Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth
PHILADELPHIA Nanoparticle delivery of diphtheria toxin-encoding DNA selectively expressed in ovarian
cancer cells reduced the burden of ovarian
tumors in mice, and researchers expect this therapy could be tested in humans within 18 to 24 months, according to a report in Cancer Research , a journ...
2 reproductive factors are important predictors of death from ovarian cancer
PHILADELPHIA Researchers from the Centers for Disease Control and Prevention (CDC) found that survival among women with ovarian
cancer is influenced by age of menarche and total number of lifetime ovulatory cycles.
This finding suggests that hormonal activity over the course of a woman's lifet...
Genetic factors implicated in survival gap for breast, ovarian or prostate cancer
NEW YORK (July 8, 2009) A new finding reveals that African-American patients with breast, ovarian, and prostate cancer tend to die earlier than patients of other races with these cancers, even when they receive identical medical treatment and when socioeconomic factors are controlled for. The fin...
Genetic testing for breast or ovarian cancer risk may be greatly underutilized
Although a test for gene mutations known to significantly increase the risk of hereditary breast or ovarian
cancer has been available for more than a decade, a new study finds that few women with family histories of these cancers are even discussing genetic testing with their physicians or other h...
Promising new treatment option for women with recurrent ovarian cancer
Combining the new drug trabectedin with pegylated liposomal doxorubicin provides clinical benefit to women with relapsed ovarian
cancer, according to new results presented at the 33rd Congress of the European Society for Medical Oncology (ESMO) in Stockholm.
The combination, which importantly ...
TG2 identified as potential therapeutic target in chemo-resistant ovarian cancer
HOUSTON, TX Scientists from The University of Texas M. D. Anderson Cancer Center have found overexpression of tissue type transglutaminase (TG2) in ovarian
cancer is associated with increased tumor cell growth and adhesion, resistance to chemotherapy and lower overall survival rates. When resea...
Oocyte-specific gene mutations cause premature ovarian failure
Mutations in a gene called FIGLA cause premature ovarian
failure in at least a percentage of women who suffer from the disorder, said researchers from Baylor College of Medicine in Houston and Shandong University in China in a report that appears online today in the American Journal of Human Genet...
Mutation of the COX2 gene can double or treble a woman's risk of ovarian cancer
Barcelona, Spain: Researchers in Portugal have discovered that a specific mutation of the COX2 gene seems to play a role in the onset of ovarian
cancer, increasing womens susceptibility to developing the disease.
The discovery raises the possibility that, if the findings are confirmed by furthe...
Studies to find better ways to preserve human eggs, ovarian tissue under way
The goal is to make human eggs, ovarian
tissue, blood vessels, even whole organs available when needed.
To get there, researchers are directly comparing slow-freezing techniques, used successfully for decades to preserve sperm and embryos, to a more rapid method of cryopreservation that trans...
Researchers identify ovarian cancer biomarkers
Researchers have identified markers unique to the cells of blood vessels running through ovarian
tumors. The finding, while preliminary, could one day improve screening, diagnosis and treatment for this disease.
The team of researchers from the University of Michigan, University of Pennsylvania, ...
RNA splicing factor implicated in ovarian tumor cell growth
An RNA-binding protein that is overproduced in ovarian
cancer may present a new target for diagnosis or treatment of ovarian
and other cancers, according to researchers at the University of Illinois at Chicago.
Researchers in the UIC College of Pharmacy found that interfering with the production ...
Breakthrough vaccine to treat chemo-resistant ovarian cancer
Cancer Treatment Centers of America announced today its plans to launch a new cancer vaccine therapy that expands treatment options for thousands of women with advanced stage ovarian
cancer. This innovative treatment will be offered by Cancer Treatment Centers of America and developed by AVAX Techn...
Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial
A molecular "off" switch packaged in a tiny sphere penetrates deeply into ovarian
cancer tumor cells, stifling a troublesome protein and drastically reducing the size of tumors, researchers at The University of Texas M. D. Anderson Cancer Center report in the Aug. 15 edition of Clinical Cancer Rese...
Mass. General study finds potential ovarian cancer stem cells
Massachusetts General Hospital (MGH) researchers have identified potential ovarian
cancer stem cells, which may be behind the difficulty of treating these tumors with standard chemotherapy. Understanding more about the stem-like characteristics of these cells could lead to new approaches to treati...
