Rejection in Biological News

Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants

CINCINNATI Screening for mutations in a gene that helps the body metabolize a kidney transplant anti-rejection drug may predict which children are at higher risk for side effects, including compromised white blood cell count or organ rejection, according to new research. Published online Feb. ...

Female plant 'communicates' rejection or acceptance of male

COLUMBIA, Mo. Without eyes or ears, plants must rely on the interaction of molecules to determine appropriate mating partners and avoid inbreeding. In a new study, University of Missouri researchers have identified pollen proteins that may contribute to the signaling processes that determine if a...

Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection

After several years of battling recurring infections, the last thing a patient and her doctors ever expected was that the cause of her problems might actually help millions live longer, more active lives. Now, researchers have high hopes because Edward Goetzl and his colleagues from the University...

Embryonic stem cells might help reduce transplantation rejection

Researchers have shown that immune-defense cells influenced by embryonic stem cell-derived cells can help prevent the rejection of hearts transplanted into mice, all without the use of immunosuppressive drugs. The University of Iowa and the Iowa City Veterans Affairs (VA) Medical Center finding...

Children's Hospital researchers identify genetic mutation that may predict organ rejection

Using a novel combination of cutting-edge technologies to scan the human genome, researchers at Children's Hospital of Pittsburgh of UPMC have identified a genetic mutation that identifies transplant recipients who experience rejection. Known as a single nucleotide polymorphism (SNP), the genet...

Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level

Carnegie Mellon University scientist Chien Ho and his colleagues have developed a promising tool that uses magnetic resonance imaging (MRI) to track immune cells as they infiltrate a transplanted heart in the early stages of organ rejection. This pre-clinical advance, described in an upcoming issue...

New type of rejection blocker protects kidneys after transplant

In an international clinical trial, a new drug that selectively blocks immune responses has proved as effective in preventing acute kidney transplant rejection as cyclosporine, the standard anti-rejection treatment. Patients who took the experimental drug, a co-stimulatory blocker called belatac...

Can a new implant coating technique create a new six million dollar man?

... vastly improve the lives of people who have undergone complicated total joint replacement surgeries so they can better walk, run and ultimately avoid rejection of the implant by their bodies. "The surface chemistry, structure and morphology of our new coatings resemble biological material," explains Prof....

GARP makes the difference

...al role of the GARP protein. Until now, scientists had only little distinguishing features to aid them in separating T cells that trigger a transplant rejection from those that inhibit such a reaction: they mainly looked at molecular features that both cell types have the one more, the other less. "It's like ...

Rutgers research tackles childhood epilepsy

... dysplasia, a malformation of the brain that is most often the cause of childhood epilepsy. Introducing the drug rapamycin, originally used to prevent rejection in organ transplants, suppressed epileptic seizures in the mice. Epilepsy is the third most common neurological disorder in the United States after...

Novel antibody prevents infection by hepatitis C virus

...d-stage liver failure are not routinely used during surgery due to the patients' weakened condition and because of the strong medication used to avoid rejection of the new liver. After re-infection with HCV, nearly 40 percent of patients suffer rapid liver failure. To close that clinical gap, the new antibo...

Joint statement by German science organizations on green genetic engineering

...hat the ban is an isolated decision on a particular case, not a fundamental rejection of green genetic engineering. Europe's highest licensing authority, the EFS...ld even remotely suggest the need to abandon the technology. A complete rejection of green genetic engineering would do lasting damage to Germany as a locati...

World premiere in stem cell research in Montreal

...cipients are condemned to take medications against rejection of the transplanted organ and suffer the side effe...howing that bone marrow stem cells can prevent the rejection typically directed against solid organs," Dr. Sauvageau said. rejection occurs because the immune system cells manufacture...

Stem cell therapy makes cloudy corneas clear, according to Pitt researchers

... PITTSBURGH, April 9 Stem cells collected from human corneas restore transparency and don't trigger a rejection response when injected into eyes that are scarred and hazy, according to experiments conducted in mice by researchers at the University of Pittsburgh ...

