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First successful reverse vasectomy on endangered species performed at the National Zoo

Veterinarians at the Smithsonian's National Zoo have performed the first successful reverse vasectomy on a Przewalski's horse ( E. ferus przewalskii ; E. caballus przewalskii classification debated), pronounced zshah-VAL-skeez. Przewalksi's horses are a horse species native to China and Mongolia...

New data from NIH lab confirms protocol to reverse type 1 diabetes in mice

New data published in the Nov. 24 issue of Science provide further support for a protocol to reverse type 1 diabetes in mice and new evidence that adult precursor cells from the spleen can contribute to the regeneration of beta cells. In 2001 and 2003, researchers at Massachusetts General Hospita...

Scientists reverse evolution

University of Utah scientists have shown how evolution works by reversing the process, reconstructing a 530-million-year-old gene by combining key portions of two modern mouse genes that descended from the archaic gene. "It provides further evidence at the molecular level of how evolution has oc...

Drug triggers body's mechanism to reverse aging effect on memory process

A drug made to enhance memory appears to trigger a natural mechanism in the brain that fully reverses age-related memory loss, even after the drug itself has left the body, according to researchers at UC Irvine. Professors Christine Gall and Gary Lynch, along with Associate Researcher Julie Laut...

Intensive statin therapy may partially reverse plaque build-up in arteries

A study presented today at the American College of Cardiology's 55th Annual Scientific Session demonstrates, for the first time, that very intensive cholesterol lowering with a statin drug can regress (partially reverse) the buildup of plaque in the coronary arteries. This finding has never bef...

New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease

The discovery that bone-marrow derived stem cells can regenerate damaged renal cells in an animal model of Alport syndrome provides a potential new strategy for managing this inherited kidney disease and offers the first example of how stem cells may be useful in repairing basement membrane matrix ...

Researchers reverse juvenile diabetes in animal model

Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center researchers Massimo Trucco, MD, and Nick Giannoukakis, PhD, observed marked amelioration of diabetes in a mouse model by a novel treatment strategy involving specific modification of the animal's own dendritic cells, there...

Amphetamines reverse Parkinson's disease symptoms in mice

Amphetamines, including the drug popularly known as Ecstasy, can reverse the symptoms of Parkinson's disease in mice with an acute form of the condition, according to new research at Duke University Medical Center. The researchers caution that the findings in animals do not suggest Parkinson's d...

Researchers develop gene therapy to reverse pulmonary arterial hypertension

A University of Alberta research team has discovered important new information they hope will lead to more effective treatments for pulmonary arterial hypertension (PAH)--a deadly form of high blood pressure in the pulmonary arteries caused by uncontrolled cell growth. Therapies are currently limit...

U of MN researchers reverse memory loss in mice

Researchers at the University of Minnesota were able to reverse memory loss in mice with significant brain degeneration for the first time, a breakthrough that offers hope to the estimated 4 million people living with Alzheimer's disease. Researchers first manipulated the genetic makeup of the mi...

Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers

University of North Carolina at Chapel Hill researchers have made a discovery that may have implications for the treatment of liver-based genetic defects such as hemophilia A and B in humans. Mouse embryonic stem cells treated in culture with a growth factor and then injected into the liver reve...

New cancer drug delivery system is effective and reversible

..."You can change aptamers to target a different type of cancer, you can change the therapeutic molecules to fight cancer or other diseases, and you can reverse the dose," Cheng said. "That's a lot of tools in the toolbox. It has great potential." ...

Wastewater produces electricity and desalinates water

...ource in some parts of the world. Its availability in the future will be even more problematic. Many locations already desalinate water using either a reverse osmosis process -- one that pushes water under high pressure through membranes that allow water to pass but not salt -- or an electrodialysis process ...

Music is the engine of new U-M lab-on-a-chip device

...other, I can vary the strength of the individual notes within the chords to move a given drop faster or slower." Burns describes the set-up as the reverse of a bell choir. Rather than ringing a bell to create sound waves in the air, which are heard as music, this system uses music to create sound waves i...

