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Response in Biological News

Early detection and quick response are key to defense against anthrax attack

NEW YORK (July 24, 2009) -- A large attack on a major metropolitan area with airborne anthrax could affect more than a million people, necessitating their treatment with powerful antibiotics. A new study finds that in order for a response to be effective, quick detection and treatment are essentia...

Strong immune response to new siRNA drugs in development may cause toxic side effects

New Rochelle, NY, May 20, 2009Small synthetic fragments of genetic material called small interfering RNA (siRNA) can block production of abnormal proteins; however, these exciting new drug candidates can also induce a strong immune response, causing toxic side effects. Understanding how siRNA stim...

Tumor growth and chemo response may be predicted by mathematical model

The aggressiveness of tumors and their susceptibility to chemotherapy may become easier to predict based on a mathematical model developed at The University of Texas Health Science Center at Houston. In spite of extensive experimental and clinical studies, the process of cancer growth is not we...

HudsonAlpha investigator develops rapid response swine flu test

Huntsville, Ala. Dr. Jian Han, faculty investigator at the HudsonAlpha Institute for Biotechnology, has completed development of a rapid response, molecular-level assay for swine flu, the current strain of the H1N1 family of the influenza virus. The test, which can confirm swine flu in less than ...

Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer

DENVER, CO and AUCKLAND, NZ (April 21, 2009) MIS416, a novel microparticle-based immune response modifier, demonstrated the ability to significantly reduce the number and size of metastatic tumors in preclinical mouse models of lung and breast cancers, Innate Therapeutics (formerly Virionyx Corpo...

Early isolation linked to enhanced response to cocaine

NEW ORLEANSDrug addiction affects millions of people around the world, causing numerous problems ranging from emotional and psychological difficulties to physical and health issues. Initial drug use can be motivated by curiosity or peer pressure, but in some animals, such as rats, it can also be t...

Early isolation linked to enhanced response to cocaine

NEW ORLEANSDrug addiction affects millions of people around the world, causing numerous problems ranging from emotional and psychological difficulties to physical and health issues. Initial drug use can be motivated by curiosity or peer pressure, but in some animals, such as rats, it can also be t...

New evidence explains poor infant immune response to certain vaccines, says MU researcher

COLUMBIA, Mo. For years, researchers and physicians have known that infants' immune systems do not respond well to certain vaccines, thus the need for additional boosters as children develop. Now, in a new study from the University of Missouri, one researcher has found an explanation for that poo...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

Cold Spring Harbor, N.Y. Being able to accurately predict how a given cancer will respond to chemotherapy would spare patients with non-responsive tumors the burden of undergoing toxic and ultimately unhelpful treatment. Just as important, knowing which of a patient's cancer-causing genetic lesi...

DNA repair mechanisms relocate in response to stress

Like doctors making house calls, some DNA repair enzymes can relocate to the part of the cell that needs their help, a collaborative team of scientists at Emory University School of Medicine has found. The signal that prompts relocation is oxidative stress, an imbalance of cellular metabolism c...

A paradigm shift in immune response regulation

Over the past decade various pieces of the puzzle how signal transmission controls immunity have been coming together. Now, in Cell an international team reports a paradigm shift in the regulation of immune response. Their results show that interaction with a linear ubiquitin chain is crucial fo...

Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet

COLUMBUS, Ohio Scientists have determined that a specific gene plays a role in the weight-gain response to a high-fat diet. The finding in an animal study suggests that blocking this gene could one day be a therapeutic strategy to reduce diet-related obesity and associated disorders, such as ...

Molecule that suppresses immune response under study in type 1 diabetes

AUGUSTA, Ga. - The idea is to teach the immune system of children at high risk for type 1 diabetes not to attack the insulin-producing cells of the pancreas. "We want to create a no-go zone," said Dr. Andrew Mellor, immunologist who directs the Medical College of Georgia Immunotherapy Center. T...

