Reveals

NYU Study Reveals How Brain's Immune System Fights Viral Encephalitis

New York University biologists have uncovered how the innate immune system in mice's brains fights viral infection of neurons. The findings, published as the cover study in the latest issue of Virology, show that proteins in neurons fight the virus at multiple stages--by preventing the formation of viral RNA and proteins, and blocking the virus' release, which could infect other cells in the brai...

A bacterial genome reveals new targets to combat infectious disease

More than a billion people are at risk for infection with filarial nematodes, parasites that cause elephantiasis, African river blindness, and other debilitating diseases in more than 150 million people worldwide. The nematodes themselves play host to bacteria that live within their cells, but in this case, the relationship is classic mutualism, with each benefiting from the other. Indeed, the Wo...

Needling Chromosomes Reveals Cell Division Secret

By impaling individual chromosomes with glassneedles one thousandth the diameter of a human hair, a Duke Universitygraduate student has tested their "stickiness" to one another duringcell division. Her uncanny surgical skills have added a piece to thelarge and intricate puzzle of how one cell divides into two -- aprocess fundamental to all organisms.In the Dec. 14, 2004, issue of Current Bi...

Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

As you read this, cells in your eye are transmitting information to your brain, while cells in your heart and arteries work just as hard to keep that brain alive. Every one of these cells -- and others throughout the body -- depends on an internal process called endocytosis to keep the flow of cellular nutrients and information healthy and strong. It's an incredibly important life process,...

First real-time view of developing neurons reveals surprises, say Stanford researchers

Scientists have believed that neurons need a long period of fine-tuning and training with other neurons before they take on their adult role. But after using new technology for the first time to watch these cells develop, a team of researchers at the Stanford University School of Medicine found that neurons come into this world with a good idea about what they'll become as adults. The work...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

Gastric and colorectal cancers account for more than 1 million deaths worldwide every year and several research groups have been working to identify the molecular events that result in the initiation and progression of these tumors. It has been established that interfering with the function of one gene, called Adenomatous Polyposis Coli (APC) has a profound effect on the cells lining the innermos...

Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

First-of-its-kind analysis published in the Feb. 8 PNAS supports the concept of a basic wiring diagram for all eukaryotes. Researchers in California, Israel, and Germany have compared three distantly related species ?baker's yeast, a worm, and the fruit fly ?and reported that protein "wiring" connections in one species are often conserved in all three. This first-of-its-kind analysis of t...

NYU study reveals how brain's immune system fights viral encephalitis

New York University biologists have uncovered how the innate immune system in mice's brains fights viral infection of neurons. The findings, published as the cover study in the latest issue of Virology, show that proteins in neurons fight the virus at multiple stages--by preventing the formation of viral RNA and proteins, and blocking the virus' release, which could infect other cells in the brai...

Study reveals new technique for fingerprinting environmental samples

Groundbreaking research led by the U.S. Department of Energy Joint Genome Institute (DOE JGI) demonstrates for the first time that the signatures of the genes alone in terrestrial and aquatic samples can accurately diagnose the health of the sampled environments. This study, published in the April 22nd edition of the journal Science positions large-scale genome sequencing to accelerate advances i...

Study reveals dramatic difference between breast cancers in US and Africa

A study comparing, for the first time, breast cancers from Nigeria, Senegal and North America has found that women of African ancestry are more likely to be diagnosed with a more virulent form of the disease than women of European ancestry. Researchers from the University of Chicago, working with colleagues at the University of Calabar in Nigeria and the University of North Carolina, foun...

UCSD research reveals mechanism involved with type of fatal epilepsy

Researchers at University of California, San Diego (UCSD) have found that Lafora disease, an inherited form of epilepsy that results in death by the age of 30, can be caused by mutations in a gene that regulates the concentration of the protein laforin. These findings are reported in the current issue of Proceedings of the National Academy of Sciences (PNAS). Lafora disease is characterize...

Study reveals candidate targets for anti-retroviral therapeutics

The increased frequency of drug resistance in isolates of the AIDS virus, HIV, makes identification of new antiviral targets an urgent necessity. Host genes required to support the replication of HIV are a potential source of such novel targets, but relatively few appropriate target genes have been identified in animal cells thus far. A new study, conducted by Dr. Suzanne Sandmeyer and colleagues...

Chimp genome reveals a retroviral invasion

It's been known for a long time that only 2% -- 3% of human DNA codes for proteins. Much of the rest of our genomes -- often referred to as junk DNA -- consists of retroelements: genomic elements that are transcribed into RNA, reverse-transcribed into DNA, and then reinserted into a new spot in the genome. Human endogenous retroviruses make up one class of these retroelements. Retroviruses can in...

