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Protein that promotes cancer cell growth identified

LA JOLLA, Calif., July 24, 2009 Scientists at Burnham Institute for Medical Research (Burnham) have found that the Caspase-8 protein, long known to play a major role in promoting programmed cell death (apoptosis), helps relay signals that can cause cancer cells to proliferate, migrate and invade ...

Prairie dog research promotes caring, conservation

The Northern Arizona University biology professor states the case for protecting the species in Prairie Dogs: Communication and Community in an Animal Society , recently published by Harvard University Press. The book, featuring the research of Slobodchikoff and co-authors Bianca Perla, a Uni...

Advancement in tissue engineering promotes oral wound healing

Tampa, Fla. (Feb. 3rd, 2009) Oral tissue engineering for transplantation to aid wound healing in mouth (oral cavity) reconstruction has taken a significant step forward with a Netherlands-based research team's successful development of a gum tissue (gingival) substitute that can be used for recon...

Dense tissue promotes aggressive cancers

New research may explain why breast cancer tends to be more aggressive in women with denser breast tissue. Breast cancer cells grown in dense, rigid surroundings step up their invasive activities, Vanderbilt-Ingram Cancer Center investigators report in the Sept. 9 issue of Current Biology . The...

Cellular self-eating promotes pancreatitis

To survive tough times, cells sometimes resort to a form of self-cannibalism called autophagy. But as Hashimoto et al. reveal, autophagy can have a down side, destroying the pancreas by prematurely activating a digestive enzyme. In autophagy, a vesicle swallows a portion of cytoplasm and ferries...

Iridescence workshop promotes nature's nanotechnology

TEMPE, Ariz. The phrase sex sells takes on special significance when scientists and students gather. While natures showiest subjects step out to promote reproductive success and survival with bright colors, flash and iridescence in feathers, scales, petals and wings, biologists, physicists, behav...

Synthetic compound promotes death of lung-cancer cells, tumors

DALLAS Nov. 12, 2007 Human lung-cancer tumors grown in mice have been shown to regress or disappear when treated with a synthetic compound that mimics the action of a naturally occurring death-promoting protein found in cells, researchers at UT Southwestern Medical Center report. The findings...

Salk scientists hammer out a pathway that promotes muscle cell survival in mice

Scientists at the Salk Institute for Biological Studies have identified an enzyme that pumps up a cell’s ability to maintain healthy muscle and restores normal muscle function in genetically engineered mice with weak muscles. The study, published online in Nature Medicine, is the first to explore t...

Serotonin, acting in a specific brain region, promotes sleep in fruit flies

Researchers have found that the neurotransmitter serotonin, known to affect many behaviors, also appears to promote lasting, quality sleep in an animal model for understanding how sleep is regulated. While central to the lives of most animals, the proper regulation sleep remains a largely enigmatic...

Meth promotes spread of virus in HIV-infected users

Researchers at the University at Buffalo have presented the first evidence that the addictive drug methamphetamine, or meth, also commonly known as "speed" or "crystal," increases production of a docking protein that promotes the spread of the HIV-1 virus in infected users. The investigators ...

A Jekyll and Hyde of cytokines: IL-25 both promotes and limits inflammatory diseases

The same signal responsible for promoting the type of immune responses that cause asthma and allergy can also limit the type of inflammation associated with debilitating diseases like inflammatory bowel disease, arthritis and multiple sclerosis, according to researchers from the University of Penns...

Texas scientists discover how a hepatitis C protein promotes liver cancer

Scientists at the University of Texas Medical Branch at Galveston (UTMB) have identified a key biochemical connection between the hepatitis C virus and liver cancer. The molecular mechanism is similar to the one that links the human papilloma virus (HPV), the cause of genital warts, and cervical ...

Have a taste for fat? Yes! A sensor in the mouth promotes preference for fatty foods

The sense of taste informs the organism about the quality of ingested food. It comprises five sub-modalities that perceive sweet, salt, sour, bitter, and umami stimuli. The possibility for an additional taste modality directed to lipid has often been suggested because many animals exhibit a sponta...

Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis

The complex and life-sustaining series of steps by which hematopoietic stem cells (HSC) give rise to all of the body's red and white blood cells and platelets has now been discovered to depend in large part on a single protein called Mcl-1. This finding, from an investigator at St. Jude Children's ...

Argonne to showcase science and technology at community open house

...d technology. Argonne conducts basic scientific research to better understand the world we live in, develops and evaluates advanced energy sources, promotes environmental stewardship and helps protect our nation and its economic competiveness. Argonne also operates world-class user facilities to help advan...

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

...iladelphia (July 27, 2009) DLX5, a gene crucial for embryonic development, promotes cancer by activating the expression of the known oncogene, MYC, according t...the current paper, the researchers discover that DLX5 binds to and actively promotes the activity of a gene known as MYC, which evidence has demonstrated is a p...

New advance in revolutionary 'bullet fingerprinting' technique

...ould be significant. "Previous recovery methods include applying powder to the material which can actually damage the evidence. This new technique promotes a naturally occurring process which does not involve adding anything to, or damaging, the evidence. Instead, it employs heat and humidity to promote t...

Hormone clue to root growth

...r of cells in the root in order to control root growth. Gibberellin normally acts by signaling the removal of proteins which repress growth, and so promotes root cell production. The new research shows that mutant plants that do not produce gibberellin are unable to increase their cell production rate and ...

Research network wins approximately £5.7 million to target human and animal diseases in Africa

...g helping to develop courses and research skills for African researchers. This interdisciplinary partnership embodies the 'one health' approach, which promotes collaborations between human and animal health sectors. The link between SACIDS and LIDC also fulfils many of LIDC's aims to address complex internati...

Colorectal cancer

...s than in non-metastatic tumors. "Our investigations show that the particular gene BAMBI is associated with two import signaling pathways and thus promotes metastasis formation," Dr. Fritzmann said. "These signaling pathways (Wnt and TGF-beta) are, among other things, important in the developing embryo." ...

Carnegie Mellon's Kris Matyjaszewski recieves EPA's Presidential Green Chemistry Challenge Award

...sfer Radical Polymerization (ATRP), a widely used method for preparation of functional polymers. The EPA's Presidential Green Chemistry Challenge promotes research and development of less-hazardous alternatives to existing technologies in an effort to reduce or eliminate waste, particularly hazardous was...

The battle for CRTC2: How obesity increases the risk for diabetes

...ses of drugs that might help to lower blood sugar by disrupting this alternative pathway," says Montminy. It had been well established that obesity promotes insulin resistance through the inappropriate inactivation of a process called gluconeogenesis, where the liver creates glucose for fuel and which ordi...

Caltech researchers explore how cells reconcile mixed messages in decisions about growth

...rise above the threshold, it overrides the effects of cell-cell contact and promotes cell division and tissue growth. Both factors can potentially be manipul...press a protein called E-cadherin, which is a tumor suppressor protein that promotes adhesion of one cell to another. "This makes the cells less willing to divi...

Major breakthrough in early detection and prevention of AMD

...demy of Sciences' Institute of Medicine. The research team discovered that CCR3 not only provides a unique signature for CNV, but the gene actively promotes the growth of these abnormal blood vessels in the eye. Thus the same anti-CCR3 antibodies used to detect CNV could potentially be useful as a clinical...

Protein regulates movement of mitochondria in brain cells

...xygen in the brain can drop even further in instances such as a stroke, when blood flow to a portion of the brain is cut off. This decrease in oxygen promotes the expression of HUMMR which, in turn, mobilizes mitochondria. More mitochondria in the correct position may mean the cell has a greater capacity to...

Zebra mussels hang on while quagga mussels take over

.... Because the mussels filter the microorganisms, the waters today are surprisingly clear, allowing light to penetrate to greater depths, which in turn promotes prolific, nuisance algae blooms. Quagga mussels may be the reason Diporea, a small shrimp-like species that serves as a food source for larger fis...

Ernst-Ludwig Winnacker awarded the Order of the Rising Sun

...ion as Secretary-General of the International Human Frontier Science Program Organization (HFSPO) in Strasbourg. The HFSPO, which was founded in 1989, promotes international research in the life sciences, aiming in particular to improve the promotion of young scientists and researchers. ...

