Phase in Biological News

Biolex presents Locteron US Phase 2a hepatitis C data at EASL

Biolex Therapeutics, Inc. announced that the results from its United States Phase 2a clinical trial (the "PLUS" trial) of Locteron will be presented today at the 44th Annual Meeting of the European Association for the Study of the Liver (EASL) in Copenhagen, Denmark. Locteron, controlled-release i...

NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays

Cambridge, MA January 7, 2009 Phylonix Pharmaceuticals, Inc. today announced that it has been awarded a $1,250,369 Phase II Small Business Innovation Research Grant (SBIR) from the National Institute of General Medical Sciences of the National Institutes of Health (NIH) to develop in vivo zebra...

Positive results in Phase 2 trial of treatment of C-difficile-associated diarrhea

Princeton, N.J. and Jamaica Plain, Mass., November 3, 2008 Medarex, Inc. (Nasdaq: MEDX) and The Massachusetts Biologic Laboratories (MBL) of the University of Massachusetts Medical School (UMMS) today announced that a Phase 2 trial of an anti- C. difficile antibody combination treatment in patie...

PTC124 shows activity in cystic fibrosis; Phase 2 proof-of-concept data published in Lancet

SOUTH PLAINFIELD, NJ August 20, 2008 New phase 2 data published today in The Lancet show that the investigational oral drug PTC124 demonstrates activity in nonsense-mutation cystic fibrosis (CF). The data show that treatment with PTC124 results in statistically significant improvements in the...

Improved foam for varicose veins found to be safe in preliminary results from phase II trial

WINSTON-SALEM, N.C. A small group of patients with a common heart defect who were treated for varicose veins with an injectable microfoam experienced no neurological, visual or cardiac changes as a result of the treatment, according to preliminary results from a phase II trial. The results are be...

Mom's obesity during conception phase may set the stage for offspring's obesity risk

BETHESDA, MD -- The number of overweight and obese Americans continues to grow rapidly. Today, 50 percent of adults are overweight and up to 20 percent are obese. While the number of overweight/obese children is at an all time high, the steady increase of overweight infants -- individuals under 11...

HGS announces positive Phase 2 LymphoStat-B at ACR meeting

ROCKVILLE, Maryland November 9, 2007 Human Genome Sciences, Inc. (Nasdaq: HGSI) today announced the presentation of Phase 2 clinical results demonstrating that LymphoStat-B (belimumab) achieved a sustained improvement in disease activity across multiple clinical measures, decreased the frequency...

CABI helps phase out dangerous pesticide in EU

Methyl bromide is a highly toxic fumigant pesticide which is injected into soil to sterilise it before planting crops. It is also used as a post-harvest decontaminant of products and storage areas. Although it is highly effective in eradicating pests such as nematodes, weeds, insects and rodents,...

SinuNase Phase 3 show almost 100 percent of chronic sinusitis cases are from fungal-induced inflamma

TAMPA, Fla.September 10, 2007--Accentia Biopharmaceuticals (NASDAQ: ABPI) announces evidence that most, if not all cases of chronic sinusitis (CS), are due to a fungal-induced inflammation as originally proposed by investigators at the Mayo Clinic. The data were collected as part of the Companys ...

NIH announces phase III clinical trial of creatine for Parkinson's disease

The NIH National Institute of Neurological Disorders and Stroke (NINDS) today is launching a large-scale clinical trial to learn if the nutritional supplement creatine can slow the progression of Parkinson's disease (PD). While creatine is not an approved therapy for PD or any other condition, it ...

Ebola DNA vaccine produces immune responses in all fully vaccinated volunteers in Phase 1 trial

Vical Incorporated announced today that an Ebola vaccine candidate administered using Vical's proprietary DNA delivery technology was safe and well tolerated, and produced both antibody and T-cell Ebola-specific responses in all healthy volunteers who received the full 3 doses of vaccine. The Pha...

Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer

Researchers today presented preliminary safety and efficacy data for E7389 in the treatment of advanced, refractory breast cancer during the San Antonio Breast Cancer Symposium. E7389 is a synthetic analog of halichondrin B (HB), which is a natural product shown in preclinical studies to have high...

Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses

The International Genomics Consortium’s (IGC) Expression Project for Oncology (expO) has released clinically annotated gene expression profiles for 60 tumor specimens, completing the initial phase of the nation’s first and eventually largest public database dedicated to standardized gene expression...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

At first, we thought that gene expression was modulated only by transcription factors. Then we found that the RNA resulting from transcription could be regulated by the RISC complex (siRNA-mediated degradation via Dicer). And now it seems that regulation at the RNA level is even more complex than ...

Advances in lung cancer research announced at conference

...discussed the release this week by Threshold Pharmaceuticals Inc. and the Virginia G. Piper Cancer Center at Scottsdale Healthcare of results from two phase I clinical trials for a drug called TH-302. The two clinical trials are both evaluating the safety and effectiveness of TH-302, a drug activated in...

First human gets new antibody aimed at hepatitis C virus

...l School (UMMS) today announced the beginning of a phase 1 clinical trial, testing the safety and activity ...for the next step in this program, which will be a phase 2 study in liver transplant patients." HCV attac...people who have volunteered to participate in this phase 1 study. These subjects' participation will help o...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

...erage size of 350 cubic millimeters after three weeks, but treated tumors did not grow beyond their initial 25 cubic millimeters. Wellstein says a phase I clinical trial of the therapy is in the discussion stage, but much remains to be worked out. For example, it is uncertain how the antibody should be...

Stem cell research: From molecular physiology to therapeutic applications

...he Chinese Academy of Medical Sciences is Executive Director of the National Center for Stem Cell Research. His group has taken stem cell therapy into phase II clinical trials in China, and is the leading runner in stem cell therapeutics. They have identified a mesenchymal stem cell (MSC) population from h...

DOE-funded research projects win 46 R&D 100 Awards for 2009

...cial Retina Project see Lawrence Livermore National Lab Fire-resistive phase change material - the first-ever organic fire-resistive material when incor... plant and animal fats and blended with cellulose insulation, are the first phase change materials to fulfill all requirements in the U.S. flammability tests...

New drug may reduce heart attack damage

... by the drug, dramatically improving the patient's chances of a full recovery after a heart attack. Safety trials of Dz13 are now underway ahead of phase 1 human trials. A paper outlining the animal study appears this month in the high-impact cardiovascular journal Arteriosclerosis, Thrombosis and Vasc...

Carnegie Mellon team makes sequestration recommendations

... the FGSB and any remediation or compensation necessary during long-term stewardship. Create a stopgap federal indemnity program for the stewardship phase of "first-mover" geologic sequestration projects. Develop an "opt-in" federal regulatory regime providing the Federal Energy Regulatory Commission...

Penn-Wistar team gains insight into HIV vaccine failure

...s. The findings were published on-line July 20 in Nature Medicine . The phase II STEP vaccine trial was stopped after an interim analysis showed no effic... Vaccine Center, analyzed blood samples from 40 healthy participants in the phase I safety trial of the STEP HIV vaccine for immune response to Ad5 particles...

The right messenger for a healthy immune response

...mmune diseases may develop," says Wei: without Beta-Interferon, the immune system may not be able to learn how to tolerate itself during the embryonic phase and that it should not fight against self-structures. "Our findings can help to develop or improve new therapeutics to combat autoimmune diseases such...

Facile synthesis of nanoparticles with multiple functions advanced in Singapore

... from a mixture. At IBN, the transfer of the metal ions from the aqueous phase to the organic phase was successfully applied towards the synthesis of a variety of metallic, al...

Researchers achieve major breakthrough with water desalination system

...rated chemical demineralization process that was also developed here at UCLA. This first field study with the M3 was a major achievement and the first phase of our high-recovery RO process demonstration program." Andi Rahardianto, a postdoctoral researcher on the team, said that the approach taken by...

'Show me the money!' MDA greenlights grants

...clerosis (ALS), or Lou Gehrig's disease. Ilieva hopes to find a way to use genetic therapy to treat hereditary ALS. "It will also enable my final phase postdoctoral training; thereby providing me what I hope is a major career development opportunity that will form the basis for my own independent care...