Scattered light rapidly detects tumor response to chemotherapy

DURHAM, N.C. -- New technology developed by Duke University bioengineers can help clinicians more precisely detect whether specific cancer drugs are working, and should give basic researchers a powerful new tool to better understand the underlying mechanisms of cancer development. By interpreti...

Top scientific meeting urges coordinated response to economic and environmental crises

A fix for the economy must address ecological threats, a top international scientific meeting here has urged. Human society is moving dangerously beyond the planet's natural limits in a striking parallel to the financial debt crisis. "We're running the planet like a subprime loan," Dr. Johan Rocks...

How eating fruit and vegetables can improve cancer patients' response to chemotherapy

RIVERSIDE, Calif. The leading cause of death in all cancer patients continues to be the resistance of tumor cells to chemotherapy, a form of treatment in which chemicals are used to kill cells. Now a study by UC Riverside biochemists that focuses on cancer cells reports that ingesting apigeni...

Forsyth scientists trigger cancer-like response from embryonic stem cells

Boston--Scientists from The Forsyth Institute, working with collaborators at Tufts and Tuebingen Universities, have discovered a new control over embryonic stem cells' behavior. The researchers disrupted a natural bioelectrical mechanism within frog embryonic stem cells and trigged a cancer-like r...

Millisecond brain signals predict response to fast-acting antidepressant

Images of the brain's fastest signals reveal an electromagnetic marker that predicts a patient's response to a fast-acting antidepressant, researchers have discovered. "Such biomarkers that identify who will benefit from a new class of antidepressants could someday minimize trial-and-error pres...

Early parenting plays key role in infants' physiological response to stress

In infancy, genes are the key influence on a child's ability to deal with stress. But as early as 6 months of age, parenting plays an important role in changing the impact of genes that may put infants at risk for responding poorly to stress. That's the message from a new study by researchers a...

Individuals vary their immune response according to age, sex and the costs

Is it always good to respond maximally when pathogens or disease strike, or should individuals vary their immune response to balance immediate and future costs? This is the question evolutionary physiologists Oliver Love, Katrina Salvante, James Dale, and Tony Williams asked when they examined how...

Infection blocks lung's protective response against tobacco smoke

An infection that often goes undetected can block the lung's natural protective response against tobacco smoke, according to researchers at National Jewish Health. The findings, recently published online and scheduled to appear in the October issue of Infection and Immunity, suggest one mechanis...

Blood pressure response to daily stress provides clues for better hypertension treatment

How the body regulates blood pressure in response to daily stress is the focus of a study geared toward helping people whose pressure is out of control. "Research shows that two-thirds of patients' high blood pressure is not controlled despite the best efforts of their doctors. That is terribl...

Humans' response to risk can be unnecessarily dangerous, finds Tel Aviv University study

The traffic light ahead of you is turning yellow. Do you gun the engine and speed through the intersection, trusting that others will wait for their green, or do you slow down and wait your turn? That depends more on experience than personality, according to new research from Tel Aviv Universit...

Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway

Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the efficacy of imiquimod, a clinically important immune response modifier with potent antiviral and antitumor activity, is dependent on the Opioid Growth Factor (OGF)-OGF receptor (OGF...

Scattered nature of Wisconsin's woodlands could complicate forests' response to climate change

MADISON - If a warmer Wisconsin climate causes some northern tree species to disappear in the future, it's easy to imagine that southern species will just expand their range northward as soon as the conditions suit them. The reality, though, may not be nearly so simple. A model developed by Uni...

Emergency response and nanotechnology

Learning from Past Emergency Response In a special session running all day Wednesday, presenters will share lessons learned during past incidents involving emergency evacuations, including some involving radiation releases, and the ensuing emergency response (some involving radiation). Presente...

Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer

This release is available in Spanish . Cancer is a disease characterised by important metabolic alterations. Not only these adaptative changes give higher proliferative capacity to cancer cells, but they also contribute to higher resistance to chemotherapeutic agents. The research group led...