Double trouble for water life

...wth in receiving waters worldwide. The increasing levels of nitrogen and phosphorus are of particular concern because an excess of these two nutrients promotes accelerated production of plant-based organic matter (or eutrophication) to the extent that excessive production, including harmful algal blooms, cont...

ChloroFilms announces video contest winners

... 15th the winners of its competition for new plant biology videos on YouTube. Over $8,000 in cash prizes were awarded in this first competition, which promotes the creation of fresh, attention-getting and informative videos about plant life. Grand prize winner (with $1,000 cash prize) is Ela Lamblin of ...

Key protein regulating inflammation may prove relevant to controlling sepsis

...ciences (PNAS) and entitled, "Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP," provides fresh insight about how cells tha...o help the body clear infection, excessive inflammation, on the other hand, promotes cellular changes that lead to the uncontrolled growth of cells that charact...

UC Davis bioengineer receives Hartwell Foundation grant to address skull fusion disorder of infants

...rounding them, known as the extracellular matrix, may be providing improper instructions to the cells. "If we can deliver a different matrix one that promotes the growth of healthy tissue our hope is that we can eliminate secondary surgeries," he said. With $300,000 in funding from The Hartwell Foundatio...

Lithium may help radiation target cancer, spare healthy tissue

... during radiation treatments. In the May 1 issue of the Journal of Clinical Investigation , Fen Xia, M.D., Ph.D., and colleagues show that lithium promotes DNA repair in healthy cells but not in brain tumor cells. The findings suggest that lithium treatment could offer a way to protect healthy brain tissu...

Springer launches StemCellGateway.net

...herapy News, Biology News Net, and Medical News Today. "We are working to establish Springer as a major source of stem cell information. The portal promotes our increasingly successful stem cell publishing program, by allowing researchers to access relevant data in one place," said Ray Coln, Director of J...

Countries unite to reduce animal use in product toxicity testing worldwide

...ureau within Health Canada, and Masahiro Nishijima, Ph.D. for the Japanese Centre for the Validation of Alternative Methods (JaCVAM). The agreement promotes enhanced international cooperation and coordination on the scientific validation of non- and reduced-animal toxicity testing methods. If the toxicity ...

New mediator of smoking recruits

...c in smoking-initiated lung disease. The article from Prasse et al "suggest[s] that chronic nicotine stimulation induced by cigarette smoking promotes macrophage and Langerhans cell accumulation in the lung via an increase in [osteopontin production]." Osteopontin and cellular receptors for nicotine ...

$10 million Simons Foundation gift supports new initiative with Institute for Advanced Study

...ollege and the Sloan-Kettering Institute for Cancer Research. He also is a member of the university's Center for Studies in Physics and Biology, which promotes experimental collaborations to study both the physical properties of biological systems and the application of physical techniques to the modeling of ...

Burnham researchers present at 100th AACR Meeting

...s the Chemopreventative Effect of Ursodeoxycholic Acid by Activating Nuclear Receptor FXRα in Colorectal Cancer and Genetic Deletion of FXRα promotes Colon Tumorigenesis in ApcMin/+ Mice Adam Richardson, Ph.D., will present The Role of Pentose Phosphate Pathway in the Warburg Effect. ...

SIRT1 takes down tumors

...ion is still a mystery. The researchers say that the results don't necessarily conflict with studies suggesting that SIRT1 is pro-tumor. Whether SIRT1 promotes or prevents cancer probably depends on the situation. ...

Human ES cells progress slowly in myelin's direction

...opposed to the 2 weeks taken by mouse ES cells. They also report another difference between mouse and human ES cells: a growth factor called Fgf2 that promotes oligodendrocyte development in mouse ES cells actually stalls it in human ES cells. As Dr Zhang reveals, these findings were quite unexpected. 'Thi...

Roberta A. Pagon receives lifetime award in genetics from March of Dimes

...important international resource for genetic testing information. The site promotes the appropriate use of genetic testing in patient treatment and personal de...or the Collaboration, Education, and Test Translation (CETT) Program, which promotes the collaborative development of new tests for rare genetic diseases for us...
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