Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols
HARBOR, N.Y. (Wed., Aug. 5, 2009) Vectors derived from retroviruses are useful tools for long-term gene transfer because they allow stable integration of transgenes and propagation into daughter cells. Lentiviral vectors are preferred because they can transduce non-proliferating ce...
Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols
HARBOR, N.Y. Many proteins do not function by themselves as stand-alone units. Instead, multiple proteins associate to form larger structures called protein complexes. The May issue of Cold Spring
Harbor Protocols ( www.cshprotocols.org/TOCs/toc5_09.dtl ) features a set of metho...
Basic guides to PCR, labeling neurons featured in Cold Spring Harbor Protocols
HARBOR, N.Y. (Wednesday, April 1, 2009) Along with new cutting-edge methods, Cold Spring
Harbor Protocols is home to an in-depth library of basic laboratory methods. The April issue ( www.cshprotocols.org/TOCs/toc4_09.dtl ) features two of these standard techniques.
New ecopsychology journal will premiere in spring 2009
New Rochelle, NY, March 20, 2009 Ecopsychologyan emerging field that explores the psychological origins of environmental issues and ways in which ecology and psychology interact on individual, societal, and global levelsis the focus of a new online peer-reviewed journal, Ecopsychology to be ...
Protein function and chromatin structure methods featured in Cold Spring Harbor Protocols
HARBOR, N.Y. (Tues., March 3, 2009) Two new methods for analyzing the roles played by proteins in cells are featured in the March issue of Cold Spring
Harbor Protocols ( www.cshprotocols.org/TOCs/toc3_09.dtl ). Thomas J. Wandless and colleagues from Stanford University ( http://w...
Little Salt Spring underwater archeological site in Florida receives new funding
SARASOTA COUNTY, FL (February 19, 2009)The Gulf Coast Community Foundation of Venice has awarded the University of Miami (UM) $250,000 toward expansion of research and educational facilities at the underwater archeological and ecological preserve, Little Salt Spring
(LSS), in North Port, Sarasota ...
Cold Spring Harbor Protocols features stem cell differentiation, plant RNAi methods
HARBOR, N.Y. (Mon., Feb. 2, 2009) -- By using OP9-DL1 cells as a support system, researchers can study the differentiation of embryonic stem cells into mature components of the immune system. This month's issue of Cold Spring
Harbor Protocols ( www.cshprotocols.org/TOCs/toc2_09.d...
Cold Spring Harbor Protocols features organ and cell culture methods
HARBOR, N.Y. (Mon., Nov. 3, 2008) Understanding the function of organs like the brain, kidney, and reproductive tissues requires experimental systems that allow for the study and manipulation of developing cells and tissues in the laboratory. This month's issue of Cold Spring
Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
A research team at Cold Spring
Harbor Laboratory (CSHL) is clarifying a previously unappreciated way that cellular processes are disrupted in cancer.
Last year, scientists from the same CHSL team discovered that a "splicing factor" called SF2/ASF--a protein that changes the instructions for ho...
Cold Spring Harbor Protocols highlights gene silencing, cancer cell biology methods
HARBOR, N.Y. Combining the specificity of small interfering RNA (siRNA) silencing with the versatility of lentiviral vectors gives researchers a powerful tool for the investigation of gene function both in vivo and in vitro. This month's issue of Cold Spring
Harbor Protocols ( w...
A 'field guide' to the landscape of Cold Spring Harbor Laboratory
HARBOR, N.Y. A new book, Grounds for Knowledge , is an attractive guide to CSHL's mix of historic and modern buildings and the striking landscape that surrounds them. It was written by historic preservationist and tree enthusiast Elizabeth L. Watson, who, together with her husba...
Watson-inspired innovation in research at Cold Spring Harbor Laboratory
HARBOR, N.Y. The appointment of James Watson as Director of Cold Spring
Harbor Laboratory in 1968 set off an explosive development of research at Cold Spring
Harbor Laboratory (CSHL), as he recruited widely and wisely teams of investigators with diverse scientific interests. In a n...
Cold Spring Harbor Protocols features methods for analyzing genomes and plant cells
HARBOR, N.Y. (Monday, June 2, 2008) With the sequencing of the human genome came the startling revelation that the number of copies of a genes and other DNA sequences can vary widely between individuals. This copy number variation (or CNV), contributes to our species' genetic diver...