Researchers achieve major breakthrough with water desalination system

...arly saturated with calcium sulfate salts, accomplishing this with just one reverse osmosis (RO) stage. "In this specific field study by our team, in the first part of the reverse osmosis process, 65 percent of the water that was fed in was recovered as d...

Seals quickly respond to gain and loss of habitat under climate change

...f Holocene climate change. We learned that new habitat emerging within the species' migratory range could be quickly taken advantage of, but that the reverse was not true. The movement patterns of seals from this Antarctic breeding site would have been unlikely to take them near other potential breeding si...

Cells use import machinery to export their goods as well

...s, called post-Golgi vesicles, export cargo made by the cell's protein factory. Scientists have long believed that other, similar vesicles handle the reverse function, importing life-supporting nutrients and proteins through an independent process. By using a finely honed type of microscopy to more precisel...

Researchers observe single protein dimers wavering between two symmetrically opposed structures

... delicate balance of energy that is needed between conformational structures of proteins in a cell, leading to disease. If so, a drug might be able to reverse those kinds of imbalances." ...

Another JDRF partner moves research forward with collaboration agreement for diabetes treatment

...nc., a wholly owned member of the Roche Group, to further develop and potentially commercialize a novel antigen-specific immunotherapeutic designed to reverse the immune response that causes type 1 diabetes. To date, JDRF has awarded more than $29 million in research funding to 25 companies through its ...

Specific genetic cause of fetal alcohol-related developmental disorders found

...at control learning, memory and emotional behaviors. "In light of our current finding, we can begin testing specific dietary supplements that could reverse the epigenetic alterations that disrupt the regulation of Dio3," Sittig said. "When given to the mother or newborn, this might correct the imprinting ...

Simple drug treatment may prevent nicotine-induced SIDS: Study

...nown as hypoxiawhich may result in a higher incidence of SIDS. In the same study on rats, they found that the diabetic medication 'glibenclamide' can reverse the effects of nicotine exposure, increasing the newborn's ability to respond to hypoxia and likely reducing the incidence of SIDS. The findings ar...

Liver disease 'shrunk' by blood-pressure drug

... A blood-pressure medicine has been shown to reverse the effects of early-stage liver failure in some patients. Newcastle University researchers analysed a small clinical trial of losartan, a drug nor...

Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue

...tments, resulting in large numbers of people living with heart failure. This advance has lead to another health hurdle: The only therapy available to reverse the decline in cardiac function is heart transplantation, and donor hearts are very scarce. Clinical trials of myocardial stem cell therapy traditio...

Environmental exposures may damage DNA in as few as three days

...rently being used as targets of cancer drugs." Dr. Baccarelli said the study results indicate that early interventions might be designed which would reverse gene programming to normal levels, reducing the health risks of exposure. "We need to evaluate how the changes in gene reprogramming we observed are...

True grit

...nter of the tip is a matrix of larger and softer calcite crystals. While in most such materials a matrix of hard fibers contains a softer filling, the reverse is true for the urchins' tooth: a matrix of relatively soft calcite fibers holds the harder magnesium calcite crystals, which allows these crystals to...

Avian flu research sheds light on swine flu outbreak

...nd coughing." In his study, Perez used the avian H9N2 influenza virus, one that is on the list of candidates for human pandemic potential. Using reverse genetics, a technique whereby individual genes from viruses are separated, selected, and put back together, Perez and his team created a hybrid human-...

DNA barcoding of mosquito species deployed in bid to end elephantiasis

... mostly due to human impacts population growth, industrial development, pollution and climate change," says Dr. Edwards. "Efforts to stabilize and reverse this trend are hampered by biodiversity knowledge banks that are incomplete, fragmented and not easily accessible to those who need them to set enviro...