Gene expression profile helps predict chemotherapy response in ovarian cancer patients
A newly identified gene expression profile could help predict how patients with advanced ovarian
cancer will respond to chemotherapy treatment. Described in a study in the November 1, 2005 issue of The Journal of Clinical Oncology (JCO), the new findings further establish an important role for micr...
Human Eggs Can Develop From Ovarian Surface Cells In Vitro
Research has shown for the first time that human eggs may develop directly from cultured ovarian
surface epithelium (OSE) cells derived from adult human ovaries. Oocytes derived from the culture of OSE cells developed in vitro into mature eggs suitable for fertilization and development into an embr...
BRCA1 causes ovarian cancer through indirect, biochemical route
Mutated BRCA1 genes cause ovarian
cancer indirectly, by interfering with the biochemical signals one ovarian
cell sends to another, according to a team of researchers led by scientists at the USC/Norris Comprehensive Cancer Center and the Keck School of Medicine of the University of Southern Califo...
Women often opt to surgically remove their breasts, ovaries to reduce cancer risk
... PHILADELPHIA Many women at high risk for breast or ovarian
cancer are choosing to undergo surgery as a precautionary measure to decrea...arriers of BRCA1 and BRCA2 gene mutations to reduce the risk for breast and ovarian
Evaluated by gene type, bilateral risk-reducing salpingo-oophor...
Pitt researchers find promising candidate protein for cancer prevention vaccines
...ious work, we found that women who developed an immune response to MUC1, typically after pelvic surgery, mumps or mastitis, have a much lower risk for ovarian
cancer," Dr. Finn said. "Cyclin B1 and MUC1 are part of a big family of self-proteins that become over-produced during cancer development, so they hav...
A 'heart healthy' diet and ongoing, moderate physical activity may protect against cognitive decline
...strenuous physical activity has been shown to decrease lifetime exposure to ovarian
hormones in women and has been found to play a protective role against breast cancer. However reduction in ovarian
hormone exposure has been associated with increased risk of cognitive impai...
2 Fred Hutchinson Cancer Research Center scientists receive Presidential Early Career Award
Prior to joining the Hutchinson Center faculty in 2004, she worked at the National Cancer Institute on the Prostate, Lung, Colorectal and ovarian
Cancer Screening Trial. This experience provided Peters with a wealth of collaborative projects, giving her broad-based experience in nutritional and ...
Ovarian transplantation: First baby is born after a new technique
...moges, France, described a new, two-step method of ovarian
transplant that has produced excellent results in ...e said that his team's technique worked to restore ovarian
function quickly and already one patient from his ...r sickle cell anaemia. After transplanting her own ovarian
tissue she started ovulating in four months and be...
Ovarian transplantation: New technique gives greatly improved results in this delicate operation
...Amsterdam, The Netherlands: Ultra-fast freezing of ovarian
tissue from women who have lost their fertility as...oss or preservation of oocytes in fresh and frozen ovarian
tissue of 15 young women undergoing cancer treatme...er fresh ovary transplantation for the duration of ovarian
function and pregnancy outcome, and tested spare t...
UC Davis begins $2.8 million in studies of agricultural nitrogen's impacts
... common cold;
High concentrations of nitrates in groundwater, which can cause methemoglobinemia, or "blue baby disease," and possibly bladder and ovarian
Nitrogen runoff in bays and coastal areas, where it makes algae numbers spike then crash, drawing oxygen from the water and leading ...
Cancer: The cost of being smarter than chimps?
...her rates of cancer? That's a question that has nagged at John McDonald, chair of Georgia Tech's School of Biology and chief research scientist at the ovarian
Cancer Institute, for a while. Now, after an initial study, it seems that McDonald is on to something. The new study is available online in the journa...
Common chemotherapy drug triggers fatal allergic reactions
... the U.S., Europe and Japan. The most common cancer diagnosis for these patients with allergic reactions was lung cancer followed by breast cancer and ovarian
Stem cell protein offers a new cancer target
...rectly that LIN28 can transform cells to a cancerous state, and that it is abundant in a variety of advanced human cancers, particularly liver cancer, ovarian
cancer, chronic myeloid leukemia, germ cell tumors and Wilm's tumor (a childhood kidney cancer). They believe that overall, LIN28 and a related protei...
