Tumor suppressor gene in flies may provide insights for human brain tumors
SINGAPORE and DURHAM, N.C. In the fruit fly's developing brain, stem cells called neuroblasts normally divide to create one self-renewing neuroblast and one cell that has a different fate. But neuroblast growth can sometimes spin out of control and become a brain tumor.
Researchers at Duke-NU...
Skin cancer study uncovers new tumor suppressor gene
National Institutes of Health (NIH) researchers have identified a gene that suppresses tumor growth in melanoma, the deadliest form of skin cancer. The finding is reported today in the journal Nature Genetics as part of a systematic genetic analysis of a group of enzymes implicated in skin cance...
Design of a compound that stabilizes the main natural suppressor of tumors
This press release is available in Spanish .
An interdisciplinary team of researchers, headed by Ernest Giralt at the Institute for Research in Biomedicine (IRB Barcelona) and Javier de Mendoza at the "Institut Catal d'Investigaci Qumica" (ICIQ, Tarragona), have discovered a substance with ...
Two suppressor molecules affect 70 genes in leukemia
COLUMBUS, Ohio By restoring two small molecules that are often lost in chronic leukemia, researchers were able to block tumor growth in an animal model.
The research, using human chronic lymphocytic leukemia (CLL) cells, also showed that loss of the two molecules affects 70 genes, most of whic...
La Jolla Institute discovers novel tumor suppressor
SAN DIEGO (August 3, 2009) La Jolla Institute for Allergy & Immunology researchers studying an enzyme believed to play a role in allergy onset, instead have discovered its previously unknown role as a tumor suppressor
that may be important in myeloproliferative diseases and some types of lymphoma...
Novel regulatory mechanism identified for key tumor suppressor p53
Collaborating scientists from The Wistar Institute in Philadelphia and The Vienna Biocenter in Austria have identified a novel mechanism involved in normal repression of the p53 protein, perhaps the single most important molecule for the control of cancer in humans.
The new molecular pathway des...
Structure determined for p53 tumor suppressor protein as bound to DNA for anti-cancer activity
More than half of human cancers involve mutations in the p53 tumor-suppressor gene, suggesting the critical role played by the normal p53 protein in defending against cancer. Similarly, roughly 95 percent of cancer-causing mutations in the p53 protein occur in its DNA-binding core domain, pointing ...
Little known DNA repair enzyme may be a tumor suppressor gene
Use of the amino acid supplement L-arginine following a heart attack does not improve certain cardiac functions and measurements and may be associated with an increased risk of death, according to a study in the January 4 issue of JAMA.
L-arginine is a widely available dietary supplement and is p...
Restoring silenced suppressor gene kills lung-cancer cells
A new study suggests that restoring a gene often silenced in lung cancer causes the cells to self-destruct. The findings could lead to a new strategy for treating the disease.
The research focused on a gene known as WWOX, which is lost or silenced in a large majority of lung cancers, and in canc...
Researchers discover how tumor suppressor gene works
A team of University of Minnesota researchers has discovered how a gene that suppresses the development of melanoma and other human cancers works. The study points the way to treatments based on the function of the gene. The researchers, led by Zigang Dong, director of the university's Hormel Insti...
Natural tumor suppressor in body discovered by UCSD medical researchers
A natural tumor suppressor
that could potentially be turned on in certain cancer cells to prevent the formation of tumors has been discovered by researchers at the University of California, San Diego (UCSD) School of Medicine.
Located on chromosome 18 and called PH domain Leucine-rich repeat Pro...
UC San Diego engineer provides insights to decades-old DNA squabble
... end, it boils down to the protein machinery that makes up and regulates chromatin," he explained. "You could have mutations in the oncogenic or tumor suppressor
genes that lead to cancer or you could have abnormalities in the proteins that regulate chromatin around these genes leading to cancer."
The next s...
Caltech researchers explore how cells reconcile mixed messages in decisions about growth
...'re exposed to."
You can achieve a similar result, Asthagiri adds, by creating cells that overexpress a protein called E-cadherin, which is a tumor suppressor
protein that promotes adhesion of one cell to another. "This makes the cells less willing to divide," he notes, "which means they need a higher level ...
Research uncovers clues to virus-cancer link
...mor stages expressed higher levels of KSHV miRNA.
In second study, published June 4 in the journal Blood, the team looked for the presence of tumor suppressor
mRNAs in primary effusion lymphoma and Kaposi's Sarcoma.
