POL in Biological News

Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone

...ntion of HIV infection Hongjie Liu, Ph.D. Virginia Commonwealth University, Richmond, VA $119,930 A pilot study of a text-messaging-enhanced pol HIV intervention program: Men involved in transactional sex with other men represent an important source of HIV transmission in China, especially sinc...

CSHL scientists discover new way in which ubiquitin modifies transcriptional machinery

...NA polymerase II (abbreviated by scientists as RNA pol II). This enzyme is composed of 12 modules, each w...at Asr1 has the unique ability of homing in on RNA pol II molecules that are actively turning on genes, w...hesizes that Asr1 might selectively glom on to RNA pol II molecules that are making mistakes in copying o...

New gene-silencing pathway found in plants

... eukaryotes share three essential RNA polymerases: pol I, II, and III. These polymerases are indispensab... any of those, you die," says Pikaard. "However, pol IV and pol V -- which only plants have -- you don't need them...

Stowers Institute's Shilatifard Lab identifies new role for factor critical to transcription

...he timing and location of transcript elongation by pol II is essential for development. In a paper publis...y causing temporary interruptions of the action of pol II in the fruit fly (Drosophila melanogaster). "Biological mechanisms such as the 'pausing' of pol II at nearby promoters have been found at many reg...

Research sheds light on the mechanics of gene transcription

...gan to be transcribed. The researchers also tagged pol II with a fluorescent marker to track its movement...ed by Webb -- the researchers found that over time pol II began to recycle itself within newly formed "co...s is, to our knowledge, the first demonstration of pol II recycling at a specific gene in vivo." Lis and...

Massive dinosaur discovered in Antarctica sheds light on life, distribution of sauropodomorphs

... sauropods coexisted with their basal sauropodomorph cousins, including Glacialisaurus hammeri, during the Late Triassic and Early Jurassic, Smith and pol conclude in their research findings. ...

International team compares 12 fruit fly genomes

...long thought that the rate of transcription is limited by the time it takes pol II to be recruited to the promoter region, where it copies a strand of DNA ... But increasing evidence in Drosophila and other organisms indicates that pol II frequently exists in a "paused" state at the promoter: Already having ma...

Genetic contributions to human brain morphology and intelligence

...of the superior occipitofrontal fascicle, and the corpus callosum [Hulshoff pol et al., 2006]. For the genetic analyses, structural equation modeling and v...ncentrated in areas that are under considerable genetic influence [Hulshoff pol et al., 2006]. A genetic approach to find genes involved in brain struc...

20th ECNP Congress 2007, Oct. 13-17, Vienna, Austria

...and discuss the therapeutic consequences of these findings. Genetic contributions to human brain morphology and intelligence: Hilleke Hulshoff pol presents persuasive evidence how genetic factors influence the brain structure opening new insights into the reciprocal gene-environment developmental...

Africa's first large-scale HIV vaccine study launches

...se a cold in humans or be passed from person to person. The adenovirus is the carrier or vector which transports copies of three HIV genes called gag, pol and nef. The vaccine is made in the laboratory and does not contain live HIV. The test vaccine therefore cannot cause infection. The hope is that...

Pathway toward gene silencing described in plants

...ce of RNA Polymerase IVa (Pol IVa) by looking at a pol IVa mutant and noting that the rest of the protein... the RNA-dependent RNA polymerase 2 (RDR2) mutant, pol IVa is unaffected, but the function of all the ot...re that emerged from this logical approach is that pol IVa gets things started, churning out RNA that the...

Fossil find: 'Godzilla' crocodile had head of a dinosaur, fins like a fish

...La Plata in Argentina uncovered the crocodile's fossil bones in Patagonia ; pol used sophisticated software to map the features of those bones and determin...eth. None were larger than D. andiniensis, and none were as robust. Yet, pol found that the gargantuan crocodile was more closely related to the smalles...

Clearing jams in copy machinery

...t two different DNA polymerases, the high fidelity pol III replicase and the low fidelity pol IV, coordinate their action to cross obstacles enc...selves at the same time to one beta sliding clamp. pol III copies the original DNA, and acts as a proofre...

New RNA polymerase discovered in plants

... to humans. In all eukaryotes, the RNA polymerases pol I, II, and III perform the same distinct , though ...tions in different species. But then along came pol IV. Pikaard first noticed the evidence for a fourt...I), which makes the largest of the ribosomal RNAs, pol II which makes RNAs for protein-coding genes, or...