Cold Spring Harbor Protocols features classic approaches for analyzing chromosomes
HARBOR, N.Y. (Thursday, May 1, 2008) Recent discoveries have led to a revolution in the field of epigenetics, the study of gene regulation through the modulation of chromatin. These newly elaborated principles have brought the study of chromosomes and chromatin structure to the for...
Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy
Harbor, NY In the neuromuscular disease called spinal muscular atrophy, or SMA, a protein deficiency caused by a single gene mutation leads to serious damage in growing nerve cells and the muscles they control.
Now, in laboratory experiments, researchers at Cold Spring
Cold Spring Harbor Protocols features methods to screen genomes and analyze evolution
HARBOR, N.Y. (Tuesday, April 1, 2008) Identifying genes that are important in specific tissues or processes in the mouse used to be a monumental task. New technologies and strategies have simplified this search, making it effective for even the smallest laboratories. This months i...
RNA-based methods for developmental studies are featured in Cold Spring Harbor Protocols
HARBOR, N.Y. (Fri., Feb. 1, 2008) This months issue of Cold Spring
Harbor Protocols ( www.cshprotocols.org/TOCs/toc2_08.dtl ) highlights two methods to understand developmental processes in plants and flies. Both methods involve work with RNA and are freely accessible on the Web ...
Cold Spring Harbor Laboratory to play central role addressing key questions in plant biology
Harbor, NY Cold Spring
Harbor Laboratory (CSHL) will play a central role in an important new initiative called the iPlant Collaborative, funded by the National Science Foundation (NSF). The Collaborative will define and address grand challenge questions in plant biology that have glob...
Cold Spring Harbor Laboratory's lung cancer research program awarded $100,000 grant
Harbor, NY Cold Spring
Harbor Laboratorys (CSHL) researcher Raffaella Sordella, Ph.D. was awarded $100,000 by Joans Legacy: The Joan Scarangello Foundation to Conquer Lung Cancer. The two-year grant will fund CSHLs pioneering lung cancer research involving a new class of genetic mutat...
Cold Spring Harbor Protocols highlights a method that captures cell growth and activity
HARBOR, N.Y. (Thurs., Nov. 1, 2007) This months issue of Cold Spring
Harbor Protocols ( www.cshprotocols.org ) features a cutting-edge method that provides a snapshot of growth and activity patterns in mixed populations of cells. The protocol is freely accessible online ( http://...
From brains to behavior: Cold Spring Harbor Protocols features methods for neuroscience research
HARBOR, N.Y. (Mon., Oct. 1, 2007) Research in the field of neuroscience is constantly expanding to provide knowledge about biological mechanisms that underlie our ability to experience and interact with the world around us. To facilitate such research, two neuroscience methods are fea...
Lighting up life: Cold Spring Harbor Protocols presents tips for creating glowing plants
Just over a decade ago, biologists isolated a unique protein from jellyfish that could be inserted into other organisms—from E. coli to pigs—and cause them to radiate a brilliant green color. This green fluorescent protein (GFP) has allowed biologists to make many new discoveries regarding how li...
Genetic snooze button governs timing of spring flowers
In the long, dark days of winter, gardeners are known to count the days until spring. Now, scientists have learned, some plants do exactly the same thing.
Addressing scientists here today (Aug. 9) at a meeting of the American Society of Plant Biologists, University of Wisconsin-Madison researche...
Agricultural research key to food security
...TWAS, the Academy of Sciences for the Developing World must involve a renewed concentration on agricultural research in the South.
Writing in the spring
issue of the TWAS Newsletter, el-Beltagy outlines the steps that will be needed to ensure that developing countries can take advantage of cutting-edge...
Restoring a natural root signal helps to fight a major corn pest
...eat, the Federal Office of Consumer Protection and Food Safety (BVL) establishes safety zones and enacts the use of the insecticide chlothianidine. In spring
2008 this insecticide was directly applied on the seeds, but during sowing it was unintentionally emitted as dust from abraded seeds, contaminated flo...
August 2009 Geology and GSA Today media highlights
...y sources from the arid lands around the northern boundary of China and the deserts on the northern margin of the Tibetan Plateau. However, the modern spring
dust in Beijing is characterized by totally different isotopic compositions, which indicate an additional contribution (about 50%) from the desertifie...
