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Reverses in Biological News

Anti-cancer drug prevents, reverses cardiovascular damage in mouse model of premature aging disorder

An experimental anti-cancer drug can prevent -- and even reverse -- potentially fatal cardiovascular damage in a mouse model of progeria, a rare genetic disorder that causes the most dramatic form of human premature aging, National Institutes of Health (NIH) researchers reported today. In a s...

Drug reverses mental retardation caused by genetic disorder

UCLA researchers discovered that an FDA-approved drug reverses the brain dysfunction inflicted by a genetic disease called tuberous sclerosis complex (TSC). Because half of TSC patients also suffer from autism, the findings offer new hope for addressing learning disorders due to autism. Nature ...

Blood vessel protein reverses macular degeneration, diabetic retinopathy in mice

SALT LAKE CITY Two major eye diseases and leading causes of blindnessage-related macular degeneration and diabetic retinopathycan be reversed or even prevented by drugs that activate a protein found in blood vessel cells, researchers at the University of Utah School of Medicine and several other i...

Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model

Rats with erectile dysfunction, or ED, that were injected with a gene therapy vector containing either of two nerve growth factors were able to regain normal function after four weeks, according to a study conducted by University of Pittsburgh School of Medicine researchers. These findings are bei...

Changing length of days reverses how estrogen affects aggressiveness in mice

New research shows how simply varying the length of daylight to which mice are exposed to can change how aggressively they react to other mice. The study found that in the short days of winter, the class of hormones called estrogens acts to increase aggression in males of a particular type of mo...

Experimental drug reverses key cognitive deficits, pathology in Alzheimer's

A new drug that enhances the activity of a key brain cell receptor involved in Alzheimer's disease (AD) reverses learning and memory deficits in mice engineered to have pathological hallmarks of the disease. What's more, the drug, called AF267B, reduces both of the pathologies--the brain-clogging b...

Stem cell microenvironment reverses malignant melanoma

Northwestern University researchers have demonstrated how the microenvironments of two human embryonic stem cell (hESC) lines (federally approved) induced metastatic melanoma cells to revert to a normal, skin cell-like type with the ability to form colonies similar to hESCs. The researchers also sh...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

University of Pittsburgh investigators have for the first time used gene therapy to successfully treat heart failure and other degenerative muscle problems in an animal model that is genetically susceptible to a human muscular dystrophy. Reporting in the Oct. 25 edition of the journal Circulation, ...

Genetic therapy reverses nervous system damage in animal model of inherited human disease

By injecting a therapeutic gene directly into the brain, researchers have treated a naturally occurring genetic disease in cats. This is the first genetic disease affecting the central nervous system to be successfully treated in an animal larger than mice and rats. If this approach can be successf...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

Gene therapy methods that specifically target muscle may reverse the symptoms of a rare form of muscular dystrophy, according to new research in mice conducted by medical geneticists at Duke University Medical Center. Infants born with the inherited muscular disorder called Pompe disease usually di...

Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates

The replenishment of missing neurons in the brain as a treatment for Parkinson disease reached the stage of human trials over 15 years ago, however the field is still in its infancy. Researchers from Kyoto University have now shown that dopamine-producing neurons (DA neurons) generated from monkey ...

Placenta-derived stem cells may help sufferers of lung diseases

...cal exposure, radiation or pathogens. These diseases can ultimately lead to loss of normal lung tissue and organ failure. No known therapy effectively reverses or stops the fibrotic process. Placenta-derived stem cells are known to be able to engraft in solid organs, including the lungs. Human term placent...

Neural stem cell differentiation factor discovered

...s the formation of neurons and the maturation of oligodendrocytes" explains Mirko Schmidt at the Institute of Neurology. Inhibition of Notch signaling reverses the situation and more neural stem cells differentiate into neurons. This is exactly what happened upon the addition of EGFL7. In order to verify thei...

Argonne scientists discover possible mechanism for creating 'handedness' in biological molecules

...etization direction in relation to the high-intensity X-ray beam created an excess of one chirality over another. Changing the magnetization direction reverses the spin polarization of the secondary, or low-energy, electrons emitted from the substance. Iron is a common element and is magnetic in many form ...

Low-gravity training machine reduces joint, muscle impacts, says CU-Boulder study

...nology was designed to effectively increase the weight of the astronauts to stem muscle atrophy and bone loss in low-gravity conditions, the G-Trainer reverses the process, said Grabowski. In the past, sports trainers and researchers have used climbing harnesses over treadmills or flotation devices in deep...

