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Promising in Biological News

Pitt researchers find promising candidate protein for cancer prevention vaccines

PITTSBURGH, Aug. 4 Researchers at the University of Pittsburgh School of Medicine have learned that some healthy people naturally developed an immune response against a protein that is made in excess levels in many cancers, including breast, lung, and head and neck cancers. The finding suggests t...

UC Davis bench-to-bedside research: Promising treatment in clinical trials

DAVIS, CALIF.A new drug developed at the University of California, Davis to treat diabetes, hypertension and inflammatory has entered Phase II of human clinical trials to evaluate its efficacy. The compound, a soluble epoxide hydrolase enzyme (s-EH) inhibitor, is "a first-in-class drug which m...

Therapeutic hypothermia is promising strategy to minimize tissue damage

New Rochelle, NY, March 19, 2009Recognition of the benefits of cooling strategies to protect the brain and spinal cord after traumatic injury has led to a wealth of cutting edge research, prime examples of which are featured in a special hypothermia issue of Journal of Neurotrauma , a peer-review...

Research uncovers promising target to treat chronic abdominal pain

COLUMBUS, Ohio High levels of a protein linked to the way pain signals are sent to the brain led to a decrease in abdominal pain in a recent study in mice. Researchers say the finding suggests the protein might someday serve as the basis of new treatments for chronic pain associated with a nu...

Landscape-scale treatment promising for slowing beetle spread

Mountain pine beetles devastating lodgepole pine stands across the West might best be kept in check with aerial application of flakes containing a natural substance used in herbal teas that the insects release to avoid overcrowding host trees, according to a team of scientists. Findings from t...

Researchers identify promising gene target for neuroblastoma therapy

BOSTON--Researchers at Dana-Farber Cancer Institute have identified a set of previously unknown mutations in a single gene in 8 percent of neuroblastomas, tumors of the nervous system that occur in young children and account for approximately 15 percent of all childhood cancer deaths. The disco...

UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome

RIVERSIDE, Calif. A UC Riverside-led team of biomedical scientists has found that a readily available drug called minocycline, used widely to treat acne and skin infections, can be used to treat Fragile X syndrome , the most common inherited cause of mental impairment and the most common cause o...

Prosthetic vein valve designed to direct blood flow shows promising pre-clinical results

Engineers at the Georgia Institute of Technology have developed a prosthetic vein valve to help improve the lives of those suffering from a condition known as chronic venous insufficiency. The condition, which affects more than seven million people in the United States alone, occurs when valves in...

Immunotherapy in high-risk pediatric sarcomas shows promising response

PHILADELPHIA Based on a pilot study in children with sarcoma, researchers at the National Institutes of Health (NIH) believe that immunotherapy could prove beneficial in treating high-risk forms of this cancer. The researchers tested a novel dendritic vaccine as well as a standard flu vaccine...

New treatment approach promising for lymphoma patients in the developing world

Preliminary results suggest that patients with aggressive non-Hodgkin's lymphoma in the developing world might benefit from a modified chemotherapy regimen, researchers say. At the ESMO Conference Lugano (ECLU) organized by the European Society for Medical Oncology, a group headed by Prof. Hamd...

UIC researchers make promising finding in severe lung disease

Researchers at the University of Illinois at Chicago have identified a novel function for an enzyme that plays a role in the tissue injury in acute respiratory distress syndrome, also known as ARDS. The finding offers a new therapeutic target for the prevention and treatment of lung inflammatio...

Biodesign's Rittmann offers promising perspectives on society's energy challenge

Perhaps there is no greater societal need for scientific know-how than in finding new ways to meet future energy demands. Skyrocketing gas prices, an uncertain oil supply, increasing demand from around the world, and the looming threat of climate change have made identifying and developing realist...

Unique whey protein is promising supplement for strict PKU diet

MADISON Individuals with a rare genetic condition known as phenylketonuria, or PKU, receive a difficult-to-follow prescription. They must severely limit their consumption of protein, completely avoiding mealtime staples such as meat, cheese and even bread. Not surprisingly, for many, diet is a co...

