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Association of herpesvirus with lung disorder questioned

Contrary to the results of a recent U.S. study, investigators in Japan found no association between a herpesvirus infection and a potentially life-threatening form of high blood pressure, as reported in the March 1 issue of The Journal of Infectious Diseases, now available online. The researchers reported that they were not able to detect human herpesvirus 8 (HHV-8), also known as the Kap...

University of Manchester makes made-to-measure skin and bones a reality using inkjet printers

Made-to-measure skin and bones, which couldbe used to treat burn victims or patients who have suffered severedisfigurements, may soon be a reality using inkjets which can printhuman cells.Scientists at The University of Manchester have developed thebreakthrough technology which will allow tailor-made tissues and bonesto be grown, simply by inputting their dimensions into a computer....

Yellowstone microbes fueled by hydrogen, according to U. of Colorado study

Microbes living in the brilliantly coloredhot springs of Yellowstone National Park use primarily hydrogen forfuel, a discovery University of Colorado at Boulder researchers saybodes well for life in extreme environments on other planets and couldadd to understanding of bacteria inside the human body.A team of CU-Boulder biologists led by Professor Norman Pace, one ofthe world's leading expe...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

Physicians at Emory University School ofMedicine are conducting a clinical trial using stem cells generatedwithin the bone marrow to grow new blood vessels that could improvecirculation in patients with blockages in the arteries of their legs --a condition called (PVD). Individuals with PVD...

UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims

UCLA investigators reviewed pharmaceutical ads in American medical journals and found that nearly one-third contained no references for medical claims; while the majority of references to published material was available, only a minority of company data-on-file documents were provided upon request; and the majority of original research cited in the ads was funded by or had authors affiliated with...

Researchers find how protein allows insects to detect and respond to pheromones

University of Washington TechTransferrecently licensed software that will give scientists a huge advantagein the fight against disease.The software, known as Rosetta, predicts how proteins fold, informationthat is highly valuable to biological and biomedical researchers.UW Tech Transfer's Digital Ventures licensed Rosetta software withoutcharge to the Institute for Systems Biology (ISB), a...

Signaling protein builds bigger, better bones in mice

In a new study, researchers present a “cautionary tale?about what may go wrong when using the fledgling science of proteomics to devise a diagnostic test for cancer. In the February 16 issue of the Journal of the National Cancer Institute, researchers from The University of Texas M. D. Anderson Cancer Center detail why an experimental test intended to identify early ovarian cancer from a...

Cytoplasm affects the number of vertebrae in carp-goldfish clones

The March 2005 issue of Biology of Reproduction contains a report of some intriguing findings in cloned offspring created when nuclei from one genus of fish were transplanted to enucleated eggs of another genus of fish. The seven offspring, cloned from nuclei of common carp and egg cytoplasm of goldfish, were virtually identical to the nuclear donor species, Cyprinus carpio, in appearance...

Study finds more than one-third of human genome regulated by RNA

For many years, DNA and proteins have beenviewed as the real movers and shakers in genomic studies, with RNA seenas little more than a messenger that shuttles information between thetwo. But researchers from Whitehead Institute for Biomedical Researchand Massachusetts Institute of Technology have discovered that smallRNA molecules called microRNAs regulate thousands of human genes--morethan...

Gene therapy converts dead bone graft to new, living tissue

Researchers have created a way to transform the dead bone of a transplanted skeletal graft into living tissue in an experiment involving mice. The advance, which uses gene therapy to stimulate the body into treating the foreign splint as living bone, is a promising development for the thousands of cancer and trauma patients each year who suffer with fragile and failing bone grafts. The findings w...

Female sex hormones play a vital role in defense against sexually transmitted diseases

Two McMaster University studies, to be published in the Journal of Virology, show that sex hormones have a profound effect on susceptibility of female mice to the herpes simplex virus, type 2 (HSV-2 ), one of the most common sexually transmitted diseases. Charu Kaushic, assistant professor and supervisor of the studies, says the implication of this work is quite significant. "The research...

Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.

Few things about growing older are asinevitable and obvious as “going gray,?yet scientists have been unableto explain the precise cause of this usually unwelcome transformation.In a report posted today on the Web site of the journal Science,researchers from Dana-Farber Cancer Institute and Children’s HospitalBoston say they have found the cellular cause of graying hair whileinvestigating th...

Papers of DNA Pioneer and Nobel Laureate Francis Crick Added to National Library of Medicine’s Profiles in Science Web Site

The National Library of Medicine, a part of the National Institutes of Health, is proud to present an extensive selection from the papers of one of the twentieth century’s greatest scientists, Francis Crick, on its Profiles in Science Web site. Don't miss Crick's This la...

Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems

Deficiencies of growth hormone and similar compounds may reduce cancer and kidney disease late in life, but also may lead to cartilage degeneration and impaired memory and learning ability, according to research at Wake Forest University Baptist Medical Center and four other institutions. The researchers used a rat model to explore the effects of growth hormone and another compound, IGF-1...