Research Reveals Functions Of Harmful Shellfish Pathogens

Providing safer shellfish is the goal of Agricultural Research Service (ARS) scientists who are studying the means by which pathogenic bacteria enter shellfish. In the United States, two pathogenic bacteria from the genus Vibrio are of concern: V. vulnificus and V. parahaemolyticus. These bacteria are naturally found in shellfish and seawater, particularly when water temperatures are warm,...

Survey reveals women and doctors aren't talking about HPV

Eighty-eight percent of women rely on their healthcare providers to learn about gynecological issues, yet only 19 percent said their doctor has talked to them about cervical cancer and its cause - the human papillomavirus (HPV) - according to a new survey released by the Association of Reproductive Health Professionals (ARHP). HPV is extremely common, affecting an estimated 80 percent of sexually...

Brain Scan Study of Smokers Reveals Signature of Craving

Not all smokers are alike when it comes to cravings, and a new study conducted by researchers at Duke University Medical Center suggests the difference may lie in their brains' sensitivity to drug cues. The researchers found that smokers who report a greater urge to smoke after a period of abstinence also exhibit stronger brain activity after viewing smoking-related images, such as others smoking...

Bioinformatics reveals new gene regulation system

By comparing 140 sequenced bacterial genomes, researchers have uncovered a system for regulating genes essential to bacterial replication ?and they did it solely by computer keystrokes and mouse clicks. Mikhail Gelfand, a Howard Hughes Medical Institute international research scholar at the Institute for Information Transmission Problems (IITP) in Moscow, and his postdoctoral fellow, Dmit...

New tool reveals secrets of migrating cells

Called two-photon laser-scanning microscopy, it has revealed, for...

Genetic study of Neanderthal DNA reveals early split between humans and Neanderthals

In the most thorough study to date of the Neanderthal genome, scientists suggest an early human-Neanderthal split. The two species have a common ancestry, say the authors, but do not share much else after evolving their separate ways. The study, published in this week's issue of Science, also finds no evidence of genetic admixture between Neanderthals and humans. The study helps to explain...

Cholera pathogen reveals how bacteria generate energy to live

Researchers at Rensselaer Polytechnic Institute have discovered new details about how bacteria generate energy to live. In two recently published papers, the scientists add key specifics to the molecular mechanism behind the pathogen that causes cholera. The work could provide a better understanding of this pathogen, while also offering insight into how cells transform energy from the environment...

Carnegie Mellon University research reveals how cells process large genes

Important messages require accurate transmission. Big genes are especially challenging because they combine many coding segments (exons) that lie between long stretches of non-coding elements (introns). During processing, introns are snipped out and exons pasted together to form a template for proteins called messenger RNA (mRNA). Mistakes in RNA processing can reduce the expression of a function...

Analysis of flower genes reveals the fate of an ancient gene duplication

In a step that advances our ability to discern the ancient evolutionary relationships between different genes and their biological functions, researchers have provided insight into the present-day outcome of a single gene duplication that occurred over a hundred million years ago in an ancestor of modern plants. The work is reported in Current Biology by a team led by Brendan Davies of the Univer...

Computer modeling reveals hidden conversations within cells

University of California, San Diego biochemists have developed a computer program that helps explain a long-standing mystery: how the same proteins can play different roles in a wide range of cellular processes, including those leading to immune responses and cancer. Prior to the UCSD team's findings, which are published in the September 16 issue of the journal Science, many scientists ex...

Study reveals genomics of inflammation from severe injury

Could improve prediction of patient outcomes, lead to tailored treatmentsWhen it comes to inflammation, too much of a good thing can be deadly. In some severely injured patients, this normal healing process can develop into a lethal, whole-body response, including bloodstream infection (sepsis) and multiple organ failure. How and why inflammation turns from healing to harming is still mysterious,...

First big influenza genome study reveals flu evolution

Which flu did you get? TIGR scientists survey five New York flu seasons , the researchers report the first large-scale project to sequence the influenza virus. The study offers a unique snapshot...

Genetic analysis of cavefish reveals more about evolution

A multi-institutional study offers additional insight into the evolutionary process by examining how albinism evolves in cavefish. Researchers, including New York University Biology Professor Richard Borowsky, examined two populations of Mexican cavefish and found that albinism in both populations was linked to Oca2--a pigmentation gene also responsible for the most common form of albinism in hu...

PET imaging reveals the immune system at work

For clinicians, the ability to look routinely inside the body and see -- at the level of the cell -- how it confronts disease is a distant dream. But in a series of experiments with genetically engineered mice, a team of researchers from the Howard Hughes Medical Institute (HHMI) at the University of California Los Angeles has taken a key step toward realizing that vision by demonstrating the abi...