Cancer and arthritis therapy may be promising treatment for diabetes

New Haven, Conn.An antibody used to treat certain cancers and rheumatoid arthritis appears to greatly delay type 1 diabetes in mice, Yale School of Medicine researchers report in the Journal of Clinical Investigation. Even better, the beneficial effects of the antibody continue to be observed ...

New book defines promising young field of adult neurogenesis

COLD SPRING HARBOR, N.Y. Studies of the birth and incorporation of neurons into the brains of mature animalsa process known as adult neurogenesispromise intriguing insights into the mechanisms of normal brain function and into the causes of depression and other psychiatric disorders. A new boo...

UIC researchers find promising new targets for antibiotics

University of Illinois at Chicago researchers have identified new sites on the bacterial cell's protein-making machinery where antibiotics can be delivered to treat infections. "The primary challenge of antibiotic therapy has been fighting infections caused by the pathogens which became resista...

A new plant-bacterial symbiotic mechanism promising for crop applications

The growth of most plants depends on the presence of sufficient amounts of nitrogen contained in the soil. However, a family of plants, the legumes, is partially free of this constraint thanks to its ability to live in association with soil bacteria of the Rhizobium, genus, capable of fixing nitro...

UCSF brain tumor vaccine trial shows promising results

A vaccine for treating a recurrent cancer of the central nervous system that occurs primarily in the brain has shown promise in preliminary data from a clinical trial at the University of California, San Francisco. Known as a glioma, this cancerous tumor is always fatal. Findings from a group ...

Preliminary study finds holographic imaging system promising for cancer treatment planning

The device looks like something out of an old science fiction movie, but researchers at Rush University Medical Center in Chicago say it holds promise in the treatment of cancer. The Perspecta® Spatial 3D system, developed by Actuality Systems, Inc., creates holographic images inside a 24-inch ...

New study suggests promising drug combinations for sleeping sickness

Results from a clinical trial evaluating new drug combinations for sleeping sickness, carried out by the international humanitarian medical aid agency Medecins Sans Frontieres (MSF), and its research arm, Epicentre, have now been published in the journal PLoS Clinical Trials. African trypanos...

Brown seaweed contains promising fat fighter, weight reducer

The study, which was directed by Scripps Research Professor Benjamin Cravatt, Ph.D., is being published in the September 8 issue of The Journal of Biological Chemistry. The new study describes a pathway-different than the one previously suggested-for the biosynthesis of neurotransmitter lipids, N...

Vaccine for brain tumors shows promising results

A vaccine for treating a recurrent cancer of the central nervous system that occurs primarily in the brain, known as glioma, has shown promising results in preliminary data from a clinical trial at UCSF Medical Center. Findings from the first group of six patients in the study, being conducted at...

Analysis of breast-cancer gene role offers promising target

Researchers at UT Southwestern Medical Center have for the first time described how multiple copies of a gene are responsible for metastases in early-stage breast cancer and poor prognosis for patients. In a study published in this week's issue of the Proceedings of the National Academy of Sci...

Combination therapy shows promising results in patients with advanced lung cancer

An early phase study pairing an experimental targeted therapy with a common anti-inflammatory produced promising results in patients with advanced lung cancer, researchers at UCLA's Jonsson Cancer Center reported. Pairing the targeted therapy Tarceva with the anti-inflammatory drug Celebrex incr...

New research promising for improving brain cell survival after brain injury

Scientists at Melbourne's Howard Florey Institute have found a protein in the brain that can save neurons from dying after experiencing traumatic brain injury from incidents such as stroke, car accidents and falls. The team, led by Professor Seong-Seng Tan, has discovered that thisnaturally occu...

Mechanism identified for promising neurological drug

Researchers at the San Francisco VA Medical Center have identified the mechanism by which minocycline, a medication currently being studied for the treatment of neurodegenerative diseases including Parkinson's disease and Huntington's disease, protects brain and nerve cells from damage. In the st...

