1

...n function as a suppressor of RNA silencing (SRS). tat helps HIV-1 to elude the cell's natural RNAi defen...te animals," explains Dr. Jeang. "Our finding that tat is an SRS also helps explain the long-standing bio...vation that when HIV-1 is engineered to be lacking tat but contains alternative transcriptional activator...

An HIV Protein Plays a Surprising Role in Gene Activation

... work with human cell lines and find evidence that tat can also stimulate PIC assembly. While most transcription factors bind to DNA, tat binds to an area at the end of newly emerging vira...ransactivation response element (TAR). Once bound, tat recruits a cellular complex called P-TEFb (consist...

Novel Enzyme Shows Potential As An Anti-HIV Target

...of its skeleton crew. The HIV transcription factor tat (“transactivator of transcription?, for example, i...ctors, and Tat. Unlike most transcription factors, tat activates transcription by binding to RNA, specifi... called the trans-acting responsive element (TAR). tat binding to TAR requires recruiting the enzyme cycl...