Regulating

A new mechanism of regulating RNA degradation

As any dedicated video game player knows, the first requireme...

Depression gene may weaken mood-regulating circuit

A brain scan study suggests that a suspect gene may increase susceptibility to anxiety and depression* by weakening a circuit for processing negative emotion. People with the depression-linked gene variant showed less gray matter and weaker connections in the mood-regulating circuit. How well the circuit was connected accounted for nearly 30 percent of their anxious temperament, researchers at th...

Mechanism regulating tooth shape formulation found

One of the remaining challenges for evolutionary developmental studies of mammals, whose evolution is best known from their teeth, is how their tooth shape is altered during development. Researchers of the University of Helsinki together with their Japanese colleagues from the University of Kioto now propose a 'balance of induction' mechanism directing the placement of tooth shape features called...

Researchers Discover Gene That Determines Asthma Susceptibility By Regulating Inflammation

Disruption of a single gene, Nrf2, plays a critical role in determining the susceptibility to asthma. A research team led by Shyam Biswal, PhD, at the Johns Hopkins Bloomberg School of Public Health found the absence of Nrf2 exacerbated allergen-mediated asthma in mice models. The study’s findings, published in the July 4, 2005, edition of the Journal of Experimental Medicine, may hold therapeuti...

Protein's role in regulating cell death sets direction for cancer research

A protein called calpain can be the key either preventing or promoting the cell death, a Queen's University study has found. "This work provides proof in principle that pharmacological inhibition of calpain may be used to block cell death in situations where this is not desirable, such as in neuronal cells of Alzheimer's or Parkinson's patients, but to promote cell death in cancer cells w...

Scientists discover new regulating mechanism in cells

Researchers here have discovered a new mechanism used by cells ?and manipulated by retroviruses ?to control the making of certain essential proteins, including some involved in cancer. The study by researchers with The Ohio State University Comprehensive Cancer Center ?Arthur G. James Cancer Hosp...

Regulating the nuclear architecture of the cell

An organelle called the nucleolus resides deep within the cell nucleus and performs one of the cell's most critical functions: it manufactures ribosomes, the molecular machines that convert the genetic information carried by messenger RNA into proteins that do the work of life. Gary Karpen and Jamy Peng, researchers in the Life Sciences Division of the Department of Energy's Lawrence Berk...