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Southwestern in Biological News

UT Southwestern researchers probe kidney damage, protection in lupus

DALLAS April 21, 2009 Kidney damage associated with the autoimmune disease lupus is linked to a malfunction of immune cells that causes them to congregate in and attack the organs, researchers at UT Southwestern Medical Center have discovered in a mouse study. In a separate study with an inte...

Diabetics on high-fiber diets might need extra calcium, report UT Southwestern researchers

DALLAS March 24, 2009 The amount of calcium your body absorbs might depend, in part, on the amount of dietary fiber you consume. Researchers at UT Southwestern Medical Center report that patients with noninsulin-dependent diabetes (type 2) excreted less calcium through their urine when they ...

Two UT Southwestern researchers awarded Sloan fellowships

DALLAS March 2, 2009 Two researchers at UT Southwestern Medical Center have been named Alfred P. Sloan Research Fellows, an award intended to "support the work of exceptional young researchers early in their academic careers, and often at pivotal stages in their work." Dr. Jennifer Kohler and...

UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound

DALLAS Feb. 24, 2009 Sleep experts know that the mental clarity lost because of a few sleepless nights can often be restored with a good night's rest. Now, UT Southwestern Medical Center researchers have identified a key molecular mechanism that regulates the brain's ability to mentally compensa...

UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease

DALLAS Jan. 30, 2009 Screening a chemical library of 200,000 compounds, researchers at UT Southwestern Medical Center have identified two new classes that can be used to study and possibly manipulate a cellular pathway involved in many types of cancer and degenerative diseases. "The identific...

Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover

DALLAS Jan. 28, 2009 Mice with increased levels of a natural brain chemical don't gain weight when fed a high-fat diet, researchers at UT Southwestern Medical Center have found. The chemical, orexin, works by increasing the body's sensitivity to the "weight-loss hormone," leptin, the researc...

UT Southwestern scientist honored among best in Texas research

DALLAS Jan. 8, 2009 Dr. Rama Ranganathan, professor of pharmacology at UT Southwestern Medical Center, was recognized today as one of the state's top rising stars in research by The Academy of Medicine, Engineering and Science of Texas (TAMEST). Dr. Ranganathan was named a recipient of one of...

UT Southwestern researchers identify gene linked to inherited form of fatal lung disease

DALLAS Dec. 19, 2008 Researchers at UT Southwestern Medical Center have determined that a mutation in a gene known for its role in defending the lungs against invading pathogens is responsible for some inherited cases of a lethal lung disease affecting older adults. The same mutation may also be...

'Deranged calcium signaling' contributes to neurological disorder, UT Southwestern researchers find

DALLAS Nov. 25, 2008 Defective calcium metabolism in nerve cells may play a major role in a fatal genetic neurological disorder that resembles Huntington's disease, researchers at UT Southwestern Medical Center have found in a mouse study. The disease, called spinocerebellar ataxia 3 also kn...

UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development

DALLAS Oct. 22, 2008 The Bill and Melinda Gates Foundation announced today that it has awarded a UT Southwestern Medical Center scientist a grant to pursue innovative vaccine research. The $100,000 grant to Dr. Ellen Vitetta, director of the Cancer Immunobiology Center at UT Southwestern, is ...

RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report

DALLAS Oct. 21, 2008 Conventional wisdom has been that respiratory syncytial virus (RSV) a common virus that causes infection in the lungs comes and goes in children without any long lasting impact. A study conducted in mice by UT Southwestern Medical Center researchers, however, suggests...

Waste from gut bacteria helps host control weight, UT Southwestern researchers report

DALLAS Oct. 17, 2008 A single molecule in the intestinal wall, activated by the waste products from gut bacteria, plays a large role in controlling whether the host animals are lean or fatty, a research team, including scientists from UT Southwestern Medical Center, has found in a mouse study. ...

Antidepressants need new nerve cells to be effective, UT Southwestern researchers find

DALLAS Aug. 28, 2008 Researchers at UT Southwestern Medical Center have discovered in mice that the brain must create new nerve cells for either exercise or antidepressants to reduce depression-like behavior. In addition, the researchers found that antidepressants and exercise use the same bi...

