PRED

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

A scientist at the Marine BiologicalLaboratory (MBL) has published the results of an EPA-funded clam embryostudy that supports her hypothesis that, when combined, the pollutantsbromoform, chloroform, and tetrachloroethylene--a chemical cocktailknown as BCE--can act synergistically to alter a key regulator in nervecell development. While scientists have previously studied the effectsof these...

Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation

Measuring the quantity of a certain type of immune cell DNA in the blood could help physicians predict whether a bone marrow stem cell transplant will successfully restore a population of infection-fighting cells called T lymphocytes in a child. This research, by investigators at St. Jude Children's Research Hospital, is published in the journal Blood. This finding could help physicians p...

Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients

Multiple sclerosis (MS) can be an unpredictable disease. It develops when the body's immune system attacks healthy nerve cells and disrupts normal nerve signaling. Patients experience a wide range of symptoms—including tingling, paralysis, pain, fatigue, and blurred vision—that can appear independently or in combination, sporadically or persistently. Although symptoms appear in no particular orde...

Super predators and mass extinctions

Mass extinctions seem to occur on Earth roughly every 26 million years, leading some scientists to propose that they may be caused by rare collisions with comets or asteroids. A researcher in Poland thinks it may be possible that extraordinary predators are at fault instead. Adam Lipowski (Adam Mickiewicz University) constructed a numerical model of many species competing for both food and...

Biomarkers isolated from saliva successfully predict oral and breast cancer

Screening for breast cancer and the early detection of other tumors one day may be as simple as spitting into a collection tube or cup, according to recent studies by UCLA researchers. In one early study based on a risk model, presented here at the 96th Annual Meeting of the American Association for Cancer Research, the UCLA scientists reported that genetic "biomarkers" isolated in saliva...

Chromosome Deletion Predicts Aggressive Neuroblastoma

When genes are deleted on a particular section of chromosome 11, the result is an aggressive form of the childhood cancer neuroblastoma. A new study suggests that detecting this genetic deletion during the initial evaluation of children with neuroblastoma may indicate to physicians that they should recommend a more aggressive regimen of chemotherapy to fight the cancer. Edward F. Attiyeh,...

Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia

A new study is providing scientists with a better understanding of why some pediatric acute lymphoblastic leukemia (ALL) patients fail to respond to treatment even when existing clinical predictive criteria point towards a positive treatment outcome. The research, published in the April issue of Cancer Cell, is likely to facilitate development of new strategies to combat drug resistance and treat...

Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol

Researchers at The University of Texas M. D. Anderson Cancer Center have developed a way to test whether the new targeted therapy Tarceva and the widely used chemotherapy drug Taxol are effectively killing tumor cells. They say that with further refinement, the test may make it possible to accurately assess whether patients are responding to these agents, as well as potentially others, within day...

Analysis Of Human Genome To Predict The Development Of Illnesses

The GARBAN project, drawn up by Navarre University, will enable the identification of therapeutic targets for cancer, depression and hepatitis. The School of Engineering at Navarre University and its Centre for Technical Studies and Research in Gipuzkoa (CEIT) have launched an advanced biochemical analysis tool that will help in predicting the evolution of diseases, accelerate their diagno...

At the molecular level, the predator is the prey

An evolutionary arms race between predatory garter snakes and their newt quarry is turning out to be something of an illusion. At the molecular level, another battle rages. And in this second, miniature realm, it's the newt who's the aggressor. Biologists at Indiana University Bloomington, Utah State University and the University of Utah present evidence in this week's Nature that a toxin...

Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines

The ability to select and develop compounds that act on specific cellular targets has just gained a computational ally ?a mathematical algorithm that predicts the precise effects a given compound will have on a cell’s molecular components or chemical processes. Using this tool, drug developers can design compounds that will act on only desired gene and protein targets, eliciting therapeutic respo...

Ocean climate predicts elk population in Canadian Rockies

Mark Hebblewhite can look at specific climate statistics from the north Pacific Ocean and tell you how the elk are doing in Banff National Park. The University of Alberta doctoral student is the first researcher to show a correlation between the North Pacific Oscillation (NPO) and a mammal population. Based on many climate-related ocean measurements, researchers are able to determine posit...

Understanding biases in epidemic models important when making public health predictions

Mathematical models have become invaluable decision-making tools for public health officials. As demonstrated during the United Kingdom's foot-and-mouth epidemic of 2001, models can be useful in two ways: they can reveal the underlying characteristics of an infection and they can allow the comparison of alternative control measures. Often, however, such models make implicit assumptions that may s...