'Microfluidic palette' may paint clearer picture of biological processes
... The masterpieces that spring
from the talents of Rembrandt, Van Gogh and other artists often begin with the creation of a gradient of colors on a palette. In a similar manner, res...
Smaller than expected, but severe, dead zone in Gulf of Mexico
...456 square miles. The forecast was driven primarily by the high nitrate loads and high freshwater flows from the Mississippi and Atchafalaya rivers in spring
2009 as measured by the U.S. Geological Survey.
Rabalais believes the smaller than expected dead zone is due to unusual weather patterns that re-o...
Results of national assessment of first responder location systems to be announced Aug. 3
...runs from Aug. 3 to 4. The assessment was conducted by WPI researchers this spring
with funding from the Department of Homeland Security and oversight from th... The indoor location systems developed by six companies were reviewed this spring
at the Massachusetts Police Academy in New Braintree. Funded by a $430,000 ...
Technology improves salmon passage at hydropower dams
... percent of juvenile Chinook salmon that pass through the lower 100 miles of the Snake River and its three hydroelectric dams survived the trek in the spring
of 2008, according to a joint study between PNNL and the U.S. Army Corps of Engineers' Portland District.
The information was gathered by surgically...
Spring cold snap helps with stream ecosystem research
...ng an overall decrease in productivity in the late spring
and summer. A research paper published in this mon...ate change: Stream ecosystem responses to the 2007 spring
freeze" describes how a small change in canopy cov...in the stream that drives the ecosystem during the spring
months could be shortened with climate change if l...
IOS Press announces launch of Journal of Berry Research
...iological interest. Reflecting increasing recognition of the need for a rigorously peer-reviewed publication in this area, IOS Press has announced the spring
2010 launch of the Journal of Berry Research .
According to Editor-in-Chief Maurizio Battino, PhD, DSc, MD (Hon), Universit Politecnica della Marc...
Early initiation of Arctic sea-ice formation
... sea ice formed in autumn and winter and melted in spring
and summer, as seasonal sea ice does today," they ...d within the sea ice and then bloomed there in the spring
when there was enough sunlight. They would have be...e potentially important implications for climate. spring
sea ice and summer cloud formation would have redu...
Scientists report first remote, underwater detection of harmful algae, toxins
...elicans and cormorants that ingested sardines and anchovies, which had accumulated the domoic acid by feeding on a bloom of the toxic algae.
In the spring
of 1998, a mass mortality of sea lions in and around the Monterey Bay area was attributed to the sea lions' feeding on domoic acid contaminated anchov...
Baylor researchers unravel mystery of DNA conformation
...ly underwound and overwound in its natural state."
DNA appears a perfect spring
that can be stretched and then spring
back to its original conformation. How far can you stretch it before someth...
UAB students' Nintendo Wii CPR earns American Heart Association support
...Heart Association wanted a better sense of how it might work, so we assigned the research to our senior year biomedical engineering students this past spring
semester for their senior project."
The UAB team worked on the Wii CPR project for its Design in BME biomedical engineering course, which required ...
Iron and biological production in the high-latitude North Atlantic
... nitrate persist into the summer period, after the spring
bloom has ceased. This represents an inefficiency ...g in concert, might be sufficient to terminate the spring
bloom leaving some nitrate unused. However, there...eviously been suspected, but helps explain why the spring
phytoplankton bloom does not continue well into th...
CSHL scientists harness logic of 'Sudoku' math puzzle to vastly enhance genome-sequencing capability
... Cold spring
Harbor, N.Y. A math-based game that has taken the world by storm with its ... of medical genetics, suggests a new report by a team of scientists at Cold spring
Harbor Laboratory (CSHL). The report will be published as the cover story i...
Study of agricultural watersheds and carbon losses
...ons and cornsoybean rotations fertilized at three nitrogen rates, and continuous corn rotations fertilized with lagooned swine effluent applied in the spring
or fall of each year. The study was funded by the USDA through Consortium for Agricultural Soils Mitigation of Greenhouses program and through the CSR...
Troubled waters: Low Apalachicola River flow may hurt gulf fisheries
...ood web in the region. The strongest connection between the river flow rate and the offshore water properties is seen during the late winter and early spring
months, which coincide with the spawning period of several reef fish species.
"It is possible that if the natural flow of the river is reduced by...