New designer lipid-like peptide with lipid nanostructures for drug delivery systems
Scientists from Institute of Biophysics and Nanosystems Research (IBN), Austrian Academy of Sciences and of Centre for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, USA report the study of “Tuning Curvature and Stability of Monoolein Bilayers by Designer Lipid-Like Pept...
UCLA AIDS Institute researchers find a peptide that encourages HIV infection
UCLA AIDS Institute researchers have discovered that when a crucial portion of a peptide
structure in monkeys that defends against viruses, bacteria and other foreign invaders is reversed, the peptide
actually encourages infection with HIV.
The findings, published in the April issue of AIDS Resea...
Synthetic peptide targets latent papilloma virus infections
While a newly marketed vaccine promises to drastically reduce human papilloma virus (HPV) infections, the major cause of cervical cancer, a new discovery by University of California, Berkeley, researchers could some day help the millions of people already infected and at constant risk of genital wa...
Does a peptide affect the heart's response to social isolation?
A team of researchers investigating the effects of oxytocin, a peptide
produced by the brain that regulates social behavior, has found that it can prevent detrimental cardiac responses in adult female animals exposed to social isolation. The findings may provide further insight into how these mecha...
Defense peptide found in primates may block some human HIV transmissions
As primates evolved 7 million years ago, the more advanced species stopped making a protein that University of Central Florida researchers believe can effectively block the HIV-1 virus from entering and infecting blood cells.
HIV-1 often mutates quickly to overcome antiviral compounds designed t...
New peptide antibiotic isolated from American oyster
North Carolina Sea Grant researchers have isolated a new peptide
antibiotic from the American oyster that may have implications for managing many diseases in oysters.
The new antimicrobial peptide
"American oyster defensin" (AOD) may protect against bacteria in Crassostrea virginica, a species th...
Discovery clarifies role of peptide in biological clock
A biologist at Washington University in St. Louis is giving the VIP treatment to laboratory mice in hopes of unraveling more clues about our biological clock.
VIP is not "very important person," but vasoactive intestinal polypeptide (VIP), a neuropeptide originally found in the gut, that is also...
Product improves peptide identification for proteomics research
Agilent Technologies Inc. (NYSE: A) today introduced a high-performance ion trap mass spectrometer (MS) that allows pharmaceutical and academic life-science researchers to identify 60 to 80 percent more peptides than preceding models in proteomics applications, such as protein identification and bi...
Toward an explanation for Crohn's disease?
...that will recognize invading bacteria and then trigger the immune response. This study demonstrates that the NOD2 receptor preferentially recognizes a peptide
called N-glycolyl-MDP, which is only found in a specific family of bacteria called mycobacteria. When mycobacteria invade the human body, they cause a...
Singapore nanotechnology combats fatal brain infections
bacteria and fungal infections with novel peptide
nanoparticles developed by scientists at the Insti...disability and brain damage in patients.
nanoparticles, on the other hand, contain a membra...brain that require treatment. The ability of IBN's peptide
nanoparticles to traverse the blood brain barrier ...
The battle for CRTC2: How obesity increases the risk for diabetes
...nd why thin people can become insulin-resistant.
The Salk team, led by Marc Montminy, Ph.D., a professor in the Clayton Foundation Laboratories for peptide
Biology, discovered how a condition known as ER (endoplasmic reticulum) stress, which is induced by a high fat diet and is overly activated in obese p...
Tips from the journals of the American Society for Microbiology
Newly Developed Antimicrobial peptide
May Protect Mice from Lethal Bacterial Infections ... from Japan suggest that a synthetic antimicrobial peptide
identified as L5 may prevent death in mice sufferi...y researchers developed the cationic antimicrobial peptide
L5 out of antibacterial proteins from Sarcophaga ...
Stress puts double whammy on reproductive system, fertility
... GnIH, discovered nine years ago in birds and known to be present in humans and other mammals. This small protein hormone, a so-called RFamide-related peptide
(RFRP), puts the brakes on reproduction by directly inhibiting GnRH.
The common thread appears to be the glucocorticoid stress hormones, which not ...
Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals
...agues have discovered that the Opioid Growth Factor (OGF, [Met5]-enkephalin), a clinically important antitumor agent, is dependent on shuttling of the peptide
and the OGF receptor from the cytoplasm to the nucleus. This discovery may provide valuable information to understanding the etiology and pathogenesi...