Ambati study published in PNAS

...hatic vessels. In fact, the formation of lymphatic vessels after corneal transplantation is purported to be a major mechanism through which transplant rejection occurs. Ambati's lab found that corneal injections of siRNA suppressed both blood and lymphatic vessel growth via endothelial cell toxicity. Won Gi...

'Seeing' stem cells helps in fight against peripheral arterial disease

...ransplanting stem cells derived from bone marrow (not embryonic stem cells), accompanied by necessary immune-suppressing drugs, has had mixed results. rejection by the body's immune system is a likely reason for transplant failure. Because X-ray agents are toxic to stem cells, tracking of stem cell therapy can...

Researcher seeks to turn stem cells into blood vessels

... of new blood vessels. They possess another advantage: If the adult cells are taken from the patient who will ultimately receive the treatment, tissue rejection is unlikely. But adult stem cells have drawbacks as well: They are more difficult to isolate and cannot easily be made to multiply in the lab. Ger...

Researchers explore new driver of transplant rejection: Platelets

...ransplant patients in the long run because chronic rejection as contrasted with acute or immediate organ rejection is a major complication for which there is little...s new opportunities for attacking organ injury and rejection head-on, says Rabb. The traditional target of curr...

Molecule that suppresses immune response under study in type 1 diabetes

...or. A team of MCG scientists led by Drs. Mellor and Munn showed in research published in Science in 1998 that the fetus expresses IDO to help avoid rejection by the mother's immune system. They also are exploring its therapeutic potential in transplantation and cancer. ...

Researchers engineer pancreatic cell transplants to evade immune response

...tes, recipients must take immunosuppressant medications in order to prevent rejection of these beta foreign cells. "Ultimately, even with immunosuppressive ther...rate that genetically engineered beta cells can be made highly resistant to rejection and can basically correct diabetes. This technique could conceivably be app...

Attitudes towards assisted reproduction and preimplantation genetic diagnosis

...ose the sex of a future baby meets with widespread rejection (mean score below 4 points). The data that foll...nant meets with more divided opinions, though with rejection predominating in most societies. Mean values stood...tion to choose the sex of a baby provokes outright rejection in all the countries analyzed (mean score below 3 ...

Children's Hospital scientists achieve repair of injured heart muscle in lab tests of stem cells

...sy from his or her muscle, isolate and purify the myoendothelial cells, and re-inject them into the injured heart muscle, thereby avoiding any risk of rejection by introducing foreign cells." Results of this study are published in the Dec. 2 issue of the Journal of the American College of Cardiology . T...

Adult stem cell breakthrough

...shows it is possible to produce a tissue-engineered airway with mechanical properties that permit normal breathing and which is free from the risks of rejection seen with conventional transplanted organs. The patient has not developed antibodies to her graft, despite not taking any immunosuppressive drugs. Lun...

TECNALIA investigates advanced biomaterials to make more reliable and hardwearing medical implants

...of the patient, in such a way that repeat surgical operations are avoided; the reliability and the integration of the implants are enhanced and tissue rejection avoided; the recuperation times for patients are significantly cut and the implants are operational in a minimum time; the state and progress of the i...

Parkinson's Disease Foundation announces award of $150,000

... "personalized regenerative therapy" for Parkinson's disease. One benefit to 'personalized' cell treatment is that it would avoid the issue of immune rejection that can be found with other stem cell therapies. Dr. Emborg noted, "With funding from PDF, we can conduct preliminary investigations that should...

Heart valves that grow with the patient

...ined from the blood of the recipient and propagated. Within a few weeks, a quasi-natural heart valve then emerges in this bioreactor, that exhibits no rejection response or other faults, but instead grows with the patient after the implantation. The foundation for this innovation in medicine and medical tec...

Stem cell research to benefit horse owners and trainers

...ll be no risk of horses rejecting the tissue generated from the stem cells. Dr Irina Polejaeva, ViaGen's Chief Scientific Officer, said the risk of rejection will be overcome because the cells generated are genetically identical to the horse receiving treatment. Dr John van Veenendaal, specialist equine ...

