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Ras in Biological News

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

Research in the laboratory of Assistant Professor Frank J. Slack at Yale University has identified a new way that a familiar gene is regulated in lung cancer, presenting new possibilities for diagnosis and treatment. The work is reported in March issues of the journals Cell and Developmental Cell. ...

Cancer-causing protein can also help fight the tumors it causes

...rsity's Department of Neurobiology have found that ras has the ability to transfer from cancer cells into...th the immune and original cells alike." "When ras transfers from one cell to another, it strengthens...e system. The immune cell that adopts the mutated ras gets activated and reacts against the cancerous ce...

Zebrafish provide a model for cancerous melanoma in humans

...nown to lead to cancer. In some cases, the type of ras mutation is a predictor of a patient's response to...erland generated several zebrafish with changes in ras or other RAS-regulated proteins to create a useful... to identify a pathway that reduced the effects of ras mutations on melanoma progression in zebrafish. ...

New drug agent knocks out multiple enzymes in cancer pathway

...hways in tumor cells, focusing on a protein called ras since nearly a third of all human cancers involve a mutation in the ras gene that causes cell signaling to go awry. These ...ymes, called FPPS and GGPPS, which are upstream of ras in the cell survival pathway. Inhibiting these enz...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators

...fenburger, PhD, at Massachusetts General Hospital, Boston, Massachusetts, is working to identify new protein networks that interact with the oncogenic ras signaling pathway, which is rewired in over half of colorectal cancer cases. Targeting these new interactions in combinatorial therapy may become an ...

JCI online early table of contents: Jan. 19, 2009

...are associated with excessive activation of either ras or PI3K signaling pathways, and many therapies aim...of breast cancer caused by excessive activation of ras and PI3K. Further, silencing the FAK gene arrested...t cancer cells with excessive activation of either ras or PI3K signaling pathways. The authors therefore ...

Mayo researchers identify dangerous 'two-faced' protein crucial to breast cancer spread and growth

... aggressive, able to grow in conditions that other cancer cells can't. They specifically found that p120 activates a family of molecules that includes ras and Rho, which promote cell growth and movement. "What is really interesting here is that p120 is acting like a tumor suppressor when it is bound t...

Gene's newly explained effect on height may change tumor disorder treatment

...uch research focused on neurofibromin's effects on ras protein activity, which is linked to cell growth, ...roliferation and cancer. Normally, NF1 deactivates ras proteins. In its absence, scientists believe unchecked ras can promote cancer development. To learn more,...

Emissions irrelevant to future climate change?

...Mokhov and Alexey Eliseev from the A.M. Obukhov Institute of Atmospheric Physics RAS, in Moscow, Russia. The authors used a climate model known as IAP ras CM to study how feedback between our climate and the carbon cycle changes over time. In their simulations, the authors assumed that fossil fuel emissi...

Fox Chase researchers discover a method for clamping down on a cancer-promoting enzyme

...enzyme becomes active. Previous studies have linked PAK1 activity with breast cancer and have shown the enzyme is important in pathways involving the ras oncogene, which is thought to cause up to 30 percent of all cancers. In the April 24 issue of the journal Chemistry & Biology, the researchers deta...

Yale scientists show that a microRNA can reduce lung cancer growth

...7 negatively regulates a well-known determinant of human lung cancers, the ras oncogene . In collaboration with scientists at Asuragen, the Slac...t let-7 can be applied as an intranasal drug to reduce tumor formation in a ras mouse model lung cancer. We believe that our studies provide the first ...

Why the switch stays on

...tween a rogue version of a specific protein called ras and its binding partner protein Raf can block the ...no acids. In the chain of 189 amino acids of which ras is composed, the position in question is at the 61...ets stuck on when Raf is present and the defective ras has position 61 as a leucine or one of the few ami...

Dealing deadly cancers a knockout punch

...rease a treatment's overall toxicity. Dual Mechanism Reovirus works by entering and replicating within cancer cells containing an activated ras pathway, a mutation present in about two-thirds of all human cancers. Reovirus enters a cancer cell, makes thousands of copies of itself, and then cau...

Leukemia drug turns mini-molecules up, cancer genes down

...miRNA molecule, let-7, lowered the activity of the ras oncogene, an important cancer-causing gene. (Oncog...en looked at miRNA let-7, a known regulator of the ras oncogene, and likewise found that high levels of this miRNA were associated with low ras activity. They established a cause and effec...