"We chose these two cancers because, while they are both associated with the same virus, ...
Test detects molecular marker of aging in humans
...cells and tissues age, the expression of a key protein, called p16INK4a, dramatically increases in most mammalian organs. Because p16INK4a is a tumor suppressor
protein, cancer researchers are interested in its role in cellular aging and cancer prevention.
Now the team has proven that the same biomarker is ...
Stress puts double whammy on reproductive system, fertility
...duction by directly inhibiting GnRH.
The common thread appears to be the glucocorticoid stress hormones, which not only suppress GnRH but boost the suppressor
GnIH - a double whammy for the reproductive system.
"We know stress affects the top-tier reproductive hormone, GnRH, but we show, in fact, that str...
American Chemical Society's Weekly PressPac -- June 3, 2009
...uce proteins. Malfunctions in these activators could lead to altered transcription patterns that lead to disease. For example, variations in the tumor suppressor
gene p53 are found in more than half of all human cancers.
Mapp describes discovery of a group of molecules that could be used to help scientists b...
Tips from the American Journal of Pathology
...clinical outcome. In addition, tumor onset in mice was accelerated in the absence of stromal caveolin-1. Caveolin-1 may therefore function as a tumor suppressor
in the stromal microenvironment and serve as a new prognostic marker for breast cancer progression.
Dr. Mina Bissell, who is not associated with t...
Key protein regulating inflammation may prove relevant to controlling sepsis
...sts described their results showing the importance of WIP1 as an effective suppressor
of inflammation and explained how the body was able to cope with an excess ...κB, is also responsible for "ordering" the destruction of the tumour suppressor
This discovery, published in the February 2009 issue of t...
SIRT1 takes down tumors
...uggest that it does. But other work indicates that the protein aids tumors. For example, SIRT1 chops off acetyl groups, which can inactivate the tumor suppressor
Yuan et al. determined SIRT1's effect on the transcription factor c-Myc, whose expression surges in many breast, colon, and liver cancers. The...
A miR boost enables acute leukemia cells to mature
...tting this miR back into leukemia cell lines and leukemia cells from patients causes a drop in global DNA methylation and reactivates protective tumor suppressor
genes, which allows the cells to differentiate and mature."
Getting down to cancer basics
...n now pursue. These are genes that occupy the central control position of gene activity and act to keep cells from turning cancerous. When such 'tumor suppressor
genes' are inactivated, other genes can run riot.
The consequence of mutation in UTX is to bring about changes in activity of other genes through e...
Regulatory molecule for tumor formation or suppression identified by Singapore, US researchers
...edical School, Frank McKeon, Ph.D., commented, "This is an elegant use of zebrafish models to uncover how a single microRNA can regulate the p53 tumor suppressor
gene. The strength of this regulation suggests that we will hear more about the microRNA-125b in specific human cancers in the near future." Dr. McKe...
Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators
...le negative regulators of insulin signaling are already known to function in tumor suppression, this study may lead to the identification of new tumor suppressor
Ken S. Lau, PhD, with his sponsors Kevin M. Haigis, PhD, and Douglas A. Lauffenburger, PhD, at Massachusetts General Hospital, Boston, M...
Research shows cell's inactive state is critical for effectiveness of cancer treatment
...al Sloan-Kettering Cancer Center (MSKCC) found elevated levels of the tumor suppressor
protein p53 in hematopoietic stem cells (HSCs) immature cells in the bone ...entified two new targets of the p53 protein Necdin and Gfi-1 tumor growth suppressor
genes that also regulate quiescence. Researchers lowered the expression of ...
Salk researchers develop novel glioblastoma mouse model
... oncogenes in a tissue-specific manner or shut down the expression of tumor suppressor
genes in the whole tissue. "But we know that tumors generally develop from ...arate brain regions of mice lacking one copy of the gene encoding the tumor suppressor
p53: the hippocampus, which is involved in learning and memory; the subvent...
In lung cancer, silencing one crucial gene disrupts normal functioning of genome
... increase in methylation levels of the other two genes.
Silencing of the RASSF1A and CDKN2A genes makes sense, said Herceg, because these are tumor suppressor
genes known to be inactivated in lung cancer. But the role of MTHFR has been less clear, he said. The enzyme produced by the gene plays a role in proc...
Johns Hopkins scientists pull protein's tail to curtail cancer
...enetic engineering," he says.
