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Regulatory in Biological News

Food counterfeiting, contamination outpace international regulatory systems

CHICAGO Intentionally contaminated Chinese milk killed several children and sickened 300,000 more, causing concern around an increasingly connected world economy. Demand for inexpensive products virtually guarantees future repeats of food adulteration and counterfeiting from overseas, Michigan St...

New data suggest 'jumping genes' play a significant role in gene regulatory networks

CHICAGO, IL--Research performed in the Center for Biomolecular Science & Engineering (CBSE) at the University of California, Santa Cruz, suggests that mobile repetitive elements--also known as transposons or "jumping genes"--do indeed affect the evolution of gene regulatory networks. David Haus...

Caltech researchers help unlock the secrets of gene regulatory networks

PASADENA, Calif.-- A quartet of studies by researchers at the California Institute of Technology (Caltech) highlight a special feature on gene regulatory networks recently published in the Proceedings of the National Academy of Sciences ( PNAS ). The collection of papers, "Gene Networks in De...

New regulatory mechanism discovered for cell identify and behavior in forming organs

CINCINNATI Two proteins interact in a previously unknown molecular mechanism that may have broad implications in future studies looking for the causes of defective organs in fetuses, metastatic cancers and other diseases, according to researchers at Cincinnati Children's Hospital Medical Center. ...

Use of nanomaterials in food packaging poses regulatory challenges

Washington, DC Engineered nanoscale materials (ENMs), which contain novel properties that offer potential benefits for use in food packaging, raise new safety evaluation challenges for regulators and industry, according to a report released today by the Project on Emerging Nanotechnologies (PEN) ...

Type 1 diabetes triggered by 'lazy' regulatory T-cells: McGill researchers

This release is also available in French . A research team led by Dr. Ciriaco A. Piccirillo of McGill Universitys Department of Microbiology and Immunology has discovered that in some individuals, the specialized immunoregulatory T-cells that regulate the bodys autoimmune reactions may los...

Master regulatory gene of epithelial stem cells identified

The skin’s ability to replace the tissue it sloughs off is controlled by a variety of genes. A new study from Harvard Medical School published in the May 4 issue of Cell, however, identifies a "master regulator" of this regeneration process not only for skin, but for many epithelial tissues includi...

Scripps research study shows humans and plants share common regulatory pathway

The study was published in an advance online edition of the Proceedings of the National Academy of Sciences during the week of April 9, 2007. The study provides new evidence that Nod1, a member of the Nod-like Receptor (NLR) protein family, is activated by the protein SGT1, which also activates R...

Novel regulatory mechanism identified for key tumor suppressor p53

Collaborating scientists from The Wistar Institute in Philadelphia and The Vienna Biocenter in Austria have identified a novel mechanism involved in normal repression of the p53 protein, perhaps the single most important molecule for the control of cancer in humans. The new molecular pathway des...

New methods offer insight into regulatory DNA

Through the Human Genome Project, the HapMap Project and other efforts, we are beginning to identify genes that are modified in some diseases. More difficult to measure and identify are the regulatory regions in DNA ?the 'managers' of genes ?that control gene activity and might be important in caus...

Key brain regulatory gene shows evolution in humans

Researchers have discovered the first brain regulatory gene that shows clear evidence of evolution from lower primates to humans. They said the evolution of humans might well have depended in part on hyperactivation of the gene, called prodynorphin (PDYN), that plays critical roles in regulating pe...

Smoking damages key regulatory enzyme in the lung

Study in Journal of Nuclear Medicine uses PET, radiotracer to track enzyme in smokers, nonsmokersRESTON, Va.-- Smoking appears to reduce a key enzyme in the lungs, possibly contributing to some of smoking's deleterious health effects, according to a study published in the September issue of the Jou...

Master regulatory gene found that guides fate of blood-producing stem cells

Researchers from the University of Pennsylvania School of Medicine found that a protein called NF-Ya activates several genes known to regulate the development of hematopoietic stem cells (HSC), or blood-producing stem cells, in bone marrow. Knowing the details of this pathway may one day lead to ne...

