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Pancreatic in Biological News

Newly discovered epidermal growth factor receptor active in human pancreatic cancers

Finally some promising news about pancreatic cancer, one of the most fatal cancers, due to the difficulties of early detection and the lack of effective therapies: Johns Hopkins University pathologist Akhilesh Pandey has identified an epidermal growth factor receptor aberrantly active in approxima...

Device protects transplanted pancreatic cells from the immune system

LA JOLLA, Calif., April 9, 2009Scientists at Burnham Institute for Medical Research (Burnham) and the University of California San Diego (UC San Diego) School of Medicine have demonstrated in mice that transplanted pancreatic precursor cells are protected from the immune system when encapsulated i...

Compendium of pancreatic cancer biomarkers established as strategic approach to early-detection

A cancer scientist from Johns Hopkins has convinced an international group of colleagues to delay their race to find new cancer biomarkers and instead begin a 7,000-hour slog through a compendium of 50,000 scientific articles already published to assemble, decode and analyze the molecules that mig...

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

Researchers at the Tulane University School of Medicine, New Orleans, Louisiana have discovered that the HIV-1 protease inhibitors (PIs), such as nelfinavir included in highly active antiretroviral therapy (HAART) regimen for the treatment of HIV-1 patients, induce deleterious effects on insulin s...

Tiny samples could yield big predictive markers for pancreatic cancer

A handful of proteins, detected in incredibly tiny amounts, may one day help doctors distinguish between a harmless lesion in the pancreas and a potentially deadly one, say researchers at Fox Chase Cancer Center. The researchers believe that these protein biomarkers, if confirmed in subsequen...

U-M researchers ID gene involved in pancreatic cancer

ANN ARBOR, Mich. Researchers from the University of Michigan Comprehensive Cancer Center have identified a gene that is overexpressed in 90 percent of pancreatic cancers, the most deadly type of cancer. Expression of the gene, Ataxia Telangiectasia Group D Complementing gene, called ATDC, is o...

DNA repair patterns may predict risk of pancreatic cancer

PHILADELPHIA Genetic variations in DNA repair patterns may increase risk of pancreatic cancer by as much as threefold or decrease it by as much as 77 percent, depending on the genes involved, according to a report published in the January 15, 2009, issue of Clinical Cancer Research , a journal o...

Researchers engineer pancreatic cell transplants to evade immune response

In a finding that could significantly influence the way type 1 diabetes is treated, researchers at Albert Einstein College of Medicine of Yeshiva University have developed a technique for transplanting insulin-producing pancreatic cells that causes only a minimal immune response in recipients. ...

UC Davis researchers discover Achilles' heel in pancreatic cancer

UC Davis Cancer Center researchers have discovered a metabolic deficiency in pancreatic cancer cells that can be used to slow the progress of the deadliest of all cancers. Published in the October issue of the International Journal of Cancer , study results indicate that pancreatic cancer cell...

Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells

PHILADELPHIA A research team, led by investigators at the Department of Surgery at Jefferson Medical College of Thomas Jefferson University and the Kimmel Cancer Center at Jefferson, has achieved a substantial "kill" of pancreatic cancer cells by using nanoparticles to successfully deliver a dead...

Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer

New understanding of a protein that spurs the growth of pancreatic cancer could lead to a new vaccine against the deadly disease, said researchers at Baylor College of Medicine in Houston in a report appearing in the current edition of the journal Molecular Cancer Therapeutics. The protein call...

Elusive pancreatic stem cells found in adult mice

Just as many scientists had given up the search, researchers have discovered that the pancreas does indeed harbor stem cells with the capacity to generate new insulin-producing beta cells. If the finding made in adult mice holds for humans, the newfound progenitor cells will represent an obvious t...

Naturally-occurring apple compounds reduce risk of pancreatic cancer

Eating flavonol-rich foods like apples may help reduce the risk of pancreatic cancer, says a team of international researchers. Quercetin, which is found naturally in apples and onions, has been identified as one of the most beneficial flavonols in preventing and reducing the risk of pancreatic c...