Impact of floods on soils

...educing conditions. The authors believe that once the reducing reactions take place in the field and disaggregation has occurred, the process will not reverse itself because the natural drainage will carry away the released chemicals and the chemistry of the soil-water system will not return to the original ...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

...ations provide additional insight into the mechanisms that act to selectively destroy the blood vessels supporting tumor growth and spread and also to reverse the ability of tumors to suppress the body's natural immune response, resulting in the mobilization of important inflammatory and other anti-tumor com...

FANTOM findings boost for biologists

.../fantom.gsc.riken.jp/4/ ). Further research published in BMC Bioinformatics highlights two new data-driven normalization methods for quantitative reverse transcriptase polymerase chain reaction (qPCR) experiments with larger data sets. Another study published in Genome Biology includes the first genom...

2009 ASPB Summer Undergraduate Research Fellowship award announcement

...rted my adventure in plant biology in the summer of 2008, when I was first exposed to yeast hybrid systems. The project titled above is going to use a reverse 2-hybrid system to screen for mutated SAUR19 proteins that no longer interact with a known protein interactor. This project can both elucidate the dom...

CSHL-led team identifies key decision-point at which cells with broken DNA repair themselves or die

...ar signals can't be sent without helper enzymes like PTPs that remove phosphate molecules from specific locations, and kinase enzymes that perform the reverse role that of adding phosphates. Another vital piece of the puzzle in the current work involves Dr. Kim, who recently spent 15 months in the Tonk...

Impact of floods on soils

...educing conditions. The authors believe that once the reducing reactions take place in the field and disaggregation has occurred, the process will not reverse itself because the natural drainage will carry away the released chemicals and the chemistry of the soil-water system will not return to the original ...

A miR boost enables acute leukemia cells to mature

...study by Ohio State University cancer researchers shows that boosting the level of a molecule called miR-29b in acute myeloid leukemia (AML) cells can reverse gene changes that trap the cells in an immature, fast growing state of development. The study discovered how the miR reactivates silenced genes, w...

UBC study first to show evolution's impact on ecosystems

...ironments impact the evolution of new species. Now experiments conducted at the University of British Columbia are showing for the first time that the reverse is also true. Researchers from the UBC Biodiversity Research Centre created mini-ecosystems in large aquatic tanks using different species of three...

Ocera Therapeutics licenses novel treatment for acute hepatic encephalopathy from UCLB

...apeutics. "By directly reducing blood levels of ammonia, OCR-002 has the potential not only to improve symptoms of encephalopathy but may also help to reverse this life-threatening condition and reduce healthcare costs by minimising a patient's time in intensive care." "There is a significant unmet clinic...

Difference in fat storage may explain lower rate of liver disease in African-Americans

...id. "This may be protective," Dr. Browning said. "In animal studies, if subcutaneous fat is increased as opposed to visceral fat, you can actually reverse fatty liver disease." Scientists aren't sure why the location of fat storage matters. "This seems to argue that there is a fundamental differen...

Stanford scientists find new solutions for the arsenic-poisoning crisis in Asia

...its way into the groundwater more than 100 feet below the surface. Solving that mystery could have significant implications for policymakers trying to reverse the mass poisoning, said Stanford University soil scientist Scott Fendorf. "How does the arsenic go from being in the sediment loads, in solids, in...

Carbon sinks losing the battle with rising emissions

...hrough shifts in atmospheric composition, temperature and rainfall changes, deforestation, fire frequency and insect attacks, all of which can slow or reverse sinks or initiate sources of CO 2 to the atmosphere. Release of carbon presently locked in frozen soil, as both CO 2 and methane (a more potent gr...

Stem cells replace stroke-damaged tissue in rats

... have shown they are able to overcome some of the many challenges in translating the potential of using stem cells into reality. "The potential to reverse the disabling effects of stroke seems to have been proved. However the development of stem cell therapy for stroke survivors is still in the early st...
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