Nanoscale coating protect products -- and the economy

...conditions within the human body that can cause hairline cracks to form in heart valves or holes in artificial joints, for example, preventing implant rejection or failure. Relying on 'Dorothy' Achieving the right characteristics for these protective coatings depends on choosing the right combination o...

Multiple disease-related research gets green light from the NIH

...mal activation of blood coagulation pathways causes damage to the body. The diseases include multiple sclerosis (MS), rheumatoid arthritis, transplant rejection and sepsis, a leading cause of hospital deaths. In particular, Dr. Smiley's laboratory is studying fibrin, a blood-clotting protein that frequently ac...

Human embryonic stem cell secretions minimized tissue injury after heart attack

.... Unlike the more common approach of directly administering stem cells for therapy, this new method carries negligible risk of tumour formation or rejection by the body. In the pig research model, this approach minimised heart injury after a heart attack, a particularly important consideration since...

Loneliness undermines health as well as mental well-being

...niversity of Chicago shows. The studies, reported in a new book, Loneliness: Human Nature and the Need for Social Connection, show that a sense of rejection or isolation disrupts not only abilities, will power and perseverance, but also key cellular processes deep within the human body. The findings su...

Researchers devise means to create blood by identifying earliest stem cells

...k in humans, it would allow patients getting bone marrow transplants to have their own stem cells creating the blood they need, significantly reducing rejection risk. ...

Mate choice in plants

... the style ECM where recognition and acceptance or rejection of the pollen takes place. Compatible pollen tub... ECM and the pollen are needed for recognition and rejection or acceptance. The most widespread SI system ...n S-RNase and SLF, by itself is not sufficient for rejection of incompatible pollen. Other factors not linked ...

New VeriEye SDK from Neurotechnology Enables Development of Reliable, Cost-effective Biometric Iris Recognition Systems

...logy's VeriEye iris recognition algorithm achieved the following results at a matching speed of 50,000 iris templates per second: -- 0.11% False rejection Rate (FRR) at a False Acceptance Rate (FAR) of 0.1% -- 0.16% FRR at FAR=0.01%, and -- 0.33% FRR at FAR=0%. These are the best known results eve...

Drug reverses mental retardation caused by genetic disorder

...he findings in its online June 22 edition. Using a mouse model for TSC, the scientists tested rapamycin, a drug approved by the FDA to fight tissue rejection following organ transplants. Rapamycin is well-known for targeting an enzyme involved in making proteins needed for memory. The UCLA team chose it b...

Engineer develops detergent to promote peripheral nerve healing

...y of Texas at Austin that treats donor nerve grafts to circumvent an immune rejection response has been used to create acellular nerve grafts now used successful...nerve is stripped of the cellular lipid components, which causes the immune rejection response when implanted. Schmidt's laboratory spent four years developing t...

Livermore researchers use carbon nanotubes for molecular transport

... than a human hair, and were able to determine the rejection mechanism within the pores. "Hydrophobic, narro...t the ions and the team was able to understand the rejection mechanism. "Our study showed that pores with a ...hile carbon nanotube membranes can achieve similar rejection as membranes with similarly sized pores, they will...

BBVA Foundation international study on attitudes to stem cell research

...e scale) while remaining countries were all in the rejection zone. CREATION OF HYBRID EMBRYOS Faced wit...ies. The baseline scenario meets with attitudes of rejection (below 5 on an acceptance scale from 0 to 10) in m...rges in Denmark, the Netherlands and Sweden, where rejection of the creation of hybrids appears to have less to...

UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells

...sing gene and then re-inserting the cells back into the same person. This treatment eliminates the complications of graft-versus-host disease or host rejection that can occur in allogeneic transplants (therapy where the cell donor is different from the recipient). In the current study, 630 immunodeficient ...

US Patent Office rejects company's claim for bean commonly grown by Latin American farmers

... according to Mexican government sources. The patent office issued a preliminary decision in 2003 rejecting all the patent claims and gave a final rejection in December 2005. Proctor filed an appeal through the USPTO, and in accordance with USPTO rules, the patent remained in force while the appeal was bei...