Revea

Elusive HIV shape change revealed; Key clue to how virus infects cells

Structural biologists at Children's Hospital Boston and Harvard Medical School have shown how a key part of the human immunodeficiency virus (HIV) changes shape, triggering other changes that allow the AIDS virus to enter and infect cells. Their findings, published in the Feb. 24 issue of the journal Nature, offer clues that will help guide vaccine and treatment approaches. Researchers led...

Timing is everything: First step in protein building revealed

Timing is everything, it seems, even inscience. A team led by Johns Hopkins scientists has unraveled the firststep in translating genetic information in order to build a protein,only to find that it's not one step but two.In a series of experiments, the scientists found that when yeast'sprotein-building machinery recognizes the starting line for a gene'sinstructions, it first alters its str...

NYU Study Reveals How Brain's Immune System Fights Viral Encephalitis

New York University biologists have uncovered how the innate immune system in mice's brains fights viral infection of neurons. The findings, published as the cover study in the latest issue of Virology, show that proteins in neurons fight the virus at multiple stages--by preventing the formation of viral RNA and proteins, and blocking the virus' release, which could infect other cells in the brai...

Researchers reveal the infectious impact of salmon farms on wild salmon

A new study published in the March 30th edition of the prestigious scientific journal Proceedings of the Royal Society B (a publication of the UK's national academy of science) shows that the transfer of parasitic sea lice from salmon farms to wild salmon populations is much larger and more extensive than previously believed. This quantitative analysis of parasite transfer is a scientific...

A bacterial genome reveals new targets to combat infectious disease

More than a billion people are at risk for infection with filarial nematodes, parasites that cause elephantiasis, African river blindness, and other debilitating diseases in more than 150 million people worldwide. The nematodes themselves play host to bacteria that live within their cells, but in this case, the relationship is classic mutualism, with each benefiting from the other. Indeed, the Wo...

Needling Chromosomes Reveals Cell Division Secret

By impaling individual chromosomes with glassneedles one thousandth the diameter of a human hair, a Duke Universitygraduate student has tested their "stickiness" to one another duringcell division. Her uncanny surgical skills have added a piece to thelarge and intricate puzzle of how one cell divides into two -- aprocess fundamental to all organisms.In the Dec. 14, 2004, issue of Current Bi...

Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

As you read this, cells in your eye are transmitting information to your brain, while cells in your heart and arteries work just as hard to keep that brain alive. Every one of these cells -- and others throughout the body -- depends on an internal process called endocytosis to keep the flow of cellular nutrients and information healthy and strong. It's an incredibly important life process,...

Scientists reveal molecular secrets of the malaria parasite

In an innovative project with implicationsfor malaria vaccine development, scientists have used genomics,proteomics and gene expression studies to trace how malaria parasitesevolve on a molecular level as they move between their hosts and insectvectors.That focus on the parasites' complex life cycle is helping researchersunderstand when different genes switch on and off as the pathogensmet...

Studies reveal methods viruses use to sidestep immune system

A series of studies by researchers at UT Southwestern Medical Center sheds light on the mechanisms used by viruses to thwart a host's immune defenses and may aid in the development of more effective drugs to fight hepatitis C and West Nile viruses, as well as the flu and the common cold. In a study to appear in a March issue of the Journal of Virology and currently available online, UT So...

First real-time view of developing neurons reveals surprises, say Stanford researchers

Scientists have believed that neurons need a long period of fine-tuning and training with other neurons before they take on their adult role. But after using new technology for the first time to watch these cells develop, a team of researchers at the Stanford University School of Medicine found that neurons come into this world with a good idea about what they'll become as adults. The work...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

Gastric and colorectal cancers account for more than 1 million deaths worldwide every year and several research groups have been working to identify the molecular events that result in the initiation and progression of these tumors. It has been established that interfering with the function of one gene, called Adenomatous Polyposis Coli (APC) has a profound effect on the cells lining the innermos...

Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

First-of-its-kind analysis published in the Feb. 8 PNAS supports the concept of a basic wiring diagram for all eukaryotes. Researchers in California, Israel, and Germany have compared three distantly related species ?baker's yeast, a worm, and the fruit fly ?and reported that protein "wiring" connections in one species are often conserved in all three. This first-of-its-kind analysis of t...

Family trees of ancient bacteria reveal evolutionary moves

A geomicrobiologist at Washington University in St. Louis has proposed that evolution is the primary driving force in the early Earth's development rather than physical processes, such as plate tectonics. Carrine Blank, Ph.D., Washington University assistant professor of geomicrobiology in the Department of Earth & Planetary Sciences in Arts & Sciences, studying Cyanobacteria ?bac...