Identification of specific genes predicts which patients will respond to Hepatitis C treatment

For the first time, physicians at University Health Network and University of Toronto have identified a small subset of genes that can predict whether a patient with chronic Hepatitis C will be able to respond to current treatments. The study, published in t...

UNC computer, marine scientists collaborate to predict flow of toxic waters from Katrina

In the immediate wake of Hurricane Katrina, scientists and research centers from across the country came together to generate information on the contaminated floodwaters and offer it to hazardous materials experts and public health officials. In a matter of hours, the University of North Carolina at Chapel Hill's Marine Sciences Program and Renaissance Computing Institute (RENCI), together...

Rensselaer researchers develop approach that predicts protein separation behavior

Applying math and computers to the drug-discovery process, researchers at Rensselaer Polytechnic Institute have developed a method to predict protein separation behavior directly from protein structure. This new multi-scale protein modeling approach may reduce the time it takes to bring pharmaceuticals to market and may have significant implications for an array of biotechnology applications, inc...

Study: Predatory dinosaurs had bird-like pulmonary system

What could the fierce dinosaur T. rex and a modern songbird such as the sparrow possibly have in common? Their pulmonary systems may have been more similar than scientists previously thought, according to new research from Ohio University and Harvard University. Though some scientists have proposed that predatory dinosaurs had lungs similar to crocodiles and other reptiles, a new study pub...

Researchers predict infinite genomes

TIGR scientists probe new pan-genome But scientists at The Institute for Genomic Research (TIGR) have come to a startling conclusion. Armed with the powerful tools of comparative g...

Modification of program enables prediction of gene transcription

A modification to an "ace" gene prediction program by computer scientists at Washington University in St. Louis now enables scientists to predict the very beginnings of gene transcription start sites and where the first splice occurs thereby defining the first exon of the gene. The modification to the gene prediction software TWINSCAN is called N-SCAN. Michael Brent, Ph.D. professor of com...

Computers close in on protein structure prediction

Rosetta@home lets public participate in structure prediction. The findings, which were reported in the September 16, 2005, issue of the journal Science, provide a glimmer of hope th...

Sensor web simulation investigates technique to improve prediction of pollution across the globe

For asthmatics and for anyone with respiratory problems, air pollution can significantly impair simple everyday activities. NASA is trying to tie together satellites and stations on the ground to develop a "sensor web" to track this pollution and improve air quality forecasts. Understanding how tropospheric or near-surface-level ozone is produced, distributed and transported from city to c...

Using the genomic shortcut to predict bacterial behavior

Turning plants such as corn, soybeans and sunflowers into fuel uses much more energy than the resulting ethanol or biodiesel generates, according to a new Cornell University and University of California-Berkeley study. "There is just no energy benefit to using plant biomass for liquid fuel," says David Pimentel, professor of ecology and agriculture at Cornell. "These strategies are not su...

Eleven gene 'signature' reliably predicts cancer prognosis

The rather new concept of "tumor stem cells" maintains that a rare, stem cell-like population of cancer cells exists among the mix of other cells found in a tumor and that these tumor stem cells are responsible for tumor progression and metastasis. In a revolutionary study appearing in the June 1 print issue of The Journal of Clinical Investigation, Gennadi Glinsky and colleagues from the Sidney...

Researchers use brain scans to predict behavior

By peering into the minds of volunteers preparing to play a brief visual game, neuroscientists at Washington University School of Medicine in St. Louis have found they can predict whether the volunteers will succeed or fail at the game. "Before we present the task, we can use brain activity to predict with about 70 percent accuracy whether the subject will give a correct or an incorrect r...

Creeping crinoids! Sea lilies crawl to escape predators, new video shows

With their long stalks and feathery arms, marine animals known as sea lilies look a lot like their garden-variety namesakes. Perhaps because of that resemblance, scientists had always assumed that sea lilies stayed rooted instead of moving around lik...

Scientists learn to predict protein-stabilizing ability of small molecules

Prostate cancer is the second leading cause of death among American men. It is estimated that one in six males will develop the disease during his lifetime. However, promising new treatment options have been developed to help combat this threatening disease. One of the most innovative of these treatments is robotic-assisted laparoscopic prostatectomy (removal of the prostate...

Sea slug mixes chemical defense before firing at predators

When threatened by predators, sea slugs defend themselves by ejecting a potent inky secretion into the water consisting of hydrogen peroxide, ammonia and several types of acids. A team of researchers with the Atlanta-based Center for Behavioral Neuroscience (CBN) has found that this secretion is produced from normally inert chemicals stored separately in two glands. The discovery, published in th...

Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs

A team of researchers led by scientists at Memorial Sloan-Kettering Cancer Center have discovered that a new class of drugs -- now in early stage clinical trials -- work best in patients with mutations in the BRAF gene. BRAF is a protein that plays a central role in the growth and survival of cancer cells and is mutated in the majority of patients with melanoma and in a minority of patients with...

Gene expression profile helps predict chemotherapy response in ovarian cancer patients

A newly identified gene expression profile could help predict how patients with advanced ovarian cancer will respond to chemotherapy treatment. Described in a study in the November 1, 2005 issue of The Journal of Clinical Oncology (JCO), the new findings further establish an important role for microarray gene profiling as a predictor of clinical outcome in ovarian cancer, and could eventually pro...

Predators keep the world green, ecologists find

Predators are, ironically, the key to keeping the world green, because they keep the numbers of plant-eating herbivores under control, reports a research team lead by John Terborgh, a professor of environmental science at Duke University's Nicholas School of the Environment and Earth Sciences. Their findings confirm the answer to one of ecology's oldest and thorniest questions: why is the...

Evolutionary biology research techniques predict cancer

In diverse ecosystems, packed with wildly different species, evolution whizzes along. As different species accumulate mutations, some adapt particularly well to their environment and prosper. It happens in marine sediments, mountain forests ?and, as a new study illustrates, in precancerous tumors, too. In a study published online today in Nature Genetics, Carlo Maley, Ph.D., a researcher a...

Predicting success

Chemotherapy drugs, given intravenously, are the mainstay of the fight against cancer. But doctors know that sometimes these drugs effect a complete cure, while other times they can be nearly ineffective. How to turn some of those failures into successes? A team of scientists at the Weizmann Institute, headed by Prof. Hadassa Degani of the Biological Regulation Department, has come up with a non-...

Sweet 'water taste' paradoxically predicts sweet taste inhibitors

A scientific paradox linking artificial sweeteners such as saccharin with a sensory experience in which plain water takes on a sweet taste has guided researchers to an increased understanding of how humans detect sweet taste. Reporting in an advance online publication in Nature, scientists from the Monell Chemical Senses Center describe how certain artificial sweeteners, including sodium...

Animal brains 'hard-wired' to recognize predator's foot movements, Queen's study suggests

The reason people can approach animals in the wild more easily from a car than by foot may be due to an innate "life detector" tuned to the visual movements of an approaching predator's feet, says Queen's University psychologist Niko Troje. "We believe this visual filter is used to signal the presence of animals that are propelled by the motion of their feet and the force of gravity," sug...

Predicting chemotherapy outcome

Studying the gene-expression profiles of patients with colorectal cancer might help predict their response to chemotherapy. In a study published today in the open access journal Genome Biology, researchers identified in the tumours of colorectal cancer patients almost 700 genes whose expression was different between patients who subsequently responded well to combined chemotherapy and patients wh...

Scientists develop malaria forecasting tool to predict disease risk

A new tool to predict epidemics of malaria up to five months in advance has been developed by a scientist at the University of Liverpool. The model uses predictions of climate variability to indicate the level of risk of an epidemic up to five months in advance of the peak malaria season ?the earliest point at which predictions have ever been made. The model will assist doctors and health...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

Cancer researchers are working toward a future in which each patient's tumor will act like a crystal ball, revealing how oncologists should treat the cancer to obtain the best outcome. Currently, physicians cannot predict which patients with prostate cancer should receive extra therapy after surgery - or whether some of these patients have an indolent disease that does not even require su...

Predicting successful outcomes in living-donor liver transplants

A new study on identifying which patients were likely to have poor outcomes following a living-donor liver transplant (LDLT) found that measuring how a certain non-toxic dye was eliminated by the liver shortly after surgery was an accurate indicator of liver function, and therefore a reliable indicator of the outcome of the procedure. The study used a simple non-invasive device to measure the dye...

Mayo Clinic study finds two genes predict outcome for breast cancer patients

Mayo Clinic researchers report that the expression of two novel genes within the tumors of women with early stage breast cancer may allow identification of women who are and are not at risk for early relapse or cancer-related death. Results of the study are published in the April 1 issue of Clinical Cancer Research. "The HOXB13 and IL17BR gene profile was previously discovered as a potent...

Insect predation sheds light on food web recovery after the dinosaur extinction

The recovery of biodiversity after the end-Cretaceous mass extinction was much more chaotic than previously thought, according to paleontologists. New fossil evidence shows that at certain times and places, plant and insect diversity were severely out of balance, not linked as they are today. The extinction took place 65.5 million years ago. Labeled the K-T extinction, it marks the beginning of t...