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La Jolla Institute discovers novel tumor suppressor

SAN DIEGO (August 3, 2009) La Jolla Institute for Allergy & Immunology researchers studying an enzyme believed to play a role in allergy onset, instead have discovered its previously unknown role as a tumor suppressor that may be important in myeloproliferative diseases and some types of lymphoma...

Got zinc? New zinc research suggests novel therapeutic targets

Everyone knows that vitamins "from A to zinc" are important for good health. Now, a new research study in the August 2009 print issue of the Journal of Leukocyte Biology ( http://www.jleukbio.org ) suggests that zinc may be pointing the way to new therapeutic targets for fighting infections. Spe...

Funxional successfully completes initial clinical trial of FX125L, an anti-inflammatory drug with a novel mechanism of action

CAMBRIDGE (UK). 8th July 2009 / b3c newswire / - Funxional Therapeutics Ltd (Funxional) has announced today the successful completion of the first Phase I study with FX125L , an orally available small molecule which belongs to a new therapeutic class named Broad Spectrum Chemokine Inhibitors ( BS...

International collaboration by scientists culminates in novel ion channels database

An important resource consolidating understanding of the roles played by Ion channels in drug action is now available for scientists and students. The International Union of Basic and Clinical Pharmacology (IUPHAR) announce the publication of a new ion channels database, covering both the voltag...

UC Davis grant zeroes in on novel asthma diagnosis and treatment

DAVIS--An entomology professor at the University of California, Davis who discovered a novel therapeutic target for treating inflammation, has received a three-year $750,000 grant from the American Asthma Foundation to investigate whether his discovery will work on asthma, a chronic disea...

ExcellGene and Khner achieved milestone in development of novel 250 Liter mammalian cell culture bioreactors

May 12, 2009 / b3c newswire / - ExcellGene SA, Monthey and Adolf Kühner AG, Birsfelden announce today that they achieved an important milestone in the development of a revolutionary cell culture technology for scale up and manufacturing from suspension cultured mammalian cells. As part of a...

Study finds novel genetic risk factors for kidney disease

A team of researchers from the United States, the Netherlands and Iceland has identified three genes containing common mutations that are associated with altered kidney disease risk. One of the discovered genes, the UMOD gene, produces Tamm-Horsfall protein, the most common protein in the urine of...

IVCC and Syngenta start project for novel insecticidal active ingredient for malaria control

IVCC and Syngenta, a leading innovator in insecticidal technology, have launched a project to develop a new insecticidal active ingredient for public health applications, as part of IVCC's strategy to break the impasse in development of mosquito control products. Improved and sustainable control ...

MIT: Novel needle could cut medical complications

CAMBRIDGE, Mass.--Each year, hundreds of thousands of people suffer medical complications from hypodermic needles that penetrate too far under their skin. A new device developed by MIT engineers and colleagues aims to prevent this from happening by keeping needles on target. The device, which i...

Ocera Therapeutics licenses novel treatment for acute hepatic encephalopathy from UCLB

LONDON and SAN DIEGO, April 2, 2009 University College London Business PLC (UCLB) and Ocera Therapeutics Inc., a privately held biopharmaceutical company, announced the signing of an exclusive worldwide licensing agreement for UCL-L1V and all assets and technologies related to the compound for th...

Forget the freezer: Research suggests novel way to control water behavior

Researchers may be able to "freeze" water into a solid, not by cooling but by confining it to narrow spaces less than one-millionth of a millimeter wide, according to new results from an interdisciplinary team of scientists and engineers. It's more than a neat trick -- a deeper understanding of...

Breaking the barrier: Discovery of anti-resistance factors and novel ocean drugs

Investigations into coral disease, red tides and other marine environmental issues have led to discoveries of new chemicals as a source for pharmaceuticals. These chemicals function as antibiotics for microorganism providing survival advantages and may be usable in human health care. Research ...

Mayo Clinic researchers suspect a novel gene is causing restless legs syndrome in a large family

JACKSONVILLE, Fla. In 2005, a woman who had trouble sleeping asked Siong-Chi Lin, M.D., for help. Dr. Lin, a sleep disorders specialist at the Mayo Clinic campus in Florida, diagnosed restless legs syndrome. This common neurologic disorder interrupts sleep because of unpleasant sensations in the...