NYU study reveals how brain's immune system fights viral encephalitis

New York University biologists have uncovered how the innate immune system in mice's brains fights viral infection of neurons. The findings, published as the cover study in the latest issue of Virology, show that proteins in neurons fight the virus at multiple stages--by preventing the formation of viral RNA and proteins, and blocking the virus' release, which could infect other cells in the brai...

Iron exporter revealed that may explain common human disorder

The first direct evidence that a single protein is critical in the cellular export of iron may help to explain human hemochromatosis, researchers report in the March issue of Cell Metabolism. Hemochromatosis--which affects one in every 200 to 300 people in Western populations --causes tissues of the body to become overloaded with iron. Left untreated, the hereditary disease can lead to org...

Birds brains reveal source of songs

Scientists have yearned to understand how the chirps and warbles of a young bird morph into the recognizable and very distinct melodies of its parents. Neuroscientists at the McGovern Institute for Brain Research at MIT now have come one step closer to understanding that process. They've shown for the first time how a particular brain region in birds serves as the source of vocal creativity....

Study reveals new technique for fingerprinting environmental samples

Groundbreaking research led by the U.S. Department of Energy Joint Genome Institute (DOE JGI) demonstrates for the first time that the signatures of the genes alone in terrestrial and aquatic samples can accurately diagnose the health of the sampled environments. This study, published in the April 22nd edition of the journal Science positions large-scale genome sequencing to accelerate advances i...

Brain Scans Reveal How Gene May Boost Schizophrenia Risk

Clues about how a suspect version of a gene may slightly increase risk for schizophrenia* are emerging from a brain imaging study by the National Institutes of Health's (NIH) National Institute of Mental Health (NIMH). The gene variant produced a telltale pattern of activity linked to production of a key brain messenger chemical. The study found that increased activity in the front of the...

Study reveals dramatic difference between breast cancers in US and Africa

A study comparing, for the first time, breast cancers from Nigeria, Senegal and North America has found that women of African ancestry are more likely to be diagnosed with a more virulent form of the disease than women of European ancestry. Researchers from the University of Chicago, working with colleagues at the University of Calabar in Nigeria and the University of North Carolina, foun...

UCSD research reveals mechanism involved with type of fatal epilepsy

Researchers at University of California, San Diego (UCSD) have found that Lafora disease, an inherited form of epilepsy that results in death by the age of 30, can be caused by mutations in a gene that regulates the concentration of the protein laforin. These findings are reported in the current issue of Proceedings of the National Academy of Sciences (PNAS). Lafora disease is characterize...

Study reveals candidate targets for anti-retroviral therapeutics

The increased frequency of drug resistance in isolates of the AIDS virus, HIV, makes identification of new antiviral targets an urgent necessity. Host genes required to support the replication of HIV are a potential source of such novel targets, but relatively few appropriate target genes have been identified in animal cells thus far. A new study, conducted by Dr. Suzanne Sandmeyer and colleagues...

Scientists reveal the shape of a protein that helps retroviruses break into cells

The biggest mass extinction in Earth history some 251 million years ago was preceded by elevated extinction rates before the main event and was followed by a delayed recovery that lasted for millions of years. New research by two University of Washington scientists suggests that a sharp decline in atmospheric oxygen levels was likely a major reason for both the elevated extinction rates and the v...

Chimp genome reveals a retroviral invasion

It's been known for a long time that only 2% -- 3% of human DNA codes for proteins. Much of the rest of our genomes -- often referred to as junk DNA -- consists of retroelements: genomic elements that are transcribed into RNA, reverse-transcribed into DNA, and then reinserted into a new spot in the genome. Human endogenous retroviruses make up one class of these retroelements. Retroviruses can in...

Research Reveals Functions Of Harmful Shellfish Pathogens

Providing safer shellfish is the goal of Agricultural Research Service (ARS) scientists who are studying the means by which pathogenic bacteria enter shellfish. In the United States, two pathogenic bacteria from the genus Vibrio are of concern: V. vulnificus and V. parahaemolyticus. These bacteria are naturally found in shellfish and seawater, particularly when water temperatures are warm,...

NASA probe could reveal comet life, scientists claim

Cardiff (UK) scientists are playing a major role in a NASA mission, which they believe could reveal living matter in the icy layers beneath the surface of a comet. NASA's Deep Impact spacecraft will make a historic encounter with Comet Tempel-1 on 4th July, when a metre-long projectile will crash into the comet and tunnel through its outer layers, producing a crater and a plume of gas and...