LSUHSC student awarded top national honor for diabetes research
...SUHSC research team found that ACE2 gene therapy improves pancreatic beta cell function and restores glucose stability by increasing the activity of a peptide
called Angiotensin (1-7), or Ang (1-7). ...
Our brains make their own marijuana: We're all pot heads deep inside
...l proteins, called peptides, from the brains of mice and determining their amino acid sequence. The extracted proteins were then compared with another peptide
previously known to bind to, but not activate, the receptor (THC) affected by marijuana. Out of the extracted proteins, several not only bound to the ...
Alzheimer's disease therapeutic prevents long-term damage from TBI in pre-clinical studies
...e designed to prevent build-up of amyloid, a toxic peptide
found in the brain. This peptide
clogs the brains of Alzheimer's patients but it is... the investigators sought to understand if amyloid peptide
contributed to secondary injury. Amyloid peptides ...
Scripps research team identifies key molecules that inhibit viral production
...f the actual virus itself.
"We went for the simplest solution, taking a peptide
from core to see if we could block the interaction," Strosberg said, "and i... HCV production by 68 percent and 63 percent, respectively; a third related peptide
showed 50 percent inhibition. When added to HCV-infected cells, each of the...
Peptides-on-demand: McGill researcher's radical new green chemistry makes the impossible possible
"Currently, to generate peptides you must use a peptide
synthesizer, an expensive piece of high-tech equip...searchers to construct a single, simple "skeleton" peptide
which can be modified into any other peptide
needed with the addition of a simple reagent.
Common gene variants increase risk of hypertension, may lead to new therapies
...nd variants associated with changes in natriuretic peptide
levels were then tested in the same individuals fo...y the heart when it is stressed, and screening for peptide
levels is widely used to diagnose heart failure, a...rently premature to advocate screening natriuretic peptide
levels or gene variants to diagnose hypertension r...
Breaking the barrier: Discovery of anti-resistance factors and novel ocean drugs
...o coral disease has resulted in thousands of new bacterial isolates producing highly selective antimicrobial compounds yielding highly selective small peptide
Gene therapy reversed heart damage in heart failure
...The rats were treated with a gene that generates a peptide
called ARKct, which was administered to he...data show that beta blockers and the ARKct peptide
are compatible and can be given together," Dr. Koc..."
In future trials in humans, the ARKct peptide
will be administered with beta blockers, which are...
Single virus used to convert adult cells to embryonic stem cell-like cells
...nes' DNA, it begins making a protein. However, when it tries to read the 2A peptide
DNA that resides between the genes, the machinery momentarily stops, allowi...gene, creates that gene's protein, stalls when reaching another piece of 2A peptide
DNA, and releases the second gene's protein. The process continues until th...
Epilepsy drug shows potential for Alzheimer's treatment
...ieved to be caused by the gradual accumulation in the brain of amyloid-beta peptide
which is toxic to nerve cells. This is thought to be caused by a key enzyme...ually switching off in later life. One of NEP's roles is to clear the toxic peptide
from the brain, and plaques begin to form as it gradually switches off, lea...
Cancer cell 'bodyguard' turned into killer
...cal Research in La Jolla, Calif., have developed a peptide
that converts the Bcl-2 protein from a cancer cell...ournal in October.
The key to the conversion is peptide
NuBCP-9, a string of nine amino acids that bind to...d outside the petri dish, researchers injected the peptide
and its mirror-image molecule into cancer tumors i...
Mitochondria could be a target for therapeutic strategy for Alzheimer's disease patients
...the role of CypD in Alzheimer's disease has not been elucidated.
In this paper, Dr. Yan and colleagues demonstrate that CypD interacts with Aβ peptide
within the mitochondria of Alzheimer's disease patients and a transgenic mouse model of Alzheimer's disease. The cortical mitochondria isolated from A...
Syracuse University researchers discover new way to attack some forms of leukemia
...am identified a tiny component of the MLL proteina peptide
sequence that contains just six amino acidsthat is...itch in normal cells. The team members called this peptide
sequence the "Win" motif. They discovered that a synthetic version of this peptide
acts like a drug that breaks apart the MLL molecul...