UH team analyzes Hurricane Ike's effects on waterways, fish contamination

...isting fish-consumption advisories remain appropriate. With this year's storm season under way, the UH engineering team's project is entering a new phase as participants collect and analyze fresh samples from Galveston Bay and related waterways. Cullen College of Engineering professor Hanadi Rifai, ...

World's largest ocean observatory takes shape

... "Scientists and staff at NEPTUNE Canada are delighted to begin the final phase of installation following a decade of planning," says Dr. Chris Barnes, dir...iness, Technology and Economic Development. "Today's beginning of the final phase of installing the world's first regional cabled ocean observatory moves us ...

Forsyth scientists suggest linkages between obesity and oral bacterial infection

...ia are likely complex. The observed relationship may be circumstantial as being related to diet or opportunistic due to metabolic changes. In the next phase of this research, Dr. Goodson plans to further examine this relationship by initially conducting a controlled cohort study to see if this initial obse...

Funxional successfully completes initial clinical trial of FX125L, an anti-inflammatory drug with a novel mechanism of action

...Ltd (Funxional) has announced today the successful completion of the first phase I study with FX125L , an orally available small molecule which belongs to a...apeutic class named Broad Spectrum Chemokine Inhibitors ( BSCIs ). The phase I, single ascending dose study was conducted in the United States. FX125L w...

Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients

...tory and Critical Care Medicine addresses a dilemma in IPF care that currently is unsolved. "Approximately 10 percent of patients develop an acute phase that in most cases is lethal," Dr. Kaminski explained. "There has been very little understanding of the molecular basis of this syndrome, but because ...

Nitrogen research shows how some plants invade, take over others

... this one began in 1999 with data taken in 2006. He has other projects in the mid-stage of 10- to 20-year timeframes, one looking at the establishment phase of pines, and another on grassland systems and their invasive species and abundance. He said his research field does require patience and longterm fun...

Stanford researchers publish comprehensive model for medical device development

...e major phases and decision gates include: phase 1/Gate 1: Initiation, opportunity, and risk analysis. phase 2/Gate 2: Formulation, concept, and feasibility. phase 3/Gate 3: Design, development, verification, and v...

First riser-drilling research operations undertaken

... combination with inclement weather expected, due to passing typhoons, and riser drilling down to depths of more than 2,000 meters below surface, this phase of NanTroSEIZE is considered one of the most challenging tasks in ocean-drilling history. The average speed of the Kuroshio current in the surveyed...

DuoCort: New chronotherapy for adrenal insufficiency

... b3c newswire / - DuoCort publishes data from its phase I study for the rare and life threatening disease ...to improve outcomes for patients. Results from the phase I study in healthy volunteers, evaluating the safe...with adrenal insufficiency. Data from a subsequent phase II/III trial in patients with primary adrenal insu...

ESHRE launches international study of polar body screening

...earchers intend to carry out an international randomised trial. The first phase will begin in September 2009 in two centres: the University of Bonn, German...t European countries later the same year. Oocytes to be used in the pilot phase will be obtained from volunteer patients who have given consent for their u...

CWRU receives $5 million from Ohio Third Frontier Commission

...e the commercialization of MultiStem cell therapy by running a FDA approved phase II clinical trial to evaluate the performance of the cells. Juventas T...lop its lead drug product, stromal cell derived factor 1 (SDF-1), through a phase I clinical trial for critical limb ischemia. Emerging programs Wi...

Europe and China watching Earth together

...rnal Relations, praised the accomplishments of the programme, saying it is an example of "good cooperation, trust and shared interests." The first phase of Dragon developed the exploitation of ESA EO data in China via joint projects led by Chinese and European scientists. Dragon 2 expanded this by addi...

NIH expands Human Microbiome Project; funds sequencing centers and disease projects

...equencing centers that participated in the initial phase of the project. These centers will work together ...bridge, Mass., which participated in the jumpstart phase of the Human Microbiome Project, is expected to participate in this phase of the project. The Human Microbiome Project ...

Green tea may affect prostate cancer progression

...es have evaluated the change in biomarkers, which might predict disease progression. Cardelli and colleagues conducted this open-label, single-arm, phase II clinical trial to determine the effects of short-term supplementation with green tea's active compounds on serum biomarkers in patients with prosta...