New technique helps identify multiple DNA regulatory sites

Just as the printing press revolutionized the creation of reading matter, a "nano-printing" technique developed at MIT could enable the mass production of nano-devices currently built one at a time. The most immediate candidate for this innovation is the DNA microarray, a nano-device used to dia...

OneWorld Health drug receives 'Orphan' designation from U.S. and European regulatory agencies

The Institute for OneWorld Health, the first nonprofit pharmaceutical company in the U.S., announced today it has received Orphan Drug Designation from the two leading regulatory agencies in the world, the Food and Drug Administration (FDA) and the European Agency for the Evaluation of Medicinal Pr...

White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role

A new research study identifies a critical inhibitory step that is a key component of the feedback circuit regulating the balance between neutrophil production and destruction. The research, published in the March issue of Immunity, suggests that the process for disposal of dying neutrophils is act...

Researchers rein in regulatory RNAs

A team of scientists led by Dr. Kuniya Abe from the RIKEN BioResource Center in Japan has performed one of the most comprehensive genome-wide experimental analyses of sense-antisense transcripts to date. Their findings are published in the April issue of the journal Genome Research. Sense-antisen...

White blood cell waste disposal system plays critical regulatory role

A new research study identifies a critical inhibitory step that is a key component of the feedback circuit regulating the balance between neutrophil production and destruction. The research, published in the March issue of Immunity, suggests that the process for disposal of dying neutrophils is act...

Carnegie donates landmark clones to biology

...e same mechanism at the cell membrane to regulate the uptake of the vital nutrient nitrogen. Previous Carnegie work indicated that plants have a novel regulatory mechanism that controls nutrient uptakeneighboring pore-like structures at a plant cell's surface physically interact to control the uptake. "Since pl...

Plankton Power and RTDC announce proposed algae-to-biofuels pilot facility on Cape Cod

...cres of land on the Massachusetts Military Reservation (MMR) in Bourne, Massachusetts, supported by the Massachusetts National Guard pending legal and regulatory reviews. The pilot facility will provide the required infrastructure for testing commercial scale-up of a breakthrough algae-growth technology resulti...

Common allergy drug reduces obesity and diabetes in mice

...he second study, researchers found that a kind of white blood cell called a regulatory T cell, once thought to manage only other white blood cells, also acts as a...oslin Diabetes Center discovered that a class of immune system cells called regulatory T cells, or Tregs, were abundant in the abdominal fat tissue of normal-weig...

Carnegie Mellon team makes sequestration recommendations

...hout new federal regulations that create a uniform regulatory environment. This is the conclusion of a set of ...to federal law and agency rules needed to overcome regulatory and legal barriers to large-scale deployment of ca...ial-scale facilities before finalizing many of the regulatory details. For this reason, developing an "adaptive ...

Iowa State University researchers develop process for 'surgical' genetic changes

...t regulations often slow the movement of research from the lab to the field. Wright and Townsend hope the precision of this technique will speed the regulatory process. "In the random process, regulators would say, 'You really don't know what you're doing,'" said Townsend. "With this new technology, we can ...

$20 million NIH grant to transform clinical research at UIC

.... To provide support for research, the center offers six "core" services: statistical design and analysis, clinical interface, biomedical informatics, regulatory support and advocacy, community engagement and research, and translational technologies and resources. The center includes educational programs fo...

22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey

...consultation meetings on specific topics, ECNP aims to facilitate the dialogue and exchange advice between the participating parties, i.e. scientists, regulatory authorities and the pharmaceutical industry. Invitation: meet the scientists! Experts will be available for questions by journalists in the cou...

Data published in the New England Journal of Medicine support use of raxibacumab (ABthrax) for the treatment of inhalation anthrax

...atment for inhalation anthrax in both rabbits and monkeys," said Sally D. Bolmer, Ph.D., R.A.C, lead author and Senior Vice President, Development and regulatory Affairs, HGS. "Raxibacumab acted quickly to provide a significant survival benefit to animals showing clinical signs of disease caused by exposure to...

Dietary supplements manufacturers gain new tool to help ensure quality products

...d ingredients. In addition to these standards, the DSC includes general and regulatory information, guidance documents, appendices, and macro/microscopy, thin lay...edient suppliers, dietary supplements manufacturers, contract laboratories, regulatory bodies and independent consultants to raise the quality of supplements and ...