Burnham researchers turn cancer friend into cancer foe
...rch today announced that scientists have created a peptide
that binds to Bcl-2, a protein that protects cance...ess that usually keeps cancer cells in check. This peptide
(called NuBCP-9) and its enantiomer (mirror-image ...ld Satterthwait, Ph.D. and others.
The NuBCP-9 peptide
was created from Nur77, a potent pro-apoptotic pro...
Food for thought -- regulating energy supply to the brain during fasting
"We have all seen the sub-prime mortgage crisis," says Marc Montminy, M.D., Ph.D., a professor in the Clayton Foundation Laboratories for peptide
Biology who led the current study. "If you take out a loan, sooner or later you've got to pay your debt, and the same is true in fasting metabolism." ...
Discovery of natural compounds that could slow blood vessel growth
... by a number of proteins, like the sequence of the peptide
building blocks, the team first categorized the 40...chers then used computer programs and compared the peptide
families to all of the proteins encoded by the gen...owth and survival, they added different amounts of peptide
to dishes containing roughly 2,000 cells and after...
A second career for a growth factor receptor: keeping nerve axons on target
...e show a direct interaction between these two systems."
Collaborating with Kuo-Fen Lee, Ph.D., professor in the Clayton Foundation Laboratories for peptide
Biology, the O'Leary team observed a defect in mice genetically engineered to lack p75. Through their synaptic connections, retinal axons develop a tw...
Researchers seeking to identify Alzheimer's risk focus on specific blood biomarker
...e in the Proceedings of the National Academy of Sciences during the week of Sept. 8, 2008 suggest that individuals with elevated levels of a certain peptide
in the blood plasma, Amyloid Beta 42 (A42), are at increased risk of developing Alzheimer's disease and that the decline of A42 in the bloodstream may...
American Chemical Society's Weekly PressPac -- Sept. 3, 2008
...eatures are key to the effective use of AMPs as antibiotics, they say.
ARTICLE #4 FOR IMMEDIATE RELEASE
"Synthesis of Bioinorganic Antimicrobial peptide
Potential Therapeutic Properties"
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D. Matthew Eby...
New once-a-week treatment for type 2 diabetes developed by Mount Sinai researcher
...s lives," said Dr. Jim Woodgett, Director of Research at the Samuel Lunenfeld Research Institute. "Dr. Drucker is a world-expert in the development of peptide
hormone-based therapies for the treatment of human disease and this is an excellent example of moving discovery through to therapeutic application."
New master switch found in the brain that regulates appetite and reproduction
...the daisy chain of signals that run between body fat and the brain," says Marc Montminy, Ph.D., a professor in the Clayton Foundation Laboratories for peptide
Biology, who led the study. "It likely plays a pivotal role in how much we, as humans, eat and whether we have offspring."
It is just as important a...
Chemists make beds with soft landings
...that soft-landing can be used to prepare ultrapure peptide
layers on substrates. The question we faced was, i...nto the surface.
When the chemists examined the peptide
shapes in the solution and the resulting thin film... Wang.
Next, the team would like to create thin peptide
layers using different support surfaces and a diff...
Slipping through cell walls, nanotubes deliver high-potency punch to cancer tumors in mice
...doing is so-called 'passive targeting,' which is using the leaky vasculature of the tumor," he said. "But a more active targeting would be attaching a peptide
or antibody to the nanotube drug, one that will bind more specifically to the tumor, which should further enhance the treatment efficacy."
UT Health Science Center researchers study diet and autism
...is a protein in wheat; casein and whey are proteins in milk. Casomorphin, a peptide
in milk; and gliadomorphin, a peptide
in gluten, are thought to be related to changes in behavior in these childr...
Treatment corrects severe insulin imbalance in animal studies
...ycemia) or too high, resulting in diabetes.
The new study makes use of a peptide
(an amino acid compound) called exendin-(9-39) that blocks the action of a ...ng, her study team expects to progress to a larger clinical trial. "If this peptide
can be developed into a treatment for children with this common form of HI,...
NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008
...ues in people with Alzheimer's disease, NYU researchers have found that the peptide
not only plays a toxic role in the neurodegenerative disease but also is cr...d memory consolidation in the normal brain. The rat study, which controlled peptide
levels in a region of the brain that is important in learning and memory, s...