Scientists uncover new target in cancer mutation puzzle

...r. "We have very little understanding of how ras and p53 or any other potent gene mutations coopera...th features of cancer cells dependent upon p53 and ras mutations. For cancer to develop, several mut...s must arise and collaborate within a single cell. ras and p53 mutations are particularly dangerous, impl...

Study uncovers mutation responsible for Noonan Syndrome

...sts made recombinant versions of the mutants and expressed them in mammalian cells, where it was discovered that they promoted excessive activation of ras and its downstream target, MAP kinase, the same pathway activated by PTPN11 mutations. "These results are the first example of activating mutatio...

Natural anti-viral enzyme helps keep cancer cells alive, researchers find

...es known to be involved in keeping cancer cells alive and proliferating. They soon narrowed the focus to one called RalB. This molecule is part of the ras family of enzymes, which are mutated in 30 percent of all cancers and in 90 percent of pancreatic cancers. The UT Southwestern scientists knew tha...

Creation of antibiotic in test tube holds promise for better antibiotics

...esearch also showed that NisC has unexpected structural similarities with mammalian farnesyl transferases, which are important for the activity of the ras protein which when mutated is implicated in 25 percent of breast cancers. Preventing farnesylation possibly could prevent the cancerous effects, becau...

Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs

... several of the most effective compounds were also inhibitors of the MEK protein. "We find that all tumors with the BRAF mutation and some with the ras mutation are sensitive to drugs that inhibit MEK," explained Dr. Neal Rosen, Professor of Medicine and a member and laboratory head in the Molecular P...

Recreating 'Flowers for Algernon' with a happy ending

...ke grooves on a record," said Silva. "But surplus ras tips the balance between switching signals on and ...an searching for a safe drug that would zero in on ras and overcome its hyperactivity without causing har...and shared what he'd learned: statins work on the ras protein that is altered by NF1 and play a key role...

UNC scientists discover new role for protein as fundamental inhibitor of cell movement

...e added. The other activators of PAK1 include relatives of the notorious ras family of tumor promoters, the GTPases Rac and Cdc42. CIB1 activation of PA... now we know why ?it was probably CIB1 that was activating PAK1 and not the ras relatives." In illustrating the role that CIB1 plays in cell migration a...

Hormones and growth: The control of body size and developmental growth rate in fruit flies

...essing an activated form of the signaling molecule ras in the endocrine prothoracic gland. This precociou...ler body size than normal. In contrast, inhibiting ras in the prothoracic gland prevented ecdysone releas...of their findings, the investigators conclude that ras activity in the prothoracic gland regulates body s...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

...or p53 pathways could trigger melanoma. They found that in combination with ras and hTERT, the expression of cyclin-dependent kinase 4 (CDK4),which promote... melanoma in human tissue. Similarly, inhibition of p53, when combined with ras and hTERT, resulted in invasive melanoma. The scientists also investigat...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

...or p53 pathways could trigger melanoma. They found that in combination with ras and hTERT, the expression of cyclin-dependent kinase 4 (CDK4),which promote... melanoma in human tissue. Similarly, inhibition of p53, when combined with ras and hTERT, resulted in invasive melanoma. The scientists also investigat...

Engineered skin offers clues to melanoma development

...or p53 pathways could trigger melanoma. They found that in combination with ras and hTERT, the expression of cyclin-dependent kinase 4 (CDK4),which promote... melanoma in human tissue. Similarly, inhibition of p53, when combined with ras and hTERT, resulted in invasive melanoma. The scientists also investigat...

Researchers use 3-D imaging system to unveil swimming behavior of microscopic plankton

...ere captured during three experiments lasting several weeks at two sites in the Red Sea's Gulf of Aqaba, near the coral reef of Eilat in Israel and at ras Burka on the coast of Egypt's Sinai Peninsula. At the sites scuba divers attached Fish TV's sonar head ("transducer") on a large underwater tripod rai...

Scientists inhibit cancer gene

... communication among cells. When mutated, however, ras is an "oncogene" or cancer-causing gene that has b...cer and leukemia. Attempts to inhibit activated ras have had limited success until now, but the Huntsm...group of enzymes that regulate the function of the ras gene. These enzymes, called diacylglycerol kinases...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

...lled 'Ras' turned on inside cells," said Casey. ras is a normal genetic component of the cell, but mut..., promoting uncontrolled cell growth. Mutations in ras that permanently activate it have been found in ha...d a "methyl group" to Ras. This methyl tag enables ras to be directed to its final destination in the cel...
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