Canadian researchers set to study impact of nanomaterials on aquatic ecosystems

...around the world are seeking solid scientific data upon which to base their regulatory standards," said Greg Goss, project co-leader and professor of biological s...es within our ecosystem, and inform and facilitate the development of sound regulatory policies in this area.The goal is to expedite the safe use of nanotechnolog...

Anti-biotech groups obstruct forest biotechnology

...trees, scientists argue in a new report. Steps must be taken to create a regulatory environment that considers genetically modified trees on a scientific, case...use of the enormous benefits, that industry has learned to wade through the regulatory maze and bureaucratic hurdles in a number of countries, including the Unite...

Stanford researchers publish comprehensive model for medical device development

...sophisticated devices that may be exempt from most regulatory requirements. The five major phases and decision g...e of the advent of advanced technologies, stricter regulatory requirements, and the increasing importance of rei...ved, and brought to market. The pace at which such regulatory requirements can be met determines when the device...

Trio of signals converge to induce liver and pancreas cell development in the embryo

...ance along the correct path is provided by genetic regulatory proteins that attach to chromosomes, marking part ... nucleus of every cell must be loosened a bit. The regulatory proteins help with this, exposing a small domain n...ly progenitor cells to activate genes encoding the regulatory proteins. The...

Phthalic symbol

...ng as priority pollutants by the US Environmental Protection Agency, the European Union, the China National Environmental Monitoring Centre, and other regulatory authorities. Weizhong Wu of the College of Environmental Sciences and Engineering, at Peking University, in Beijing, and Xianlin Meng of Harbin Ins...

Improved method developed to test carcinogen risk

... to assess the danger of some of the most common carcinogens in the world may be questionable. They may, or may not, be accurate. "In the past, our regulatory agencies have done the best they can with the data they have available," Bailey said. "The key is that now we have animal models that can far more acc...

Another JDRF partner moves research forward with collaboration agreement for diabetes treatment

...s to lower the risk for larger pharmaceutical companies to create biotech partnerships and carry the products through expensive, late-stage trials and regulatory approvals. The goal, he said, is to bring cures and treatments for type 1 diabetes to market faster. Other IDDP partners that have created simila...

Enzyme doesn't act alone in atrial fibrillation

...yme. Further studies with similar models showed this as an effective treatment. "More trials are needed, but this is a promising way to target one regulatory event that contributes to atrial fibrillation," Wehrens said. "These findings could lead to new drug therapies for arrhythmias and better patient car...

New piece found in the puzzle of epigenetics

...s scientists have known that the numerous biological functions of an organism are not regulated solely by the DNA sequence of its genes: Superordinate regulatory mechanisms exist that contribute to determining the fate of genes. Although they are not anchored in the DNA, they can even be passed on to subsequent...

They are young and need the job: A second chance for dangerous T-cells

...oreactive T-cells are very readily reeducated into regulatory T-cells. Under identical conditions, however, olde...s from blood. Possibly, they could then be used as regulatory T-cells in therapies for autoimmune diseases such ...eath. Some of them are 'reeducated' into so-called regulatory T-cells. While these still possess a T-cell recept...

GARP makes the difference

... silent and thus inhibit organ rejection. Theoretically, these drugs are not necessary because the immune system has its own unique "peace makers": regulatory T cells (Tregs), a special group of helper T cells, an important cell type of the immune system. Tregs inhibit immune reactions and are thus of specia...

Common chemotherapy drug triggers fatal allergic reactions

...Bennett said. "Physicians should be diligent in reporting adverse events to regulatory agencies to better monitor the impact of Cremophor on patient safety. Physi... the report, Bennett and Raisch reviewed adverse event reports submitted to regulatory agencies in the U.S., Europe and Japan. The most common cancer diagnosis fo...

American Chemical Society's Weekly PressPac -- June 3, 2009

...ulatory, educational and cultural factors. One, for instance, involves a shift in mindset in which business executives view sustainability not just as regulatory compliance but as a pathway to innovation. ARTICLE #3 FOR IMMEDIATE RELEASE "Overcoming Nontechnical Barriers to the Implementation of Sustainab...
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