New study reveals promising osteoporosis treatment

A New York University College of Dentistry professor has developed a calcium phosphate-based supplement that -- even at low concentrations -- significantly improves bone strength and thickness without the side effects of many current drug treatments. Dr. Racquel Z. LeGeros, a Professor of Biomateri...

NIAID researchers show how promising TB drug works

Scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have determined how a promising drug candidate attacks the bacterium that causes tuberculosis (TB). Published online this week in Proceedings of the National Academy of Scie...

Discarded placentas deliver researchers promising cells similar to embryonic stem cells

Routinely discarded as medical waste, placental tissue could feasibly provide an abundant source of cells with the same potential to treat diseases and regenerate tissues as their more controversial counterparts, embryonic stem cells, suggests a University of Pittsburgh study to be published in the...

Researchers develop promising new gene network analysis method

Compared with a long-used linear model, a correlation-based statistical method is a more reliable way to map complex gene interactions and pinpoint genes that may be potential cancer treatment targets, according to new Brown University research. The research is important because it describes a p...

Researchers find promising cancer-fighting power of synthetic cell-signaling molecule

Novel anti-cancer compounds called Enigmols suppress the growth of human cell lines representing cancers of the prostate, breast, colon, ovary, pancreas, brain and blood, and reduce tumors in three animal studies, new research shows. In addition, Enigmols did not show side effects at effective do...

Silence the gene, save the cell: RNA interference as promising therapy for ALS

Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland have used RNA interference in transgenic mice to silence a mutated gene that causes inherited cases of amytrophic lateral sclerosis (ALS), substantially delaying both the onset and the progression rate of the fatal mot...

Gene therapy promising for growing tooth-supporting bone

A University of Michigan research team has found that introducing a growth factor protein into a mouth wound using gene therapy helped generate bone around dental implants, according to a new paper in the February issue of the journal Molecular Therapy. In a patient with a sizeable mouth wound, ...

Gene vaccine for Alzheimer's disease shows promising results

UT Southwestern Medical Center at Dallas researchers have found a way of stimulating the immune systems of mice to fight against amyloid proteins that cause the devastating plaques that are characteristic of Alzheimer's disease. For years scientists have examined the possibility of using a protein-...

Another Look Finds Promising Proteomics Test is Not Biologically Plausible

In a new study, researchers present a “cautionary tale?about what may go wrong when using the fledgling science of proteomics to devise a diagnostic test for cancer. In the February 16 issue of the Journal of the National Cancer Institute, researchers from The University of Texas M. D. Anderson ...

Navigating in the ocean of molecules

... effect." Thus, the researchers identify structurally simple scaffolds with promising characteristics as the starting point in the quest for new active agents: c...w inhibitors of pyruvate kinase. The inhibition of this enzyme is seen as a promising approach to the treatment of cancer and malaria. An even more detailed s...

NIH stimulus funding supports Emory biomedical scientists

... Health presents a tremendous opportunity for Emory scientists, along with researchers throughout the United States, to begin projects that are highly promising but might not have been funded otherwise, and to extend successful projects that could soon be translated into treatments for patients," says David St...

New cancer drug delivery system is effective and reversible

... drug that effectively kills cancer cells but has troublesome side effects when administered intravenously. Tests in cells grown in the lab yielded promising results. Four days after they exposed the cells to the new drug-delivery system, 59.5 percent of the breast cancer cells had died, while less than 12 ...

Plankton Power and RTDC announce proposed algae-to-biofuels pilot facility on Cape Cod

...n and commitment of our consortium partners to achieve the infrastructure, resources, and collaboration necessary to advance commercial development of promising algae-to-biofuel technology on the Cape," said Curtis S. Felix, CEO and Founder of Plankton Power. "The MMR location is ideal for this pilot projectth...

New computer simulation helps explain folding in important cellular protein

...r in biology or chemistry consists of two structurally similar units that are held together by intra- or intermolecular forces.) "One particularly promising approach is to investigate the thermodynamics of protein folding through examining the energy landscape," Landau explained. "By doing this, we can lea...
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