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Screening in Biological News

Cancer's distinctive pattern of gene expression could aid early screening and prevention

AUGUSTA, Ga. Distinctive patterns of genes turned off or left on in healthy versus cancerous cells could enable early screening for many common cancers and maybe help avoid them, Medical College of Georgia scientists say. Researchers are comparing chemical alterations, called DNA methylatio...

Growing Demand for Rapid Screening and Detection Systems Pushes the European Maritime Security Market, Finds Frost & Sullivan

LONDON, July 6 /PRNewswire/ -- Delays in cargo screening significantly extend the time of goods at port. This process could be shortened with foolproof and rapid screening and detection systems. At the same time, increased illegal immigration and smuggling augment the need for efficient access con...

Pitt team finds molecule that regulates heart size by using zebrafish screening model

PITTSBURGH, July 5 Using zebrafish, researchers at the University of Pittsburgh have identified and described an enzyme inhibitor that allows them to increase the number of cardiac progenitor cells and therefore influence the size of the developing heart. The findings are described in the advance...

Colon cancer screening technique shows continued promise in new study

Recent clinical trials show that a new colon cancer screening technique created by Northwestern University researchers has a high enough sensitivity that it could potentially be as or more successful than a colonoscopy in screening for colon cancer. The technique uses optical technology, called...

American College of Medical Genetics affirms importance of newborn screening dried blood spots

The American College of Medical Genetics (ACMG) has issued a new Position Statement on the Importance of Residual Newborn Screening Dried Blood Spots. In May 2006, ACMG recommended that all newborns in the United States be uniformly screened for 29 conditions. Tremendous progress has been made in ...

New high-throughput screening technique makes probing puzzling proteins possible

Understanding the tens of thousands of proteins that compose the human proteome has emerged as a key challenge of this century, and research efforts to date have already enabled major advances in drug discovery and understanding basic biology. But many potential avenues have been blocked by lack o...

States expand newborn screening for life-threatening disorders

WHITE PLAINS, N.Y., FEB. 18, 2009 Regardless of where they are born in the United States, nearly all newborns now receive mandated screening for many life-threatening disorders, a remarkable public health advance of the last four years, according to a new report issued today by the March of Dimes...

Rural areas able to increase screening capacity for colorectal cancer

CAREFREE, A.Z. - Arizona has the ability to expand colorectal cancer screening capacity; this potential increase was more pronounced in rural as compared to urban regions, according to data presented at the American Association for Cancer Research conference on the Science of Cancer Health Dispari...

Genetic risk factors may tailor prostate cancer screening approaches

Men with a family history of prostate cancer and African-American men are particularly susceptible to the disease, with a twofold to sevenfold increased risk. Assessing risk in these populations has been difficult. "There have been years of effort to try to identify genes and genetic mutations ...

Nanoscopic screening process to speed drug discovery

Researchers at Wake Forest University are using nanotechnology to search for new cancer-fighting drugs through a process that could be up to 10,000 times faster than current methods. The "Lab-on-Bead" process will screen millions of chemicals simultaneously using tiny plastic beads so small tha...

Tel Aviv University researchers create new stem cell screening tool

Stem cell research is the next great leap in medicine. In the future, new tissue grown in a laboratory could replace a failing heart, or new cells take the place of damaged cells in the brain. Rather than using stem cells from embryonic sources, which opens difficult ethical and complicated scient...

Colorectal cancer screening rates still too low

PHILADELPHIA Although colorectal cancer screening tests are proven to reduce colorectal cancer mortality, only about half of U.S. men and women 50 and older receive the recommended tests, according to a report in the July 2008 issue of Cancer Epidemiology, Biomarkers and Prevention , a journal o...

A screening strategy using zebrafish targets genes that protect against hearing loss

A small striped fish is helping scientists understand what makes people susceptible to a common form of hearing loss, although, in this case, its not the fishs ears that are of interest. In a study published on February 29 in the open-access journal PLoS Genetics, researchers at the University of ...