Genetic analysis of Asian elephants in India reveals some surprises

Researchers in India and from The Earth Institute at Columbia University have discovered that one of the few remaining populations of Asian elephants in India is actually two genetically distinct groups. The results of the study, which appear in the current issue of the journal Animal Conservation, could have far-reaching implications in conservation plans for the endangered elephants as well as...

Marsupial genome reveals insights into mammalian evolution

The genetic code of marsupials has now been documented for the first time. An international team led by Kathy Belov from the University of Sydney's Faculty of Veterinary Science published an analysis of the marsupial genome in the open access journal PLoS Biology. The paper details the evolution of an important cluster of immune genes known as the MHC using available genome sequences of the gray...

Whole-genome study at Johns Hopkins reveals a new gene associated with abnormal heart rhythm

Using a new genomic strategy that has the power to survey the entire human genome and identify genes with common variants that contribute to complex diseases, researchers at Johns Hopkins, together with scientists from Munich, Germany, and the Framingham Heart Study, U.S.A., have identified a gene that may predispose some people to abnormal heart rhythms that lead to sudden cardiac death, a condi...

Largest study of human 'interactome' reveals a novel way

Discoveries made during the first large-scale analysis of interactions between proteins in our cells hold promise for identifying new genes involved in genetic diseases, according to researchers at Johns Hopkins and the Institute of Bioinformatics (IOB) in Bangalore. The findings, reported in the March issue of Nature Genetics, were made using a database of more than 25,000 protein-protein...

Mouse study reveals human X-SCID gene therapy poses substantial cancer risk

New animal studies conducted at the Salk Institute for Biological Studies show that the only human gene therapy treatment to date considered to be largely successful, is, in fact, riskier than realized. The Salk researchers, led by Inder Verma, Ph.D., a professor in the Laboratory of Genetics, discovered that the healthy copy, which replaces the defective gene can itself promote cancer de...

HortResearch science reveals the natural potential of apples

Fruit lovers worldwide may soon enjoy new, healthier, tastier apples, following the release this week of crucial genetic data which fruit breeders say will help revolutionise the produce industry. Researchers at New Zealand's world renowned fruit science company HortResearch, announced today that they would complete the public release of the world's most extensive collection of apple DNA s...

High-resolution light microscope reveals the fundamental mechanisms of nerve communication

In a simultaneous publication (Science Express, 13th April 2006), STED microscopy revealed the spatial distribution of the bruchpilot protein and aided neurobiologists from the European Neuroscience Institute and the University of Würzburgin understanding the protein's central role in the formation of active synaptic zones. STED microscopy radically distinguishes itself from conventional farfield...

Novel method reveals how menthol discovery could point towards new or improved pain therapies

This new understanding could lead to potential advances in pain therapy, the researchers said. Moreover, the scientists envision that their method may be potentially useful in studying the activation mechanism of other drugs and proteins. "Because our ability to sense temperature is closely linked to our ability to sense pain, it is not surprising that the misregulation of temperature-act...

New study reveals promising osteoporosis treatment

A New York University College of Dentistry professor has developed a calcium phosphate-based supplement that -- even at low concentrations -- significantly improves bone strength and thickness without the side effects of many current drug treatments. Dr. Racquel Z. LeGeros, a Professor of Biomaterials and Biomimetics and of Implant Dentistry, presented her research on the supplement at the Americ...

Study reveals classic symbiotic relationship between ants, bacteria

Ants that tend and harvest gardens of fungus have a secret weapon against the parasites that invade their crops: antibiotic-producing bacteria that the insects harbor on their bodies. Writing today in the journal Science, an international team led by University of Wisconsin-Madison bacteriologist Cameron Currie illustrates the intricate and ancient nature of this mutualistic relationship....

Fruit fly reveals a potential connection between dementia and cancer

By expressing a protein associated with Alzheimer's disease in the brain of the fruit fly, researchers have demonstrated an intriguing link between neuronal death and proteins previously associated with cancer. Neurons in the brai...

Enzyme crystal structure reveals 'unexpected' genome repair functions

The study is being published in an advance online version of the journal Molecular Cell. The research looked at XPB helicase from an archaea, a single cell organism similar to bacteria. Helicases are enzymes that unwind or separate the strands of the nucleic acid double helix, an action that is critical to transcription and nucleotide excision repair (NER), as well as other cell processes...

Amber reveals ecology of 30 million year old spiders

Scientists at The University of Manchester and the Manchester Metropolitan University have carried out the first comparative scientific study of ancient spiders trapped in amber more than 30 millions years ago. The study of fossilised spiders from the Baltic (Poland) and the Dominican (Caribbean) regions has revealed new insights into the ecologies of spiders dating back to the Cenozoic pe...