Birth records hold pancreatic cancer clue

Pregnancies in Jerusalem in the 1960s and 1970s may hold vital clues about how pancreatic cancer and diabetes are linked. According to research published in the online open access journal BMC Medicine, women with a history of gestational diabetes had a higher risk of developing pancreatic cancer l...

Low levels of key protein may indicate pancreatic cancer risk

BOSTON--A protein that dwindles in response to obesity and a sedentary lifestyle may one day help doctors predict which people are at increased risk for pancreatic cancer, new research by Dana-Farber Cancer Institute and collaborating scientists indicates. In a report in the Aug. 15 issue of Ca...

Obesity and lack of exercise could enhance the risk of pancreatic cancer

PHILADELPHIA Obesity and aversion to exercise have become hallmarks of modern society and a new study suggests that a blood protein linked to these lifestyle factors may be an indicator for an increased risk of developing pancreatic cancer. Researchers from the Dana Farber Cancer Institute repor...

Scientists identify pancreatic cancer stem cells

Researchers at the University of Michigan Medical Center have, for the first time, identified human pancreatic cancer stem cells. Their work indicates that these cells are likely responsible for the aggressive tumor growth, progression, and metastasis that define this deadly cancer. In the Februa...

Genetic pathways to curable and incurable forms of pancreatic cancer identified

Pancreatic ductal adenocarcinoma is an almost uniformly fatal disease regardless of the stage at time of diagnosis. However, a small percentage of patients develop a form of ductal adenocarcinoma associated with cystic lesions that can be detected earlier, is less aggressive and has a 50 percent lo...

Protein found to shield pancreatic cancer cells from self-destruction

An overexpressed protein protects human pancreatic cancer cells from being forced to devour themselves, removing one of the body's natural defenses against out-of-control cell growth, researchers at The University of Texas M. D. Anderson Cancer Center report in the March issue of Molecular Cancer R...

Encouraging results in pancreatic cancer research

Researchers at SUNY Downstate Medical Center and the Brooklyn VA Hospital have found that when a human protein, PNC-28, is administered to pancreatic tumor cells in animals, the tumors are destroyed. The research was reported in the October 1st edition of the International Journal of Cancer. Mat...

Gene therapy potential for treatment of pancreatic cancer

A gene responsible for the production of a protein called vasostatin may prove a promising new way of treating pancreatic cancer, suggests research published ahead of print in Gut. Pancreatic cancer is the fifth leading cause of cancer deaths in the developed world, and is extremely difficult to ...

New imaging technology shown to detect pancreatic inflammation in type 1 diabetes

A key obstacle to early detection of type 1 diabetes - as well as to rapid assessment of the effectiveness of therapeutic intervention - has been the lack of direct, non-invasive technologies to visualize inflammation in the pancreas, an early manifestation of disease. Instead, clinicians have had ...

Disease progression model of pancreatic cancer developed by Penn researchers

Building on previous work, researchers at the University of Pennsylvania School of Medicine have developed an animal model of pancreatic cancer that closely mimics disease progression in humans. From this, they hope to develop new treatments for this deadly disease. Advanced pancreatic cancer is am...

Protein handlers should be effective treatment target for cancer and Alzheimer's

...s that control some of them, disables tumor formation in the liver and probably the breast. Researchers are also now examining brain tumors as well as pancreatic and prostate cancer. They also want to know whether ramping up the activity of molecular chaperone can essentially make them act young again and ha...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

...protein that binds to it, the growth factor pleiotrophin (PTN), are both also over-expressed in other difficult-to-treat cancers, such as melanoma and pancreatic tumors. "We have found that PTN drives metastasis of those cancers, suggesting that antibody treatment may be additionally useful in those cancers," W...

Stem cell research: From molecular physiology to therapeutic applications

...reating Parkinson's disease and his research using pancreatic progenitor cells for treating diabetes has demonst...differentiation of human embryonic stem cells into pancreatic beta cells to treat diabetes. He is one of the two...ripotent stem cell differentiation into functional pancreatic islet cells and discusses the challenges for futur...

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

...ely promotes the activity of a gene known as MYC, which evidence has demonstrated is a potent factor in numerous cancers, including lymphoma, lung and pancreatic cancer. Their studies were performed in mouse cancer models and in human cell cultures. "While MYC has a definite role in cancer, MYC also has an i...