NC State scientist finds soft tissue in T. rex bones

Conventional wisdom among paleontologists states that when dinosaurs died and became fossilized, soft tissues didn't preserve ?the bones were essentially transformed into "rocks" through a gradual replacement of all organic material by minerals. New research by a North Carolina State University paleontologist, however, could literally turn that theory inside out. Dr. Mary Schweitzer, assis...

Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells

An estrogen-like chemicalcommonly used to synthesize plastic food containers has been shown toencourage the growth of a specific category of prostate cancer cell,potentially affecting the treatment efficacy for a subset of prostatecancers.According to a study published in the January 1 issue of CancerResearch, such prostate cancer cells proved to be vulnerable toexposure to the chemical BP...

Harnessing microbes, one by one, to build a better nanoworld

Applied Biosystems (NYSE:ABI), an Applera Corporation business, today announced the introduction of the Applied Biosystems Advanced Gene Expression Service Provider Program, a new program for service providers who are interested in accessing Applied Biosystems comprehensive solution for gene expression analysis, including the highly sensitive Expression Array System for whole genome analysis and...

Bone Density Recovers After Teens Stop Injected Contraceptive

Lower bone density appears to recover in adolescent females once they stop using the injected contraceptive depot medroxyprogesterone acetate (DMPA), according to a study funded by the National Institute of Child Health and Human Development of the National Institutes of Health. Previous studies had shown that women who use DMPA, marketed under the brand name Depo-Provera, experience a lo...

NASA links nanobacteria to kidney stones and other diseases

Nanobacteria (NB), a novel self-replicating, mineralizing agent, has been identified by National Aeronautics and Space Administration (NASA) scientists as a potential culprit in kidney stone formation among astronauts. With the potential for future exploratory space missions to the moon and Mars, longer missions, and exposure to the elements of outer space, health is a major concern for astronaut...

Dead zone area in Gulf could be increasing, researchers say

The "dead zone" area of the Gulf of Mexico ?a region that annually suffers from low oxygen which can result in huge marine life losses ?has appeared much earlier this year, meaning it could be potentially larger in 2005 and affect marine life more adversely than normal, researchers are reporting. A team of scientists from Texas A&M University, Texas A&M at Galveston, Louisiana Stat...

New component of the 'brakes' on nerve regeneration found

Among the principal obstacles to regenerating spinal cord and brain cells after injury is the "braking" machinery in neurons that prevents regeneration. While peripheral nerves have no such machinery and can readily regenerate, central nervous system (CNS) neurons have their brakes firmly in place and locked. Now, two groups of scientists have independently found a new component of that b...

Increased risk of osteoporosis associated with gene that one in five people have

About nineteen percent of people have a genetic variation that may increase susceptibility to osteoporosis, a new study reveals. Researchers at Washington University School of Medicine in St. Louis demonstrated that in women the variant gene speeds up the breakdown of estrogen and is associated with low density in the bones of the hip. The study will be reported in the February issue of t...

Single stem cells from bone heal a broken heart

Myocardial infarction results in irreversible damage to the heart that can cause congestive heart failure. The lasting damage results from the limited ability of the myocardium to regenerate and self-repair. Douglas Losordo and colleagues from Tufts University now document the existence of a previously unrecognized subset of human bone marrow–derived stem cells with therapeutic potency for myocar...

Gene therapy promising for growing tooth-supporting bone

A University of Michigan research team has found that introducing a growth factor protein into a mouth wound using gene therapy helped generate bone around dental implants, according to a new paper in the February issue of the journal Molecular Therapy. In a patient with a sizeable mouth wound, replacing a tooth takes more than simply implanting a new one---the patient also needs the bone...

Two are better than one

Cancer patients may one day benefit from treatment with mixtures of customized antibodies. In a study published recently in the Proceedings of the National Academy of Sciences (USA), a team of Weizmann Institute scientists have demonstrated how the right combination might form a web that destroys the cancer cell's communication network, ultimately demobilizing the cell. Three decades of in...

Measuring hormone cuts antibiotic use in half in pneumonia patients

Measuring a hormone in the blood can help doctors greatly reduce the number of days pneumonia patients have to take antibiotics to cure their infection, according to a study to be presented at the American Thoracic Society International Conference on May 24. In the study, pneumonia patients whose level of the hormone procalcitonin was measured during the course of their illness took antibi...

Scientists discover that three overlapping signals in embryo help get the backbone right

A major step in the development of the vertebrate embryo - the establishment of a back that morphs into a brain, spinal cord and muscles - turns out to be so important that the body uses at least three signals to make sure it happens properly. The discovery, reported this month in the journal Developmental Cell by researchers at the University of California, Berkeley, finally explains an...