The benefits of green tea in reducing an important risk factor for heart disease

... first time that green tea has been shown to have a short-term beneficial effect on the large arteries. Another study has already shown that green tea reverses endothelial dysfunction in smokers. Green tea, which originates in China but is now consumed throughout the world, is made with pure leaves, and ha...

UF scientists discover compound that could lead to new blood pressure drugs

...h.D., an assistant professor in the UF College of Medicines department of pathology, immunology and laboratory medicine. We discovered a compound that reverses the fibrosis that makes the blood vessels more rigid. The American Heart Association estimates that 72 million people in the United States have hig...

Early treatment of stomach infection may prevent cancer

...omach cancer, researchers from the Massachusetts Institute of Technology (MIT) say that prompt treatment of Helicobacter pylori (H. pylori) infections reverses damage to the lining of the stomach that can lead to cancer. In the May 1 issue of Cancer Research, a journal of the American Association for Cance...

Human hormone blocker found to help prevent obesity and diabetes: study

...was able to reverse well established diet-induced obesity and related metabolic abnormalities. The new study is entitled, "GIP Receptor Antagonism reverses Obesity, Insulin Resistance, and Associated Metabolic Disturbances Induced in Mice by Prolonged Consumption of High-Fat Diet." It was conducted by Pau...

Study finds first-ever genetic animal model of autism

...om one neuron to the next is increased in this mouse model. Now we can test drugs that decrease this effect directly in the mice and ask whether this reverses their social interaction deficits, Dr. Powell says. For now, the mainstay of autism treatment is still behavioral therapy. The earlier we can get pat...

Clot-dissolving agent may be beneficial in treatment of severe frostbite

...en skin is warmed again. Inflammation during thawing typically stimulates clotting that blocks small blood vessels, leading to cell death. Because tPA reverses this clotting, blood flow is restored before permanent damage is done. “Based on the dramatic improvements in perfusion [blood flow] and reductio...

Scientists find hormone activity explains adolescent mood swings

...and pharmacology at SUNY Downstate Medical Center, report findings demonstrating that a hormone normally released in response to stress, THP, actually reverses its effect at puberty, when it increases anxiety. This hormone normally acts like a tranquilizer, acting at sites in the brain that "calm" brain ...

Gardenia fruit compound starting point for diabetes therapy

... A Gardenia fruit extract traditionally used in Chinese medicine to treat the symptoms of type 2 diabetes does indeed contain a chemical that reverses some of the pancreatic dysfunctions that underlie the disease, researchers report in the June 7, 2006, Cell Metabolism. The chemical therefore represe...

Gene linked to rare disease activates fat breakdown

...ells inhibit the removal of stored triglycerides. Finally, the addition of normal CGI-58 in cells having the CDS mutation restores lipid breakdown and reverses the abnormal triglyceride accumulation typical of patients with the lipid storage disease. "These data establish an important biochemical function ...

When it comes to gene transcription, random pauses aren’t quite so random, study finds

...0-base pair sequence that triggers one of two types of long pauses in RNAP--a "backtracking pause" associated with gene regulation in which the enzyme reverses direction briefly; or a "hairpin pause, " named for tiny hairpin-shaped structures that sometimes form when an RNA strand binds to itself. "Kristin...

Drug triggers body's mechanism to reverse aging effect on memory process

... A drug made to enhance memory appears to trigger a natural mechanism in the brain that fully reverses age-related memory loss, even after the drug itself has left the body, according to researchers at UC Irvine. Professors Christine Gall and Gary Ly...

Researchers develop gene therapy to reverse pulmonary arterial hypertension

...apy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. It's published in the June issue of The Jo...lable drug, Dichloroacetate, selectively enhances apoptosis in PAH and thus reverses PAH, prolonging the survival of rats. Because this oral therapy has already...

Scientists create digital bacteria to forge advances in biomedical research

...strophysics at the University of Chicago. Before shifting to Cluzel's lab, Emonet worked with Rosner in devising simulations to understand how the sun reverses its magnetic field every 11 years. Each digital cell in AgentCell is a virtual Escherichia coli, a single-celled bacterium, which is equipped with ...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

...e. "What we are showing is a proof of principle that stopping the synthesis of a protein that is necessary for the formation of the telltale plaques reverses the progression of the disease, and more importantly, the cognitive function of these mice, which had already been impaired, has now recovered," says ...

Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems

...1 are required for optimal performance on tests of learning and memory throughout life," they said. "Growth hormone/IGF-1 replacement in older animals reverses the age-related decline in cognitive function." The group also found that "cartilage degeneration that normally accompanies aging is accelerated by...
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