Herceptin and chemo improves response rates without major adverse effects in HER2 breast cancer

Berlin, Germany: Women with a particularly aggressive form of breast cancer seem to do better if they are treated with a combined anthracycline and taxane chemotherapy regimen before surgery, together with trastuzumab (Herceptin) before and after surgery, according to results from the largest mult...

Yale scientists create artificial 'cells' that boost the immune response to cancer

New Haven, Conn. Using artificial cell-like particles, Yale biomedical engineers have devised a rapid and efficient way to produce a 45-fold enhancement of T cell activation and expansion, an immune response important for a patients ability to fight cancer and infectious diseases, according to an...

'Nonlinear' ecosystem response points to environmental solutions

CORVALLIS, Ore. The preservation of coastal ecosystem services such as clean water, storm buffers or fisheries protection does not have to be an all-or-nothing approach, a new study indicates, and a better understanding of how ecosystems actually respond to protection efforts in a nonlinear fashi...

Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity

Philadelphia, PA, January 8, 2008 Schizophrenia is a developmental disorder with a large genetic component contributing to increased risk. Available antipsychotic medications treat some of the symptoms of schizophrenia, but are typically effective in only a subset of patients. Unfortunately, it...

Cell response to stress signals predicts tumors in women with common pre-breast cancer

A specific biological response to cellular stress may predict the likelihood of future tumor formation of the most common, non-invasive form of pre-malignant breast cancer-- ductal carcinoma in situ, or DCIS. This information could potentially be used in a clinical setting to determine which ...

Triage study challenges notions of emergency medical response to disaster

NEW YORK (Oct. 31, 2007) -- In the face of terrorism and catastrophic natural disasters, modern regional trauma systems that improve survival for critically injured patients are more vital than ever. Yet many fundamental assumptions underlying these systems -- such as the notion that it is im...

Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas

Researchers have found that vaccination against influenza strains seem to be more effective in a semi-urban population than in a rural population of schoolchildren in Gabon, Africa, according to an article in the Journal of Infectious Diseases, published by the University of Chicago Press in partn...

Agent that triggers immune response in plants is uncovered

Although plants lack humans' T cells and other immune-function cells to signal and fight infection, scientists have known for more than 100 years that plants still somehow signal that they have been attacked in order to trigger a plantwide resistance. Now, researchers at the Boyce Thompson Institu...

UVA researchers explain cell response to skin-damaging UV rays

CHARLOTTESVILLE, Va., Oct. 1, 2007 -- Its well known that overexposure to ultraviolet rays from the sun can cause major skin problems, ranging from skin cancer to sunburns and premature wrinkles. A tan, for example, is natures own UV protection and an unhealthy sign that your skin is damaged. ...

Auto immune response creates barrier to fertility; could be a step in speciation

Plant biologists at the Max Planck Institute of Developmental Biology and the University of North Carolina at Chapel Hill have discovered that an autoimmune response, triggered by a small number of genes, can be a barrier to producing a viable offspring. Studying Arabidopsis thaliana, sometimes...

Key to out-of-control immune response in lung injury found

Researchers at the University of Illinois at Chicago College of Medicine have discovered how a protein modulates the inflammatory response in sudden, life-threatening lung failure. The protein's previously unknown role is reported in the August issue of Nature Medicine. Acute Respiratory Distr...

The right messenger for a healthy immune response

Researchers from the Molecular Immunology group at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany have now shown that Beta-Interferon also plays a crucial role during an immune response: without Beta-Interferon immune cells are unable to show "wanted posters" of pathoge...

For cancer cells, genetics alone is poor indicator for drug response

BOSTON, Mass. (April 12, 2009) In certain respects, cells are less like machines and more like people. True, they have lots of components, but they also have lots of personality. For example, when specific groups of people are studied in aggregate (conservatives, liberals, atheists, evangelicals)...
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