One gene links newborn neurons with those that die in diseases such as Alzheimer's

In certain parts of the brain, cells called neurons go through a cycle of death and replenishment. New research from Rockefeller University's Fernando Nottebohm, Ph.D., shows that these replaceable neurons share something in common with the neurons that die in people with diseases such as Alzheimer's and Parkinson's: both have unusually low levels of a protein called UCHL1. "It would be ir...

OneWorld Health drug receives 'Orphan' designation from U.S. and European regulatory agencies

The Institute for OneWorld Health, the first nonprofit pharmaceutical company in the U.S., announced today it has received Orphan Drug Designation from the two leading regulatory agencies in the world, the Food and Drug Administration (FDA) and the European Agency for the Evaluation of Medicinal Products (EMEA), for paromomycin to treat visceral leishmaniasis (VL). VL, also known as kala a...

Gladstone investigators discover how resting T cells avoid HIV infection

Scientists have discovered the mechanism that enables some CD4 T cells -- the main target of HIV -- to thwart the virus. The discovery, reported on April 13 in the online version of Nature, could open the door to an entirely new strategy for preventing the spread of HIV infection in the body's cells, according to the senior author of the study, Gladstone Institute of Virology and Immunology Direc...

Mother birds increase progesterone to hatch females

In mammals, sperm from the male determines the sex of the offspring. In birds, however, it is the female's sex chromosome that determines offspring sex. Now, Cornell University researchers think they understand the mechanism that several bird species use to bias the sex ratios of their offspring toward female. By experimenting with domestic chickens, they have determined that the presence...

Alarm pheromone causes aphids to sprout wings

Chemical communication within insect species is often much more sophisticated than expected. When aphids are attacked by predators such as ladybird beetles, they release an alarm pheromone, (E)-â-farnesene, that has long been known to cause other aphids to walk around or drop from the plant. In a paper soon to appear in Ecology Letters, researchers at the University and Max-Planck-Institut...

Whole-body MRI Takes Less Than 20 Min To Scan A Patient's Entire Body For Cancer Spread To Bone

Whole-body MRI with an automatic moving table is effective for evaluating the entire skeleton in patients with suspected bone metastasis (cancer that has spread to the bone from other parts of the body) in a single imaging scan-and it only takes between 15 and 18 minutes, say two different European studies. For one study, researchers from the Clinica Girona in Catalonia, Spain, performed w...

Alcohol consumption disrupts breastfeeding hormones

Despite age-old claims advising breastfeeding moms that alcoholic beverages can improve their nursing performance, researchers at the Monell Chemical Senses Center report that even moderate doses of alcohol affect the hormones responsible for lactation in a counterproductive manner. "This information is important for women," comments lead author Julie Mennella, PhD, a biopsychologist. "If...

Bugs, even 'bad' ones, can be educationally beneficial, new book says

We have much to learn from bad bugs, according to Gilbert Waldbauer, whose book "Insights From Insects: What Bad Bugs Can Teach Us" was published March 1 (Prometheus Books). "We know a lot about pests, because so much money is spent on their research," said Waldbauer, professor emeritus of entomology at the University of Illinois at Urbana-Champaign. Of the 900,000 known species of insect...

Researchers pioneer new gene therapy technique using natural repair process

Harnessing the strength of a natural process that repairs damage to the human genome, a researcher from UT Southwestern Medical Center has helped establish a method of gene therapy that can accurately and permanently correct mutations in disease-causing genes. By artificially initiating a DNA repair process known as homologous recombinat...

Researchers discover key gene involved in bark beetle pheromone production

University of Nevada, Reno scientists have ended a decade-long controversy over the process by which bark beetles make pheromones: they manufacture their own monoterpenes ?the fragrant substances plants produce and which are often used in perfumes. It had been thought that insects and other animals were incapable of making these substances. "The goal of our research is ultimately to contro...

Stem cells in bone marrow replenish mouse ovaries

Previously unrecognized stem cells found in the bone marrow and blood of mice can "restock" a depleted ovary with new egg cells within weeks, according to new research published in this week's issue of the journal Cell. This finding provides direct evidence to overturn a long-held dogma in reproductive biology, that female mice generate egg cells only during fetal development and thus are...

New method shows it is possible to grow bone for grafts within a patient's body

An international team of biomedical engineers has demonstrated for the first time that it is possible to grow healthy new bone reliably in one part of the body and use it to repair damaged bone at a different location. The research, which is based on a dramatic departure from the current practice in tissue engineering, is described in a paper titled "In vivo engineering of organs: The bon...

One hit of crystal meth causes birth defects

A single prenatal dose of methamphetamine ?commonly known as speed ?may be enough to cause long-term neurodevelopmental problems in babies, say University of Toronto researchers. In research published in the August issue of Free Radical Biology and Medicine, U of T pharmacy and pharmacology professor Peter Wells and his colleagues determined that exposing pregnant mice only once to methamp...