Limiting fructose may boost weight loss, UT Southwestern researcher reports

DALLAS July 24, 2008 One of the reasons people on low-carbohydrate diets may lose weight is that they reduce their intake of fructose, a type of sugar that can be made into body fat quickly, according to a researcher at UT Southwestern Medical Center. Dr. Elizabeth Parks, associate professo...

UT Southwestern researchers identify new targets for RNAs that regulate genes

DALLAS July 6, 2008 Tiny strands of genetic material called RNA a chemical cousin of DNA are emerging as major players in gene regulation, the process inside cells that drives all biology and that scientists seek to control in order to fight disease. The idea that RNA (ribonucleic acid) is...

UT Southwestern researchers create molecule that nudges nerve stem cells to mature

DALLAS June 15, 2008 Inspired by a chance discovery during another experiment, researchers at UT Southwestern Medical Center have created a small molecule that stimulates nerve stem cells to begin maturing into nerve cells in culture. This finding might someday allow a person's own nerve stem...

Geology and biology meet in the history of US southwestern desert surface waters

Boulder, CO, USA The history of surface waters in the arid deserts of the U.S. southwestern Great Basin and lower Colorado River region has fascinated scientists for over two centuries. A new publication by the Geological Society of America covers a wide diversity of closed basins, ancient lake b...

Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research

DALLAS June 2, 2008 UT Southwestern Medical Center researchers have genetically engineered a laboratory mouse in which pancreatic beta cells can regenerate after being induced to die. The new animal model's regenerative ability may provide future insights into improved treatments of diabetes, wh...

Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find

DALLAS May 20, 2008 Mutations in two genes that control electrical excitability in a portion of the brain involved in sleep create a human-like insomnia disorder in mice, UT Southwestern Medical Center researchers have found. The findings may help scientists better understand the disorder and pr...

NIH awards $6.5 million grant to UT Southwestern to develop new antibiotic

DALLAS March 25, 2008 Researchers at UT Southwestern Medical Center have been awarded a $6.5 million grant from the National Institute of Allergy and Infectious Diseases to develop a new anti-microbial compound to target bacterial pathogens such as Salmonella and Escherichia coli. Though many...

Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report

DALLAS Jan. 20, 2008 Using embryonic stem cells from mice, UT Southwestern Medical Center researchers have prompted the growth of healthy and more importantly, functioning muscle cells in mice afflicted with a human model of Duchenne muscular dystrophy. The study represents the first time t...

UT Southwestern scientist honored among best in Texas research

DALLAS Jan. 10, 2008 Dr. Beth Levine, chief of infectious diseases at UT Southwestern Medical Center, was recognized today as one of the states top rising stars in research by The Academy of Medicine, Engineering and Science of Texas (TAMEST). Dr. Levine was named a recipient of one of four E...

UT Southwestern secures $5 million NIH grant for lupus research

DALLAS Dec. 19, 2007 The division of rheumatic diseases in the Department of Internal Medicine at UT Southwestern Medical Center has been awarded a five-year, $5 million grant from the National Institutes of Health to fund the Center of Research Translation, which will investigate the autoimmune...

BMI criteria for obesity surgery should be lowered, UT Southwestern researcher suggests

DALLAS Dec. 18, 2007 UT Southwestern Medical Center researchers have found that the existing body mass index criteria for obesity surgery often excludes a group of obese patients at risk of cardiovascular disease. The study, appearing in the December issue of the journal Surgery for Obesity...

UT Southwestern researchers identify hundreds of genes controlling female fertility

DALLAS Sept. 21, 2007 Researchers at UT Southwestern Medical Center have found nearly 350 genes related to female fertility. Their research may open the door to much wider study in the poorly understood field of infertility. This study gives us a way to begin to understand the causes of femal...

Napoleon's mysterious death unmasked, UT Southwestern researcher says

A new investigation into Napoleon Bonaparte's cause of death might finally put to rest nearly 200 years of lingering mysteries about the illness that killed the French emperor during his island exile, a UT Southwestern Medical Center scientist reports. American, Swiss and Canadian researchers ap...