'Normal' cells far from cancer give nanosignals of trouble

... A new Northwestern University-led study of human colon, pancreatic and lung cells is the first to report that cancer cells and their non-cancerous cell neighbors, although quite different under the microscope, share v...

Trio of signals converge to induce liver and pancreas cell development in the embryo

...at tissues regenerate and how stem cells can be used for new therapies. With regenerated cells, researchers hope to one day fill the acute shortage in pancreatic and liver tissue available for transplantation in cases of type I diabetes and acute liver failure. Previous studies on pancreas and liver develop...

Colon cancer screening technique shows continued promise in new study

...nder way for multicenter clinical validation. The work builds on previous success in using a suite of optical technologies to detect both colon and pancreatic cancer. ...

USC researchers present diabetes findings at American Diabetes Association Scientific Sessions

...ts avoid "post exercise hypoglycemia," the role of pancreatic beta cells in the progression of diabetes, and how...rcise and Post-Exercise Induced Hypoglycemia). pancreatic Beta Cell Mass in Development of Diabetes Tom ...ch Center will discuss his research on the role of pancreatic beta cell mass in the regulation of blood sugar, a...

Society of Interventional Radiology Foundation awards $191,000 in grants

...ional Radiology Foundation's Dr. Ernest J. Ring Academic Development Grant for his research in "MR-guided Transplantation of Magnetoencapsulated Human pancreatic Islet Cells in a Diabetic Swine Model." This grant, named after the founder of the SIR Foundation, is designed to provide support to junior interventi...

GenWay Biotech obtains exclusive rights to AMDL's DR-70 cancer test in US and Canada

...f cancer, including lung, breast, stomach, liver, colon, rectal, ovarian, esophageal, cervical, trophoblastic, thyroid, malignant lymphoma, brain and pancreatic cancer making it one of the most versatile cancer biomarkers available. The GenWay team is looking forward to the future impact of the DR-70 test i...

When cells reach out and touch

...roduction in five additional commonly studied human and mouse cell lines, including human breast cancer cells, human colorectal cancer cells and human pancreatic cancer cells. They also tested fruit fly cells to determine whether or not the phenomenon is restricted to mammals. In all tested cell lines, inclu...

Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals

...properties of these native peptides in a variety of clinical studies. OGF has proven successful in a Phase I clinical, trial, and Phase II trials for pancreatic cancer and squamous cell carcinoma of the head and neck are in progress. Co-author Dr. McLaughlin states: "Given the extraordinary biological control...

LSUHSC public health researcher finds reason for weight gain

...es. The researchers offer a couple of possible explanations for their findings. The absence of chewing when consuming liquids may result in decreased pancreatic responses. Beverages also clear the stomach sooner than solid food and may induce weaker satiety signals in the gastrointestinal tract. "Our study su...

LSUHSC student awarded top national honor for diabetes research

...ed that the improvement in glucose stability could be achieved by enhancing pancreatic beta cell function. Beta cells are located in islet cell clusters throughou...experiments, the LSUHSC research team found that ACE2 gene therapy improves pancreatic beta cell function and restores glucose stability by increasing the activit...

Novocell awarded seminal stem cell patent

...y announced that it has received U.S. Patent 7,510,876 with claims covering human definitive endoderm cells, an essential cell for generating not only pancreatic type cells, which Novocell is developing for use as a cell therapy for diabetes, but also other endoderm lineage-derived tissues and organs such as lu...

Human adult testes cells can become embryonic-like

...ble of morphing into any cell type that a body needs, from brain neurons to pancreatic tissue. And because they produced these stem cells without the use of ad...ect that uses testes spermatogonial stem/progenitor cells that morphed into pancreatic cells to treat diabetes in mouse models of human diabetes. ...

TGen's Dr. Von Hoff wins award for cancer research

...n Hoff, a world-renowned cancer scientist and one of the leading experts in pancreatic cancer. In November, Dr. Von Hoff was named Arizona's Community Service Le...s many of which have been shown to increase patient survival. Study of pancreatic and other forms of cancer. Dedication to teaching. Entrepreneurial ...
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