Fighting obesity and illness with a novel approach to nutrition

The syndrome's principal clinical manifestations are abdominal obesity and high levels of a type of blood fat called triglycerides which are a strong predictor for a person's risk for stroke. The potential complications are serious: hardening of the arteries, an increased risk of cardiovascular di...

Studies point to novel target for treating arrhythmias

Abnormal heart rhythms arrhythmias are killers. They strike without warning, causing sudden cardiac death, which accounts for about 10 percent of all deaths in the United States. Vanderbilt investigators have discovered a new molecular mechanism associated with arrhythmias. Their findings, repo...

Salk researchers develop novel glioblastoma mouse model

LA JOLLA, CAResearchers at the Salk Institute for Biological Studies have developed a versatile mouse model of glioblastomathe most common and deadly brain cancer in humansthat closely resembles the development and progression of human brain tumors that arise naturally. "Mouse models of human ...

Stowers Institute's Workman Lab discovers novel histone demethylase protein complex

The Stowers Institute's Workman Lab has discovered a novel histone demethylase protein complex characterized in work published today in Molecular Cell . The Histone H3 protein is an important component of chromatin, the packing material wrapping up chromosomal DNA and preventing unwanted tra...

A little wine boosts omega-3 in the body: Researchers find a novel mechanism for a healthier heart

Moderate alcohol intake is associated with higher levels of omega-3 fatty acids in plasma and red blood cells. This is the major finding of the European study IMMIDIET that will be published in the January issue of the American Journal of Clinical Nutriti on, an official publication of the Americ...

A novel target for therapeutics against Staph infection

Researchers at the Texas A&M Health Science Center Institute of Biosciences and Technology, and the University of Edinburgh have uncovered how a bacterial pathogen interacts with the blood coagulation protein fibrinogen to cause methicillin-resistant Staphylococcus aureus (MRSA) infections, a fi...

Corn researchers discover novel gene shut-off mechanisms

University of Delaware scientists, in collaboration with researchers from the University of Arizona and South Dakota State University, have identified unusual differences in the natural mechanisms that turn off, or "silence," genes in corn. The discovery, which was made by comparing the impact ...

3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), disrupt the quality of life for patients, put a tremendous burden on family caregivers, and cost society billions of dollars annually. The most consistent risk factor for develop...

UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development

DALLAS Oct. 22, 2008 The Bill and Melinda Gates Foundation announced today that it has awarded a UT Southwestern Medical Center scientist a grant to pursue innovative vaccine research. The $100,000 grant to Dr. Ellen Vitetta, director of the Cancer Immunobiology Center at UT Southwestern, is ...

GEN reports on novel tools for deciphering biological networks

New Rochelle, NY, October 17, 2008Systems biology scientists from diverse areas of research are developing a range of methods to model pathways, interpret data, and derive therapeutic targets from biological networks, reports Genetic Engineering and Biotechnology News (GEN). A major focal point of...

Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer

A research team at Cold Spring Harbor Laboratory (CSHL) is clarifying a previously unappreciated way that cellular processes are disrupted in cancer. Last year, scientists from the same CHSL team discovered that a "splicing factor" called SF2/ASF--a protein that changes the instructions for ho...

Children's National researchers develop novel anti-tumor vaccine

WASHINGTON, DCA novel anti-tumor vaccine for neuroblastoma and melanoma developed by scientists and clinicians at Children's National Medical Center in collaboration with investigators from the University of Iowa is showing significant impact on tumor growth in mice, according to new research ...

LIAI launches new division to look at novel approaches to heart disease and inflammation

SAN DIEGO (September 30, 2008) While cholesterol-lowering drugs and new technologies have significantly advanced the nation's battle against heart disease, it continues to rank as the No. 1 killer of U.S. men and women. But if researchers at the La Jolla Institute for Allergy & Immunology (LIAI)...

Conaway Lab identifies novel mechanism for regulation of gene expression

The Stowers Institute's Conaway Lab has demonstrated that an enzyme called Uch37 is kept in check when it is part of a human chromatin remodeling complex, INO80. The results were published in today's issue of Molecular Cell . Uch37 is a "deubiquitinating enzyme" that can remove protein tags (...