NAU discovery could help feed millions
...he sterilization technology derived from Mayer's research, done by Patricia Hoyer and and Glenn Sipes at UofA, investigated potential damage caused to ovarian
follicles in women exposed to certain chemicals in industrial settings. Of particular interest was a chemical compound known as 4-vinylcyclohexene die...
ACLU -- Myriad Genetics lawsuit will become landmark case
... Genetic Engineering & Biotechnology News (GEN). ( www.genengnews.com ) The ACLU charged that the patenting of two human genes linked to breast and ovarian
cancer will inhibit medical research. The organization also claims that the patents are invalid and unconstitutional.
"This is going to turn into o...
Association for Molecular Pathology joins ACLU to challenge gene patents
...lawsuit charging that patents on two human genes associated with breast and ovarian
cancer are unconstitutional and should be invalidated. Individuals with cer...A2, are at a significantly higher risk for developing hereditary breast and ovarian
The lawsuit, Association for Molecular Pathology, et al. v. U....
Breast health center gives TGen new research opportunities
...curate diagnostic tests and smarter treatment options for newly-diagnosed breast cancer patients,'' said Dr. Heather Cunliffe, head of TGen's Breast & ovarian
Cancer Research Unit.
The new center is located in John C. Lincoln's Medical Offices 3, 19646 N. 27th Ave., just southwest of Interstate 17 and Loo...
UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs
...ancer, his findings could have relevance to other cancers that show aggressive properties. For example, Muc4 is also expressed in pancreatic, lung and ovarian
"Muc4 is likely a central cellular mechanism for metastasis of many cancers, and we will be continuing this important work to prove th...
AIUM presents 2009 William J. Fry Memorial Lecture award
Dr Kurtz has been involved in 8 grants, including one as principal investigator of a multicenter study on the diagnosis and staging of ovarian
cancer, awarded by the National Cancer Institute of the National Institutes of Health. The recipient of the AIUM William J. Fry Memorial Lecture award...
Two Hutchinson Center researchers named HHMI Early Career Scientists
... role of DNA repair in promoting drug resistance in cancer cells. He identified a repair pathway that is often inactivated in patients with breast and ovarian
cancers, as well as the childhood predisposition to cancer known as Fanconi anemia. Reactivation of the pathway, he discovered, can help tumors become...
2009 Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research
...hD, Fred Hutchinson Cancer Research Center, Seattle: for Early Detection of ovarian
and Lung Cancers
For many years, scientists have unsuccessfully attempte... the development of a highly sensitive blood test for cancers, particularly ovarian
and lung, both of which are notoriously difficult to detect in their initia...
AIUM to Host 2009 Annual Convention in New York
...2) Guided Tour of the Fetal Heart: Step by Step; (3) Doppler Critical Care Ultrasound: Current Applications and Future Challenges; and (4) Recognizing ovarian
Cancer and How to Screen for It.
Easton honored with inaugural AACR Outstanding Investigator Award in Breast Cancer Research
...ns of breast cancer. As a result of his work, Easton established the Breast Cancer Linage Consortium, which provided the first estimates of breast and ovarian
cancer risk in BRCA1 mutation carriers and developed a risk model that is used daily in clinics worldwide.
Most recently, Easton assisted in ident...
M.I.N.D. Institute researchers call for fragile X testing throughout the lifespan
...n in the United States.
The premutation can cause attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder in children; primary ovarian
failure (early menopause) in women; and FXTAS, or fragile X- associated tremor-ataxia syndrome, in older adults.
The Hagermans and their colleagues...
Mechanisms of cardiovascular disease and cancer give clues to new therapies
...olecules promoting growth and retarding the natural process of apoptosis (cell death) involved in eliminating cells. Some tumour cells, for example in ovarian
carcinoma, exploit endothelins to suppress their death while migrating to other parts of the body in the metastasis process, enabling the tumour to sp...
December 2008 highlights from Biology of Reproduction
... At the time of birth, mouse ovaries are essentially a bag full of primordial oocytes, around which primordial follicles are forming. This key time in ovarian
development establishes the population of oocytes and follicles and instigates evelopment of a cohort of follicles. If follicles fail to form, the res...