Raf in Biological News

Why the switch stays on

...protein called Ras and its binding partner protein raf can block the switch from being turned off. The...iochemistry and the lead author of the paper, that raf secures one of the two so-called switch regions in...ncer cells. "The switch only gets stuck on when raf is present and the defective Ras has position 61 a...

Researchers shed light on mechanism of action used by anti-cancer drug

...ngs by Grant’s team, reported in the Journal of Biologic Chemistry, showed that in human leukemia cells, sorafenib lethality was less a consequence of raf inhibition, but rather reflected interference with the synthesis of Mcl-1. They found that sorafenib interfered with Mcl-1 translation, a process in w...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

...melanoma. In contrast, melanocytes that did not receive hTERT remained in an early stage of benign growth. Finally, the team looked at the PI3K and raf pathways, frequently implicated in the development of melanoma. They found the expression of active PI3K, together with CDK4, hTERT, and inhibition of...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

...melanoma. In contrast, melanocytes that did not receive hTERT remained in an early stage of benign growth. Finally, the team looked at the PI3K and raf pathways, frequently implicated in the development of melanoma. They found the expression of active PI3K, together with CDK4, hTERT, and inhibition of...

Engineered skin offers clues to melanoma development

...melanoma. In contrast, melanocytes that did not receive hTERT remained in an early stage of benign growth. Finally, the team looked at the PI3K and raf pathways, frequently implicated in the development of melanoma. They found the expression of active PI3K, together with CDK4, hTERT, and inhibition of...