Scientists identify novel inhibitor of human microRNA

Scientists at The Wistar Institute and their colleagues have identified, for the first time, a molecule that can regulate microRNAs short strands of RNA that play a vital role in gene expression and are closely associated with cancer. The discovery points the way to the development of a new gener...

Using novel tool, UD researchers dig through cell 'trash' and find treasure

A person's trash can reveal valuable information, as detectives, historians and identity thieves well know. Likewise, a cell's "trash" may yield certain treasures, University of Delaware researchers have found. Using a new technique they developed, scientists at UD's Delaware Biotechnology Inst...

GIANT-Coli: A novel method to quicken discovery of gene function

COLLEGE STATION, Aug. 6, 2008 Think researchers know all there is to know about Escherichia coli, commonly known as E. coli? Think again. "E. coli has more than four thousand genes, and the functions of one-fourth of these remain unknown," says Dr. Deborah Siegele, a biology professor at Texas A&...

Genetic Engineering & Biotechnology News reports on novel hit-to-lead drug discovery

New Rochelle, NY, July 8, 2008Biotech and pharmaceutical firms are developing a host of new technologies designed to streamline the complicated drug discovery process, reports Genetic Engineering and Biotechnology News ( GEN ). Most successful approaches rely on a combination of high-throughput ...

Hebrew University develops novel approach for treating mitochondrial disorders

A novel concept for the treatment of mitochondrial disorders using directed enzyme replacement therapy (DERT) has won for a Hebrew University of Jerusalem doctoral candidate one of this year's Kaye Innovation Awards. The awards were presented at this year's 71st meeting of the Hebrew University Bo...

A novel X-ray source could be brightest in the world

ARGONNE, Ill. (June 20, 2008) The future of high-intensity x-ray science has never been brighter now that scientists at U.S. Department of Energy's Argonne National Laboratory have devised a new type of next generation light sources. "The free electron laser oscillator (X-FELO) we are proposin...

A survivor in Greenland: A novel bacterial species is found trapped in 120,000-year-old ice

A team of Penn State scientists has discovered a new ultra-small species of bacteria that has survived for more than 120,000 years within the ice of a Greenland glacier at a depth of nearly two miles. The microorganism's ability to persist in this low-temperature, high-pressure, reduced-oxygen, a...

Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure

(PHILADELPHIA) Scientists at Jefferson Medical College have received a five-year, $11.6 million grant from the National Heart, Lung and Blood Institute to study molecular mechanisms of cardiac injury that lead to heart failure and potential repair processes that occur in the adult failing heart. ...

Glypican-3 gene function in regulating body size helps inform novel cancer treatments

Toronto (May 13, 2008) - In a leading study that has implications for the development of novel therapies for a number of breast, lung and ovarian cancers that have lost the expression of a gene called glypican-3 (GPC3), Sunnybrook researchers have discovered how the loss of the GPC3 gene induces o...

UD researchers discover novel 'gene toggles' in world's top food crop

University of Delaware researchers, in collaboration with U.S. and international colleagues, have found a new type of molecule--a kind of micro-switch--that can turn off genes in rice, which is the primary source of food for more than half the world's population. The discovery is reported in the M...

Workman Lab characterizes novel regulator of chromosome function

The Stowers Institute's Workman Lab has shed new light on a novel histone acetyltransferase protein complex called ATAC. Acetyltransferases are enzymes that introduce a new acetyl functional group into histone proteins, a process by which all chromosome functions are controlled. The findings ...

Scientists uncover a novel mechanism that regulates carbon dioxide fixation in plants

A team of Biotechnology and Biological Sciences Research Council (BBSRC) funded scientists at the University of Essex has discovered a new mechanism that slows the process of carbon dioxide fixation in plants. The research, published today (4 March 2008) in the Proceedings of the National Acad...

NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness

Genomatix Software with businesses in Munich, Germany and Ann Arbor, Michigan released today that the group of Kenneth R. Boheler at the National Institute on Aging, National Institutes of Health, Baltimore, Md published some remarkable work on embryonic stem (ES) cells. In their work they first...
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