Simple screening questionnaire for kidney disease outperforms current clinical practice guidelines

NEW YORK (Feb. 28, 2007) -- The general public is not sufficiently aware that chronic kidney disease (CKD) is a serious and progressive medical condition. It remains under-diagnosed and under-treated. Understandably so, since in its early stages CKD is often asymptomatic, making individuals with t...

New screening strategy for detection of chagas disease in children

A new targeted screening strategy could make the diagnosis and treatment of Chagas disease more feasible in low-resource settings, concludes a new study, publishing on December 26, 2007, in the open-access journal PLoS Neglected Tropical Diseases. Trypanosoma cruzi, the single-cell parasite th...

ESHRE launches international study of polar body screening

Amsterdam, The Netherlands: The efficacy of preimplantation genetic screening (PGS) has been one of the most hotly disputed subjects in assisted reproduction over the past few years. None of the trials carried out so far has shown conclusively whether it works or not. Now the European Society of H...

New technique for cancer screening

Graz, Austria Current research suggests that a new technique to determine tumor methylation status can be used in archived tissue samples. The related report by Balic et al, "High quality assessment of DNA methylation in archival tissues from colorectal cancer patients using quantitative high-re...

Oral rinses used for tracking HPV-positive head and neck cancers holds promise for cancer screening

PHILADELPHIA A study published in the journal Clinical Cancer Research, a journal of the American Association for Cancer Research, validates a non-invasive screening method with future potential for detection of human papillomavirus (HPV)-positive head and neck cancers. In the study, resear...

Southwest Pilots Launch TSA Demonstration Project to Test Biometric Screening

Pilot Program Works to Strengthen Security for Anyone with Access to the Cockpit BALTIMORE and WASHINGTON, Sept. 17 /PRNewswire-USNewswire/ -- Today a Southwest Airlines pilot will be the first aircrew member to be screened by the Transportation Security Administration (TSA) using an advance...

NCI grant launches clinical trials for colon cancer screening

EVANSTON, Ill. --- A Northwestern University biomedical engineer who has developed optical technology shown to be effective for the early detection of colon cancer has received a $7.5 million grant over five years from the National Cancer Institute to further study an instrument that potentially c...

MIT: 'Micro' livers could aid drug screening

CAMBRIDGE, Mass.--MIT researchers have devised a novel way to create tiny colonies of living human liver cells that model the full-sized organ. The work could allow better screening of new drugs that are potentially harmful to the liver and reduce the costs associated with their development. Li...

Newborn screening can cause unnecessary parental stress

Virtually all babies in the U.S. have their heels pricked soon after birth to get a blood sample for genetic testing. These "heel stick" tests identify rare metabolic disorders before they cause irreversible damage, but as more disorders are added to the screening ?many states now test for 30 or mo...

UT Southwestern researchers develop screening test for cells that activate immune system

UT Southwestern Medical Center researchers are the first to create a large-scale, cell-based screening method that identifies which compounds activate immune-response cells that hold promise for future cancer-fighting vaccines. The new screening technique can scan thousands and even millions of c...

NIH creates nationwide network of molecular libraries screening centers

The National Institutes of Health (NIH) today announced it is awarding $88.9 million in grants to nine institutions over three years to establish a collaborative research network that will use high-tech screening methods to identify small molecules that can be used as research tools. Small molecule...

Boosting HIV screening can increase survival and is cost effective

Expanded HIV screening can increase patient life span, prevent the spread of the disease, and is cost effective, researchers at Yale, Harvard and the Massachusetts General Hospital report in the February 10 issue of the New England Journal of Medicine (NEJM). The study's findings are part of a t...

MetaChip provides quick, efficient toxicity screening of potential drugs

A large, multisite trial designed to examine the safety and preliminary effectiveness of two candidate topical microbicides to prevent HIV infection has opened to volunteer enrollment. The trial, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National In...

Marine microbes creating green waves in industry

...ng advantage of the natural diversity of marine organisms that has arisen through evolution in different environments and coupling that with high-tech screening systems. We are looking to find naturally occurring microbes that already have a built-in capacity to do the chemical reactions we want to perform in ...