UT Southwestern researchers find gene mutation that leads to 'broken hearts'

Researchers at UT Southwestern Medical Center have identified a group of fruit fly gene mutations responsible for "broken hearts" in the embryonic stages of development, a discovery that could help identify genes that cause human heart defects. "We engineered a fruit fly so that the heart would ...

DNA end caps may lead to cancer treatments, UT Southwestern researchers report

The two ends of human DNA have different structures that are treated differently as a cell divides, UT Southwestern Medical Center researchers have found in a study that could help lead to cancer therapies. The study ?published in the Feb. 3 issue of the journal Molecular Cell ?focuses on the en...

UT Southwestern researchers unravel control of growing blood vessels

Researchers at UT Southwestern Medical Center have discovered a basic mechanism by which smooth muscle cells that line the blood vessels can grow ?sometimes abnormally ?suggesting methods of treatment for various coronary diseases. Abnormal growth of cells inside blood vessels is involved in hypert...

UT Southwestern researchers develop screening test for cells that activate immune system

UT Southwestern Medical Center researchers are the first to create a large-scale, cell-based screening method that identifies which compounds activate immune-response cells that hold promise for future cancer-fighting vaccines. The new screening technique can scan thousands and even millions of c...

UT Southwestern researchers discover master switch in cell death

Researchers at UT Southwestern Medical Center have found an enzyme vital for controlling the early stages of cell death ?a beneficial and normal process when it works right, but malignant in a variety of cancers when it malfunctions. The researchers are now examining tissue from cancer patients ...

Carnegie Mellon's Jean VanBriesen leads research team on Monongahela River

...WaterQUEST). "The public has expressed increased concern about the produced water that may result from ongoing development of the southwestern Pennsylvania Marcellus Shale formation, which is reported to contain more than 300 trillion cubic feet of natural gas," VanBriesen said. ...

August 2009 Geology and GSA Today media highlights

...ene climate change preserved in hyrax middens from southwestern Africa B.M. Chase et al., Arid Environmental Sys...e up for debate. U-Pb zircon ages from the southwestern Karoo basin, South Africa -- Implications for the ...portant Permian-Triassic boundary is marine in the southwestern sector of the basin, making the Karoo the only bas...

$2 million grant aids study of lung cancer in people who never smoked

... DALLAS July 21, 2009 Researchers at UT southwestern Medical Center are among an elite group of cancer scientists to share a $2 million grant to find biomarkers for lung cancer that develops in people wh...

Down Under dinosaur burrow discovery provides climate change clues

...University and Japan, Martin identified the 95-million-year-old skeletal remains of a small adult dinosaur and two juveniles in a fossilized burrow in southwestern Montana. They later named the dinosaur species Oryctodromeus cubicularis , meaning "digging runner of the lair." The researchers hypothesized that...

UTSA infectious disease researchers advancing vaccine against Valley fever

... In addition, people with compromised T-cell immunity, the elderly and certain racial groups, such as African-Americans and Filipinos who live in the southwestern United States, have an increased incidence of the infection's symptoms, caused by the inhalation of Coccidioides spores. In approximately 40% of ...

Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine

...s from the National Institutes of Health, she found a linkage between the meprin gene and vulnerability to diabetic nephropathy in Pima Indians in the southwestern United States. "These types of transitional research that provide sound basic understanding of a disease process, coupled with detailed examinatio...

Five outstanding young gastroenterologists receive AGA Foundation 2009 Research Scholars Award

...cal School, Mayo Clinic, Stanford University School of Medicine, University of Chicago, University of North Carolina, Chapel Hill, University of Texas southwestern Medical Center, and Washington University, St. Louis. The AGA Research Scholar Awards program addresses the critical problem of a lack of funding f...

Scientists urge global action to preserve water supplies for billions worldwide

...malayas, and other extreme weather events in recent decades. Major rivers in both regions, like China's Yellow River and the Colorado River in the southwestern United States, routinely fail to reach the ocean now. These extremes are signs of the climate- and societally induced stresses that will be exacerbate...

UCI awarded $45 million for infectious disease research

...for coccidioidomycosis (also known as valley fever), a fungal disease that primarily affects the lungs. It occurs in California and other parts of the southwestern U.S. and in northern Mexico. "An important part of our work is to find better methods for diagnosing infectious diseases in shorter amounts of tim...
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