The flexible tail contains a cluster of four amino acids the building blocks of proteins that regulate this tumor suppressor
known as PTEN. When chemically modified, these amino acids act to "glue" the tail back to the body of PTEN and prevent the attachment of PTEN to the m...
Apolipoprotein(a): A natural regulator of inflammation
...y of apo(a) apolipoprotein that may function as a natural and cell specific suppressor
of the inflammatory response in vivo. In addition, a mechanism for this nov...n, inhibits neutrophil recruitment in vivo and functions as a cell specific suppressor
of the inflammatory response."
Dr. Steven R. Goodman, Editor-in-Chief of...
GUMC researchers find gene function 'lost' in melanoma and glioblastoma
...eir discovery suggests that PTPRD may play a tumor suppressor
role in a wide variety of different cancers.
"Over the past decade several dozen tumor suppressor
genes have been identified, but only a minority of...TPRD seems to be one of these broad spectrum tumor suppressor
genes," says the study's lead investigator, Todd W...
Mayo researchers identify dangerous 'two-faced' protein crucial to breast cancer spread and growth
...f molecules that includes Ras and Rho, which promote cell growth and movement.
"What is really interesting here is that p120 is acting like a tumor suppressor
when it is bound to E-cadherin, and like a tumor promoter when it isn't," Dr. Anastasiadis says.
The researchers believe these findings could help...
New journal shows half-broken gene is enough to cause cancer
... Tumour suppressor
genes do not necessarily require both alleles to be knocked out before dise... of researchers from Erasmus MC, Rotterdam, who investigated SMAD4, a tumor suppressor
gene implicated in pancreatic and colorectal cancer. They found that having...
UC Davis researchers discover a key to aggressive breast cancer
...ing to have a better outcome than those with less," she said.
Results of the current study further support the notion that Lig-1 serves as a tumor suppressor
gene, though more work is needed to confirm this outcome. Sweeney and her team are gathering more evidence to support this theory and to determine whe...
How eating fruit and vegetables can improve cancer patients' response to chemotherapy
Xuan Liu , a professor of biochemistry, and Xin Cai, a postdoctoral researcher working in her lab, found that apigenin localizes tumor suppressor
p53, a protein, in the cell nucleus a necessary step for killing the cell that results in some tumor cells responding to chemotherapy.
The study, ...
Children's National researchers develop novel anti-tumor vaccine
...role in how the vaccine impacts tumor growth by suppressing the development of the specific immune cells needed to combat the tumor. By adding a T-reg suppressor
such as cyclosphosphamide or anti-CD25 antibody, the scientists were able to have a greater impact on preventing tumor growth using the ISAP approach....
Breast cancer cells recycle to escape death by hormonal therapy
...ill no doubt be studied further, she says.
Dr. Schoenlein believes breast cancer survival during macroautophagy requires high activity of the tumor suppressor
protein Rb and low levels of the lipid ceramide. Ceramide is vital but causes cell death at high levels. MCG researcher Erhard Bieberich and colleague...
Sir David Lane honored with Royal Gold Medal by Royal Society of Edinburgh
...Biomedical Research Council, has received the Royal Gold Medal for his outstanding contribution to cancer research through his discovery of p53 tumour suppressor
The Royal Gold Medal is one of the highest accolades from the Royal Society of Edinburgh and is given to recipients whose intellectual ende...
'1-hit' event provides new opportunity for colon cancer prevention, say Fox Chase researchers
...-suppressor genes, in order to develop cancer. This theory, called the two-hit hypothesis, guided scientists around the globe in their quest for tumor suppressor
genes. Now Knudson, a Fox Chase Cancer Center Distinguished Scientist and senior advisor to the Center president, and colleagues offer evidence that a...
Early stage colon cancer characterized by inactivation of gatekeeper gene
Prior to these new findings, scientists knew that a tumor suppressor
gene called APC is disrupted in most cases of human colon cancer. APC disru...research, the same team of researchers reported that RUNX3 is a major tumor suppressor
of gastric cancer.
Leading the Singapore team is Yoshiaki Ito, M.D., NUS...
International team reveals first prognosticator of survival in aggressive cancer
... (Philadelphia, PA September 4, 2008) The tumor suppressor
gene pRb2/p130 may provide the first independent prognostic biomarker in cases of soft tissue sarcoma (STS), according to an international collaborati...