Survey reveals women and doctors aren't talking about HPV

Eighty-eight percent of women rely on their healthcare providers to learn about gynecological issues, yet only 19 percent said their doctor has talked to them about cervical cancer and its cause - the human papillomavirus (HPV) - according to a new survey released by the Association of Reproductive Health Professionals (ARHP). HPV is extremely common, affecting an estimated 80 percent of sexually...

Researchers reveal secrets of flying snakes

It seems size does matters after all. But for flying snakes, smaller is better, according to University of Chicago researchers. "Despite their lack of wing-like appendages, flying snakes ar...

Researchers reveal secret of key protein in brain and heart function

Brown University biologists have solved the structure of a critical piece of synapse-associated protein 97 (SAP97) found in abundance in the heart and head, where it is believed to play a role in everything from cardiac contractions to memory creation. Results are published in The Journal of Biological Chemistry. Dale Mierke, associate professor of medical science at Brown, said that knowi...

Vitamin A's paradoxical role in influencing symmetry during embryonic development revealed

In this week's journal Nature, scientists at the Salk Institute for Biological Studies report that they have solved one of the "holy grail" puzzles of developmental biology: the existence of a mechanism that insures that the exterior of our bodies is symmetrical while inner organs are arranged asymmetrically. In research with zebra fish, as a model for human biology, Juan-Carlos Belmonte a...

Brain Scan Study of Smokers Reveals Signature of Craving

Not all smokers are alike when it comes to cravings, and a new study conducted by researchers at Duke University Medical Center suggests the difference may lie in their brains' sensitivity to drug cues. The researchers found that smokers who report a greater urge to smoke after a period of abstinence also exhibit stronger brain activity after viewing smoking-related images, such as others smoking...

Malaria mechanism revealed

By determining the molecular structure of a protein that enables malaria parasites to invade red blood cells, researchers have uncovered valuable clues for rational antimalarial drug design and vaccine development. The findings are reported in the July 29 issue of the journal Cell. Malaria causes approximately 400 million clinical cases and 2 million deaths annually, with more than 80% of...

Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine

Two studies by researchers at the University of Chicago show how the bacteria that cause the plague manage to outsmart the immune system and how, by slightly altering one of the microbe's tools, the researchers produced what may be the first safe and effective vaccine. Both papers -- one published online July 28 in Science Express and one in the August issue of Infection and Immunity -- fo...

Improved statistical tools reveal many linked loci

An innovative new statistical method, described in the open-access journal PLoS Biology, streamlines the computation required to identify all the potential locations in the genome that influence a particular physical trait, or phenotype. Thanks to the new method developed by John Storey, Joshua M. Akey, and Leonid Kruglyak, researchers have a more efficient genome-mining technique to help them id...

Camera Traps Reveal Rare Asiatic Cheetahs

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Bioinformatics reveals new gene regulation system

By comparing 140 sequenced bacterial genomes, researchers have uncovered a system for regulating genes essential to bacterial replication ?and they did it solely by computer keystrokes and mouse clicks. Mikhail Gelfand, a Howard Hughes Medical Institute international research scholar at the Institute for Information Transmission Problems (IITP) in Moscow, and his postdoctoral fellow, Dmit...

Scientists reveal how disease bacterium survives inside immune system cell

New research on a bacterium that can survive encounters with specific immune system cells has strengthened scientists' belief that these plentiful white blood cells, known as neutrophils, dictate whether our immune system will permit or prevent bacterial infections. A paper describing the research was released today online in The Journal of Immunology. Frank R. DeLeo, Ph.D., of Rocky Mountain Lab...

Field of beams - Novel system uses polarized light pulses to reveal crop health

Mathematical models have become invaluable decision-making tools for public health officials. As demonstrated during the United Kingdom's foot-and-mouth epidemic of 2001, models can be useful in two ways: they can reveal the underlying characteristics of an infection and they can allow the comparison of alternative control measures. Often, however, such models make implicit assumptions that may s...

New tool reveals secrets of migrating cells

Called two-photon laser-scanning microscopy, it has revealed, for...

How satellite tracking revealed the migratory mysteries of endangered Atlantic loggerhead turtles

Their journeys are among the longest in the animal kingdom and they have largely remained a mystery until now. An international team of scientists led by the University of Exeter have uncovered the migratory secrets of endangered loggerhead turtles in West Africa and the results could have huge implications for strategies to protect them. In a paper in the journal Current Biology, Dr Brend...

Genetic study of Neanderthal DNA reveals early split between humans and Neanderthals

In the most thorough study to date of the Neanderthal genome, scientists suggest an early human-Neanderthal split. The two species have a common ancestry, say the authors, but do not share much else after evolving their separate ways. The study, published in this week's issue of Science, also finds no evidence of genetic admixture between Neanderthals and humans. The study helps to explain...