Pinhead-size worms + robot = new antibiotics

...ctiveness against drug-resistant bacteria. A much better test would involve screening of potential new antibiotics in living animals infected with bacteria to se...e scientists describe successful use of such a whole-animal high throughput screening test automated with a robot to test the effects of 37,000 potential drugs...

Study links virus to some cases of common skin cancer

...ost DNA. "If it proves to be a cancer-causing virus, and if it proves to be common in the general population, it might be something we should begin screening people for," she says. ...

Stem cell research: From molecular physiology to therapeutic applications

...nal Stem Cell Bank in Beijing, where clinical grade stem cell lines and patient specific cell lines have been created for future drug target candidate screening and therapeutic applications. Professor Qi Zhou has written a summary on human parthenogenetic embryonic stem cells as one potential resource for stem...

Scientists discover gene mutation responsible for hereditary neuroendocrine tumor

...g tumors. "Individuals with familial PGLs tend to be affected at a younger age with tumors at multiple sites," says Rutter. "Including hSDH5 in DNA screening will allow for more comprehensive genetic testing, as well as earlier detection and treatment." ...

SRI announces selection by the National Cancer Institute as a Chemical Biology Consortium center

...al investigator of SRI's CBC program and the Comprehensive Chemical Biology screening Center. She will collaborate with Mary Tanga, Ph.D., an SRI senior director...ter. As the principal investigator of the Comprehensive Chemical Biology screening Center, Sambucetti was invited to join the CBC Steering Committee, an NCI a...

New technique can fast-track better ionic liquids for biomass pre-treatments

...atment with the EmimAc ionic liquid. Their results demonstrate that this label-free visualization and mapping technique can provide a means of rapidly screening a wide range of ionic liquids for pre-treating switchgrass and other biomass material. "Our approach can be used to evaluate the deconstruction of ...

2 Fred Hutchinson Cancer Research Center scientists receive Presidential Early Career Award

...ior to joining the Hutchinson Center faculty in 2004, she worked at the National Cancer Institute on the Prostate, Lung, Colorectal and Ovarian Cancer screening Trial. This experience provided Peters with a wealth of collaborative projects, giving her broad-based experience in nutritional and genetic epidemiol...

Funxional successfully completes initial clinical trial of FX125L, an anti-inflammatory drug with a novel mechanism of action

...atforms in FXTs portfolio all of which originated in the University of Cambridge. BSCIs were discovered based upon a strategy that exploits functional screening to develop novel new classes of drugs. FX125L is the lead drug candidate in this novel class, while other BSCIs have been identified as back up molecu...

'Normal' cells far from cancer give nanosignals of trouble

...the tumor site and are the same in at least three different types of cancer. Given its ability to detect these changes, PWS could be used in the early screening of a variety of cancers." Backman and his Northwestern colleagues recently developed PWS, which provides researchers with unprecedented information...

First cGMP feeder-independent pluripotent stem cell banks released for distribution

... the WCBF cleanrooms with complete cGMP testing and documentation. Cell banks are offered as research banks derived from the cGMP master cell bank for screening cell properties, as well as cGMP working cell banks, derived from the same fully tested master cell bank under cGMP conditions. Derek Hei, director...

Frost & Sullivan Looks at Biometrics Advancement in Civil Security: Exploring Opportunities for Today and Beyond

...l security industry is opening up numerous opportunities to implement these evolving technologies across all domains including border control, airport screening and surveillance. (Logo: http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO ) Highlights of the briefing include analyses of: trends, cu...

Chromosomal problems affect nearly all human embryos

...ising finding meant that current techniques used in preimplantation genetic screening (PGS), where embryos are screened genetically in order to select the best e... say that their work has important implications for preimplantation genetic screening (PGS) in fertility treatment. PGS is routinely used in many fertility centr...

Will IVF work for a particular patient? The answer may be found in her blood

...tantly changing expression of human genes." Previous studies in the field of gene-expression have focused on single genes as opposed to genome-wide screening of all the human genes with high density DNA microarrays, as used by Dr. Allen and her team. The advent of tools like microarrays that can simultaneou...
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